{"id":"https://openalex.org/W7038727206","doi":null,"title":"Integrative neural behavior in a mammalian nervous system revealed using calcium imaging","display_name":"Integrative neural behavior in a mammalian nervous system revealed using calcium imaging","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W7038727206"},"language":"en","primary_location":{"id":"pmh:oai:pqdtoai.proquest.com:3434068","doi":null,"is_oa":false,"landing_page_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3434068","pdf_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3434068","source":{"id":"https://openalex.org/S7407064308","display_name":"ProQuest Demo Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Bayguinov, Peter Orlinov","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Bayguinov, Peter Orlinov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12237","display_name":"Congenital gastrointestinal and neural anomalies","score":0.06430000066757202,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/migrating-motor-complex","display_name":"migrating motor complex","score":0.7919999957084656},{"id":"https://openalex.org/keywords/enteric-nervous-system","display_name":"enteric nervous system","score":0.8920000195503235},{"id":"https://openalex.org/keywords/colonic-motility","display_name":"colonic motility","score":0.6650000214576721},{"id":"https://openalex.org/keywords/calcium-imaging","display_name":"calcium imaging","score":0.8560000061988831},{"id":"https://openalex.org/keywords/enteric-neurons","display_name":"enteric neurons","score":0.675000011920929},{"id":"https://openalex.org/keywords/myenteric-plexus","display_name":"myenteric plexus","score":0.8489999771118164},{"id":"https://openalex.org/keywords/inhibitory-motor-neurons","display_name":"inhibitory motor neurons","score":0.7429999709129333},{"id":"https://openalex.org/keywords/enterochromaffin-cells","display_name":"enterochromaffin cells","score":0.9380000233650208},{"id":"https://openalex.org/keywords/5-ht3-receptor","display_name":"5-HT3 receptor","score":0.8790000081062317},{"id":"https://openalex.org/keywords/hirschsprung-disease","display_name":"Hirschsprung disease","score":0.8679999709129333},{"id":"https://openalex.org/keywords/aganglionosis","display_name":"aganglionosis","score":0.9599999785423279},{"id":"https://openalex.org/keywords/interstitial-cells-of-cajal","display_name":"interstitial cells of Cajal","score":0.8019999861717224},{"id":"https://openalex.org/keywords/mitotracker","display_name":"MitoTracker","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C2777439022","wikidata":"https://www.wikidata.org/wiki/Q586582","display_name":"Enteric nervous system","level":2,"score":0.899399995803833},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7788000106811523},{"id":"https://openalex.org/C2776032975","wikidata":"https://www.wikidata.org/wiki/Q5018833","display_name":"Calcium imaging","level":3,"score":0.7185999751091003},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.6337000131607056},{"id":"https://openalex.org/C2776907353","wikidata":"https://www.wikidata.org/wiki/Q1890233","display_name":"Myenteric plexus","level":3,"score":0.6068000197410583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5537999868392944},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.5468999743461609},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.5152999758720398},{"id":"https://openalex.org/C2781199646","wikidata":"https://www.wikidata.org/wiki/Q739865","display_name":"Submucous plexus","level":4,"score":0.45989999175071716},{"id":"https://openalex.org/C201539569","wikidata":"https://www.wikidata.org/wiki/Q2596185","display_name":"Interstitial cell of Cajal","level":3,"score":0.4537999927997589},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.40400001406669617},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.3828999996185303},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.37220001220703125},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3628000020980835},{"id":"https://openalex.org/C171139928","wikidata":"https://www.wikidata.org/wiki/Q2915553","display_name":"Motor system","level":2,"score":0.3531999886035919},{"id":"https://openalex.org/C33789571","wikidata":"https://www.wikidata.org/wiki/Q410959","display_name":"Muscarinic acetylcholine receptor","level":3,"score":0.3264000117778778},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.3255000114440918},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.3073999881744385},{"id":"https://openalex.org/C152478114","wikidata":"https://www.wikidata.org/wiki/Q660910","display_name":"Neurophysiology","level":2,"score":0.29670000076293945},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.28859999775886536},{"id":"https://openalex.org/C2777372248","wikidata":"https://www.wikidata.org/wiki/Q171064","display_name":"Autonomic nervous system","level":4,"score":0.28760001063346863},{"id":"https://openalex.org/C104966671","wikidata":"https://www.wikidata.org/wiki/Q12167532","display_name":"Cholinergic neuron","level":3,"score":0.28700000047683716},{"id":"https://openalex.org/C2778562939","wikidata":"https://www.wikidata.org/wiki/Q1298791","display_name":"Synchronization (alternating current)","level":3,"score":0.28610000014305115},{"id":"https://openalex.org/C2780196419","wikidata":"https://www.wikidata.org/wiki/Q1762173","display_name":"Nerve net","level":2,"score":0.27000001072883606},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.266400009393692},{"id":"https://openalex.org/C103072069","wikidata":"https://www.wikidata.org/wiki/Q5058372","display_name":"Cellular neuroscience","level":2,"score":0.26570001244544983},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.25040000677108765}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:pqdtoai.proquest.com:3434068","doi":null,"is_oa":false,"landing_page_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3434068","pdf_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3434068","source":{"id":"https://openalex.org/S7407064308","display_name":"ProQuest Demo Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1547991634","https://openalex.org/W1950051402","https://openalex.org/W4410878820","https://openalex.org/W4315488019","https://openalex.org/W4311428473","https://openalex.org/W2213993614","https://openalex.org/W4315434537","https://openalex.org/W1577107970","https://openalex.org/W4313855442","https://openalex.org/W4253851817"],"abstract_inverted_index":{"Historically,":[0],"research":[1,57],"on":[2,47,58,492],"nervous":[3,36,90,666],"systems":[4],"has":[5,39,312],"been":[6,40],"hindered":[7],"by":[8,438],"the":[9,15,24,33,41,64,77,88,93,102,118,121,128,137,141,167,215,248,257,276,307,322,327,331,334,348,356,368,385,416,443,452,455,470,473,487,493,508,536,541,547,555,563,589,606,623,628,633,639],"complexity":[10],"of":[11,32,43,52,79,82,92,127,134,152,157,214,221,240,250,259,268,278,298,303,333,350,418,445,454,489,510,528,535,551,562,608,632,659],"such":[12,514],"systems,":[13],"and":[14,84,123,159,193,201,228,231,234,286,300,354,403,468,526,565,576,600,610,630],"inability":[16],"to":[17,75,148,207,246,274,290,338,375,442,463,485,502,559,583,669],"record":[18],"activity":[19,249,417],"in":[20,67,87,112,166,187,306,330,336,342,347,367,391,396,415,472,507,546,554,580,638,649,656,663],"multiple":[21],"neurons":[22,83,252,260,281,374,397,522],"at":[23],"same":[25],"time.":[26],"As":[27],"such,":[28],"our":[29,657],"current":[30],"understanding":[31,658],"way":[34],"a":[35,98,131,150,172,244,266,377,412,431,503,644,664,671],"system":[37,91,667],"functions":[38,78,668],"result":[42],"electrophysiological":[44],"studies":[45,428,593,647],"performed":[46],"single,":[48],"or":[49,587],"small":[50],"groups":[51],"neurons,":[53,223,226,294,296,317,408,420,517],"as":[54,56,155,243,326,409,411,469],"well":[55,410],"relatively":[59],"simple":[60],"invertebrate":[61],"models.":[62],"In":[63],"work":[65,311],"presented":[66],"this":[68,650],"dissertation,":[69],"we":[70,116,179,271,380,483,572],"have":[71,180,272,287,381,429,597],"used":[72,289],"imaging":[73,111,242,533],"techniques":[74,269],"explore":[76],"several":[80],"classes":[81,220,302],"auxiliary":[85],"cells":[86,305,344,366],"enteric":[89,153,191,222,251,280,516],"murine":[94,308,474,640],"large":[95,475,641],"bowel":[96,476],"during":[97,140,384,540],"compound":[99],"motor":[100,105,236,293,407,425,615,636,674],"behavior,":[101],"colonic":[103,432,439,490,499,634],"migrating":[104,511,635],"complex":[106,637,672],"(CMMC).":[107],"Using":[108,171,569],"low-powered":[109],"Ca2+":[110,164,241,530,532,548],"whole":[113],"tissue":[114],"preparations,":[115],"explored":[117],"relationship":[119],"between":[120,136],"longitudinal":[122,564],"circular":[124,566],"muscle":[125,169,567],"layers":[126,139],"colon,":[129,556],"showing":[130],"high":[132],"degree":[133],"synchronization":[135,144,561],"two":[138,168],"CMMC.":[142,378,494],"This":[143,263,458],"is":[145,388,436,461,477],"further":[146],"shown":[147,181,382],"be":[149],"function":[151],"innervation,":[154,192],"addition":[156],"nicotinic":[158],"muscarinic":[160,599],"antagonists":[161],"disrupted":[162],"coordinated":[163],"waves":[165,196],"layers.":[170,568],"mouse":[173],"model":[174],"for":[175,401,479],"Hirschsprung\u2019s":[176],"disease":[177],"(aganglionosis),":[178],"that":[182,189,197,361,383,398,498,595,626],"CMMCs":[183],"do":[184,202],"not":[185,203],"occur":[186],"mice":[188],"lack":[190],"Ca":[194,392],"2+":[195,393],"persist":[198],"are":[199,557,604],"unsynchronized,":[200],"propagate":[204],"sufficient":[205],"distances":[206],"generate":[208,376,670],"pellet":[209,481],"propulsion.":[210],"The":[211,238],"myenteric":[212,537],"plexus":[213,538],"colon":[216],"contains":[217],"13":[218],"different":[219,301],"including":[224,518],"sensory":[225,295],"ascending":[227],"descending":[229,447],"interneurons,":[230,449],"both":[232,574,598],"excitatory":[233,406,575,614],"inhibitory":[235,292,424,448,577],"neurons.":[237,426,616],"use":[239],"technique":[245],"study":[247],"provided":[253],"little":[254],"information":[255],"regarding":[256],"class":[258],"being":[261],"observed.":[262],"dissertation":[264,651],"details":[265],"number":[267],"which":[270,318,421,435,450,585,603],"developed":[273],"facilitate":[275],"identification":[277],"these":[279,343,618],"using":[282],"post":[283],"hoc":[284],"staining,":[285],"subsequently":[288],"identify":[291],"types":[297],"interneurons":[299],"interstitial":[304],"colon.":[309],"Our":[310,495],"identified":[313,430],"AH/Dogiel":[314,371,519],"Type":[315,372,520],"II":[316,373,521],"stained":[319],"intensely":[320],"with":[321],"mitochondrial":[323],"marker,":[324],"Mitotracker,":[325],"first":[328],"responders":[329],"generation":[332,629],"CMMC":[335,471,542],"response":[337],"mucosal":[339],"stimulations.":[340],"Responses":[341],"were":[345,404,422],"abolished":[346],"presence":[349],"5-HT3":[351],"receptor":[352],"antagonists,":[353],"when":[355],"mucosa":[357,369],"was":[358],"removed,":[359],"suggesting":[360],"5-HT":[362],"release":[363,612],"from":[364,613],"enterochromaffin":[365],"activates":[370],"Furthermore,":[379],"CMMC,":[386],"there":[387],"an":[389,544,653],"increase":[390,545],"transient":[394,549],"frequency":[395,527,550],"tested":[399],"negative":[400],"NOS,":[402],"presumably":[405],"marked":[413],"decrease":[414],"NOS+ve":[419],"likely":[423,605],"Recent":[427],"occult":[433,459],"reflex,":[434],"activated":[437,586],"elongation,":[440,515],"leading":[441],"activation":[444,453],"mechanosensitive":[446],"inhibit":[451],"peristaltic":[456],"reflex.":[457],"reflex":[460],"thought":[462],"underlie":[464,560],"slow":[465],"transit":[466],"constipation,":[467],"responsible":[478],"fecal":[480],"propulsion,":[482],"sought":[484],"establish":[486],"effects":[488],"elongation":[491,500],"findings":[496,619],"show":[497],"led":[501],"nitric":[504],"oxide-mediated":[505],"reduction":[506],"amplitude":[509,525],"complexes.":[512],"During":[513],"exhibited":[523],"reduced":[524],"spontaneous":[529],"transients.":[531],"experiments":[534],"region":[539],"revealed":[543,594],"ICC-MY,":[552,584],"which,":[553],"believed":[558],"high-power":[570],"imaging,":[571],"observed":[573],"nerve":[578],"varicosities":[579],"close":[581],"apposition":[582],"inactivated":[588],"cells,":[590],"respectively.":[591],"Pharmacological":[592],"ICC-MY":[596],"NK1":[601],"receptors,":[602],"targets":[607],"ACh":[609],"TK":[611],"Collectively":[617],"offer":[620],"insight":[621],"into":[622],"neuronal":[624],"mechanism":[625],"underlies":[627],"propagation":[631],"intestine.":[642],"From":[643],"larger":[645],"perspective,":[646],"described":[648],"represent":[652],"important":[654],"step":[655],"how":[660],"neural":[661],"networks":[662],"mammalian":[665],"rhythmic":[673],"behavior.":[675]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-10-10T00:00:00"}
