{"id":"https://openalex.org/W7037133239","doi":null,"title":"The influence of CLEC16A on autophagy - a new mechanism in the pathogenesis of type 1 diabetes","display_name":"The influence of CLEC16A on autophagy - a new mechanism in the pathogenesis of type 1 diabetes","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W7037133239"},"language":"de","primary_location":{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-029275266","doi":null,"is_oa":false,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-138715","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Hochschulschrift"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-138715","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002329046","display_name":"Kilian Schober","orcid":"https://orcid.org/0000-0001-9323-9472","observed_orcids":["https://orcid.org/0000-0001-9323-9472"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Schober, Kilian 1987-","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Martin Fa\u00dfnacht","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fa\u00dfnacht, Martin 1971-","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.635699987411499,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.635699987411499,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.32249999046325684,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.03530000150203705,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clec16a","display_name":"CLEC16A","score":1.0},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9570000171661377},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9919999837875366},{"id":"https://openalex.org/keywords/thymic-epithelial-cells","display_name":"thymic epithelial cells","score":0.9670000076293945},{"id":"https://openalex.org/keywords/central-tolerance","display_name":"central tolerance","score":0.9210000038146973},{"id":"https://openalex.org/keywords/mhc-class-ii","display_name":"MHC class II","score":0.7979999780654907},{"id":"https://openalex.org/keywords/self-antigen-presentation","display_name":"autoantigen presentation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cd4-thymocytes","display_name":"CD4+ thymocytes","score":0.8759999871253967},{"id":"https://openalex.org/keywords/susceptibility-genes","display_name":"susceptibility genes","score":0.7440000176429749},{"id":"https://openalex.org/keywords/nod-mice","display_name":"NOD mice","score":0.7879999876022339},{"id":"https://openalex.org/keywords/autophagosomes","display_name":"autophagosomes","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.7603999972343445},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6800000071525574},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5224999785423279},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4896000027656555},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45890000462532043},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4332999885082245},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4050000011920929},{"id":"https://openalex.org/C193469717","wikidata":"https://www.wikidata.org/wiki/Q6556349","display_name":"Lipid-anchored protein","level":4,"score":0.3529999852180481},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.30059999227523804},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.28029999136924744},{"id":"https://openalex.org/C2780329694","wikidata":"https://www.wikidata.org/wiki/Q18033863","display_name":"ATG12","level":5,"score":0.2572999894618988}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-029275266","doi":null,"is_oa":false,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-138715","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Hochschulschrift"},{"id":"pmh:oai:opus.bibliothek.uni-wuerzburg.de:13871","doi":null,"is_oa":true,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-138715","pdf_url":null,"source":{"id":"https://openalex.org/S4306401635","display_name":"Online Publication Service of W\u00fcrzburg University (W\u00fcrzburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I25974101","host_organization_name":"University of W\u00fcrzburg","host_organization_lineage":["https://openalex.org/I25974101"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralthesis"}],"best_oa_location":{"id":"pmh:oai:opus.bibliothek.uni-wuerzburg.de:13871","doi":null,"is_oa":true,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-138715","pdf_url":null,"source":{"id":"https://openalex.org/S4306401635","display_name":"Online Publication Service of W\u00fcrzburg University (W\u00fcrzburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I25974101","host_organization_name":"University of W\u00fcrzburg","host_organization_lineage":["https://openalex.org/I25974101"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralthesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7113045839","https://openalex.org/W3161962245","https://openalex.org/W2067097574","https://openalex.org/W2589643982","https://openalex.org/W7109471783","https://openalex.org/W2975324240","https://openalex.org/W7112899892","https://openalex.org/W2969895589","https://openalex.org/W3155510221","https://openalex.org/W7113441493"],"abstract_inverted_index":{"Das":[0,60],"Gen":[1,168],"CLEC16A":[2,74,95,138,163,170],"ist":[3,41],"mit":[4,10,153,165],"der":[5,15,20,44,135,156,192],"Autoimmunerkrankung":[6],"Typ-1-Diabetes":[7,78,166],"assoziiert.":[8],"NOD-M\u00e4use":[9],"einem":[11],"Clec16a-KD":[12],"sind":[13,25,198],"vor":[14],"Entwicklung":[16,55,193],"von":[17,62,68,115,137,178,194],"Diabetes":[18],"gesch\u00fctzt,":[19],"entscheidende":[21],"Wirkungsort":[22],"f\u00fcr":[23,53,77],"Clec16a":[24],"dabei":[26],"TECs.":[27],"Im":[28],"Rahmen":[29],"zentraler":[30,56,189],"Toleranz":[31,57,190],"pr\u00e4sentieren":[32],"TECs":[33,46,84,116],"CD4+":[34,183],"Thymozyten":[35,184],"Selbstantigene":[36,49],"auf":[37],"MHC":[38,47,88,179],"II-Komplexen.":[39],"Autophagie":[40,82,114,144,172],"ein":[42,75,164],"Zellprozess,":[43],"in":[45,83,96,139,142,173],"II-Komplexen":[48,180],"zuf\u00fchrt":[50],"und":[51,85,103,127,141,191],"so":[52,186],"die":[54,66,105,113,149,176],"essentiell":[58],"ist.":[59,169],"Ortholog":[61],"CLEC16A,":[63],"ema,":[64],"f\u00f6rdert":[65,171],"Bildung":[67],"Autophagosomen.":[69],"So":[70],"wurde":[71,132],"vermutet,":[72],"dass":[73,134],"Suszeptibilit\u00e4tsgen":[76],"ist,":[79],"weil":[80],"es":[81],"somit":[86],"deren":[87],"II-Beladung":[89],"ver\u00e4ndert.":[90,181],"Die":[91,119],"vorliegende":[92,150],"Arbeit":[93,151],"schaltete":[94],"einer":[97],"humanen":[98],"Zelllinie":[99],"durch":[100,123,129],"RNAi":[101],"aus":[102,117],"untersuchte":[104,111],"autophagische":[106],"Aktivit\u00e4t":[107],"dieser":[108],"Zellen.":[109],"Au\u00dferdem":[110],"sie":[112],"NOD-Clec16a-KD-M\u00e4usen.":[118],"Beurteilung":[120],"erfolgte":[121],"morphologisch":[122],"Immunzytochemie":[124],"bzw.":[125],"-histochemie":[126],"funktionell":[128,145],"Immunoblots.":[130],"Es":[131],"gezeigt,":[133],"KD":[136],"vitro":[140],"vivo":[143],"beeintr\u00e4chtigt.":[146],"Damit":[147],"liefert":[148],"zusammen":[152],"den":[154],"Ergebnissen":[155],"Arbeitsgruppe":[157],"Kissler":[158],"einen":[159],"m\u00f6glichen":[160],"Erkl\u00e4rungsansatz,":[161],"warum":[162],"assoziiertes":[167],"TECs,":[174],"was":[175],"Selbstantigen-Beladung":[177],"Selbstreaktive":[182],"f\u00fchren":[185],"zum":[187],"Verlust":[188],"Typ-1-Diabetes.":[195],"Weitere":[196],"Untersuchungen":[197],"jedoch":[199],"notwendig,":[200],"um":[201],"diese":[202],"Hypothese":[203],"zu":[204],"bekr\u00e4ftigen.":[205]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2025-10-10T00:00:00"}