{"id":"https://openalex.org/W7042841915","doi":null,"title":"The role of canonical and non-canonical inflammasomes in a model of oxidative stress-induced retinal degeneration","display_name":"The role of canonical and non-canonical inflammasomes in a model of oxidative stress-induced retinal degeneration","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W7042841915"},"language":"en","primary_location":{"id":"pmh:oai:tara.tcd.ie:2262/107340","doi":null,"is_oa":true,"landing_page_url":"https://tcdlocalportal.tcd.ie/pls/EnterApex/f?p=800:71:0::::P71_USERNAME:ESILKE","pdf_url":"https://www.tara.tcd.ie/bitstreams/63203f6b-34c6-469d-b783-6abffc0408bf/download","source":{"id":"https://openalex.org/S4306400387","display_name":"Trinity's Access to Research Output (TARA) (Trinity College Dublin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205274468","host_organization_name":"Trinity College Dublin","host_organization_lineage":["https://openalex.org/I205274468"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.tara.tcd.ie/bitstreams/63203f6b-34c6-469d-b783-6abffc0408bf/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061457324","display_name":"Eoin Silke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Silke, Eoin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5061457324"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.05000000074505806,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.0340999998152256,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inflammasome","display_name":"inflammasome","score":0.8259999752044678},{"id":"https://openalex.org/keywords/non-canonical-inflammasome","display_name":"non-canonical inflammasome","score":0.9070000052452087},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8330000042915344},{"id":"https://openalex.org/keywords/retinal-degeneration","display_name":"retinal degeneration","score":0.9959999918937683},{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.9929999709129333},{"id":"https://openalex.org/keywords/sodium-iodate","display_name":"sodium iodate","score":0.8220000267028809},{"id":"https://openalex.org/keywords/pycard","display_name":"PYCARD","score":0.8180000185966492},{"id":"https://openalex.org/keywords/asc","display_name":"ASC","score":0.7739999890327454},{"id":"https://openalex.org/keywords/caspase-11","display_name":"caspase-11","score":0.968999981880188},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.9390000104904175},{"id":"https://openalex.org/keywords/knockout-mice","display_name":"knockout mice","score":0.4390000104904175},{"id":"https://openalex.org/keywords/optical-coherence-tomography","display_name":"optical coherence tomography","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C2781040256","wikidata":"https://www.wikidata.org/wiki/Q7316761","display_name":"Retinal degeneration","level":3,"score":0.8223000168800354},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.7286999821662903},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.7111999988555908},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6603999733924866},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.5785999894142151},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.5252000093460083},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.48539999127388},{"id":"https://openalex.org/C2778024200","wikidata":"https://www.wikidata.org/wiki/Q2346242","display_name":"Retinal pigment epithelium","level":3,"score":0.4754999876022339},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.4066999852657318},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.4036000072956085},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3783000111579895},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.3646000027656555},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32899999618530273},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.328000009059906},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30480000376701355},{"id":"https://openalex.org/C2776253728","wikidata":"https://www.wikidata.org/wiki/Q422964","display_name":"Biliverdin","level":5,"score":0.2800000011920929},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2786000072956085},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.26089999079704285},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2596000134944916},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2574999928474426},{"id":"https://openalex.org/C2778231335","wikidata":"https://www.wikidata.org/wiki/Q4113701","display_name":"Outer nuclear layer","level":3,"score":0.25209999084472656}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:tara.tcd.ie:2262/107340","doi":null,"is_oa":true,"landing_page_url":"https://tcdlocalportal.tcd.ie/pls/EnterApex/f?p=800:71:0::::P71_USERNAME:ESILKE","pdf_url":"https://www.tara.tcd.ie/bitstreams/63203f6b-34c6-469d-b783-6abffc0408bf/download","source":{"id":"https://openalex.org/S4306400387","display_name":"Trinity's Access to Research Output (TARA) (Trinity College Dublin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205274468","host_organization_name":"Trinity College Dublin","host_organization_lineage":["https://openalex.org/I205274468"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"}],"best_oa_location":{"id":"pmh:oai:tara.tcd.ie:2262/107340","doi":null,"is_oa":true,"landing_page_url":"https://tcdlocalportal.tcd.ie/pls/EnterApex/f?p=800:71:0::::P71_USERNAME:ESILKE","pdf_url":"https://www.tara.tcd.ie/bitstreams/63203f6b-34c6-469d-b783-6abffc0408bf/download","source":{"id":"https://openalex.org/S4306400387","display_name":"Trinity's Access to Research Output (TARA) (Trinity College Dublin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205274468","host_organization_name":"Trinity College Dublin","host_organization_lineage":["https://openalex.org/I205274468"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7042841915.pdf","grobid_xml":"https://content.openalex.org/works/W7042841915.grobid-xml"},"referenced_works_count":147,"referenced_works":["https://openalex.org/W774723499","https://openalex.org/W1494802998","https://openalex.org/W1561041814","https://openalex.org/W1568398137","https://openalex.org/W1587650589","https://openalex.org/W1864325817","https://openalex.org/W1882905539","https://openalex.org/W1904683780","https://openalex.org/W1937289336","https://openalex.org/W1963651026","https://openalex.org/W1969157499","https://openalex.org/W1974007609","https://openalex.org/W1974615320","https://openalex.org/W1978437552","https://openalex.org/W1978810668","https://openalex.org/W1979600366","https://openalex.org/W1985144223","https://openalex.org/W1985970823","https://openalex.org/W1989249407","https://openalex.org/W1996609490","https://openalex.org/W1998983498","https://openalex.org/W2000399151","https://openalex.org/W2003605139","https://openalex.org/W2008645520","https://openalex.org/W2008961838","https://openalex.org/W2009361447","https://openalex.org/W2010766264","https://openalex.org/W2014217588","https://openalex.org/W2014855145","https://openalex.org/W2015146412","https://openalex.org/W2016125390","https://openalex.org/W2017213015","https://openalex.org/W2018027031","https://openalex.org/W2020391754","https://openalex.org/W2028145763","https://openalex.org/W2030997154","https://openalex.org/W2031084334","https://openalex.org/W2034060753","https://openalex.org/W2038851979","https://openalex.org/W2039763904","https://openalex.org/W2041102525","https://openalex.org/W2042816890","https://openalex.org/W2049437984","https://openalex.org/W2055743849","https://openalex.org/W2057640140","https://openalex.org/W2059563381","https://openalex.org/W2065688555","https://openalex.org/W2065711792","https://openalex.org/W2066978201","https://openalex.org/W2068186232","https://openalex.org/W2068619092","https://openalex.org/W2077050211","https://openalex.org/W2078761299","https://openalex.org/W2080827095","https://openalex.org/W2083093678","https://openalex.org/W2085006338","https://openalex.org/W2085350682","https://openalex.org/W2086919198","https://openalex.org/W2089443787","https://openalex.org/W2089933045","https://openalex.org/W2092638574","https://openalex.org/W2094655287","https://openalex.org/W2097452332","https://openalex.org/W2102167881","https://openalex.org/W2103713988","https://openalex.org/W2105123991","https://openalex.org/W2107486945","https://openalex.org/W2111099155","https://openalex.org/W2111274886","https://openalex.org/W2111586778","https://openalex.org/W2114546997","https://openalex.org/W2114769428","https://openalex.org/W2121723196","https://openalex.org/W2123215356","https://openalex.org/W2138478750","https://openalex.org/W2140126848","https://openalex.org/W2141411144","https://openalex.org/W2150110941","https://openalex.org/W2165275387","https://openalex.org/W2168995138","https://openalex.org/W2280558486","https://openalex.org/W2281454339","https://openalex.org/W2283663091","https://openalex.org/W2327009295","https://openalex.org/W2338568151","https://openalex.org/W2340046691","https://openalex.org/W2346093243","https://openalex.org/W2396750697","https://openalex.org/W2472557182","https://openalex.org/W2497398522","https://openalex.org/W2517997111","https://openalex.org/W2521454951","https://openalex.org/W2531412645","https://openalex.org/W2606744247","https://openalex.org/W2622806731","https://openalex.org/W2736346397","https://openalex.org/W2753576522","https://openalex.org/W2759013304","https://openalex.org/W2768387192","https://openalex.org/W2785175972","https://openalex.org/W2794112735","https://openalex.org/W2799515142","https://openalex.org/W2802310167","https://openalex.org/W2802512625","https://openalex.org/W2891392925","https://openalex.org/W2895986434","https://openalex.org/W2903716049","https://openalex.org/W2910704006","https://openalex.org/W2944111278","https://openalex.org/W2945213030","https://openalex.org/W2948083501","https://openalex.org/W2949099671","https://openalex.org/W2954782052","https://openalex.org/W2982596093","https://openalex.org/W2987816919","https://openalex.org/W2992534356","https://openalex.org/W2995314841","https://openalex.org/W2998643329","https://openalex.org/W3003585261","https://openalex.org/W3005365256","https://openalex.org/W3016482728","https://openalex.org/W3017005721","https://openalex.org/W3037870764","https://openalex.org/W3043630336","https://openalex.org/W3092528327","https://openalex.org/W3110912007","https://openalex.org/W3111254331","https://openalex.org/W3112273957","https://openalex.org/W3135340356","https://openalex.org/W3135885187","https://openalex.org/W3160777054","https://openalex.org/W3175670780","https://openalex.org/W3180945348","https://openalex.org/W3194696392","https://openalex.org/W3194753000","https://openalex.org/W3196772752","https://openalex.org/W3197408017","https://openalex.org/W3210432080","https://openalex.org/W4205737377","https://openalex.org/W4210681997","https://openalex.org/W4211020962","https://openalex.org/W4220766035","https://openalex.org/W4220972884","https://openalex.org/W4248078302","https://openalex.org/W4281666835","https://openalex.org/W4309654419","https://openalex.org/W4310367452"],"related_works":["https://openalex.org/W3005365256","https://openalex.org/W4403116327","https://openalex.org/W4402926150","https://openalex.org/W7134952245","https://openalex.org/W3194696392","https://openalex.org/W2949099671","https://openalex.org/W2899359307","https://openalex.org/W2012424112","https://openalex.org/W4402631160","https://openalex.org/W2613723678"],"abstract_inverted_index":{"Retinal":[0],"degenerative":[1],"diseases":[2],"like":[3],"age-related":[4],"macular":[5],"degeneration":[6,31,72,88],"(AMD)":[7],"are":[8,101],"a":[9,43],"leading":[10],"cause":[11],"of":[12,25,48,59,92,110,142],"visual":[13],"impairment.":[14],"Oxidative":[15],"stress":[16],"is":[17,42,54,63],"known":[18],"to":[19,65,74,149],"be":[20,33],"important":[21,68],"in":[22,70,84,89,103,117,124,138],"the":[23,108],"pathogenesis":[24],"AMD,":[26],"and":[27,81,97,132,160],"oxidative-stress":[28],"induced":[29,170],"retinal":[30,49,71,87,153,171],"can":[32],"studied":[34],"using":[35],"various":[36],"models.":[37],"The":[38],"sodium":[39,85],"iodate":[40],"mouse":[41],"widely":[44],"used":[45],"animal":[46],"model":[47],"degeneration,":[50],"but":[51],"its":[52],"pathobiology":[53],"not":[55,147],"well":[56],"understood.":[57],"Activation":[58],"innate":[60],"immune":[61],"pathways":[62,165],"suspected":[64],"play":[66],"an":[67],"role":[69],"secondary":[73],"oxidative":[75,151,168],"stress.":[76],"We":[77],"investigated":[78],"both":[79],"canonical":[80,111,143],"non-canonical":[82,120,163],"inflammasomes":[83,112],"iodate-induced":[86],"two":[90],"types":[91],"genetic":[93],"knockout":[94],"mice":[95,100],"(Pycard-/-":[96],"Casp11-/-).":[98],"Pycard-/-":[99,139],"deficient":[102],"ASC":[104],"protein":[105],"which":[106],"prevents":[107,119],"majority":[109],"from":[113],"forming,":[114],"whereas":[115],"deficiency":[116],"caspase-11":[118],"inflammasome":[121,144,164],"activation.":[122],"Using":[123],"vivo":[125],"optical":[126],"coherence":[127],"tomography":[128],"measurements,":[129],"histological":[130],"analysis,":[131],"TUNEL":[133],"staining":[134],"we":[135],"observed":[136],"that":[137],"mice,":[140],"loss":[141],"formation":[145],"did":[146],"appear":[148],"affect":[150],"stress-induced":[152],"damage.":[154],"However,":[155],"knocking":[156],"out":[157],"caspase-":[158],"11":[159],"thus":[161],"inhibiting":[162],"may":[166],"limit":[167],"stress-":[169],"degeneration.":[172]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}
