{"id":"https://openalex.org/W7017756348","doi":null,"title":"The Binding Behavior of Daptomycin on the Bacterial Membranes","display_name":"The Binding Behavior of Daptomycin on the Bacterial Membranes","publication_year":2018,"publication_date":"2018-07-24","ids":{"openalex":"https://openalex.org/W7017756348"},"language":"en","primary_location":{"id":"pmh:oai:bonndoc.ulb.uni-bonn.de:20.500.11811/7611","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11811/7611","pdf_url":"http://hdl.handle.net/20.500.11811/7611","source":{"id":"https://openalex.org/S4306402493","display_name":"bonndoc (University of Bonn)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I135140700","host_organization_name":"University of Bonn","host_organization_lineage":["https://openalex.org/I135140700"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"doc-type:doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/20.500.11811/7611","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Liu, Xinliang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Liu, Xinliang","raw_affiliation_strings":["Shandong , P. R. China Bonn 2018"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong , P. R. China Bonn 2018","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.8442000150680542,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.8442000150680542,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.10620000213384628,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.016200000420212746,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/daptomycin","display_name":"daptomycin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9739999771118164},{"id":"https://openalex.org/keywords/gram-positive-bacteria","display_name":"Gram-positive bacteria","score":0.6710000038146973},{"id":"https://openalex.org/keywords/lipid-ii","display_name":"lipid II","score":0.6039999723434448},{"id":"https://openalex.org/keywords/ftsw","display_name":"FtsW","score":0.6510000228881836},{"id":"https://openalex.org/keywords/membrane-depolarization","display_name":"membrane depolarization","score":0.8330000042915344},{"id":"https://openalex.org/keywords/calcium-dependence","display_name":"calcium dependence","score":0.492000013589859},{"id":"https://openalex.org/keywords/antibiotic-binding-sites","display_name":"antibiotic binding sites","score":0.33399999141693115},{"id":"https://openalex.org/keywords/vancomycin-resistance","display_name":"vancomycin resistance","score":0.5139999985694885},{"id":"https://openalex.org/keywords/super-resolution-imaging","display_name":"super-resolution imaging","score":0.5879999995231628},{"id":"https://openalex.org/keywords/lipopeptide-antibiotics","display_name":"lipopeptide antibiotics","score":0.6140000224113464},{"id":"https://openalex.org/keywords/cell-division-inhibition","display_name":"cell division inhibition","score":0.41999998688697815},{"id":"https://openalex.org/keywords/cell-aggregation","display_name":"cell aggregation","score":0.33799999952316284},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C2778651397","wikidata":"https://www.wikidata.org/wiki/Q418747","display_name":"Daptomycin","level":5,"score":0.8040000200271606},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.789900004863739},{"id":"https://openalex.org/C2777425210","wikidata":"https://www.wikidata.org/wiki/Q2903964","display_name":"Lipopeptide","level":3,"score":0.758899986743927},{"id":"https://openalex.org/C2780726299","wikidata":"https://www.wikidata.org/wiki/Q3078751","display_name":"Phosphatidylglycerol","level":5,"score":0.6905999779701233},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.614799976348877},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.5590999722480774},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.5444999933242798},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5236999988555908},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4478999972343445},{"id":"https://openalex.org/C19655278","wikidata":"https://www.wikidata.org/wiki/Q3293735","display_name":"Bacterial cell structure","level":3,"score":0.43630000948905945},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.4284000098705292},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.41990000009536743},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.41920000314712524},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.36629998683929443},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35899999737739563},{"id":"https://openalex.org/C103038307","wikidata":"https://www.wikidata.org/wiki/Q6556360","display_name":"Lipid bilayer fusion","level":3,"score":0.3506999909877777},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3434999883174896},{"id":"https://openalex.org/C2992270614","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Membrane permeability","level":3,"score":0.33230000734329224},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.3278999924659729},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.2768000066280365},{"id":"https://openalex.org/C2776634448","wikidata":"https://www.wikidata.org/wiki/Q206920","display_name":"Peptidoglycan","level":3,"score":0.2768000066280365},{"id":"https://openalex.org/C40209533","wikidata":"https://www.wikidata.org/wiki/Q5147828","display_name":"Colocalization","level":2,"score":0.27140000462532043},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.267300009727478},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2581999897956848},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.25769999623298645},{"id":"https://openalex.org/C192285135","wikidata":"https://www.wikidata.org/wiki/Q954757","display_name":"Colony-forming unit","level":3,"score":0.25529998540878296},{"id":"https://openalex.org/C26268613","wikidata":"https://www.wikidata.org/wiki/Q187643","display_name":"Cell disruption","level":2,"score":0.2540999948978424},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.2524999976158142}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:bonndoc.ulb.uni-bonn.de:20.500.11811/7611","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11811/7611","pdf_url":"http://hdl.handle.net/20.500.11811/7611","source":{"id":"https://openalex.org/S4306402493","display_name":"bonndoc (University of Bonn)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I135140700","host_organization_name":"University of Bonn","host_organization_lineage":["https://openalex.org/I135140700"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"doc-type:doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:bonndoc.ulb.uni-bonn.de:20.500.11811/7611","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11811/7611","pdf_url":"http://hdl.handle.net/20.500.11811/7611","source":{"id":"https://openalex.org/S4306402493","display_name":"bonndoc (University of Bonn)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I135140700","host_organization_name":"University of Bonn","host_organization_lineage":["https://openalex.org/I135140700"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"doc-type:doctoralThesis"},"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7017756348.pdf","grobid_xml":"https://content.openalex.org/works/W7017756348.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2113063737","https://openalex.org/W2784665958","https://openalex.org/W2520840510","https://openalex.org/W2527321527","https://openalex.org/W2115550568","https://openalex.org/W4396547382","https://openalex.org/W2584998934","https://openalex.org/W2913471392","https://openalex.org/W2599998987","https://openalex.org/W2767984528"],"abstract_inverted_index":{"Daptomycin":[0],"(DAP)":[1],"is":[2,17,56,61,252,259,427],"a":[3,147,253,301,448],"cyclic":[4],"anionic":[5],"lipopeptide":[6],"antibiotic":[7],"that":[8,46,219,316,325,409,419],"kills":[9],"gram-positive":[10,27],"bacteria":[11],"via":[12],"cell":[13,135,141,225,255,287],"membrane":[14,55,65,88,121,182,213,288],"distortion.":[15],"It":[16],"currently":[18],"approved":[19],"for":[20,156,169,429,451],"treatment":[21],"of":[22,50,70,84,89,99,122,166,178,184,204,207,214,238,292,305,312,322,333,347,395,399,416,422,433,440,454,456],"complicated":[23],"infections":[24],"caused":[25],"by":[26,200,360],"bacteria,":[28],"including":[29],"methicillin-resistant":[30],"Staphylococcus":[31],"aureus,":[32,35],"vancomycin-resistant":[33,41],"S.":[34,90,123,133,215],"coagulase-negative":[36],"staphylococci,":[37],"penicillin-resistant":[38],"streptococci":[39],"and":[40,109,137,143,149,168,191,248,274,324,418,424],"enterococci.":[42],"Recent":[43],"studies":[44],"showed":[45],"the":[47,53,68,81,87,96,120,157,161,170,173,201,205,212,236,244,262,265,272,285,290,320,330,344,370,388,393,410,414,420,430,437,443,452],"bactericidal":[48,431],"activity":[49],"DAP":[51,60,85,100,117,130,167,185,193,209,220,241,282,323,348,406,417,441],"on":[52,58,86,119,132,211,349,358],"target":[54,102,331],"dependent":[57],"Ca2+.":[59],"also":[62],"associated":[63],"with":[64,101,140,224,229,243,277,300,351],"depolarization":[66],"in":[67,74,146,297,401],"presence":[69],"phosphatidylglycerol":[71],"(PG).":[72],"Therefore,":[73],"this":[75],"study,":[76],"we":[77,127,233,336],"aimed":[78],"to":[79,115,271,284,342,372,442],"investigate":[80],"binding":[82,155,183,311,321,345,394,415,439],"behavior":[83,346],"aureus":[91,124,134],"cells":[92,298],"as":[93,95,369,385,387],"well":[94,386],"specific":[97],"interaction":[98],"molecules.":[103],"We":[104,152,217],"first":[105],"used":[106,337,368],"highly":[107],"inclined":[108],"laminated":[110],"optical":[111],"sheet":[112],"(HILO)":[113],"microscopy":[114],"visualize":[116],"location":[118],"cells.":[125],"Then,":[126],"quantitatively":[128],"analyzed":[129],"distribution":[131,291],"membranes":[136,350,403],"its":[138],"correlation":[139],"size":[142,226],"aggregate":[144,230],"formation":[145],"time-":[148],"concentration-dependent":[150],"manner.":[151],"observed":[153],"septum":[154,273],"concentrations":[158],"lower":[159],"than":[160],"minimum":[162],"inhibitory":[163],"concentration":[164,171],"(MIC)":[165],"around":[172],"MIC":[174],"until":[175],"10":[176],"min":[177],"incubation.":[179],"However,":[180],"overall":[181],"occurred":[186],"at":[187,261],"longer":[188],"incubation":[189,267,280],"times":[190],"higher":[192],"concentrations.":[194],"This":[195,435],"result":[196],"was":[197,275],"further":[198,234],"supported":[199,339],"super-resolution":[202],"imaging":[203],"localization":[206],"single":[208],"molecules":[210],"aureus.":[216],"found":[218],"accumulation":[221],"correlated":[222],"negatively":[223],"but":[227,289],"positively":[228],"formation.":[231],"Thus,":[232],"examined":[235],"colocalization":[237],"5(6)-TAMRA-X,":[239],"SE-labeled":[240],"(DAP-TMR)":[242],"FtsW-GFP":[245,293],"fusion":[246],"protein":[247],"lipid":[249,326,340,353,380],"II.":[250],"FtsW":[251],"bacterial":[254],"division":[256],"protein,":[257],"which":[258,373],"positioned":[260],"septum.":[263,444],"For":[264,279],"short":[266],"interval,":[268],"DAP-TMR":[269,313],"localized":[270],"colocalized":[276],"FtsW-GFP.":[278],"times,":[281],"bound":[283],"complete":[286],"remained":[294],"unaffected.":[295],"Furthermore,":[296],"stained":[299],"BODIPY":[302],"FL":[303,318],"conjugate":[304],"vancomycin":[306],"(Van-BDP":[307],"FL),":[308],"considerably":[309],"less":[310],"occurred,":[314],"indicating":[315,408],"Van-BDP":[317],"prevented":[319],"II":[327],"might":[328],"be":[329],"molecule":[332],"DAP.":[334,396,434,457],"Finally,":[335],"fluid":[338],"bilayers":[341],"study":[343],"different":[352],"compositions.":[354],"Bilayers":[355],"were":[356,367,382],"prepared":[357],"coverslips":[359],"vesicle":[361],"fusion.":[362],"The":[363],"neutral":[364],"phosphatidylcholine":[365],"phospholipids":[366],"matrix":[371],"PG":[374,384,400,423],"or/and":[375],"bactoprenol":[376,390,411,425],"lipids":[377,391,412,426],"(C55-PP,":[378],"C55-P,":[379],"II)":[381],"added.":[383],"three":[389],"enhanced":[392],"Surprisingly,":[397],"addition":[398],"bactoprenol-containing":[402],"significantly":[404],"strengthened":[405],"binding,":[407],"affect":[413],"combination":[421],"critical":[428],"mechanism":[432,453],"explains":[436],"preferential":[438],"Our":[445],"findings":[446],"describe":[447],"new":[449],"model":[450],"action":[455]},"counts_by_year":[],"updated_date":"2026-09-23T05:00:35.095934","created_date":"2025-10-10T00:00:00"}
