{"id":"https://openalex.org/W7020992147","doi":null,"title":"Microtubule-associated protein tau gene as risk factor for the sporadic Parkinson syndrome","display_name":"Microtubule-associated protein tau gene as risk factor for the sporadic Parkinson syndrome","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W7020992147"},"language":"en","primary_location":{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-034631882","doi":null,"is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/?id=1695496","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Hochschulschrift"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://mediatum.ub.tum.de/1695496","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Tauber, Christina Victoria Isabella","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tauber, Christina Victoria Isabella","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Lichtenthaler, Stefan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lichtenthaler, Stefan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Technische Universit\u00e4t M\u00fcnchen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Technische Universit\u00e4t M\u00fcnchen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mapt-gene","display_name":"MAPT gene","score":0.9300000071525574},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.9190000295639038},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.7820000052452087},{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.8339999914169312},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7559999823570251},{"id":"https://openalex.org/keywords/tauopathy","display_name":"tauopathy","score":0.8849999904632568},{"id":"https://openalex.org/keywords/synucleinopathies","display_name":"synucleinopathies","score":0.8690000176429749},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.6589999794960022},{"id":"https://openalex.org/keywords/postmortem-brain","display_name":"postmortem brain","score":0.9660000205039978}],"concepts":[{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.8356999754905701},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7168999910354614},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6281999945640564},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5889000296592712},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5041000247001648},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.48019999265670776},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46380001306533813},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.46309998631477356},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.45329999923706055},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4334000051021576},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.37119999527931213},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.35920000076293945},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.3061999976634979},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.3061000108718872},{"id":"https://openalex.org/C207230331","wikidata":"https://www.wikidata.org/wiki/Q18026450","display_name":"GPS2","level":5,"score":0.3052999973297119},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.2994999885559082},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2930999994277954},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.28839999437332153},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.28540000319480896},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.2782999873161316},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.2687000036239624},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.2662000060081482},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.26489999890327454},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2621999979019165},{"id":"https://openalex.org/C204390595","wikidata":"https://www.wikidata.org/wiki/Q18031397","display_name":"SCN3A","level":5,"score":0.26170000433921814},{"id":"https://openalex.org/C553089730","wikidata":"https://www.wikidata.org/wiki/Q4914021","display_name":"Binding protein","level":3,"score":0.25110000371932983},{"id":"https://openalex.org/C6856738","wikidata":"https://www.wikidata.org/wiki/Q331672","display_name":"Protein expression","level":3,"score":0.2500999867916107}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-034631882","doi":null,"is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/?id=1695496","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Hochschulschrift"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1695496","doi":null,"is_oa":true,"landing_page_url":"https://mediatum.ub.tum.de/1695496","pdf_url":null,"source":{"id":"https://openalex.org/S4306400453","display_name":"mediaTUM \u2013 the media and publications repository of the Technical University Munich (Technical University Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"}],"best_oa_location":{"id":"pmh:oai:mediatum.ub.tum.de:node/1695496","doi":null,"is_oa":true,"landing_page_url":"https://mediatum.ub.tum.de/1695496","pdf_url":null,"source":{"id":"https://openalex.org/S4306400453","display_name":"mediaTUM \u2013 the media and publications repository of the Technical University Munich (Technical University Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7058424554","https://openalex.org/W4323923084","https://openalex.org/W1980292758","https://openalex.org/W2062360332","https://openalex.org/W2150550276","https://openalex.org/W2142120135","https://openalex.org/W2331068058","https://openalex.org/W2807392285","https://openalex.org/W1153804587","https://openalex.org/W3021239427"],"abstract_inverted_index":{"The":[0,17,39],"MAPT":[1,47,76],"gene,":[2],"encoding":[3],"the":[4,34,46],"microtubule-associated":[5],"protein":[6,59],"tau,":[7],"is":[8,22],"characterized":[9],"by":[10],"two":[11],"allelic":[12],"variants":[13],"(H1":[14],"and":[15,54,58,68],"H2)":[16],"more":[18],"common":[19],"haplotype":[20,48],"H1/H1":[21],"associated":[23],"with":[24],"an":[25],"increased":[26],"risk":[27],"for":[28,33],"several":[29,74],"tauopathies,":[30],"but":[31],"also":[32],"synucleinopathy":[35],"Parkinson's":[36],"disease":[37],"(PD).":[38],"present":[40],"study":[41],"aimed":[42],"to":[43],"clarify":[44],"whether":[45],"influences":[49],"gene":[50],"expression":[51,71],"of":[52,64,73],"tau":[53],"alpa-synuclein":[55],"on":[56],"mRNA":[57,70],"levels":[60,72],"in":[61],"postmortem":[62],"brains":[63],"sporadic":[65],"PD":[66],"patients":[67],"controls.":[69],"other":[75],"haplotype-encoded":[77],"genes":[78],"were":[79],"assessed.":[80]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2025-10-10T00:00:00"}