{"id":"https://openalex.org/W7027445384","doi":null,"title":"Cell types of the human retina and its organoids at single cell resolution: developmental convergence, transcriptional identity, and disease map","display_name":"Cell types of the human retina and its organoids at single cell resolution: developmental convergence, transcriptional identity, and disease map","publication_year":null,"publication_date":null,"ids":{"openalex":"https://openalex.org/W7027445384"},"language":"en","primary_location":{"id":"pmh:oai:oak.novartis.com:38908","doi":null,"is_oa":false,"landing_page_url":"https://oak.novartis.com/38908/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400709","display_name":"The Novartis Repository (Novartis)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1283582996","host_organization_name":"Novartis (Switzerland)","host_organization_lineage":["https://openalex.org/I1283582996"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052289696","display_name":"Magdalena Renner","orcid":"https://orcid.org/0009-0009-2322-7535","observed_orcids":["https://orcid.org/0009-0009-2322-7535"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Renner, Magdalena","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Cowan, Cameron","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cowan, Cameron","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006761086","display_name":"Brigitte Gross Scherf","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gross-Scherf, Brigitte","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Goldblum, David","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Goldblum, David","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031321454","display_name":"Jacek Kr\u00f3l","orcid":"https://orcid.org/0000-0002-9828-8190","observed_orcids":["https://orcid.org/0000-0002-9828-8190"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krol, Jacek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042692382","display_name":"Tam\u00e1s Szikra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Szikra, Tamas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Papasaikas, Panagiotus","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Papasaikas, Panagiotus","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Munz, Martin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Munz, Martin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020383923","display_name":"Rachel Cuttat","orcid":"https://orcid.org/0000-0001-6019-4837","observed_orcids":["https://orcid.org/0000-0001-6019-4837"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cuttat-Theurillat, Rachel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011866704","display_name":"Annick Waldt","orcid":"https://orcid.org/0000-0002-4670-1588","observed_orcids":["https://orcid.org/0000-0002-4670-1588"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Waldt, Annick","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081392793","display_name":"Roland Diggelmann","orcid":"https://orcid.org/0000-0002-1819-0995","observed_orcids":["https://orcid.org/0000-0002-1819-0995"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diggelmann, Roland","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065405944","display_name":"Claudia P. Patino-Alvarez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patino-Alvarez, Claudia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112455273","display_name":"Nadine Gerber-Hollbach","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerber-Hollbach, Nadine","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058227744","display_name":"Sven Schuierer","orcid":"https://orcid.org/0000-0003-1659-0941","observed_orcids":["https://orcid.org/0000-0003-1659-0941"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Schuierer, Sven","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090233593","display_name":"Aldin Srdanovic","orcid":"https://orcid.org/0000-0002-1538-8752","observed_orcids":["https://orcid.org/0000-0002-1538-8752"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Srdanovic, Aldin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Balogh, Marton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Balogh, Marton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Pascal, Hasler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pascal, Hasler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086444760","display_name":"\u00c1kos Kusnyerik","orcid":"https://orcid.org/0000-0001-9333-8104","observed_orcids":["https://orcid.org/0000-0001-9333-8104"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kusnyerik, Akos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009381400","display_name":"Arnold Szab\u00f3","orcid":"https://orcid.org/0000-0001-7685-9231","observed_orcids":["https://orcid.org/0000-0001-7685-9231"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Szabo, Arnold","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017987266","display_name":"Michael Beda Stadler","orcid":"https://orcid.org/0000-0002-2269-4934","observed_orcids":["https://orcid.org/0000-0002-2269-4934"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stadler, Michael","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000470100","display_name":"Andreas R. Hierlemann","orcid":"https://orcid.org/0000-0002-3838-2468","observed_orcids":["https://orcid.org/0000-0002-3838-2468"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hierlemann, Andreas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059328359","display_name":"Hendrik P. N. Scholl","orcid":"https://orcid.org/0000-0002-7312-0316","observed_orcids":["https://orcid.org/0000-0002-7312-0316"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scholl, Hendrik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013224356","display_name":"Guglielmo Roma","orcid":"https://orcid.org/0000-0002-8020-4219","observed_orcids":["https://orcid.org/0000-0002-8020-4219"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roma, Guglielmo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059360993","display_name":"Florian Nigsch","orcid":"https://orcid.org/0000-0002-2919-8749","observed_orcids":["https://orcid.org/0000-0002-2919-8749"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nigsch, Florian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Roska, Botond","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roska, Botond","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.8446999788284302,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.8446999788284302,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.1469999998807907,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinal-development","display_name":"retinal development","score":0.7570000290870667},{"id":"https://openalex.org/keywords/retinal-cell-types","display_name":"retinal cell types","score":0.8259999752044678},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.8790000081062317},{"id":"https://openalex.org/keywords/choroid","display_name":"choroid","score":0.6850000023841858},{"id":"https://openalex.org/keywords/disease-genes","display_name":"disease-associated genes","score":0.8040000200271606},{"id":"https://openalex.org/keywords/retinal-disease","display_name":"retinal disease","score":0.4740000069141388},{"id":"https://openalex.org/keywords/cell-identity","display_name":"cell identity","score":0.3440000116825104}],"concepts":[{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.9567999839782715},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7935000061988831},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.7276999950408936},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7178000211715698},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.6129000186920166},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.5776000022888184},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5476999878883362},{"id":"https://openalex.org/C100094513","wikidata":"https://www.wikidata.org/wiki/Q180436","display_name":"Cilium","level":2,"score":0.3815000057220459},{"id":"https://openalex.org/C2776950831","wikidata":"https://www.wikidata.org/wiki/Q15635432","display_name":"Single-cell analysis","level":3,"score":0.3343999981880188},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.325300008058548},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.3230000138282776},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3158000111579895},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.30149999260902405},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.2946000099182129},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29120001196861267},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.287200003862381},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.28220000863075256},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.2757999897003174},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.26019999384880066}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:oak.novartis.com:38908","doi":null,"is_oa":false,"landing_page_url":"https://oak.novartis.com/38908/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400709","display_name":"The Novartis Repository (Novartis)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1283582996","host_organization_name":"Novartis (Switzerland)","host_organization_lineage":["https://openalex.org/I1283582996"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7221441917","https://openalex.org/W3087102910","https://openalex.org/W6906579425","https://openalex.org/W4283014723","https://openalex.org/W4315489784","https://openalex.org/W4412867290","https://openalex.org/W3118034245","https://openalex.org/W6913042472","https://openalex.org/W3005472012","https://openalex.org/W3087335571"],"abstract_inverted_index":{"Organoids":[0],"are":[1],"stem":[2],"cell-derived":[3],"artificial":[4],"organs":[5],"that":[6,28,75],"mimic":[7],"aspects":[8],"of":[9,29,44,96,102],"organ":[10,32],"development,":[11],"function":[12],"and":[13,20,40,57,64,73,92,121],"disease.":[14],"How":[15],"closely":[16],"cell":[17,21,97,110],"type":[18,22],"diversity":[19],"maturation":[23],"in":[24,68,119,125],"human":[25,50,62,90],"organoids":[26,52,70,81,120],"recapitulate":[27],"their":[30,77],"target":[31],"is":[33],"not":[34],"well":[35],"understood.":[36],"We":[37],"performed":[38],"histochemistry":[39],"sequenced":[41],"the":[42,88,93],"RNA":[43],"163,971":[45],"single":[46],"cells":[47],"from":[48,58],"improved":[49],"retinal":[51],"at":[53,83],"different":[54],"developmental":[55,104],"stages":[56],"donated":[59],"healthy":[60],"adult":[61,78,126],"retinas":[63],"choroid.":[65],"Cell":[66],"types":[67,98,111],"mature":[69],"had":[71],"morphologies":[72],"transcriptomes":[74],"resembled":[76],"equivalents.":[79],"Remarkably,":[80],"developed":[82],"a":[84,100],"similar":[85],"rate":[86],"to":[87,109],"developing":[89],"retina":[91],"transcriptome":[94],"trajectory":[95],"contained":[99],"progression":[101],"key":[103],"markers.":[105],"Mapping":[106],"disease-associated":[107],"genes":[108],"revealed":[112],"cellular":[113],"targets":[114],"for":[115],"studying":[116],"disease":[117],"mechanism":[118],"performing":[122],"targeted":[123],"repair":[124],"retinas.":[127],"\\n":[128]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}