{"id":"https://openalex.org/W7018565758","doi":null,"title":"Diversity of multinucleated giant cells by microstructures of hydroxyapatite and plasma components in extraskeletal implantation model","display_name":"Diversity of multinucleated giant cells by microstructures of hydroxyapatite and plasma components in extraskeletal implantation model","publication_year":2017,"publication_date":"2017-03-21","ids":{"openalex":"https://openalex.org/W7018565758"},"language":"en","primary_location":{"id":"pmh:oai:irdb.nii.ac.jp:01160:0004780473","doi":null,"is_oa":true,"landing_page_url":"https://nagasaki-u.repo.nii.ac.jp/records/3908","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Biomaterialia","raw_type":"doctoral thesis"},"parent_works":[],"lineage":["https://openalex.org/W7018565758"],"child_works_count":0,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://nagasaki-u.repo.nii.ac.jp/records/3908","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"\u68ee\u4e0b, \u5ee3\u592a","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"\u68ee\u4e0b, \u5ee3\u592a","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"39","issue":null,"first_page":"180","last_page":"191"},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.08749999850988388,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.05180000141263008,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multinucleated-giant-cells","display_name":"multinucleated giant cells","score":0.968999981880188},{"id":"https://openalex.org/keywords/foreign-body-giant-cells","display_name":"foreign body giant cells","score":0.9739999771118164},{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":0.9430000185966492},{"id":"https://openalex.org/keywords/rod-like-particles","display_name":"rod-like particles","score":0.777999997138977},{"id":"https://openalex.org/keywords/cathepsin-k","display_name":"cathepsin K","score":0.9459999799728394},{"id":"https://openalex.org/keywords/tartrate-resistant-acid-phosphatase","display_name":"tartrate-resistant acid phosphatase","score":0.996999979019165},{"id":"https://openalex.org/keywords/fibrin","display_name":"fibrin","score":0.7459999918937683},{"id":"https://openalex.org/keywords/plasma","display_name":"plasma","score":0.628000020980835},{"id":"https://openalex.org/keywords/foreign-body-reaction","display_name":"foreign body reaction","score":0.9160000085830688},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.7760000228881836},{"id":"https://openalex.org/keywords/subcutaneous-implantation","display_name":"subcutaneous implantation","score":0.8029999732971191},{"id":"https://openalex.org/keywords/ceramic-granules","display_name":"ceramic granules","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C77076574","wikidata":"https://www.wikidata.org/wiki/Q2152526","display_name":"Giant cell","level":2,"score":0.6891000270843506},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6317999958992004},{"id":"https://openalex.org/C87976508","wikidata":"https://www.wikidata.org/wiki/Q1498213","display_name":"Microstructure","level":2,"score":0.5649999976158142},{"id":"https://openalex.org/C82706917","wikidata":"https://www.wikidata.org/wiki/Q10251","display_name":"Plasma","level":2,"score":0.41659998893737793},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3801000118255615},{"id":"https://openalex.org/C136403682","wikidata":"https://www.wikidata.org/wiki/Q5796041","display_name":"Multinucleate","level":2,"score":0.35530000925064087},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.33250001072883606},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.2890999913215637},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.27480000257492065},{"id":"https://openalex.org/C108657112","wikidata":"https://www.wikidata.org/wiki/Q3332118","display_name":"Foreign-body giant cell","level":2,"score":0.27070000767707825},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.26829999685287476},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.2619999945163727}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:irdb.nii.ac.jp:01160:0004780473","doi":null,"is_oa":true,"landing_page_url":"https://nagasaki-u.repo.nii.ac.jp/records/3908","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Biomaterialia","raw_type":"doctoral thesis"},{"id":"pmh:oai:irdb.nii.ac.jp:01160:0004780529","doi":null,"is_oa":true,"landing_page_url":"https://nagasaki-u.repo.nii.ac.jp/records/4012","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"thesis"},{"id":"pmh:oai:naosite.lb.nagasaki-u.ac.jp:10069/37204","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10069/37204","pdf_url":null,"source":{"id":"https://openalex.org/S4306400113","display_name":"Nagasaki University's Academic Output SITE (Nagasaki University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43777268","host_organization_name":"Nagasaki University","host_organization_lineage":["https://openalex.org/I43777268"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:01160:0004780473","doi":null,"is_oa":true,"landing_page_url":"https://nagasaki-u.repo.nii.ac.jp/records/3908","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Biomaterialia","raw_type":"doctoral thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2425227402","https://openalex.org/W2088758025","https://openalex.org/W1983773077","https://openalex.org/W2578989660","https://openalex.org/W2197489357","https://openalex.org/W1996403236","https://openalex.org/W7127626492","https://openalex.org/W1974444931","https://openalex.org/W1973321874"],"abstract_inverted_index":{"Foreign":[0],"body":[1,61,76,101],"giant":[2,9],"cells":[3,10],"(FBGCs)":[4],"and":[5,50,185,195,197,218],"osteoclasts":[6],"are":[7,15,25,200],"multinucleated":[8],"(MNGCs),":[11],"both":[12],"of":[13,20,52,83,91,112,125,139,145,156,159,175,216,222],"which":[14,133,181],"formed":[16],"by":[17,106],"the":[18,67,137,143,154,214],"fusion":[19],"macrophage-derived":[21],"mononuclear":[22],"cells.":[23,47],"Osteoclasts":[24],"distinct":[26],"from":[27],"FBGCs":[28,53,147],"due":[29],"to":[30,172],"their":[31],"bone":[32],"resorption":[33],"ability;":[34],"however,":[35],"not":[36],"only":[37],"morphological,":[38],"but":[39],"also":[40],"functional":[41],"similarities":[42],"may":[43],"exist":[44],"between":[45],"these":[46],"The":[48,89],"characterization":[49],"diversity":[51],"that":[54,103,192,210],"appear":[55],"in":[56,58,73,94,170,202,207],"an":[57,72,79],"vivo":[59,74],"foreign":[60,75,100],"reaction":[62,77,102],"currently":[63],"remain":[64],"incomplete.":[65],"In":[66],"present":[68],"study,":[69],"we":[70],"investigated":[71],"using":[78],"extraskeletal":[80],"implantation":[81,90,155,205],"model":[82,206],"hydroxyapatite":[84],"(HA)":[85],"with":[86,162,178],"different":[87],"microstructures.":[88],"HA":[92,109,122,157,173,217],"granules":[93,110,123],"rat":[95],"subcutaneous":[96,204],"tissue":[97],"induced":[98,116,129,164,183,201],"a":[99,208],"was":[104,134],"accompanied":[105],"various":[107],"MNGCs.":[108],"composed":[111,124,158,174],"rod-shaped":[113,160],"particles":[114,127,161,177],"predominantly":[115,128,182],"cathepsin":[117],"K":[118],"(CTSK)-positive":[119],"FBGCs,":[120],"whereas":[121],"globular-shaped":[126,176],"CTSK-negative":[130,184],"FBGCs.":[131,188],"Plasma,":[132],"used":[135],"as":[136],"binder":[138],"ceramic":[140],"granules,":[141],"stimulated":[142],"induction":[144],"CTSK-positive":[146],"more":[148],"strongly":[149],"than":[150],"purified":[151,179],"fibrin.":[152],"Furthermore,":[153],"plasma":[163],"tartrate-resistant":[165],"acid":[166],"phosphatase":[167],"(TRAP)-positive":[168],"MNGCs":[169,199],"contrast":[171],"fibrin,":[180],"TRAP-negative":[186,198],"typical":[187],"These":[189],"results":[190],"suggest":[191],"CTSK-positive,":[193],"TRAP-positive,":[194],"CTSK-":[196],"this":[203],"manner":[209],"is":[211],"dependent":[212],"on":[213],"microstructure":[215],"presence":[219],"or":[220],"absence":[221],"plasma.":[223]},"counts_by_year":[],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2025-10-10T00:00:00"}