{"id":"https://openalex.org/W7029947867","doi":null,"title":"The lung microenvironment influences the metastatic behaviour of breast cancer cells in an innovative 3D ex vivo pulmonary metastasis model","display_name":"The lung microenvironment influences the metastatic behaviour of breast cancer cells in an innovative 3D ex vivo pulmonary metastasis model","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W7029947867"},"language":"en","primary_location":{"id":"pmh:oai:ir.lib.uwo.ca:etd-4490","doi":null,"is_oa":false,"landing_page_url":"https://ir.lib.uwo.ca/cgi/viewcontent.cgi?article=4490&context=etd","pdf_url":null,"source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Thesis and Dissertation Repository","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006658593","display_name":"Matt Piaseczny","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Piaseczny, Matt M","raw_affiliation_strings":["The University of Western Ontario"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Western Ontario","institution_ids":["https://openalex.org/I125749732"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5006658593"],"corresponding_institution_ids":["https://openalex.org/I125749732"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.46325042,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12992","display_name":"Metastasis and carcinoma case studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer-lung-metastasis","display_name":"breast cancer lung metastasis","score":0.8679999709129333},{"id":"https://openalex.org/keywords/lung-microenvironment","display_name":"lung microenvironment","score":0.9340000152587891},{"id":"https://openalex.org/keywords/3d-cell-culture","display_name":"3D cell culture","score":0.5920000076293945},{"id":"https://openalex.org/keywords/basic-fibroblast-growth-factor","display_name":"basic fibroblast growth factor","score":0.7649999856948853},{"id":"https://openalex.org/keywords/metastatic-progression","display_name":"metastatic progression","score":0.6809999942779541},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7272999882698059},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6974999904632568},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.66839998960495},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.590399980545044},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.5902000069618225},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5388000011444092},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.5371999740600586},{"id":"https://openalex.org/C118646709","wikidata":"https://www.wikidata.org/wiki/Q1657620","display_name":"CA15-3","level":4,"score":0.5009999871253967},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.44290000200271606},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4293000102043152},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4097000062465668},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.3970000147819519},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3723999857902527},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3573000133037567},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.35409998893737793},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.3336000144481659},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.30230000615119934},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2976999878883362},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2919999957084656},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.2906000018119812},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.28529998660087585},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.25440001487731934}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ir.lib.uwo.ca:etd-4490","doi":null,"is_oa":false,"landing_page_url":"https://ir.lib.uwo.ca/cgi/viewcontent.cgi?article=4490&context=etd","pdf_url":null,"source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Thesis and Dissertation Repository","raw_type":"text"},{"id":"pmh:oai:uwo.scholaris.ca:20.500.14721/35861","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.14721/35861","pdf_url":null,"source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"thesis"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W746076057","https://openalex.org/W1992891544","https://openalex.org/W2001561153","https://openalex.org/W2740581458","https://openalex.org/W4394012741","https://openalex.org/W4380318935","https://openalex.org/W2799449613","https://openalex.org/W4281651372","https://openalex.org/W2785985196","https://openalex.org/W4400688673"],"abstract_inverted_index":{"Lung":[0],"metastasis":[1,21],"remains":[2],"a":[3,121],"leading":[4],"cause":[5],"of":[6,35,48,73,82,125],"death":[7],"in":[8,45,58,77,112,116],"breast":[9,41,49,64,74,108,126,141],"cancer":[10,42,50,65,75,109,127,142],"patients.":[11],"This":[12,130],"study":[13],"established":[14],"an":[15],"innovative":[16],"3D":[17],"ex":[18],"vivo":[19,46],"pulmonary":[20],"assay":[22],"(PuMA)":[23],"to":[24,52,62,91,98],"test":[25],"the":[26,29,78,117,138,145],"hypothesis":[27],"that":[28],"lung":[30,146],"microenvironment":[31],"promotes":[32],"metastatic":[33,71,148],"behaviour":[34],"whole":[36],"population":[37],"and":[38,60,144],"stem-like":[39],"ALDHhiCD44+":[40,83],"cells.":[43],"Following":[44],"delivery":[47],"cells":[51,76,84,90,143],"mice,":[53],"lungs":[54],"were":[55],"excised,":[56],"maintained":[57],"culture":[59],"imaged":[61],"observe":[63],"growth":[66],"over":[67,94],"time.":[68],"We":[69],"observed":[70],"progression":[72],"PuMA,":[79],"most":[80],"notably":[81],"which":[85],"progressed":[86],"rapidly":[87],"from":[88],"single":[89],"multicellular":[92],"colonies":[93],"21":[95],"days":[96],"relative":[97],"their":[99],"ALDHloCD44-":[100],"counterparts":[101],"(p\u22640.05).":[102],"Although":[103],"soluble":[104],"lung-derived":[105],"bFGF":[106,115],"induced":[107],"cell":[110,128],"proliferation":[111],"vitro,":[113],"blocking":[114],"PuMA":[118],"showed":[119],"only":[120],"trend":[122],"towards":[123],"inhibition":[124],"growth.":[129],"model":[131],"system":[132],"will":[133],"be":[134],"valuable":[135],"for":[136],"elucidating":[137],"interaction":[139],"between":[140],"during":[147],"progression.":[149]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}
