{"id":"https://openalex.org/W7019795671","doi":null,"title":"Impact of maternal diet on vascular function in the offspring","display_name":"Impact of maternal diet on vascular function in the offspring","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W7019795671"},"language":"en","primary_location":{"id":"pmh:oai:eprints.soton.ac.uk:466258","doi":null,"is_oa":false,"landing_page_url":"https://eprints.soton.ac.uk/id/eprint/466258/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10068/938951","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070499408","display_name":"Joanne Rodford","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rodford, Joanne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5070499408"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.023600000888109207,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maternal-diet","display_name":"maternal diet","score":0.777999997138977},{"id":"https://openalex.org/keywords/prenatal-programming","display_name":"prenatal programming","score":0.7369999885559082},{"id":"https://openalex.org/keywords/vascular-function","display_name":"vascular function","score":0.7279999852180481},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9779999852180481},{"id":"https://openalex.org/keywords/endothelium-dependent-relaxation","display_name":"endothelium-dependent relaxation","score":0.753000020980835},{"id":"https://openalex.org/keywords/nitric-oxide-pathway","display_name":"nitric oxide pathway","score":0.7940000295639038},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.9919999837875366},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.8429999947547913},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9449999928474426},{"id":"https://openalex.org/keywords/protein-restriction","display_name":"protein restriction","score":0.6110000014305115},{"id":"https://openalex.org/keywords/folic-acid","display_name":"folic acid","score":0.7950000166893005},{"id":"https://openalex.org/keywords/methionine-restriction","display_name":"methionine restriction","score":0.8669999837875366},{"id":"https://openalex.org/keywords/mesenteric-arteries","display_name":"mesenteric arteries","score":0.7850000262260437},{"id":"https://openalex.org/keywords/resistance-arteries","display_name":"resistance arteries","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8046000003814697},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8029999732971191},{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.7973999977111816},{"id":"https://openalex.org/C2780771799","wikidata":"https://www.wikidata.org/wiki/Q109592502","display_name":"Mesenteric arteries","level":3,"score":0.732699990272522},{"id":"https://openalex.org/C2778326061","wikidata":"https://www.wikidata.org/wiki/Q1761022","display_name":"Enos","level":4,"score":0.6061999797821045},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5415999889373779},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.483599990606308},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.4778999984264374},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.4726000130176544},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46880000829696655},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.4293999969959259},{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.4226999878883362},{"id":"https://openalex.org/C16525657","wikidata":"https://www.wikidata.org/wiki/Q5201183","display_name":"Cystathionine beta synthase","level":4,"score":0.4075999855995178},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.3926999866962433},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.36959999799728394},{"id":"https://openalex.org/C201614185","wikidata":"https://www.wikidata.org/wiki/Q396833","display_name":"In utero","level":4,"score":0.35749998688697815},{"id":"https://openalex.org/C2780912031","wikidata":"https://www.wikidata.org/wiki/Q180341","display_name":"Methionine","level":3,"score":0.34860000014305115},{"id":"https://openalex.org/C2781207646","wikidata":"https://www.wikidata.org/wiki/Q707674","display_name":"Uterine artery","level":4,"score":0.34790000319480896},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.33820000290870667},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.3343000113964081},{"id":"https://openalex.org/C2992204568","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle relaxation","level":2,"score":0.3303000032901764},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.32280001044273376},{"id":"https://openalex.org/C2777663904","wikidata":"https://www.wikidata.org/wiki/Q988343","display_name":"Blood vessel","level":2,"score":0.3077000081539154},{"id":"https://openalex.org/C2777952589","wikidata":"https://www.wikidata.org/wiki/Q421910","display_name":"Phenylephrine","level":3,"score":0.3059999942779541},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30469998717308044},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.3003999888896942},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.29760000109672546},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.29339998960494995},{"id":"https://openalex.org/C2776659692","wikidata":"https://www.wikidata.org/wiki/Q719426","display_name":"Lactation","level":3,"score":0.28839999437332153},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2809999883174896},{"id":"https://openalex.org/C1918360","wikidata":"https://www.wikidata.org/wiki/Q5357720","display_name":"Electrical impedance myography","level":3,"score":0.2777999937534332},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.27570000290870667},{"id":"https://openalex.org/C2908688039","wikidata":"https://www.wikidata.org/wiki/Q408853","display_name":"Nitric Oxide Synthase Type III","level":5,"score":0.2741999924182892}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.soton.ac.uk:466258","doi":null,"is_oa":false,"landing_page_url":"https://eprints.soton.ac.uk/id/eprint/466258/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:hdl:10068/938951","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/938951","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"}],"best_oa_location":{"id":"pmh:hdl:10068/938951","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/938951","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1480646682","https://openalex.org/W2160688226","https://openalex.org/W2005271716","https://openalex.org/W2115152334","https://openalex.org/W2045058855","https://openalex.org/W1866750144","https://openalex.org/W3174096418","https://openalex.org/W2167889502","https://openalex.org/W3129824578","https://openalex.org/W2012540855"],"abstract_inverted_index":{"Female":[0],"Wistar":[1],"rats":[2],"were":[3],"mated":[4],"and":[5,22,127,205,215,226],"fed":[6],"diets":[7],"that":[8],"altered":[9,171],"in":[10,32,62,80,105,146,163,193,200,233],"protein,":[11],"folate":[12,177],"or":[13],"methionine":[14,184],"content":[15],"throughout":[16],"pregnancy.":[17],"In":[18,84],"both":[19,212,221],"the":[20,29,45,63,85,89,106,111,122,137,147,152,164,180,186,190,194,203,208,213,234,248,254,262],"male":[21,87,196,214],"female":[23,216],"PR":[24,86,148,195,199],"offspring":[25,31],"no":[26],"difference":[27],"to":[28,169,261],"control":[30],"systolic":[33],"blood":[34],"pressure":[35],"was":[36,55,71,103,117,131,143,166],"found":[37,168],"by":[38,51,100,159,236,253],"tail-cuff":[39],"plethysmography.":[40],"However,":[41,151],"endothelium-dependent":[42],"relaxation":[43,68],"of":[44,66,74,92,113,121,139,154,183,207,211,238,250,265],"small":[46,52],"mesenteric":[47,107],"arteries":[48,76,108,210],"as":[49,98,157],"assessed":[50],"wire":[53],"myography":[54],"impaired":[56],"(p<0.05),":[57],"with":[58,77,133],"a":[59,78,227,245],"specific":[60],"reduction":[61,79],"NO":[64,224],"component":[65],"this":[67],"response.":[69],"There":[70],"also":[72],"remodelling":[73],"these":[75],"smooth":[81],"muscle":[82],"content.":[83],"offspring,":[88,217],"mRNA":[90,119,240],"expression":[91,120,138],"endothelial":[93,191],"nitric":[94],"oxide":[95],"synthase":[96],"(eNOS)":[97],"measured":[99,158],"real-time":[101],"PCR":[102],"increased":[104],"(p<0.05)":[109,145],"but":[110,136],"level":[112,153],"soluble":[114],"guanylate":[115],"cyclase":[116],"unchanged.":[118],"antioxidants":[123],"manganese":[124],"superoxide":[125],"dismutase":[126],"glutamate":[128],"cysteine":[129],"ligase":[130],"unchanged":[132],"maternal":[134,173,176,187],"diet":[135,188],"heme":[140],"oxygenase-1":[141],"(HO-1)":[142],"reduced":[144,228],"males\u2019":[149],"livers.":[150],"oxidative":[155],"stress":[156],"protein":[160],"carbonyl":[161],"concentration":[162],"livers":[165],"not":[167],"be":[170,259],"following":[172],"PR.":[174],"Neither":[175],"supplementation":[178],"nor":[179],"partial":[181],"removal":[182],"from":[185,220],"prevented":[189],"dysfunction":[192,252],"offspring.":[197],"Thus,":[198],"utero":[201],"alters":[202],"structure":[204],"function":[206],"resistance":[209],"which":[218,257],"results":[219],"an":[222],"attenuated":[223],"pathway":[225],"antioxidant":[229],"defence":[230],"compensated":[231],"for":[232,247],"males":[235],"up-regulation":[237],"eNOS":[239],"expression.":[241],"This":[242],"study":[243],"provides":[244],"mechanism":[246],"induction":[249],"vascular":[251],"pre-natal":[255],"environment,":[256],"may":[258],"relevant":[260],"developmental":[263],"origins":[264],"CVD.":[266]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2025-10-10T00:00:00"}
