{"id":"https://openalex.org/W7029690185","doi":null,"title":"Links between plasma apoE and glucose metabolism, brain insulin signaling, and synaptic integrity : Relevance to Alzheimer\u2019s disease pathophysiology","display_name":"Links between plasma apoE and glucose metabolism, brain insulin signaling, and synaptic integrity : Relevance to Alzheimer\u2019s disease pathophysiology","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W7029690185"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:su-191938","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-191938","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-191938","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Edlund, Anna","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Edlund, Anna","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.04839999973773956,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.9940000176429749},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.6990000009536743},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9440000057220459},{"id":"https://openalex.org/keywords/apoe-isoforms","display_name":"APOE isoforms","score":0.6919999718666077},{"id":"https://openalex.org/keywords/cerebral-glucose-hypometabolism","display_name":"cerebral glucose hypometabolism","score":0.8169999718666077},{"id":"https://openalex.org/keywords/brain-insulin-signaling","display_name":"brain insulin signaling","score":0.7200000286102295},{"id":"https://openalex.org/keywords/synaptic-integrity","display_name":"synaptic integrity","score":0.9750000238418579},{"id":"https://openalex.org/keywords/mild-cognitive-impairment","display_name":"mild cognitive impairment","score":0.8029999732971191},{"id":"https://openalex.org/keywords/apoe-epsilon4-carriers","display_name":"APOE \u03b54 carriers","score":0.6389999985694885},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.9300000071525574},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9190000295639038}],"concepts":[{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.8264999985694885},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7638999819755554},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7573000192642212},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.6814000010490417},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5292999744415283},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.501800000667572},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4977000057697296},{"id":"https://openalex.org/C3020574416","wikidata":"https://www.wikidata.org/wiki/Q275157","display_name":"Plasma glucose","level":3,"score":0.4896000027656555},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4846999943256378},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.423799991607666},{"id":"https://openalex.org/C3020134792","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Human plasma","level":2,"score":0.4174000024795532},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3637000024318695},{"id":"https://openalex.org/C3017575891","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma levels","level":2,"score":0.3582000136375427},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.35679998993873596},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.3474999964237213},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.33660000562667847},{"id":"https://openalex.org/C2776575606","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Blood plasma","level":2,"score":0.3280999958515167},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.302700012922287},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2833999991416931},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.2809000015258789},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.27410000562667847},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.27059999108314514},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.26899999380111694},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.26440000534057617},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.25940001010894775},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.2581999897956848},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.25589999556541443}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:DiVA.org:su-191938","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-191938","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:DiVA.org:su-191938","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-191938","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3142832748","https://openalex.org/W2580241126","https://openalex.org/W2261760577","https://openalex.org/W2811122574","https://openalex.org/W7051808739","https://openalex.org/W2534239918","https://openalex.org/W3111789034","https://openalex.org/W7114776462","https://openalex.org/W4238610650","https://openalex.org/W2116248575"],"abstract_inverted_index":{"Human":[0],"apolipoprotein":[1],"E":[2],"(apoE)":[3],"exists":[4],"as":[5],"three":[6],"main":[7,106],"isoforms":[8],"called":[9],"apoE2,":[10],"apoE3,":[11],"and":[12,56,120,130,135,146,157,182,204,225,275,340,357,410,437,439,484],"apoE4,":[13],"of":[14,50,74,108,122,223,234,272,286,295,327,337,366,388,430,469],"which":[15],"the":[16,83,91,101,186,219,231,240,265,287,293,306,317,331,367,380,389,408,412,428,431,459,478,492],"E4":[17],"isoform":[18],"is":[19,76,93,404],"associated":[20,197,283],"with":[21,141,160,198,206,218,247,255,284,302,305,322,414],"increased":[22,79,315],"Alzheimer\u2019s":[23],"disease":[24],"(AD)":[25],"risk.":[26,81],"Brain":[27],"glucose":[28,58,200,213,224],"hypometabolism,":[29],"linked":[30,77],"to":[31,53,78,113,360,374,396,477],"synaptic":[32,273,328,341],"dysfunction,":[33],"occurs":[34],"years":[35],"before":[36],"symptom":[37],"onset":[38],"in":[39,42,63,90,133,139,167,171,185,202,264,270,300,316,349,384,407,411],"AD,":[40],"especially":[41],"APOE\u03b54-carriers.":[43],"An":[44],"association":[45],"between":[46,117,178],"a":[47,115,235,296],"higher":[48,199],"ratio":[49],"plasma":[51,70,84,118,127,152,179,194],"apoE4":[52,279],"apoE3":[54,195],"levels":[55,129,154,184,201,214,280,326,336,351],"cerebral":[57,220],"hypometabolism":[59],"was":[60,111,196,314],"recently":[61],"discovered":[62],"cognitively":[64,189],"healthy":[65,190],"APOE\u03b53/\u03b54":[66,191],"subjects.":[67,192],"A":[68],"lower":[69,156],"apoE":[71,85,98,119,128,153,263,313,350],"level,":[72],"regardless":[73],"isoform,":[75],"AD":[80,123,161,168,307],"How":[82],"level":[86],"affects":[87],"neurodegenerative":[88],"processes":[89],"brain":[92],"poorly":[94,424],"understood,":[95],"given":[96],"that":[97,347,377,457],"doesn\u2019t":[99],"cross":[100],"blood-brain":[102],"barrier":[103],"(BBB).":[104],"The":[105,386],"aim":[107],"this":[109],"thesis":[110],"therefore":[112],"investigate":[114],"relationship":[116],"features":[121],"pathophysiology.":[124],"We":[125,173,290,426],"explored":[126,292,427],"dimer/monomer":[131],"formation":[132],"APOE\u03b53":[134],"APOE\u03b54":[136,237,355],"homozygous":[137],"controls,":[138],"patients":[140,169],"mild":[142],"cognitive":[143],"impairment":[144],"(MCI)":[145],"AD.":[147,385],"In":[148,330],"APOE\u03b54-carriers":[149],"versus":[150,250],"non-carriers,":[151],"were":[155,165,215,281],"significantly":[158],"correlated":[159,217],"biomarkers.":[162],"ApoE3":[163],"homodimers":[164],"less":[166],"than":[170],"controls.":[172],"next":[174],"examined":[175,188],"potential":[176,232],"links":[177],"apoE,":[180],"glucose,":[181],"insulin":[183,276,338],"previously":[187],"Lower":[193],"males":[203],"subjects":[205],"body":[207],"max":[208],"index":[209],"above":[210],"25.":[211],"Plasma":[212,278],"negatively":[216,282],"metabolic":[221],"rate":[222],"neuropsychological":[226],"test":[227],"scores.":[228],"To":[229,480],"explore":[230],"effects":[233,294,324],"hepatic":[236,354],"phenotype":[238],"on":[239,325,442],"brain,":[241,266],"we":[242,333,455,472],"compared":[243],"liver":[244,258],"humanized":[245,304],"mice":[246,301],"an":[248,251,256,320],"APOE\u03b54/\u03b54":[249,257],"APOE\u03b52/\u03b53":[252],"genotype.":[253,310],"Mice":[254],"exhibited":[259],"reduced":[260],"endogenous":[261],"mouse":[262,312],"accompanied":[267],"by":[268],"changes":[269],"markers":[271],"integrity":[274],"signaling.":[277],"some":[285],"assessed":[288],"markers.":[289,329,342],"further":[291],"high-fat":[297],"diet":[298],"(HFD)":[299],"livers":[303],"risk-neutral":[308],"APOE\u03b53/\u03b53":[309],"Endogenous":[311],"hippocampus":[318],"following":[319],"HFD,":[321],"concomitant":[323],"cortex,":[332],"found":[334,383,456,473],"altered":[335],"signaling":[339],"Together,":[343],"our":[344],"findings":[345],"indicate":[346],"alterations":[348],"or":[352],"distribution,":[353],"phenotype,":[356],"HFD":[358],"contribute":[359],"AD-related":[361],"pathological":[362],"processes.":[363],"Amyloidogenic":[364],"processing":[365,441,486],"amyloid":[368],"precursor":[369],"protein":[370,391],"(APP)":[371],"gives":[372],"rise":[373],"A\u03b2":[375,381],"peptides":[376],"assemble":[378],"into":[379,451],"plaques":[382],"binding":[387],"adaptor":[390],"Fe65,":[392],"through":[393],"its":[394],"PTB2,":[395],"APP":[397,401,440,470,485],"might":[398],"enhance":[399],"amyloidogenic":[400],"processing.":[402],"Fe65":[403,420,433,443,475,493],"localized":[405],"both":[406],"cytoplasm":[409],"nucleus,":[413],"compartment-specific":[415],"biological":[416],"functions.":[417],"Mechanisms":[418],"affecting":[419],"subcellular":[421],"localization":[422,476],"are":[423],"understood.":[425],"impact":[429],"different":[432],"interaction":[434,483],"domains":[435],"WW":[436],"PTB2":[438,460],"cellular":[444,494],"localization.":[445,465,495],"By":[446],"transfecting":[447],"Fe65-domain":[448],"deletion":[449],"constructs":[450],"neuroblastoma":[452],"cell":[453],"lines,":[454],"deleting":[458],"domain":[461],"almost":[462],"abolished":[463],"nuclear":[464],"Upon":[466],"pharmacological":[467],"inhibition":[468],"secretases,":[471],"decreased":[474],"nucleus.":[479],"conclude,":[481],"Fe65-APP":[482],"may":[487],"be":[488],"important":[489],"factors":[490],"governing":[491]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}
