{"id":"https://openalex.org/W7038612633","doi":null,"title":"Investigation of immune quiescence: assessing the role of regulatory T cells and their link with IRF-1 in HIV-exposed sero-negative individuals","display_name":"Investigation of immune quiescence: assessing the role of regulatory T cells and their link with IRF-1 in HIV-exposed sero-negative individuals","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W7038612633"},"language":"en","primary_location":{"id":"pmh:oai:mspace.lib.umanitoba.ca:1993/31977","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1993/31977","pdf_url":"http://hdl.handle.net/1993/31977","source":{"id":"https://openalex.org/S4306400554","display_name":"Mspace (University of Manitoba)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I46247651","host_organization_name":"University of Manitoba","host_organization_lineage":["https://openalex.org/I46247651"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1993/31977","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Abdullahi, Abdirahman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Abdullahi, Abdirahman","raw_affiliation_strings":["MASTER OF SCIENCE Department of Medical Microbiology and Infectious Diseases University of Manitoba Winnipeg , Manitoba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MASTER OF SCIENCE Department of Medical Microbiology and Infectious Diseases University of Manitoba Winnipeg , Manitoba","institution_ids":["https://openalex.org/I46247651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I46247651"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.8773999810218811,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.8773999810218811,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.11469999700784683,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-quiescence","display_name":"immune quiescence","score":0.9710000157356262},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9929999709129333},{"id":"https://openalex.org/keywords/irf-1","display_name":"IRF1","score":0.9679999947547913},{"id":"https://openalex.org/keywords/sex-workers","display_name":"sex workers","score":0.8230000138282776},{"id":"https://openalex.org/keywords/ctla-4","display_name":"CTLA-4","score":0.8650000095367432},{"id":"https://openalex.org/keywords/hiv-seroconversion","display_name":"HIV seroconversion","score":0.8489999771118164},{"id":"https://openalex.org/keywords/cd4-t-cell-proliferation","display_name":"CD4+ T cell proliferation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/cd8-t-cell-expansion","display_name":"CD8+ T cell proliferation","score":0.9369999766349792}],"concepts":[{"id":"https://openalex.org/C144251240","wikidata":"https://www.wikidata.org/wiki/Q7068229","display_name":"Nucleofection","level":4,"score":0.44859999418258667},{"id":"https://openalex.org/C2778283623","wikidata":"https://www.wikidata.org/wiki/Q18032200","display_name":"TSG101","level":5,"score":0.36419999599456787},{"id":"https://openalex.org/C2992336715","wikidata":"https://www.wikidata.org/wiki/Q63431143","display_name":"Gestational period","level":4,"score":0.3301999866962433},{"id":"https://openalex.org/C133074676","wikidata":"https://www.wikidata.org/wiki/Q428729","display_name":"Fusible alloy","level":2,"score":0.31470000743865967},{"id":"https://openalex.org/C18743360","wikidata":"https://www.wikidata.org/wiki/Q1208096","display_name":"Diafiltration","level":4,"score":0.30300000309944153},{"id":"https://openalex.org/C2777054765","wikidata":"https://www.wikidata.org/wiki/Q6402731","display_name":"Dysgeusia","level":3,"score":0.28619998693466187},{"id":"https://openalex.org/C145741570","wikidata":"https://www.wikidata.org/wiki/Q7251534","display_name":"Proteogenomics","level":5,"score":0.2851000130176544},{"id":"https://openalex.org/C2777158700","wikidata":"https://www.wikidata.org/wiki/Q1419356","display_name":"Hyporeflexia","level":3,"score":0.2816999852657318},{"id":"https://openalex.org/C104545631","wikidata":"https://www.wikidata.org/wiki/Q464858","display_name":"Demotion","level":3,"score":0.25850000977516174},{"id":"https://openalex.org/C2781032047","wikidata":"https://www.wikidata.org/wiki/Q938793","display_name":"Articular cartilage damage","level":5,"score":0.2563000023365021},{"id":"https://openalex.org/C2777935831","wikidata":"https://www.wikidata.org/wiki/Q3144949","display_name":"Hemopericardium","level":3,"score":0.2522999942302704},{"id":"https://openalex.org/C2909186138","wikidata":"https://www.wikidata.org/wiki/Q1500373","display_name":"Hyperlactatemia","level":2,"score":0.25}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:mspace.lib.umanitoba.ca:1993/31977","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1993/31977","pdf_url":"http://hdl.handle.net/1993/31977","source":{"id":"https://openalex.org/S4306400554","display_name":"Mspace (University of Manitoba)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I46247651","host_organization_name":"University of Manitoba","host_organization_lineage":["https://openalex.org/I46247651"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"}],"best_oa_location":{"id":"pmh:oai:mspace.lib.umanitoba.ca:1993/31977","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1993/31977","pdf_url":"http://hdl.handle.net/1993/31977","source":{"id":"https://openalex.org/S4306400554","display_name":"Mspace (University of Manitoba)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I46247651","host_organization_name":"University of Manitoba","host_organization_lineage":["https://openalex.org/I46247651"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7038612633.pdf","grobid_xml":"https://content.openalex.org/works/W7038612633.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W162579416","https://openalex.org/W1499151513","https://openalex.org/W1539668795","https://openalex.org/W1575585006","https://openalex.org/W1610273108","https://openalex.org/W1947063131","https://openalex.org/W1967018933","https://openalex.org/W1977836556","https://openalex.org/W1982081931","https://openalex.org/W1982855578","https://openalex.org/W1983019708","https://openalex.org/W1984909066","https://openalex.org/W1994047615","https://openalex.org/W1995252006","https://openalex.org/W1996532235","https://openalex.org/W2001360021","https://openalex.org/W2002726823","https://openalex.org/W2005227771","https://openalex.org/W2007631222","https://openalex.org/W2013010265","https://openalex.org/W2014634158","https://openalex.org/W2019077533","https://openalex.org/W2019508559","https://openalex.org/W2021603971","https://openalex.org/W2024213191","https://openalex.org/W2024958407","https://openalex.org/W2032478431","https://openalex.org/W2037013975","https://openalex.org/W2043791508","https://openalex.org/W2043991288","https://openalex.org/W2046553170","https://openalex.org/W2048999843","https://openalex.org/W2049345643","https://openalex.org/W2055971044","https://openalex.org/W2060905466","https://openalex.org/W2063468515","https://openalex.org/W2068366465","https://openalex.org/W2072853625","https://openalex.org/W2082858693","https://openalex.org/W2083451344","https://openalex.org/W2084786488","https://openalex.org/W2096345245","https://openalex.org/W2097811455","https://openalex.org/W2098018589","https://openalex.org/W2099470418","https://openalex.org/W2101465926","https://openalex.org/W2107242383","https://openalex.org/W2108399976","https://openalex.org/W2110307583","https://openalex.org/W2110898276","https://openalex.org/W2111329034","https://openalex.org/W2114146889","https://openalex.org/W2116015828","https://openalex.org/W2116824693","https://openalex.org/W2117631259","https://openalex.org/W2121212732","https://openalex.org/W2121250603","https://openalex.org/W2125503507","https://openalex.org/W2125586839","https://openalex.org/W2127031590","https://openalex.org/W2128211931","https://openalex.org/W2131152496","https://openalex.org/W2131745573","https://openalex.org/W2132996176","https://openalex.org/W2133833496","https://openalex.org/W2148226248","https://openalex.org/W2152640863","https://openalex.org/W2153389047","https://openalex.org/W2161414269","https://openalex.org/W2162703129","https://openalex.org/W2165367950","https://openalex.org/W2166192929","https://openalex.org/W2166653928","https://openalex.org/W2167116215","https://openalex.org/W2169223579","https://openalex.org/W2169820627","https://openalex.org/W2240372320","https://openalex.org/W2420987345"],"related_works":["https://openalex.org/W1521509641","https://openalex.org/W2084444317","https://openalex.org/W2071086156","https://openalex.org/W2098018589","https://openalex.org/W7070669115","https://openalex.org/W2237356682","https://openalex.org/W2114146889","https://openalex.org/W7095846923","https://openalex.org/W2103367520","https://openalex.org/W2119546576"],"abstract_inverted_index":{"Recent":[0],"research":[1],"of":[2,5,43,67,116,120,133],"a":[3,48,127],"cohort":[4],"HIV":[6,149],"exposed":[7],"sero-negative":[8],"(HESN)":[9],"female":[10],"commercial":[11],"sex":[12],"workers":[13],"in":[14,34,57,71,98,118,140],"Nairobi":[15],"has":[16],"revealed":[17,136],"an":[18,70,102],"Immune":[19],"Quiescent":[20],"phenotype;":[21],"characterized":[22,91],"by":[23,69,78,123],"reduced":[24,114],"T":[25,31],"cell":[26],"activation":[27],"and":[28,75,86,96,100,108],"higher":[29],"regulatory":[30,45],"cells":[32],"(Tregs)":[33],"peripheral":[35],"blood.":[36],"HESN":[37,99],"women":[38],"also":[39,112],"express":[40],"lower":[41],"levels":[42],"interferon":[44],"factor-1":[46],"(IRF-1),":[47],"critical":[49],"regulator":[50],"known":[51],"to":[52],"negatively":[53],"impact":[54],"Treg":[55,109,144],"development":[56],"mice.":[58],"In":[59,126],"this":[60],"study,":[61,129],"we":[62],"analyzed":[63],"the":[64,92],"functional":[65],"capacity":[66],"Tregs":[68,83,95,119],"vitro":[72],"depletion":[73],"assay":[74],"measured":[76],"functionality":[77],"flow":[79,124,130],"cytometry.":[80,125],"Data":[81],"showed":[82],"suppressed":[84],"CD4+":[85],"CD8+":[87],"proliferation":[88],"responses.":[89],"We":[90,111],"link":[93],"between":[94,105],"IRF-1":[97,106,117],"observed":[101],"inverse":[103],"correlation":[104],"expression":[107,115,139],"proportions.":[110],"established":[113],"healthy":[121],"donors":[122],"separate":[128],"cytometric":[131],"analysis":[132],"high-risk":[134],"sex-workers":[135],"that":[137],"CTLA-4":[138],"memory":[141],"CD4+cells,":[142],"not":[143],"frequency,":[145],"was":[146],"associated":[147],"with":[148],"seroconversion.":[150]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}
