{"id":"https://openalex.org/W70319238","doi":null,"title":"Toxins of Pufferfish That Cause Human Intoxications","display_name":"Toxins of Pufferfish That Cause Human Intoxications","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W70319238","mag":"70319238"},"language":"en","primary_location":{"id":"pmh:oai:naosite.lb.nagasaki-u.ac.jp:10069/23514","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10069/23514","pdf_url":"http://hdl.handle.net/10069/23514","source":{"id":"https://openalex.org/S4306400113","display_name":"Nagasaki University's Academic Output SITE (Nagasaki University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43777268","host_organization_name":"Nagasaki University","host_organization_lineage":["https://openalex.org/I43777268"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10069/23514","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031980050","display_name":"Osamu Arakawa","orcid":"https://orcid.org/0000-0003-1556-6405","observed_orcids":["https://orcid.org/0000-0003-1556-6405"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Osamu Arakawa","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1556-6405","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014284095","display_name":"Deng\u2010Fwu Hwang","orcid":"https://orcid.org/0000-0002-3264-8675","observed_orcids":["https://orcid.org/0000-0002-3264-8675"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Deng\u2010Fwu Hwang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3264-8675","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066386536","display_name":"Shigeto Taniyama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shigeto Taniyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5003986639","display_name":"Tomohiro Takayani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomohiro Takayani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8435,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.80446097,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":null,"issue":null,"first_page":"227","last_page":"244"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11985","display_name":"Marine Toxins and Detection Methods","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11985","display_name":"Marine Toxins and Detection Methods","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11684","display_name":"Vibrio bacteria research studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tetrodotoxin","display_name":"tetrodotoxin","score":0.968999981880188},{"id":"https://openalex.org/keywords/pufferfish-poisoning","display_name":"pufferfish poisoning","score":0.8100000023841858},{"id":"https://openalex.org/keywords/paralytic-shellfish-poisoning","display_name":"paralytic shellfish poisoning","score":0.8209999799728394},{"id":"https://openalex.org/keywords/palytoxin","display_name":"palytoxin","score":0.8939999938011169},{"id":"https://openalex.org/keywords/boxfish","display_name":"boxfish","score":0.8610000014305115},{"id":"https://openalex.org/keywords/marine-bacteria","display_name":"marine bacteria","score":0.5680000185966492},{"id":"https://openalex.org/keywords/toxin-bioaccumulation","display_name":"toxin bioaccumulation","score":0.546999990940094},{"id":"https://openalex.org/keywords/foodborne-illness","display_name":"food poisoning","score":0.3540000021457672},{"id":"https://openalex.org/keywords/global-warming","display_name":"global warming","score":0.32100000977516174},{"id":"https://openalex.org/keywords/taiwan","display_name":"Taiwan","score":0.3100000023841858},{"id":"https://openalex.org/keywords/japan","display_name":"Japan","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C2776741303","wikidata":"https://www.wikidata.org/wiki/Q379842","display_name":"Tetrodotoxin","level":2,"score":0.7315744757652283},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6677463054656982},{"id":"https://openalex.org/C2780358027","wikidata":"https://www.wikidata.org/wiki/Q407752","display_name":"Neurotoxin","level":2,"score":0.5482925176620483},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.5378360748291016},{"id":"https://openalex.org/C193230392","wikidata":"https://www.wikidata.org/wiki/Q1663054","display_name":"Ingestion","level":2,"score":0.49459001421928406},{"id":"https://openalex.org/C2776876274","wikidata":"https://www.wikidata.org/wiki/Q272002","display_name":"Food poisoning","level":2,"score":0.4306219816207886},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.15690365433692932},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.10490092635154724}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:naosite.lb.nagasaki-u.ac.jp:10069/23514","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10069/23514","pdf_url":"http://hdl.handle.net/10069/23514","source":{"id":"https://openalex.org/S4306400113","display_name":"Nagasaki University's Academic Output SITE (Nagasaki University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43777268","host_organization_name":"Nagasaki University","host_organization_lineage":["https://openalex.org/I43777268"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"pmh:oai:irdb.nii.ac.jp:01160:0004785156","doi":null,"is_oa":true,"landing_page_url":"https://nagasaki-u.repo.nii.ac.jp/records/15599","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Coastal Environmental and Ecosystem Issues of the East China Sea","raw_type":"research report"},{"id":"mag:70319238","doi":null,"is_oa":false,"landing_page_url":"https://www.terrapub.co.jp/onlineproceedings/fs/nu/pdf/nu2010227.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:naosite.lb.nagasaki-u.ac.jp:10069/23514","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10069/23514","pdf_url":"http://hdl.handle.net/10069/23514","source":{"id":"https://openalex.org/S4306400113","display_name":"Nagasaki University's Academic Output SITE (Nagasaki University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43777268","host_organization_name":"Nagasaki University","host_organization_lineage":["https://openalex.org/I43777268"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W70319238.pdf","grobid_xml":"https://content.openalex.org/works/W70319238.grobid-xml"},"referenced_works_count":105,"referenced_works":["https://openalex.org/W18402857","https://openalex.org/W64835285","https://openalex.org/W132240445","https://openalex.org/W569752416","https://openalex.org/W571720025","https://openalex.org/W876182484","https://openalex.org/W1436421781","https://openalex.org/W1606849762","https://openalex.org/W1911337689","https://openalex.org/W1969325207","https://openalex.org/W1971039492","https://openalex.org/W1972457833","https://openalex.org/W1976180690","https://openalex.org/W1976335571","https://openalex.org/W1982013682","https://openalex.org/W1983333381","https://openalex.org/W1986082262","https://openalex.org/W1987064410","https://openalex.org/W1992171735","https://openalex.org/W1992364676","https://openalex.org/W1994019354","https://openalex.org/W1999672224","https://openalex.org/W2002319820","https://openalex.org/W2005942284","https://openalex.org/W2006851863","https://openalex.org/W2007053281","https://openalex.org/W2011073938","https://openalex.org/W2016359600","https://openalex.org/W2016561740","https://openalex.org/W2016789911","https://openalex.org/W2017941371","https://openalex.org/W2018217461","https://openalex.org/W2024565168","https://openalex.org/W2026187187","https://openalex.org/W2032405275","https://openalex.org/W2035560510","https://openalex.org/W2036894670","https://openalex.org/W2038798109","https://openalex.org/W2040375249","https://openalex.org/W2042383113","https://openalex.org/W2045187722","https://openalex.org/W2047036110","https://openalex.org/W2048321148","https://openalex.org/W2049528070","https://openalex.org/W2050212948","https://openalex.org/W2051340045","https://openalex.org/W2052069523","https://openalex.org/W2054272277","https://openalex.org/W2054917900","https://openalex.org/W2055591331","https://openalex.org/W2057738796","https://openalex.org/W2060805075","https://openalex.org/W2060931582","https://openalex.org/W2061833181","https://openalex.org/W2064392898","https://openalex.org/W2065857813","https://openalex.org/W2068903958","https://openalex.org/W2068969834","https://openalex.org/W2070217801","https://openalex.org/W2073763076","https://openalex.org/W2073913658","https://openalex.org/W2075046583","https://openalex.org/W2082550973","https://openalex.org/W2085257512","https://openalex.org/W2087826577","https://openalex.org/W2089096482","https://openalex.org/W2090455182","https://openalex.org/W2092340158","https://openalex.org/W2094142039","https://openalex.org/W2098165283","https://openalex.org/W2106801310","https://openalex.org/W2118186187","https://openalex.org/W2123861722","https://openalex.org/W2130623226","https://openalex.org/W2132386170","https://openalex.org/W2132877812","https://openalex.org/W2144943660","https://openalex.org/W2158392638","https://openalex.org/W2164926752","https://openalex.org/W2234446673","https://openalex.org/W2264726938","https://openalex.org/W2301023786","https://openalex.org/W2312249337","https://openalex.org/W2312617346","https://openalex.org/W2313251711","https://openalex.org/W2315271499","https://openalex.org/W2316233190","https://openalex.org/W2316586101","https://openalex.org/W2318189012","https://openalex.org/W2321395266","https://openalex.org/W2322480976","https://openalex.org/W2323099498","https://openalex.org/W2324259002","https://openalex.org/W2324383872","https://openalex.org/W2324590531","https://openalex.org/W2330739575","https://openalex.org/W2331262890","https://openalex.org/W2344141336","https://openalex.org/W2508198447","https://openalex.org/W2511251744","https://openalex.org/W2595650177","https://openalex.org/W2741107789","https://openalex.org/W3043578691","https://openalex.org/W3180023834","https://openalex.org/W4256377323"],"related_works":["https://openalex.org/W327074084","https://openalex.org/W4242103218","https://openalex.org/W7097437987","https://openalex.org/W4246612018","https://openalex.org/W2040811545","https://openalex.org/W7099824280","https://openalex.org/W2180515962","https://openalex.org/W1967662556","https://openalex.org/W4380680220","https://openalex.org/W4297515726"],"abstract_inverted_index":{"Many":[0],"marine":[1,33,286,332],"pufferfish":[2,74,88,99,283,287],"possess":[3,143,288],"a":[4,22,38,90,146,202,219,273,328],"potent":[5],"neurotoxin,":[6],"tetrodotoxin":[7],"(TTX).":[8],"In":[9,44],"general,":[10],"they":[11],"have":[12,82,174],"strong":[13],"toxicity":[14,322,365],"in":[15,104,154,160,178,192,209,214,236,265,278,296,330,337],"the":[16,50,73,85,98,105,111,114,128,155,161,210,215,232,269,279,311,331,348,364],"liver":[17,86,106],"and":[18,35,65,94,107,120,140,180,200,242,284,300,315,320,355,366],"ovary,":[19],"leading":[20],"to":[21,110,138,142,170,226,250,298,341,346],"frequent":[23],"occurrence":[24],"of":[25,41,55,68,87,122,130,157,165,205,221,228,231,252,258,294,310,368],"human":[26],"poisonings.":[27],"TTX":[28,46,69,95,123,144,151,167,206],"is":[29,47,101,197,272,362],"originally":[30],"produced":[31],"by":[32,127,306,327],"bacteria":[34],"distributes":[36],"over":[37],"wide":[39],"variety":[40,257],"aquatic":[42],"animals.":[43],"pufferfish,":[45],"derived":[48],"from":[49],"food":[51,189,259],"chain":[52],"that":[53,84,261,268],"consists":[54],"these":[56,369],"TTXbearing":[57],"organisms":[58,133],"(i.e.,":[59],"their":[60,321],"prey).":[61],"The":[62,245,308],"transfer,":[63],"accumulation,":[64],"elimination":[66],"mechanisms":[67],"taken":[70],"up":[71],"into":[72,97],"body":[75,100],"via":[76],"prey":[77],"remain":[78],"unclear.":[79],"Recent":[80],"studies":[81],"revealed":[83],"has":[89,262],"specific":[91],"TTXuptake":[92],"mechanism,":[93],"introduced":[96],"first":[102],"absorbed":[103],"then":[108],"transferred":[109],"skin":[112],"through":[113],"circulatory":[115],"system.":[116],"This":[117],"inter-tissue":[118],"transfer":[119],"accumulation":[121],"are":[124,247,317],"greatly":[125,325],"affected":[126,326],"state":[129],"maturation.":[131],"TTX-bearing":[132],"show":[134],"extremely":[135],"high":[136],"resistance":[137],"TTX,":[139,299],"seem":[141],"as":[145,277,335],"biological":[147],"defense":[148],"mechanism.":[149],"Furthermore,":[150],"may":[152,301,323],"involved":[153],"control":[156],"information":[158],"transmission":[159],"central":[162],"nervous":[163],"system":[164],"pufferfish.":[166],"poisonings":[168],"due":[169,225,340],"small":[171],"scavenging":[172],"gastropods":[173],"so":[175],"far":[176],"occurred":[177,235,264],"Taiwan":[179],"China.":[181],"Recently,":[182],"one":[183],"such":[184,334],"gastropod,":[185],"Nassarius":[186],"glans,":[187],"caused":[188],"poisoning":[190,223,254,260,305],"incidents":[191,224],"Kyushu,":[193],"Japan.":[194],"N.":[195],"glans":[196],"highly":[198],"toxic,":[199],"possesses":[201],"large":[203],"amount":[204],"not":[207],"only":[208],"viscera":[211],"but":[212],"also":[213],"muscle.":[216],"After":[217],"1990,":[218],"total":[220],"9":[222],"ingestion":[227],"boxfish":[229],"(pufferfish":[230],"family":[233],"Ostraciidae)":[234],"southwestern":[237],"Japan,":[238],"involving":[239],"13":[240],"patients":[241],"1":[243],"death.":[244],"symptoms":[246],"very":[248],"similar":[249],"those":[251],"parrotfish":[253,280],"(a":[255],"unique":[256],"sporadically":[263],"Japan),":[266],"suggesting":[267],"causative":[270],"substance":[271],"palytoxin":[274],"(PTX)-like":[275],"toxin":[276],"poisoning.":[281],"Freshwater":[282],"some":[285],"paralytic":[289],"shellfish":[290,304,316],"poison":[291],"(PSP)":[292],"instead":[293],"or":[295],"addition":[297],"cause":[302],"\u2018paralytic":[303],"pufferfish\u2019.":[307],"toxins":[309],"above":[312],"mentioned":[313],"fish":[314],"all":[318],"exogenous,":[319],"be":[324],"change":[329],"environment,":[333],"elevations":[336],"water":[338],"temperature":[339],"global":[342],"worming.":[343],"We":[344],"need":[345],"enhance":[347],"information/collaboration":[349],"network":[350],"among":[351],"East":[352],"Asian":[353],"countries":[354],"vigilantly":[356],"monitor":[357],"how":[358],"our":[359],"changing":[360],"climate":[361],"affecting":[363],"distributions":[367],"organisms.":[370]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}