{"id":"https://openalex.org/W70238687","doi":null,"title":"Early and rapid microscopy-based diagnosis of true treatment failure and MDR-TB.","display_name":"Early and rapid microscopy-based diagnosis of true treatment failure and MDR-TB.","publication_year":2006,"publication_date":"2006-11-01","ids":{"openalex":"https://openalex.org/W70238687","mag":"70238687","pmid":"https://pubmed.ncbi.nlm.nih.gov/17131784"},"language":"en","primary_location":{"id":"pmid:17131784","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17131784","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059394729","display_name":"Abdul Hamid Salim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152161","display_name":"Damien Foundation","ror":"https://ror.org/04zv2wf02","country_code":"BD","type":"other","lineage":["https://openalex.org/I4210152161"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"A Hamid Salim","raw_affiliation_strings":["Damien Foundation Bangladesh, Dhaka, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Damien Foundation Bangladesh, Dhaka, Bangladesh","institution_ids":["https://openalex.org/I4210152161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113008463","display_name":"K. J. M. Aung","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K J M Aung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105831570","display_name":"Md. Arif Hossain","orcid":"https://orcid.org/0000-0002-8449-9915","observed_orcids":["https://orcid.org/0000-0002-8449-9915"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M A Hossain","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5047935595","display_name":"Armand Van Deun","orcid":"https://orcid.org/0000-0002-1162-093X","observed_orcids":["https://orcid.org/0000-0002-1162-093X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Van Deun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4846,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.80749945,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"10","issue":"11","first_page":"1248","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tuberculosis-treatment-failure","display_name":"tuberculosis treatment failure","score":0.7599999904632568},{"id":"https://openalex.org/keywords/multidrug-resistant-tuberculosis","display_name":"multidrug-resistant tuberculosis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/sputum-smear-positive","display_name":"smear-positive sputum","score":0.9269999861717224},{"id":"https://openalex.org/keywords/dots-plus","display_name":"DOTS-Plus","score":0.7990000247955322},{"id":"https://openalex.org/keywords/rifampicin-resistance","display_name":"rifampicin resistance","score":0.6980000138282776},{"id":"https://openalex.org/keywords/isoniazid-resistance","display_name":"isoniazid resistance","score":0.8510000109672546},{"id":"https://openalex.org/keywords/resource-limited-settings","display_name":"resource-limited settings","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9290632009506226},{"id":"https://openalex.org/C2776301714","wikidata":"https://www.wikidata.org/wiki/Q259346","display_name":"Sputum","level":3,"score":0.8899540901184082},{"id":"https://openalex.org/C2776228421","wikidata":"https://www.wikidata.org/wiki/Q412318","display_name":"Ethambutol","level":4,"score":0.8338688015937805},{"id":"https://openalex.org/C2778607973","wikidata":"https://www.wikidata.org/wiki/Q422652","display_name":"Rifampicin","level":3,"score":0.771358847618103},{"id":"https://openalex.org/C2775843808","wikidata":"https://www.wikidata.org/wiki/Q192717","display_name":"Streptomycin","level":3,"score":0.6248688697814941},{"id":"https://openalex.org/C2776967927","wikidata":"https://www.wikidata.org/wiki/Q423169","display_name":"Isoniazid","level":3,"score":0.6081886887550354},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.5786293148994446},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.516857922077179},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4290555417537689},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40827029943466187},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.3539625406265259},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2509063482284546},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.19410210847854614},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013183","descriptor_name":"Sputum","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014397","descriptor_name":"Tuberculosis, Pulmonary","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D014397","descriptor_name":"Tuberculosis, Pulmonary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014397","descriptor_name":"Tuberculosis, Pulmonary","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D015169","descriptor_name":"Colony Count, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017211","descriptor_name":"Treatment Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018088","descriptor_name":"Tuberculosis, Multidrug-Resistant","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018088","descriptor_name":"Tuberculosis, Multidrug-Resistant","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018088","descriptor_name":"Tuberculosis, Multidrug-Resistant","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:17131784","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17131784","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","raw_type":"Journal Article"},{"id":"mag:70238687","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17131784","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1466499","https://openalex.org/W67148332","https://openalex.org/W81564798","https://openalex.org/W113607121","https://openalex.org/W140301915","https://openalex.org/W142797520","https://openalex.org/W199875318","https://openalex.org/W1720252267","https://openalex.org/W2003489648","https://openalex.org/W2043829585","https://openalex.org/W2046205873","https://openalex.org/W2051991972","https://openalex.org/W2057505085","https://openalex.org/W2066276702","https://openalex.org/W2071674041","https://openalex.org/W2080140270","https://openalex.org/W2136396504","https://openalex.org/W2144757794","https://openalex.org/W2153680447","https://openalex.org/W2159888518","https://openalex.org/W2272219816","https://openalex.org/W2288892332","https://openalex.org/W2295406081","https://openalex.org/W2343168389","https://openalex.org/W2406445991","https://openalex.org/W2409884147","https://openalex.org/W2411846519","https://openalex.org/W2414449675","https://openalex.org/W2415254546","https://openalex.org/W2416205260","https://openalex.org/W2425322812","https://openalex.org/W2589396392"],"related_works":["https://openalex.org/W7096157078","https://openalex.org/W7160436064","https://openalex.org/W2011797619","https://openalex.org/W2055121465","https://openalex.org/W1985983285","https://openalex.org/W7014557752","https://openalex.org/W7205015624","https://openalex.org/W2082135720","https://openalex.org/W1966304797","https://openalex.org/W2470277376"],"abstract_inverted_index":{"SETTING:":[0],"Damien":[1],"Foundation":[2],"tuberculosis":[3],"(TB)":[4],"control":[5],"project":[6],"in":[7,145,162,171],"Bangladesh.":[8],"OBJECTIVE:":[9],"Early":[10],"diagnosis":[11],"of":[12,28,33,42,160,191],"true":[13,142],"TB":[14],"treatment":[15,143],"failure":[16,144],"and":[17,41,60,72,110,141,157,184],"multidrug":[18],"resistance":[19],"(MDR)":[20],"for":[21,108,117,123,137,182],"more":[22],"efficient":[23,180],"DOTS-Plus.":[24],"DESIGN:":[25],"Prospective":[26],"comparison":[27],"performance":[29],"on":[30,66,75,79,89,94,188],"smear-positive":[31,96],"sputum":[32,84,97],"fluorescein":[34],"diacetate":[35],"(FDA)":[36],"vital":[37],"staining":[38,133],"vs.":[39,49],"culture,":[40],"slide":[43,153],"drug":[44],"susceptibility":[45],"testing":[46],"(slide":[47],"DST)":[48],"the":[50],"L\u00f6wenstein-Jensen":[51],"(LJ)":[52],"proportion":[53],"method.":[54],"RESULTS:":[55],"FDA":[56,132],"reached":[57],"92%":[58],"positive":[59],"97%":[61],"negative":[62],"predictive":[63],"value":[64],"directly":[65],"fresh":[67,90,95],"sputum,":[68],"but":[69,121],"only":[70],"94%":[71],"62%,":[73],"respectively,":[74],"transported":[76,83],"smears.":[77],"Accuracy":[78],"washed":[80],"cetylpyridinium":[81],"chloride":[82],"was":[85],"similar":[86],"to":[87],"that":[88,131],"sputum.":[91],"Slide":[92],"DST":[93,154],"failed":[98],"less":[99],"often":[100],"than":[101],"LJ":[102],"DST,":[103],"with":[104],"96%":[105],"accurate":[106,158],"results":[107,114],"rifampicin":[109],"MDR-TB":[111,161],"diagnosis.":[112],"Good":[113],"were":[115],"obtained":[116],"isoniazid":[118],"(90%":[119],"accuracy),":[120],"not":[122],"ethambutol":[124],"or":[125,149],"streptomycin.":[126],"CONCLUSIONS:":[127],"We":[128],"can":[129,167],"confirm":[130],"allows":[134],"rapid":[135],"screening":[136,183],"viable":[138],"acid-fast":[139],"bacilli":[140],"delayed":[146],"smear":[147],"converters":[148],"smear-defined":[150],"failures,":[151],"while":[152],"assures":[155],"fast":[156],"confirmation":[159],"selected":[163],"populations.":[164],"The":[165],"tests":[166],"be":[168,178],"applied":[169],"safely":[170],"resource-poor":[172],"settings.":[173],"Their":[174],"successive":[175],"use":[176],"could":[177],"an":[179,185],"strategy":[181],"early":[186],"start":[187],"standardised":[189],"regimens":[190],"DOTS-Plus":[192],"candidates.":[193]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}