{"id":"https://openalex.org/W7036701071","doi":null,"title":"Characterization of Compounds with Novel Bioactivity Against the Fungal Pathogens Candida albicans and Cryptococcus neoformans","display_name":"Characterization of Compounds with Novel Bioactivity Against the Fungal Pathogens Candida albicans and Cryptococcus neoformans","publication_year":2022,"publication_date":"2022-03-01","ids":{"openalex":"https://openalex.org/W7036701071"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/110787","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/110787","pdf_url":"https://utoronto.scholaris.ca/bitstreams/7107fcfc-b11b-4726-903a-7dbb24d8c875/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/7107fcfc-b11b-4726-903a-7dbb24d8c875/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014687933","display_name":"Alice Xue","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Xue, Alice","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5014687933"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.025800000876188278,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.021900000050663948,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antifungal-drug-discovery","display_name":"antifungal drug discovery","score":0.8659999966621399},{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cryptococcus-neoformans","display_name":"Cryptococcus neoformans","score":1.0},{"id":"https://openalex.org/keywords/hsp90-inhibitors","display_name":"Hsp90 inhibitors","score":0.925000011920929},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8299999833106995},{"id":"https://openalex.org/keywords/target-engagement","display_name":"target engagement","score":0.5929999947547913},{"id":"https://openalex.org/keywords/chemogenomic-profiling","display_name":"chemogenomic profiling","score":0.8489999771118164},{"id":"https://openalex.org/keywords/glutaminyl-trna-synthetase","display_name":"glutaminyl-tRNA synthetase","score":0.8569999933242798},{"id":"https://openalex.org/keywords/fungal-drug-resistance","display_name":"fungal drug resistance","score":0.6679999828338623},{"id":"https://openalex.org/keywords/antifungal-drug-targets","display_name":"antifungal drug targets","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C2777893358","wikidata":"https://www.wikidata.org/wiki/Q131924","display_name":"Cryptococcus neoformans","level":2,"score":0.8536999821662903},{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.7342000007629395},{"id":"https://openalex.org/C2778952914","wikidata":"https://www.wikidata.org/wiki/Q309498","display_name":"Cryptococcus","level":2,"score":0.6460999846458435},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.6018999814987183},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.576200008392334},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5232999920845032},{"id":"https://openalex.org/C121587506","wikidata":"https://www.wikidata.org/wiki/Q6888113","display_name":"Mode of action","level":2,"score":0.4950000047683716},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.45579999685287476},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4512999951839447},{"id":"https://openalex.org/C3019170707","wikidata":"https://www.wikidata.org/wiki/Q6471530","display_name":"Fungal pathogen","level":3,"score":0.4296000003814697},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4235999882221222},{"id":"https://openalex.org/C2909919671","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal drugs","level":3,"score":0.4221999943256378},{"id":"https://openalex.org/C145081991","wikidata":"https://www.wikidata.org/wiki/Q2576388","display_name":"Corpus albicans","level":3,"score":0.3955000042915344},{"id":"https://openalex.org/C2991737395","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal drug","level":3,"score":0.390500009059906},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.34779998660087585},{"id":"https://openalex.org/C2779286289","wikidata":"https://www.wikidata.org/wiki/Q149791","display_name":"Cryptococcus gattii","level":3,"score":0.34150001406669617},{"id":"https://openalex.org/C24527192","wikidata":"https://www.wikidata.org/wiki/Q17149729","display_name":"Human pathogen","level":3,"score":0.3411000072956085},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33709999918937683},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.32269999384880066},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.32199999690055847},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31380000710487366},{"id":"https://openalex.org/C2780651595","wikidata":"https://www.wikidata.org/wiki/Q411478","display_name":"Fluconazole","level":3,"score":0.31220000982284546},{"id":"https://openalex.org/C2779413141","wikidata":"https://www.wikidata.org/wiki/Q1470140","display_name":"Cryptococcosis","level":2,"score":0.3082999885082245},{"id":"https://openalex.org/C2779678110","wikidata":"https://www.wikidata.org/wiki/Q764","display_name":"Fungus","level":2,"score":0.28949999809265137},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.2863999903202057},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.273499995470047},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.27300000190734863},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.2718999981880188},{"id":"https://openalex.org/C6555983","wikidata":"https://www.wikidata.org/wiki/Q7181398","display_name":"Phenotypic screening","level":4,"score":0.2606000006198883},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.25920000672340393},{"id":"https://openalex.org/C2777752112","wikidata":"https://www.wikidata.org/wiki/Q903238","display_name":"Lead compound","level":3,"score":0.2563000023365021},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.25600001215934753}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/110787","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/110787","pdf_url":"https://utoronto.scholaris.ca/bitstreams/7107fcfc-b11b-4726-903a-7dbb24d8c875/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/110787","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/110787","pdf_url":"https://utoronto.scholaris.ca/bitstreams/7107fcfc-b11b-4726-903a-7dbb24d8c875/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7036701071.pdf","grobid_xml":"https://content.openalex.org/works/W7036701071.grobid-xml"},"referenced_works_count":190,"referenced_works":["https://openalex.org/W1182581869","https://openalex.org/W1494279257","https://openalex.org/W1500036797","https://openalex.org/W1503938960","https://openalex.org/W1551144904","https://openalex.org/W1573671038","https://openalex.org/W1803102843","https://openalex.org/W1842106696","https://openalex.org/W1964141703","https://openalex.org/W1967864456","https://openalex.org/W1968327387","https://openalex.org/W1970250905","https://openalex.org/W1973772482","https://openalex.org/W1974220691","https://openalex.org/W1978154072","https://openalex.org/W1981067425","https://openalex.org/W1981239770","https://openalex.org/W1982958549","https://openalex.org/W1985020303","https://openalex.org/W1985588649","https://openalex.org/W1986481314","https://openalex.org/W1986791722","https://openalex.org/W1988825409","https://openalex.org/W1993251792","https://openalex.org/W1993525477","https://openalex.org/W1993727333","https://openalex.org/W1993800351","https://openalex.org/W1995380559","https://openalex.org/W1995919293","https://openalex.org/W1996229802","https://openalex.org/W1999608828","https://openalex.org/W1999715990","https://openalex.org/W2001430852","https://openalex.org/W2003049729","https://openalex.org/W2004173797","https://openalex.org/W2004442716","https://openalex.org/W2008168204","https://openalex.org/W2008653558","https://openalex.org/W2008979709","https://openalex.org/W2009746802","https://openalex.org/W2012818739","https://openalex.org/W2013947447","https://openalex.org/W2019275304","https://openalex.org/W2021156563","https://openalex.org/W2021508930","https://openalex.org/W2022531767","https://openalex.org/W2023518810","https://openalex.org/W2025947534","https://openalex.org/W2028864554","https://openalex.org/W2030545256","https://openalex.org/W2038252445","https://openalex.org/W2042688172","https://openalex.org/W2042699875","https://openalex.org/W2042940085","https://openalex.org/W2045507047","https://openalex.org/W2048074482","https://openalex.org/W2049353177","https://openalex.org/W2049789253","https://openalex.org/W2050694730","https://openalex.org/W2051903523","https://openalex.org/W2054868502","https://openalex.org/W2060322845","https://openalex.org/W2064314272","https://openalex.org/W2068007547","https://openalex.org/W2068408380","https://openalex.org/W2070140841","https://openalex.org/W2074370114","https://openalex.org/W2075037143","https://openalex.org/W2078807391","https://openalex.org/W2079029484","https://openalex.org/W2082150533","https://openalex.org/W2082390299","https://openalex.org/W2083076878","https://openalex.org/W2083713217","https://openalex.org/W2085708633","https://openalex.org/W2085719025","https://openalex.org/W2087273774","https://openalex.org/W2089692302","https://openalex.org/W2090816585","https://openalex.org/W2092899154","https://openalex.org/W2094285560","https://openalex.org/W2095699986","https://openalex.org/W2095722471","https://openalex.org/W2096843844","https://openalex.org/W2096855445","https://openalex.org/W2098563304","https://openalex.org/W2099029772","https://openalex.org/W2099573346","https://openalex.org/W2107794472","https://openalex.org/W2108098152","https://openalex.org/W2108543631","https://openalex.org/W2109426592","https://openalex.org/W2114409750","https://openalex.org/W2116117181","https://openalex.org/W2116304792","https://openalex.org/W2117555017","https://openalex.org/W2118807330","https://openalex.org/W2119391289","https://openalex.org/W2119779956","https://openalex.org/W2119790759","https://openalex.org/W2120365200","https://openalex.org/W2126669478","https://openalex.org/W2127073167","https://openalex.org/W2128106097","https://openalex.org/W2128207311","https://openalex.org/W2128575896","https://openalex.org/W2133102806","https://openalex.org/W2133531126","https://openalex.org/W2134122507","https://openalex.org/W2136579557","https://openalex.org/W2138101634","https://openalex.org/W2139307267","https://openalex.org/W2139472183","https://openalex.org/W2140948740","https://openalex.org/W2141563676","https://openalex.org/W2141715793","https://openalex.org/W2142437744","https://openalex.org/W2143928468","https://openalex.org/W2145329735","https://openalex.org/W2145577370","https://openalex.org/W2148168088","https://openalex.org/W2149579582","https://openalex.org/W2150140261","https://openalex.org/W2152673223","https://openalex.org/W2156217754","https://openalex.org/W2156909654","https://openalex.org/W2158528341","https://openalex.org/W2159460045","https://openalex.org/W2162331245","https://openalex.org/W2164299395","https://openalex.org/W2167398354","https://openalex.org/W2167869241","https://openalex.org/W2168192378","https://openalex.org/W2168258419","https://openalex.org/W2170090864","https://openalex.org/W2173348076","https://openalex.org/W2213042592","https://openalex.org/W2227223477","https://openalex.org/W2254560754","https://openalex.org/W2265238401","https://openalex.org/W2267385740","https://openalex.org/W2270756322","https://openalex.org/W2311994573","https://openalex.org/W2312508087","https://openalex.org/W2332899407","https://openalex.org/W2341004121","https://openalex.org/W2341334907","https://openalex.org/W2399229449","https://openalex.org/W2415657445","https://openalex.org/W2428924804","https://openalex.org/W2461287631","https://openalex.org/W2473262875","https://openalex.org/W2492786750","https://openalex.org/W2522417827","https://openalex.org/W2523840231","https://openalex.org/W2532305189","https://openalex.org/W2551752994","https://openalex.org/W2608385659","https://openalex.org/W2611697423","https://openalex.org/W2620498574","https://openalex.org/W2738438224","https://openalex.org/W2742305482","https://openalex.org/W2772664042","https://openalex.org/W2786145714","https://openalex.org/W2791963883","https://openalex.org/W2792378492","https://openalex.org/W2794593110","https://openalex.org/W2804572516","https://openalex.org/W2890801493","https://openalex.org/W2894617241","https://openalex.org/W2898801056","https://openalex.org/W2913687673","https://openalex.org/W2921726164","https://openalex.org/W2944096460","https://openalex.org/W2953282636","https://openalex.org/W2964202280","https://openalex.org/W2969570894","https://openalex.org/W2972825272","https://openalex.org/W2995418381","https://openalex.org/W2999244147","https://openalex.org/W3007103610","https://openalex.org/W3010649296","https://openalex.org/W3011746056","https://openalex.org/W3018836291","https://openalex.org/W3026958586","https://openalex.org/W3038732491","https://openalex.org/W3082221207","https://openalex.org/W3118562358","https://openalex.org/W3127236674","https://openalex.org/W3157422722"],"related_works":["https://openalex.org/W7133094501","https://openalex.org/W7018631605","https://openalex.org/W4281747822","https://openalex.org/W3082221207","https://openalex.org/W4362682897","https://openalex.org/W4410076254","https://openalex.org/W2249483951","https://openalex.org/W4414080651","https://openalex.org/W4280648257","https://openalex.org/W2994914330"],"abstract_inverted_index":{"Systemic":[0],"fungal":[1,66,100],"diseases":[2],"represent":[3],"an":[4],"overlooked":[5],"global":[6],"health":[7],"burden,":[8],"whose":[9],"treatment":[10],"is":[11],"challenged":[12],"by":[13],"a":[14,78,141],"limited":[15],"antifungal":[16,33,40,54,114],"armamentarium":[17],"and":[18,42,70,99,131,143],"the":[19,32,65],"emergence":[20],"of":[21,38,48,77,109,127,146],"drug":[22,34],"resistance.":[23],"This":[24],"research":[25],"encompasses":[26],"two":[27],"complementary":[28],"strategies":[29],"to":[30,51],"bolster":[31],"pipeline:":[35],"rational":[36],"optimization":[37],"existing":[39],"scaffolds,":[41],"phenotype-forward":[43],"screening":[44],"with":[45,95,112],"subsequent":[46],"mode":[47],"action":[49],"identification":[50],"discover":[52],"novel":[53,113],"targets.":[55],"First,":[56],"I":[57,90,104,123],"evaluated":[58],"in":[59],"vitro":[60],"target":[61,101],"engagement,":[62],"bioactivity":[63,115],"against":[64],"pathogen":[67],"Cryptococcus":[68],"neoformans,":[69],"mammalian":[71,129],"cytotoxicity":[72],"for":[73],"over":[74],"70":[75],"analogs":[76],"previously":[79],"validated":[80],"Hsp90":[81],"inhibitor":[82,145],"scaffold.":[83],"Through":[84],"these":[85],"structure-activity":[86],"relationship":[87],"(SAR)":[88],"analyses,":[89],"identified":[91,116],"several":[92],"lead":[93],"molecules":[94,111],"improved":[96],"whole-cell":[97],"activity":[98],"selectivity.":[102],"Then,":[103],"also":[105],"performed":[106],"preliminary":[107],"characterization":[108],"nine":[110],"from":[117],"prior":[118],"large-":[119],"scale":[120],"chemical":[121],"screening.":[122],"outlined":[124],"their":[125],"spectrum":[126],"activity,":[128],"cytotoxicity,":[130],"putative":[132],"molecular":[133],"target(s)":[134],"via":[135],"chemogenomic":[136],"profiling,":[137],"identifying":[138],"NP-BTA":[139],"as":[140],"potent":[142],"selective":[144],"Candida":[147],"albicans":[148],"glutaminyl-tRNA":[149],"synthetase.":[150]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}