{"id":"https://openalex.org/W7017306289","doi":null,"title":"Alzheimr\u578b\u75f4\u5446\u306e\u8001\u4eba\u6591\u306e\u55dc\u9280\u6027\u306f\u30ae\u9178\u524d\u51e6\u7406\u306b\u3088\u308a\u6d88\u5931\u3059\u308b","display_name":"Alzheimr\u578b\u75f4\u5446\u306e\u8001\u4eba\u6591\u306e\u55dc\u9280\u6027\u306f\u30ae\u9178\u524d\u51e6\u7406\u306b\u3088\u308a\u6d88\u5931\u3059\u308b","publication_year":1989,"publication_date":"1989-03-31","ids":{"openalex":"https://openalex.org/W7017306289"},"language":"en","primary_location":{"id":"pmh:oai:gair.media.gunma-u.ac.jp:10087/1957","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10087/1957","pdf_url":null,"source":{"id":"https://openalex.org/S4306401726","display_name":"Academic Knowledge Archives of Gunma Institutes (Gumma University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165735259","host_organization_name":"Gunma University","host_organization_lineage":["https://openalex.org/I165735259"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10087/1957","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5149864179","display_name":"Haruyasu Yamaguchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yamaguchi, Haruyasu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149723745","display_name":"Shunsaku Hirai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hirai, Shunsaku","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Nakazato, Yoichi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nakazato, Yoichi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.27180168,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8849999904632568},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.953000009059906},{"id":"https://openalex.org/keywords/argyrophilia","display_name":"argyrophilia","score":0.9169999957084656},{"id":"https://openalex.org/keywords/silver-staining","display_name":"silver staining","score":0.8029999732971191},{"id":"https://openalex.org/keywords/formic-acid-pretreatment","display_name":"formic acid pretreatment","score":0.9769999980926514},{"id":"https://openalex.org/keywords/amyloid-proteins","display_name":"amyloid proteins","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C144251240","wikidata":"https://www.wikidata.org/wiki/Q7068229","display_name":"Nucleofection","level":4,"score":0.4505000114440918},{"id":"https://openalex.org/C2992336715","wikidata":"https://www.wikidata.org/wiki/Q63431143","display_name":"Gestational period","level":4,"score":0.3725000023841858},{"id":"https://openalex.org/C18743360","wikidata":"https://www.wikidata.org/wiki/Q1208096","display_name":"Diafiltration","level":4,"score":0.3278000056743622},{"id":"https://openalex.org/C2778283623","wikidata":"https://www.wikidata.org/wiki/Q18032200","display_name":"TSG101","level":5,"score":0.32589998841285706},{"id":"https://openalex.org/C180938184","wikidata":"https://www.wikidata.org/wiki/Q2142270","display_name":"Liquation","level":3,"score":0.32339999079704285},{"id":"https://openalex.org/C133074676","wikidata":"https://www.wikidata.org/wiki/Q428729","display_name":"Fusible alloy","level":2,"score":0.32280001044273376},{"id":"https://openalex.org/C2777054765","wikidata":"https://www.wikidata.org/wiki/Q6402731","display_name":"Dysgeusia","level":3,"score":0.31529998779296875},{"id":"https://openalex.org/C145741570","wikidata":"https://www.wikidata.org/wiki/Q7251534","display_name":"Proteogenomics","level":5,"score":0.29820001125335693},{"id":"https://openalex.org/C2777158700","wikidata":"https://www.wikidata.org/wiki/Q1419356","display_name":"Hyporeflexia","level":3,"score":0.29159998893737793},{"id":"https://openalex.org/C2776781215","wikidata":"https://www.wikidata.org/wiki/Q83253","display_name":"Triacetin","level":2,"score":0.28519999980926514},{"id":"https://openalex.org/C2777935831","wikidata":"https://www.wikidata.org/wiki/Q3144949","display_name":"Hemopericardium","level":3,"score":0.28290000557899475},{"id":"https://openalex.org/C2777742743","wikidata":"https://www.wikidata.org/wiki/Q19904005","display_name":"Durvalumab","level":5,"score":0.28220000863075256},{"id":"https://openalex.org/C2777968768","wikidata":"https://www.wikidata.org/wiki/Q1280161","display_name":"Emperipolesis","level":4,"score":0.28119999170303345},{"id":"https://openalex.org/C2779627259","wikidata":"https://www.wikidata.org/wiki/Q779763","display_name":"Pretext","level":3,"score":0.2786000072956085},{"id":"https://openalex.org/C135979968","wikidata":"https://www.wikidata.org/wiki/Q609809","display_name":"Protein isoform","level":5,"score":0.2782999873161316},{"id":"https://openalex.org/C104545631","wikidata":"https://www.wikidata.org/wiki/Q464858","display_name":"Demotion","level":3,"score":0.2718000113964081},{"id":"https://openalex.org/C2778843634","wikidata":"https://www.wikidata.org/wiki/Q2013780","display_name":"Ocrelizumab","level":4,"score":0.26930001378059387},{"id":"https://openalex.org/C2775917601","wikidata":"https://www.wikidata.org/wiki/Q1424050","display_name":"Sclerodactyly","level":4,"score":0.2676999866962433},{"id":"https://openalex.org/C2779645999","wikidata":"https://www.wikidata.org/wiki/Q1858477","display_name":"Frugality","level":2,"score":0.2639000117778778},{"id":"https://openalex.org/C2909186138","wikidata":"https://www.wikidata.org/wiki/Q1500373","display_name":"Hyperlactatemia","level":2,"score":0.2599000036716461},{"id":"https://openalex.org/C2781032047","wikidata":"https://www.wikidata.org/wiki/Q938793","display_name":"Articular cartilage damage","level":5,"score":0.257999986410141},{"id":"https://openalex.org/C2776356786","wikidata":"https://www.wikidata.org/wiki/Q1048573","display_name":"Tubulopathy","level":3,"score":0.2572000026702881},{"id":"https://openalex.org/C2780904289","wikidata":"https://www.wikidata.org/wiki/Q426498","display_name":"Tantalum carbide","level":3,"score":0.2524000108242035}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:gair.media.gunma-u.ac.jp:10087/1957","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10087/1957","pdf_url":null,"source":{"id":"https://openalex.org/S4306401726","display_name":"Academic Knowledge Archives of Gunma Institutes (Gumma University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165735259","host_organization_name":"Gunma University","host_organization_lineage":["https://openalex.org/I165735259"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null}],"best_oa_location":{"id":"pmh:oai:gair.media.gunma-u.ac.jp:10087/1957","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10087/1957","pdf_url":null,"source":{"id":"https://openalex.org/S4306401726","display_name":"Academic Knowledge Archives of Gunma Institutes (Gumma University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165735259","host_organization_name":"Gunma University","host_organization_lineage":["https://openalex.org/I165735259"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2032816784","https://openalex.org/W7208281156","https://openalex.org/W2415383311","https://openalex.org/W7026099926","https://openalex.org/W83420530","https://openalex.org/W2112839031","https://openalex.org/W1988002637","https://openalex.org/W2920927496","https://openalex.org/W2569345834","https://openalex.org/W4245985305"],"abstract_inverted_index":{"We":[0],"studied":[1],"the":[2,21,28,52,61,65,82,85],"effect":[3],"of":[4,27,31,67,84,88],"formic":[5,57,77],"acid":[6,78],"pretreatment":[7,62,79],"on":[8,14],"silver":[9,45],"stains":[10],"and":[11,42],"\u03b2protein":[12,71],"immunostain":[13],"brain":[15],"tissue":[16],"samples":[17],"from":[18],"patients":[19],"with":[20,56,70],"Alzheimer-type":[22],"dementia":[23],"(AID).":[24],"The":[25],"argyrophilia":[26,83],"amyloid":[29,86],"component":[30,69,87],"senile":[32],"plaques":[33],"(SP),":[34],"which":[35],"could":[36],"be":[37],"visualized":[38],"by":[39],"modified":[40],"Bielschowsky":[41],"periodic":[43],"acid-methenamine":[44],"(PAM)":[46],"stains,":[47],"was":[48],"not":[49],"visible":[50],"when":[51],"specimens":[53],"were":[54],"pretreated":[55],"acid.":[58],"In":[59],"contrast,":[60],"highly":[63],"enhanced":[64],"immunoreactivity":[66],"this":[68],"antiserum.":[72],"Our":[73],"findings":[74],"suggest":[75],"that":[76],"selectively":[80],"abolishes":[81],"SP.":[89]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}