{"id":"https://openalex.org/W7036503290","doi":null,"title":"Circulating Tumour Cells in Osteosarcoma","display_name":"Circulating Tumour Cells in Osteosarcoma","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W7036503290"},"language":"en","primary_location":{"id":"pmh:oai:ses.library.usyd.edu.au:2123/29874","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2123/29874","pdf_url":null,"source":{"id":"https://openalex.org/S4306402414","display_name":"The Sydney eScholarship Repository (The University of Sydney)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I129604602","host_organization_name":"The University of Sydney","host_organization_lineage":["https://openalex.org/I129604602"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Bollu, Bapesh Krishna","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Bollu, Bapesh Krishna","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.7900000214576721,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.7900000214576721,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.14180000126361847,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.022299999371170998,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.8679999709129333},{"id":"https://openalex.org/keywords/circulating-tumor-cells","display_name":"circulating tumor cells","score":1.0},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gd2","display_name":"GD2","score":0.7950000166893005},{"id":"https://openalex.org/keywords/epha2","display_name":"EphA2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cd45","display_name":"CD45","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cell-surface-markers","display_name":"cell surface markers","score":0.5690000057220459},{"id":"https://openalex.org/keywords/hemolysis","display_name":"hemolysis","score":0.8560000061988831},{"id":"https://openalex.org/keywords/ficoll-density-gradient","display_name":"Ficoll density gradient","score":0.9679999947547913},{"id":"https://openalex.org/keywords/metastasis-detection","display_name":"metastasis detection","score":0.652999997138977},{"id":"https://openalex.org/keywords/cell-recovery","display_name":"cell recovery","score":0.3709999918937683}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.451200008392334},{"id":"https://openalex.org/C144251240","wikidata":"https://www.wikidata.org/wiki/Q7068229","display_name":"Nucleofection","level":4,"score":0.31850001215934753},{"id":"https://openalex.org/C2779640190","wikidata":"https://www.wikidata.org/wiki/Q1956682","display_name":"Myoglobinuria","level":3,"score":0.27880001068115234},{"id":"https://openalex.org/C2778283623","wikidata":"https://www.wikidata.org/wiki/Q18032200","display_name":"TSG101","level":5,"score":0.2312999963760376},{"id":"https://openalex.org/C106131492","wikidata":"https://www.wikidata.org/wiki/Q3072260","display_name":"Filter (signal processing)","level":2,"score":0.21539999544620514},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.20559999346733093},{"id":"https://openalex.org/C145741570","wikidata":"https://www.wikidata.org/wiki/Q7251534","display_name":"Proteogenomics","level":5,"score":0.20319999754428864},{"id":"https://openalex.org/C2776356786","wikidata":"https://www.wikidata.org/wiki/Q1048573","display_name":"Tubulopathy","level":3,"score":0.20059999823570251},{"id":"https://openalex.org/C2777054765","wikidata":"https://www.wikidata.org/wiki/Q6402731","display_name":"Dysgeusia","level":3,"score":0.19200000166893005},{"id":"https://openalex.org/C2781032047","wikidata":"https://www.wikidata.org/wiki/Q938793","display_name":"Articular cartilage damage","level":5,"score":0.18799999356269836}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:ses.library.usyd.edu.au:2123/29874","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2123/29874","pdf_url":null,"source":{"id":"https://openalex.org/S4306402414","display_name":"The Sydney eScholarship Repository (The University of Sydney)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I129604602","host_organization_name":"The University of Sydney","host_organization_lineage":["https://openalex.org/I129604602"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2593760035","https://openalex.org/W3137320261","https://openalex.org/W2741811486","https://openalex.org/W2930896415","https://openalex.org/W3032639743","https://openalex.org/W4298087450","https://openalex.org/W2354945844","https://openalex.org/W4392539320","https://openalex.org/W4388776521","https://openalex.org/W2480322830"],"abstract_inverted_index":{"Introduction":[0],"There":[1,305],"is":[2,20,56,125],"now":[3],"a":[4,21,38,69,73,128,261],"growing":[5],"body":[6],"of":[7,14,62,78,122,210,252,272,294,312,317,325,373],"work":[8,359],"being":[9],"conducted":[10],"in":[11,37,266,296,320,334,369],"the":[12,31,57,63,105,113,281,292,310,315],"field":[13],"liquid":[15,18],"biopsies.":[16],"A":[17,337],"biopsy":[19],"technique":[22,129,339],"to":[23,97,103,115,126,130,322,340],"look":[24],"for":[25,107,140],"biomarkers,":[26],"arising":[27],"from":[28,302],"cancer,":[29],"within":[30],"blood":[32,159,183,203],"stream":[33],"which":[34,299],"are":[35],"accessed":[36],"non-invasive":[39],"manner.":[40],"These":[41],"may":[42,93,111],"include":[43,150,181],"circulating":[44,48,51],"tumour":[45,49,79],"cells":[46,80,165],"(CTCs),":[47],"DNA,":[50],"RNA":[52],"or":[53,117],"exosomes.":[54],"Osteosarcoma":[55,135],"most":[58],"common":[59],"bony":[60],"malignancy":[61],"paediatric":[64],"population.":[65],"Metastatic":[66],"disease":[67,109,329],"has":[68],"poor":[70],"prognosis":[71],"with":[72,163,223,276,349],"20-30%":[74],"survival.":[75],"The":[76,120,250,270],"number":[77,316],"present":[81],"at":[82,207],"distant":[83],"sites":[84],"when":[85,333],"identified":[86,319],"by":[87],"traditional":[88],"radiological":[89],"and":[90,153,166,175,187,198,221,231,241,258,314,327,330,355,363],"clinical":[91,212,371],"techniques":[92,102,174],"be":[94],"too":[95],"late":[96],"offer":[98,112],"reliable":[99],"cure.":[100],"Hence":[101],"identify":[104,131,341],"potential":[106,141],"metastatic":[108],"earlier":[110],"option":[114],"intensify":[116],"alter":[118],"therapy.":[119],"aim":[121],"this":[123],"project":[124],"develop":[127],"osteosarcoma":[132,164,268,342],"CTCs.":[133,269],"Methods":[134],"cell":[136,167,184,283],"lines":[137,148],"were":[138,205,216,235,300],"assessed":[139],"surface":[142],"markers":[143,257],"using":[144,171,218,246],"flow":[145],"cytometry.":[146],"Cell":[147],"used":[149],"143B,":[151],"HOS":[152],"MG63.":[154],"Following":[155],"this,":[156],"normal":[157,352],"control":[158,353],"samples":[160,204,215,234,289,298,331,354],"where":[161],"spiked":[162,351],"recovery":[168,284],"was":[169,244,264,306,344,347],"tested":[170],"different":[172,208],"preanalytical":[173],"processing":[176,275,279],"time":[177],"points.":[178],"Techniques":[179],"compared":[180],"red":[182],"(RBC)":[185],"lysis":[186,220,274],"Ficoll":[188],"density":[189],"gradient":[190],"processing.":[191],"Timepoints":[192],"included":[193],"fresh":[194,277],"processing,":[195],"after":[196],"24hours":[197],"frozen":[199],"samples.":[200,357],"Then":[201],"patient":[202,288,356],"collected":[206,301],"timepoints":[209],"their":[211],"course.":[213],"All":[214,233],"processed":[217],"RBC":[219,273],"stained":[222],"dioganglioside":[224],"(GD2),":[225],"Ephrin":[226],"type-a":[227],"receptor":[228],"2":[229],"(EphA2)":[230],"CD45.":[232],"run":[236],"through":[237],"BD":[238],"FACS":[239],"Symphony":[240],"then":[242],"data":[243],"analysed":[245],"FlowJo":[247],"software.":[248],"Results":[249],"use":[251,271],"GD2,":[253],"EphA2":[254],"as":[255,260],"positive":[256],"CD45":[259],"negative":[262],"marker":[263],"effective":[265],"identifying":[267],"sample":[278,365],"yielded":[280],"best":[282],"rate.":[285],"Within":[286],"our":[287],"we":[290],"noted":[291],"presence":[293],"CTCs":[295,318],"16/18":[297],"seven":[303],"patients.":[304],"no":[307],"correlation":[308],"between":[309],"timepoint":[311],"collection":[313],"relation":[321],"comparing":[323],"risk":[324],"recurrence":[326],"active":[328],"taken":[332],"remission.":[335],"Conclusion":[336],"reproducible":[338],"CTC":[343],"developed.":[345],"This":[346],"seen":[348],"both":[350],"Further":[358],"on":[360],"downstream":[361],"analysis":[362],"large":[364],"numbers":[366],"would":[367],"assist":[368],"further":[370],"translation":[372],"these":[374],"findings.":[375]},"counts_by_year":[],"updated_date":"2026-08-08T01:25:22.217667","created_date":"2025-10-10T00:00:00"}
