{"id":"https://openalex.org/W70375962","doi":null,"title":"Autoantibody to heat-shock protein 90 can mediate protection against systemic candidosis.","display_name":"Autoantibody to heat-shock protein 90 can mediate protection against systemic candidosis.","publication_year":1991,"publication_date":"1991-09-01","ids":{"openalex":"https://openalex.org/W70375962","mag":"70375962","pmid":"https://pubmed.ncbi.nlm.nih.gov/1718852","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384665"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1384665","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384665","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384665","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113541938","display_name":"Ruth Matthews","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R C Matthews","raw_affiliation_strings":["Department of Medical Microbiology, Manchester University Medical School, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology, Manchester University Medical School, U.K","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060930532","display_name":"J. Burnie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J P Burnie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030951176","display_name":"David W. Howat","orcid":"https://orcid.org/0000-0001-7296-4165","observed_orcids":["https://orcid.org/0000-0001-7296-4165"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Howat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"T Rowland","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Rowland","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"F Walton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Walton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.6253,"has_fulltext":false,"cited_by_count":146,"citation_normalized_percentile":{"value":0.97418801,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"74","issue":"1","first_page":"20","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9077000021934509,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9077000021934509,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.07320000231266022,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.9380000233650208},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.9629999995231628},{"id":"https://openalex.org/keywords/systemic-candidiasis","display_name":"systemic candidiasis","score":0.8899999856948853},{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.9959999918937683},{"id":"https://openalex.org/keywords/epitope-mapping","display_name":"epitope mapping","score":0.7229999899864197},{"id":"https://openalex.org/keywords/immunoglobulins","display_name":"immunoglobulins","score":0.49000000953674316},{"id":"https://openalex.org/keywords/passive-immunization","display_name":"passive immunization","score":0.5740000009536743},{"id":"https://openalex.org/keywords/protective-immunity","display_name":"protective immunity","score":0.4410000145435333},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.849014401435852},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7247593402862549},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.7225590944290161},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.7185747027397156},{"id":"https://openalex.org/C2779959462","wikidata":"https://www.wikidata.org/wiki/Q29887808","display_name":"Systemic candidiasis","level":4,"score":0.7034617066383362},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6096101999282837},{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.6079186797142029},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5770683288574219},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5606412291526794},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5166721343994141},{"id":"https://openalex.org/C2781241564","wikidata":"https://www.wikidata.org/wiki/Q1347450","display_name":"Epitope mapping","level":4,"score":0.47768646478652954},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3202090263366699},{"id":"https://openalex.org/C145081991","wikidata":"https://www.wikidata.org/wiki/Q2576388","display_name":"Corpus albicans","level":3,"score":0.2825216054916382},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06600159406661987},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000908","descriptor_name":"Antibodies, Fungal","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002177","descriptor_name":"Candidiasis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002177","descriptor_name":"Candidiasis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1384665","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384665","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"pmid:1718852","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1718852","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"mag:70375962","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1718852","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1384665","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384665","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.979200005531311,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1764490041","https://openalex.org/W1895973717","https://openalex.org/W1936199135","https://openalex.org/W1972109854","https://openalex.org/W1972422536","https://openalex.org/W1999352564","https://openalex.org/W2000494446","https://openalex.org/W2020518733","https://openalex.org/W2027168092","https://openalex.org/W2039800328","https://openalex.org/W2041381365","https://openalex.org/W2048061681","https://openalex.org/W2055708140","https://openalex.org/W2077241000","https://openalex.org/W2081600094","https://openalex.org/W2081778332","https://openalex.org/W2082996726","https://openalex.org/W2088321378","https://openalex.org/W2097383779","https://openalex.org/W2121736805","https://openalex.org/W2132623931","https://openalex.org/W2141236640","https://openalex.org/W2154361055","https://openalex.org/W2164596224","https://openalex.org/W2164959530","https://openalex.org/W2167441939","https://openalex.org/W2226402560","https://openalex.org/W4313310557"],"related_works":["https://openalex.org/W2153736687","https://openalex.org/W3145715512","https://openalex.org/W1967629857","https://openalex.org/W2136760823","https://openalex.org/W2013072504","https://openalex.org/W1987129147","https://openalex.org/W1878458665","https://openalex.org/W2318255072","https://openalex.org/W1999218933","https://openalex.org/W2038048862"],"abstract_inverted_index":{"Epitope":[0],"mapping":[1],"shows":[2],"that":[3,97],"patients":[4,44,53],"recovering":[5],"from":[6,41],"systemic":[7,31,107],"infection":[8],"with":[9,79],"Candida":[10],"albicans":[11],"produce":[12],"antibodies":[13,46,58],"against":[14,89,106],"both":[15],"fungal-specific":[16],"and":[17],"conserved":[18,93],"epitopes":[19,95],"of":[20,30,39,51,71,91],"the":[21,68,72,92,110],"heat-shock":[22],"protein":[23],"(hsp)":[24],"90.":[25,49],"In":[26],"a":[27,80],"mouse":[28,85],"model":[29],"candidosis,":[32],"mortality":[33],"was":[34,65,76],"halved":[35],"by":[36,67],"prior":[37],"administration":[38],"sera":[40],"two":[42],"infected":[43],"containing":[45],"to":[47,100],"hsp":[48,101],"One":[50],"these":[52],"had":[54],"no":[55],"other":[56],"candidal":[57],"detectable":[59],"on":[60],"immunoblotting.":[61],"The":[62],"protective":[63],"effect":[64],"mediated":[66],"immunoglobulin":[69],"fraction":[70],"immune":[73],"serum.":[74,83],"It":[75],"not":[77],"observed":[78],"normal":[81],"human":[82],"A":[84],"monoclonal":[86],"antibody":[87],"raised":[88],"one":[90],"peptide":[94],"suggested":[96],"an":[98],"autoantibody":[99],"90":[102],"could":[103],"mediate":[104],"protection":[105],"candidosis":[108],"in":[109],"animal":[111],"model.":[112]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
