{"id":"https://openalex.org/W7033651646","doi":null,"title":"Rho is a presynaptic activator of neurotransmitter release at pre-existing synapses in iC. elegans/i.","display_name":"Rho is a presynaptic activator of neurotransmitter release at pre-existing synapses in iC. elegans/i.","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W7033651646"},"language":"en","primary_location":{"id":"pmh:oai:oro.open.ac.uk:44159","doi":null,"is_oa":false,"landing_page_url":"https://oro.open.ac.uk/44159/1/Genes%20Dev.-2006-McMullan-65-76.pdf","pdf_url":"https://oro.open.ac.uk/44159/1/Genes%20Dev.-2006-McMullan-65-76.pdf","source":{"id":"https://openalex.org/S4306401187","display_name":"Open Research Online (The Open University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204136569","host_organization_name":"The Open University","host_organization_lineage":["https://openalex.org/I204136569"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056074198","display_name":"Rachel McMullan","orcid":"https://orcid.org/0000-0003-2677-8016","observed_orcids":["https://orcid.org/0000-0003-2677-8016"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mcmullan, Rachel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072978628","display_name":"Emma Hiley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiley, Emma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153233596","display_name":"Paul Morrison","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Morrison, Paul","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5034357547","display_name":"Stephen Nurrish","orcid":"https://orcid.org/0000-0002-2653-9384","observed_orcids":["https://orcid.org/0000-0002-2653-9384"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nurrish, Stephen J.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.850600004196167,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.850600004196167,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.07599999755620956,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.059300001710653305,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rho-gtpases","display_name":"Rho GTPases","score":0.9860000014305115},{"id":"https://openalex.org/keywords/rhoa","display_name":"RhoA","score":0.949999988079071},{"id":"https://openalex.org/keywords/presynaptic-neurotransmitter-release","display_name":"presynaptic neurotransmitter release","score":0.8379999995231628},{"id":"https://openalex.org/keywords/neuromuscular-junction","display_name":"neuromuscular junction","score":0.9580000042915344},{"id":"https://openalex.org/keywords/acetylcholine-release","display_name":"acetylcholine release","score":0.9190000295639038},{"id":"https://openalex.org/keywords/diacylglycerol","display_name":"diacylglycerol","score":0.9760000109672546},{"id":"https://openalex.org/keywords/unc-13","display_name":"UNC-13","score":0.8730000257492065},{"id":"https://openalex.org/keywords/c3-transferase","display_name":"C3 transferase","score":0.8479999899864197},{"id":"https://openalex.org/keywords/synaptic-transmission","display_name":"synaptic transmission","score":0.8550000190734863},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.9129999876022339},{"id":"https://openalex.org/keywords/rhoa-mutations","display_name":"RHOA mutations","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C2777093181","wikidata":"https://www.wikidata.org/wiki/Q15331450","display_name":"RHOA","level":3,"score":0.8294000029563904},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.6741999983787537},{"id":"https://openalex.org/C36020004","wikidata":"https://www.wikidata.org/wiki/Q106951674","display_name":"Diacylglycerol kinase","level":4,"score":0.66839998960495},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.6276000142097473},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6021999716758728},{"id":"https://openalex.org/C2777240379","wikidata":"https://www.wikidata.org/wiki/Q776995","display_name":"Neuromuscular junction","level":2,"score":0.5357999801635742},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.5313000082969666},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.5008000135421753},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4875999987125397},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.44929999113082886},{"id":"https://openalex.org/C156927020","wikidata":"https://www.wikidata.org/wiki/Q1187783","display_name":"Neurotransmitter receptor","level":3,"score":0.44609999656677246},{"id":"https://openalex.org/C148785051","wikidata":"https://www.wikidata.org/wiki/Q671136","display_name":"Synaptic vesicle","level":4,"score":0.4043999910354614},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3767000138759613},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36880001425743103},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.36649999022483826},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.36640000343322754},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.3562000095844269},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.32850000262260437},{"id":"https://openalex.org/C25274449","wikidata":"https://www.wikidata.org/wiki/Q1805481","display_name":"Long-term potentiation","level":3,"score":0.31450000405311584},{"id":"https://openalex.org/C126619667","wikidata":"https://www.wikidata.org/wiki/Q901088","display_name":"Guanine nucleotide exchange factor","level":3,"score":0.31150001287460327},{"id":"https://openalex.org/C99223954","wikidata":"https://www.wikidata.org/wiki/Q5419646","display_name":"Excitatory synapse","level":4,"score":0.3068999946117401},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.2946000099182129},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.28850001096725464},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2799000144004822},{"id":"https://openalex.org/C80161118","wikidata":"https://www.wikidata.org/wiki/Q408520","display_name":"Acetylcholine receptor","level":3,"score":0.25929999351501465},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.257099986076355},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.2547000050544739}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:oro.open.ac.uk:44159","doi":null,"is_oa":false,"landing_page_url":"https://oro.open.ac.uk/44159/1/Genes%20Dev.-2006-McMullan-65-76.pdf","pdf_url":"https://oro.open.ac.uk/44159/1/Genes%20Dev.-2006-McMullan-65-76.pdf","source":{"id":"https://openalex.org/S4306401187","display_name":"Open Research Online (The Open University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204136569","host_organization_name":"The Open University","host_organization_lineage":["https://openalex.org/I204136569"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"PeerReviewed"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1517140397","https://openalex.org/W1522964198","https://openalex.org/W1600427108","https://openalex.org/W1614445885","https://openalex.org/W1840564118","https://openalex.org/W1965080014","https://openalex.org/W1977925481","https://openalex.org/W1981090202","https://openalex.org/W1991091954","https://openalex.org/W1991355251","https://openalex.org/W1993678582","https://openalex.org/W1993837490","https://openalex.org/W2005020760","https://openalex.org/W2009945174","https://openalex.org/W2010867211","https://openalex.org/W2016979915","https://openalex.org/W2018461674","https://openalex.org/W2019731805","https://openalex.org/W2022760538","https://openalex.org/W2026068903","https://openalex.org/W2028363992","https://openalex.org/W2031494860","https://openalex.org/W2032125422","https://openalex.org/W2032295238","https://openalex.org/W2037680312","https://openalex.org/W2040997299","https://openalex.org/W2052325297","https://openalex.org/W2052818515","https://openalex.org/W2067206130","https://openalex.org/W2067349307","https://openalex.org/W2069199106","https://openalex.org/W2073162111","https://openalex.org/W2077166985","https://openalex.org/W2083995758","https://openalex.org/W2086170256","https://openalex.org/W2087447309","https://openalex.org/W2089827948","https://openalex.org/W2090091413","https://openalex.org/W2090612802","https://openalex.org/W2096791952","https://openalex.org/W2104311853","https://openalex.org/W2105280248","https://openalex.org/W2109067831","https://openalex.org/W2123196357","https://openalex.org/W2127575685","https://openalex.org/W2128300032","https://openalex.org/W2133424481","https://openalex.org/W2135212786","https://openalex.org/W2137882621","https://openalex.org/W2147756001","https://openalex.org/W2154100802","https://openalex.org/W2159565935","https://openalex.org/W2159891542","https://openalex.org/W2163850801","https://openalex.org/W2164959082","https://openalex.org/W2165427035","https://openalex.org/W2168634382","https://openalex.org/W2403035376","https://openalex.org/W4212792929","https://openalex.org/W4246590628","https://openalex.org/W7073635458"],"related_works":["https://openalex.org/W7073783618","https://openalex.org/W7047724368","https://openalex.org/W849682169","https://openalex.org/W2102554803","https://openalex.org/W4416347542","https://openalex.org/W7028491556","https://openalex.org/W1991091954","https://openalex.org/W7129017154","https://openalex.org/W2086659557","https://openalex.org/W2889694429"],"abstract_inverted_index":{"Rho":[0,24,45,72,89,128],"GTPases":[1],"have":[2,168],"important":[3],"roles":[4],"in":[5,11,23,99,121,161],"neuronal":[6,122],"development,":[7],"but":[8],"their":[9],"function":[10],"adult":[12],"neurons":[13],"is":[14,82,106,165],"less":[15],"well":[16],"understood.":[17],"We":[18,114],"demonstrate":[19],"that":[20,147],"presynaptic":[21,44],"changes":[22,120],"activity":[25],"at":[26,62,111],"iCaenorhabditis":[27],"elegans/i":[28],"neuromuscular":[29],"junctions":[30],"can":[31],"radically":[32],"change":[33],"animal":[34],"behavior":[35],"via":[36],"modulation":[37],"of":[38,54,64,71,87,96,102,108,151],"two":[39],"separate":[40],"pathways.":[41],"In":[42],"one,":[43],"increases":[46],"acetylcholine":[47],"(ACh)":[48],"release":[49,97,112],"by":[50,84,132],"stimulating":[51],"the":[52,58,74,85,100],"accumulation":[53,110],"diacylglycerol":[55],"(DAG)":[56],"and":[57],"DAG-binding":[59],"protein":[60],"UNC-13":[61,109],"sites":[63],"neurotransmitter":[65],"release;":[66],"this":[67,104],"pathway":[68,105],"requires":[69],"binding":[70,150],"to":[73,93,153,167],"DAG":[75,154,163],"kinase":[76],"DGK-1.":[77],"A":[78],"second":[79],"DGK-1-independent":[80],"mechanism":[81],"revealed":[83],"ability":[86],"a":[88,133,157],"inhibitor":[90],"(C3":[91],"transferase)":[92],"decrease":[94],"levels":[95,164],"even":[98],"absence":[101],"DGK-1;":[103],"independent":[107],"sites.":[113],"do":[115],"not":[116],"detect":[117],"any":[118],"Rho-induced":[119],"morphology":[123],"or":[124],"synapse":[125],"number;":[126],"thus,":[127],"facilitates":[129],"synaptic":[130],"transmission":[131],"novel":[134],"mechanism.":[135],"Surprisingly,":[136],"many":[137],"commonly":[138],"available":[139],"human":[140],"RhoA":[141,152,160],"constructs":[142],"contain":[143],"an":[144],"uncharacterized":[145],"mutation":[146],"severely":[148],"reduces":[149],"kinase.":[155],"Thus,":[156],"role":[158],"for":[159],"controlling":[162],"likely":[166],"been":[169],"underestimated.":[170]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}
