{"id":"https://openalex.org/W7034087750","doi":null,"title":"Targeting mitochondrial metabolism in cancer: development and validation of PEPCK-M and PYCR1 inhibitors","display_name":"Targeting mitochondrial metabolism in cancer: development and validation of PEPCK-M and PYCR1 inhibitors","publication_year":2022,"publication_date":"2022-06-30","ids":{"openalex":"https://openalex.org/W7034087750"},"language":"en","primary_location":{"id":"pmh:oai:diposit.ub.edu:2445/200981","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2445/200981","pdf_url":null,"source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tesis Doctorals - Departament - Ci\u00e8ncies Fisiol\u00f2giques","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.tdx.cat/bitstream/10803/688743/1/MAB_PhD_THESIS.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Arag\u00f3 Belenguer, Marc","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Arag\u00f3 Belenguer, Marc","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.023900000378489494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pycr1","display_name":"PYCR1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mitochondrial-metabolism","display_name":"mitochondrial metabolism","score":0.7139999866485596},{"id":"https://openalex.org/keywords/cancer-metabolic-reprogramming","display_name":"tumor metabolic reprogramming","score":0.9229999780654907},{"id":"https://openalex.org/keywords/gluconeogenesis","display_name":"gluconeogenesis","score":0.8130000233650208},{"id":"https://openalex.org/keywords/proline-biosynthesis","display_name":"proline biosynthesis","score":0.984000027179718},{"id":"https://openalex.org/keywords/virtual-screening","display_name":"virtual screening","score":0.6970000267028809},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.7929999828338623},{"id":"https://openalex.org/keywords/molecular-dynamics-simulation","display_name":"molecular dynamics simulation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.5490000247955322},{"id":"https://openalex.org/keywords/glucose-deprivation","display_name":"glucose deprivation","score":0.8080000281333923},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.5370000004768372},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.5910000205039978},{"id":"https://openalex.org/keywords/cancer-therapy-targets","display_name":"cancer therapy targets","score":0.38499999046325684},{"id":"https://openalex.org/keywords/tumor-immunosuppression","display_name":"tumor immunosuppression","score":0.32199999690055847}],"concepts":[{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.5012000203132629},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.46239998936653137},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.43130001425743103},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.42640000581741333},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3411000072956085},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3012999892234802},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2856999933719635},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2854999899864197},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2222999930381775},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.21369999647140503}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:diposit.ub.edu:2445/200981","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2445/200981","pdf_url":null,"source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tesis Doctorals - Departament - Ci\u00e8ncies Fisiol\u00f2giques","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:www.tdx.cat:10803/688743","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/688743","pdf_url":"https://www.tdx.cat/bitstream/10803/688743/1/MAB_PhD_THESIS.pdf","source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:www.tdx.cat:10803/688743","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/688743","pdf_url":"https://www.tdx.cat/bitstream/10803/688743/1/MAB_PhD_THESIS.pdf","source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7034087750.pdf","grobid_xml":"https://content.openalex.org/works/W7034087750.grobid-xml"},"referenced_works_count":422,"referenced_works":["https://openalex.org/W49766303","https://openalex.org/W75870934","https://openalex.org/W101874289","https://openalex.org/W628038580","https://openalex.org/W1495672122","https://openalex.org/W1500089654","https://openalex.org/W1503667331","https://openalex.org/W1509668278","https://openalex.org/W1533713644","https://openalex.org/W1534849470","https://openalex.org/W1538419182","https://openalex.org/W1538807883","https://openalex.org/W1539947917","https://openalex.org/W1550523741","https://openalex.org/W1553978925","https://openalex.org/W1557342740","https://openalex.org/W1573715050","https://openalex.org/W1585999638","https://openalex.org/W1593025724","https://openalex.org/W1600532461","https://openalex.org/W1602503879","https://openalex.org/W1653739410","https://openalex.org/W1657207262","https://openalex.org/W1660389086","https://openalex.org/W1751530372","https://openalex.org/W1759938974","https://openalex.org/W1772995836","https://openalex.org/W1792532087","https://openalex.org/W1831033366","https://openalex.org/W1879352431","https://openalex.org/W1904168380","https://openalex.org/W1926273606","https://openalex.org/W1934493757","https://openalex.org/W1935064934","https://openalex.org/W1963689690","https://openalex.org/W1965262464","https://openalex.org/W1967005515","https://openalex.org/W1970658820","https://openalex.org/W1970710520","https://openalex.org/W1970990976","https://openalex.org/W1971110487","https://openalex.org/W1972835861","https://openalex.org/W1973003714","https://openalex.org/W1973113504","https://openalex.org/W1973431705","https://openalex.org/W1974463407","https://openalex.org/W1975447903","https://openalex.org/W1978492018","https://openalex.org/W1980181091","https://openalex.org/W1980253503","https://openalex.org/W1981021420","https://openalex.org/W1981100453","https://openalex.org/W1981761798","https://openalex.org/W1982898258","https://openalex.org/W1986240377","https://openalex.org/W1986960362","https://openalex.org/W1986991123","https://openalex.org/W1989376891","https://openalex.org/W1990320777","https://openalex.org/W1992050864","https://openalex.org/W1993777583","https://openalex.org/W1995044319","https://openalex.org/W1996822335","https://openalex.org/W1997249761","https://openalex.org/W1997261069","https://openalex.org/W1998424488","https://openalex.org/W1999608828","https://openalex.org/W2000144783","https://openalex.org/W2002583208","https://openalex.org/W2002922559","https://openalex.org/W2003216189","https://openalex.org/W2003281617","https://openalex.org/W2003356525","https://openalex.org/W2003842905","https://openalex.org/W2008239768","https://openalex.org/W2008330105","https://openalex.org/W2009269237","https://openalex.org/W2009876678","https://openalex.org/W2010109455","https://openalex.org/W2010654843","https://openalex.org/W2010827268","https://openalex.org/W2011574523","https://openalex.org/W2012124753","https://openalex.org/W2014058353","https://openalex.org/W2014649668","https://openalex.org/W2015095581","https://openalex.org/W2015105801","https://openalex.org/W2015115839","https://openalex.org/W2016133306","https://openalex.org/W2017007251","https://openalex.org/W2018179312","https://openalex.org/W2020789296","https://openalex.org/W2021624484","https://openalex.org/W2021664757","https://openalex.org/W2022068789","https://openalex.org/W2022899908","https://openalex.org/W2023217997","https://openalex.org/W2024367581","https://openalex.org/W2026573534","https://openalex.org/W2027468963","https://openalex.org/W2028547310","https://openalex.org/W2029425171","https://openalex.org/W2029863996","https://openalex.org/W2030826687","https://openalex.org/W2030987469","https://openalex.org/W2031119511","https://openalex.org/W2032824001","https://openalex.org/W2033823674","https://openalex.org/W2033958147","https://openalex.org/W2034269086","https://openalex.org/W2035738326","https://openalex.org/W2039220817","https://openalex.org/W2039558597","https://openalex.org/W2041729369","https://openalex.org/W2042336817","https://openalex.org/W2043680682","https://openalex.org/W2044444984","https://openalex.org/W2045083218","https://openalex.org/W2046100445","https://openalex.org/W2047379648","https://openalex.org/W2049046803","https://openalex.org/W2050456292","https://openalex.org/W2051818991","https://openalex.org/W2055211166","https://openalex.org/W2055255976","https://openalex.org/W2056854155","https://openalex.org/W2057001750","https://openalex.org/W2057370954","https://openalex.org/W2058218780","https://openalex.org/W2058552694","https://openalex.org/W2059270218","https://openalex.org/W2059747280","https://openalex.org/W2059890422","https://openalex.org/W2060592426","https://openalex.org/W2063620817","https://openalex.org/W2063632665","https://openalex.org/W2063673863","https://openalex.org/W2065177893","https://openalex.org/W2065322400","https://openalex.org/W2067213531","https://openalex.org/W2070732456","https://openalex.org/W2070910260","https://openalex.org/W2072000048","https://openalex.org/W2076330933","https://openalex.org/W2076515757","https://openalex.org/W2077097398","https://openalex.org/W2077918092","https://openalex.org/W2078245176","https://openalex.org/W2078265076","https://openalex.org/W2081136502","https://openalex.org/W2081825168","https://openalex.org/W2081946324","https://openalex.org/W2082515526","https://openalex.org/W2084614836","https://openalex.org/W2085872107","https://openalex.org/W2088154247","https://openalex.org/W2089732802","https://openalex.org/W2095987251","https://openalex.org/W2097259163","https://openalex.org/W2098134455","https://openalex.org/W2099352432","https://openalex.org/W2100039832","https://openalex.org/W2102322990","https://openalex.org/W2103292784","https://openalex.org/W2106318552","https://openalex.org/W2107498856","https://openalex.org/W2107951449","https://openalex.org/W2109831966","https://openalex.org/W2110071884","https://openalex.org/W2112022192","https://openalex.org/W2112516812","https://openalex.org/W2112861594","https://openalex.org/W2114550587","https://openalex.org/W2114622275","https://openalex.org/W2115711575","https://openalex.org/W2116240218","https://openalex.org/W2117692326","https://openalex.org/W2118233996","https://openalex.org/W2119239003","https://openalex.org/W2119437574","https://openalex.org/W2119800429","https://openalex.org/W2120924443","https://openalex.org/W2121141922","https://openalex.org/W2121727754","https://openalex.org/W2125718042","https://openalex.org/W2125934521","https://openalex.org/W2127063807","https://openalex.org/W2127675410","https://openalex.org/W2128450196","https://openalex.org/W2129917557","https://openalex.org/W2132117833","https://openalex.org/W2132262459","https://openalex.org/W2133208346","https://openalex.org/W2133872445","https://openalex.org/W2135732933","https://openalex.org/W2137094186","https://openalex.org/W2138033100","https://openalex.org/W2138044466","https://openalex.org/W2138110344","https://openalex.org/W2139126860","https://openalex.org/W2140251048","https://openalex.org/W2140814324","https://openalex.org/W2143841612","https://openalex.org/W2145390243","https://openalex.org/W2145540789","https://openalex.org/W2145912883","https://openalex.org/W2147415188","https://openalex.org/W2150632176","https://openalex.org/W2151919617","https://openalex.org/W2156845076","https://openalex.org/W2160551785","https://openalex.org/W2162016905","https://openalex.org/W2163729820","https://openalex.org/W2165200432","https://openalex.org/W2165414304","https://openalex.org/W2167960276","https://openalex.org/W2171952619","https://openalex.org/W2171998177","https://openalex.org/W2173466127","https://openalex.org/W2178032222","https://openalex.org/W2180898434","https://openalex.org/W2193967519","https://openalex.org/W2205461107","https://openalex.org/W2229552798","https://openalex.org/W2230463780","https://openalex.org/W2233479562","https://openalex.org/W2234115940","https://openalex.org/W2261881668","https://openalex.org/W2263732114","https://openalex.org/W2265081928","https://openalex.org/W2266013672","https://openalex.org/W2266814182","https://openalex.org/W2292613448","https://openalex.org/W2300522002","https://openalex.org/W2301066876","https://openalex.org/W2320065448","https://openalex.org/W2322032869","https://openalex.org/W2322667504","https://openalex.org/W2326416270","https://openalex.org/W2341758899","https://openalex.org/W2342353522","https://openalex.org/W2343452853","https://openalex.org/W2346017884","https://openalex.org/W2346277289","https://openalex.org/W2395626624","https://openalex.org/W2402737866","https://openalex.org/W2413241437","https://openalex.org/W2418462368","https://openalex.org/W2418570604","https://openalex.org/W2419751303","https://openalex.org/W2464767034","https://openalex.org/W2477876155","https://openalex.org/W2479507898","https://openalex.org/W2515188071","https://openalex.org/W2519398178","https://openalex.org/W2523223625","https://openalex.org/W2540090384","https://openalex.org/W2553644640","https://openalex.org/W2557349910","https://openalex.org/W2560396365","https://openalex.org/W2573683820","https://openalex.org/W2586265133","https://openalex.org/W2587323499","https://openalex.org/W2593392007","https://openalex.org/W2593436234","https://openalex.org/W2594582892","https://openalex.org/W2603421341","https://openalex.org/W2604797031","https://openalex.org/W2607135274","https://openalex.org/W2608028058","https://openalex.org/W2608465247","https://openalex.org/W2611090362","https://openalex.org/W2611224317","https://openalex.org/W2612371147","https://openalex.org/W2612372140","https://openalex.org/W2613512560","https://openalex.org/W2620939363","https://openalex.org/W2726164542","https://openalex.org/W2728985030","https://openalex.org/W2729141866","https://openalex.org/W2731058674","https://openalex.org/W2734965995","https://openalex.org/W2750174270","https://openalex.org/W2753995352","https://openalex.org/W2758067903","https://openalex.org/W2758367201","https://openalex.org/W2760186642","https://openalex.org/W2761314975","https://openalex.org/W2762707816","https://openalex.org/W2763635693","https://openalex.org/W2763979809","https://openalex.org/W2767348608","https://openalex.org/W2769305823","https://openalex.org/W2770320302","https://openalex.org/W2770407886","https://openalex.org/W2772606519","https://openalex.org/W2782192099","https://openalex.org/W2783867527","https://openalex.org/W2783932169","https://openalex.org/W2787048720","https://openalex.org/W2789816271","https://openalex.org/W2793819765","https://openalex.org/W2797927489","https://openalex.org/W2803328077","https://openalex.org/W2803451318","https://openalex.org/W2804422202","https://openalex.org/W2808301714","https://openalex.org/W2855168245","https://openalex.org/W2883267489","https://openalex.org/W2883560796","https://openalex.org/W2885738414","https://openalex.org/W2887324870","https://openalex.org/W2895207414","https://openalex.org/W2895875588","https://openalex.org/W2902416164","https://openalex.org/W2904922853","https://openalex.org/W2905965925","https://openalex.org/W2907174268","https://openalex.org/W2908747018","https://openalex.org/W2910111050","https://openalex.org/W2910865716","https://openalex.org/W2911631458","https://openalex.org/W2914638514","https://openalex.org/W2921262115","https://openalex.org/W2922415295","https://openalex.org/W2922464366","https://openalex.org/W2923083564","https://openalex.org/W2941734641","https://openalex.org/W2943301094","https://openalex.org/W2945059856","https://openalex.org/W2945072981","https://openalex.org/W2947076807","https://openalex.org/W2947415066","https://openalex.org/W2948438687","https://openalex.org/W2948764282","https://openalex.org/W2948831670","https://openalex.org/W2953097438","https://openalex.org/W2959164548","https://openalex.org/W2964198010","https://openalex.org/W2964734840","https://openalex.org/W2965208618","https://openalex.org/W2967693430","https://openalex.org/W2968972266","https://openalex.org/W2970045605","https://openalex.org/W2971801381","https://openalex.org/W2972865130","https://openalex.org/W2978012731","https://openalex.org/W2979482962","https://openalex.org/W2986572941","https://openalex.org/W2988171854","https://openalex.org/W2988671424","https://openalex.org/W2992324722","https://openalex.org/W2995499826","https://openalex.org/W2995832176","https://openalex.org/W2997046468","https://openalex.org/W2998401174","https://openalex.org/W2998807479","https://openalex.org/W3002902597","https://openalex.org/W3006907677","https://openalex.org/W3008326445","https://openalex.org/W3009040331","https://openalex.org/W3009792425","https://openalex.org/W3011859953","https://openalex.org/W3012307045","https://openalex.org/W3013038172","https://openalex.org/W3016145305","https://openalex.org/W3018346568","https://openalex.org/W3018515813","https://openalex.org/W3019785310","https://openalex.org/W3024398531","https://openalex.org/W3033550003","https://openalex.org/W3043397081","https://openalex.org/W3047740470","https://openalex.org/W3048473052","https://openalex.org/W3048502588","https://openalex.org/W3048569636","https://openalex.org/W3049764507","https://openalex.org/W3080671367","https://openalex.org/W3083797014","https://openalex.org/W3087525848","https://openalex.org/W3087769169","https://openalex.org/W3089457445","https://openalex.org/W3096903800","https://openalex.org/W3097922107","https://openalex.org/W3100082769","https://openalex.org/W3108133179","https://openalex.org/W3111329181","https://openalex.org/W3118790373","https://openalex.org/W3120200409","https://openalex.org/W3120565585","https://openalex.org/W3125809117","https://openalex.org/W3134583647","https://openalex.org/W3134727100","https://openalex.org/W3135707657","https://openalex.org/W3151599653","https://openalex.org/W3163675482","https://openalex.org/W3171538486","https://openalex.org/W3171704558","https://openalex.org/W3173778707","https://openalex.org/W3180904899","https://openalex.org/W3182740681","https://openalex.org/W3185973406","https://openalex.org/W3200669500","https://openalex.org/W3210904158","https://openalex.org/W3216120593","https://openalex.org/W4205593852","https://openalex.org/W4205646234","https://openalex.org/W4205889056","https://openalex.org/W4205937342","https://openalex.org/W4206662285","https://openalex.org/W4206809807","https://openalex.org/W4210431358","https://openalex.org/W4213140556","https://openalex.org/W4214718081","https://openalex.org/W4220688241","https://openalex.org/W4229932172","https://openalex.org/W4236967220","https://openalex.org/W4239191476","https://openalex.org/W4245068725","https://openalex.org/W4255269256","https://openalex.org/W4299514580","https://openalex.org/W7097134372"],"related_works":["https://openalex.org/W3112853630","https://openalex.org/W7207515784","https://openalex.org/W3113221129","https://openalex.org/W2747467682","https://openalex.org/W2599565815","https://openalex.org/W2623277493","https://openalex.org/W2529105460","https://openalex.org/W7071753599","https://openalex.org/W7062497320","https://openalex.org/W7111085764"],"abstract_inverted_index":{"[spa]":[0],"La":[1],"reprogramaci\u00f3n":[2],"metab\u00f3lica":[3],"es":[4,144],"uno":[5],"de":[6,18,74,83,87,90,140,149,160,172,192,203,213,217,233,241,247,262,277,287,289,296,300,303,311,321,324,326,330,337,340],"los":[7,29,161,164],"procesos":[8,43],"que":[9,37,69,93,102,126,165],"caracterizan":[10],"el":[11,16,72,134,145,158,186,231,245,335],"cancer.":[12,111,137],"Estos":[13],"cambios":[14,61],"en":[15,41,97,107,117,169,200,239,250],"metabolismo":[17],"las":[19,26,118,190],"c\u00e9lulas":[20,27,119,234],"tumorales":[21,100],"no":[22],"solo":[23],"permiten":[24],"a":[25,113,352],"obtener":[28],"metabolitos":[30],"necesarios":[31],"para":[32,45,133,152,346],"su":[33,114,237,347],"continua":[34],"proliferaci\u00f3n,":[35],"sino":[36],"tambi\u00e9n":[38,62],"participan":[39,168],"activamente":[40],"otros":[42,123],"esenciales":[44],"la":[46,84,88,108,170,173,214,319],"progresi\u00f3n":[47,171],"del":[48,53,110,136],"cancer":[49,204,325],"(se\u00f1alizaci\u00f3n":[50],"oncog\u00e9nica,":[51],"evasi\u00f3n":[52],"sistema":[54],"inmune,":[55],"angiog\u00e9nesis,":[56],"etc.).":[57],"No":[58],"obstante,":[59],"estos":[60,290,316,338],"provocan":[63],"ciertas":[64],"dependencias":[65],"y":[66,78,86,101,122,147,154,236,258,328],"vulnerabilidades":[67],"metab\u00f3licas":[68],"pueden":[70],"ser":[71],"objetivo":[73,139],"tratamientos":[75],"farmacol\u00f3gicos.":[76],"PEPCK-M":[77,153,221,254,263],"PYCR1":[79,278,341],"son":[80,129],"dos":[81],"enzimas,":[82],"gluconeog\u00e9nesis":[85],"bios\u00edntesis":[89],"prolina":[91],"respectivamente,":[92],"est\u00e1n":[94],"sobre":[95],"expresadas":[96],"diferentes":[98],"tipos":[99],"juegan":[103],"un":[104,179,268,301,343,350],"papel":[105],"importante":[106,115],"biolog\u00eda":[109],"Debido":[112],"rol":[116],"tumorales,":[120],"nosotros":[121],"autores":[124],"proponemos":[125],"ambas":[127],"enzimas":[128,167],"dianas":[130],"terap\u00e9uticas":[131],"emergentes":[132],"tratamiento":[135,227],"El":[138,211,226],"esta":[141],"tesis":[142],"doctoral":[143],"dise\u00f1o":[146],"validaci\u00f3n":[148],"inhibidores":[150,339],"espec\u00edficos":[151],"PYCR1,":[155],"as\u00ed":[156,253],"como":[157,255,260],"estudio":[159],"mecanismos":[162],"por":[163],"estas":[166],"enfermedad.":[174],"Para":[175],"ello,":[176],"hemos":[177],"usado":[178],"enfoque":[180],"multidisciplinar":[181],"combinando":[182],"t\u00e9cnicas":[183],"computacionales":[184],"(como":[185],"docking":[187],"molecular":[188],"o":[189],"simulaciones":[191,295],"din\u00e1micas":[193],"moleculares)":[194],"e":[195,205],"experimentales":[196],"(ensayos":[197],"in":[198,206],"vitro,":[199],"l\u00edneas":[201,322],"celulares":[202,323],"vivo":[207],"con":[208,222,228,264,274,309],"modelos":[209],"animales).":[210],"inhibidor":[212,261],"isoforma":[215],"citos\u00f3lica":[216],"PEPCK":[218],"iPEPCK-2,":[219],"inhibi\u00f3":[220,244],"una":[223,280],"potencia":[224],"similar.":[225],"iPEPCK-2":[229,259],"redujo":[230],"crecimiento":[232,246],"cancer\u00edgenas":[235],"viabilidad":[238],"deprivaci\u00f3n":[240],"glucosa.":[242],"Adem\u00e1s,":[243],"tumores":[248],"insertados":[249],"ratones.":[251],"Validando":[252],"diana":[256],"terap\u00e9utica":[257],"actividad":[265,275],"antineopl\u00e1sica.":[266],"Mediante":[267],"cribado":[269],"virtual":[270],"identificamos":[271],"varias":[272],"mol\u00e9culas":[273],"inhibitoria":[276],"(con":[279],"IC50":[281],"<":[282],"200":[283],"\u00b5M).":[284],"Los":[285],"modos":[286],"uni\u00f3n":[288],"compuestos":[291,308,317],"fueron":[292],"predichos":[293],"usando":[294],"dinamica":[297],"molecular.":[298],"Despu\u00e9s":[299],"proceso":[302],"optimizaci\u00f3n":[304,348],"racional":[305],"se":[306],"obtuvieron":[307],"actividades":[310],"hasta":[312,349],"30":[313],"\u00b5M.":[314],"Interesantemente":[315],"inhibieron":[318],"proliferaci\u00f3n":[320],"mama":[327],"colon":[329],"forma":[331],"dosis-dependiente.":[332],"As\u00ed":[333],"pues,":[334],"descubrimiento":[336],"plantea":[342],"escenario":[344],"favorable":[345],"candidato":[351],"f\u00e1rmaco.":[353]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2025-10-10T00:00:00"}
