{"id":"https://openalex.org/W7017098537","doi":null,"title":"alpha Cell Function and Gene Expression Are Compromised in Type 1 Diabetes","display_name":"alpha Cell Function and Gene Expression Are Compromised in Type 1 Diabetes","publication_year":2018,"publication_date":"2018-03-06","ids":{"openalex":"https://openalex.org/W7017098537"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.umassmed.edu:oapubs-4424","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.umassmed.edu/oapubs/3413","pdf_url":"https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4424&context=oapubs","source":{"id":"https://openalex.org/S4306400883","display_name":"The Journal of the American Medical Association (JAMA) Network (American Medical Association)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173654999","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/I173654999"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications by UMMS Authors","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4424&context=oapubs","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051320789","display_name":"Marcela Bri\u0161\u0161ov\u00e1","orcid":"https://orcid.org/0000-0002-4999-3280","observed_orcids":["https://orcid.org/0000-0002-4999-3280"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brissova, Marcela","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061122991","display_name":"David M. Blodgett","orcid":"https://orcid.org/0009-0004-2545-4073","observed_orcids":["https://orcid.org/0009-0004-2545-4073"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I96062909","display_name":"Babson College","ror":"https://ror.org/01f0syq13","country_code":"US","type":"education","lineage":["https://openalex.org/I96062909"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Blodgett, David","raw_affiliation_strings":["Department of Medicine , Diabetes Division , Diabetes Center of Excellence , University of Massachusetts Medical School , Worcester , MA , USA","Math and Science Division , Babson College , Wellesley , MA 02457 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine , Diabetes Division , Diabetes Center of Excellence , University of Massachusetts Medical School , Worcester , MA , USA","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Math and Science Division , Babson College , Wellesley , MA 02457 , USA","institution_ids":["https://openalex.org/I96062909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022634163","display_name":"Dale L. Greiner","orcid":"https://orcid.org/0000-0002-5923-339X","observed_orcids":["https://orcid.org/0000-0002-5923-339X"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Greiner, Dale L.","raw_affiliation_strings":["Department of Medicine , Diabetes Division , Diabetes Center of Excellence , University of Massachusetts Medical School , Worcester , MA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine , Diabetes Division , Diabetes Center of Excellence , University of Massachusetts Medical School , Worcester , MA , USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055271857","display_name":"David M. Harlan","orcid":"https://orcid.org/0000-0002-6938-8109","observed_orcids":["https://orcid.org/0000-0002-6938-8109"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harlan, David M.","raw_affiliation_strings":["Department of Medicine , Diabetes Division , Diabetes Center of Excellence , University of Massachusetts Medical School , Worcester , MA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine , Diabetes Division , Diabetes Center of Excellence , University of Massachusetts Medical School , Worcester , MA , USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043352559","display_name":"Alvin C. Powers","orcid":"https://orcid.org/0000-0003-1941-5786","observed_orcids":["https://orcid.org/0000-0003-1941-5786"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Powers, Alvin C.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5469,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.69973177,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9136000275611877,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9136000275611877,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.08560000360012054,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.996999979019165},{"id":"https://openalex.org/keywords/pancreatic-alpha-cells","display_name":"alpha cells","score":0.8769999742507935},{"id":"https://openalex.org/keywords/glucagon","display_name":"glucagon","score":0.6850000023841858},{"id":"https://openalex.org/keywords/hypoglycemia-counterregulation","display_name":"hypoglycemia counterregulation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/islet-endocrine-cells","display_name":"islet endocrine cells","score":0.6340000033378601},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.6520000100135803},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.7839999794960022},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5609999895095825},{"id":"https://openalex.org/keywords/islet-transplantation","display_name":"islet transplantation","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C2777300450","wikidata":"https://www.wikidata.org/wiki/Q2995031","display_name":"Alpha cell","level":5,"score":0.9025999903678894},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.7667999863624573},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.7540000081062317},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.670199990272522},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6535000205039978},{"id":"https://openalex.org/C2776828364","wikidata":"https://www.wikidata.org/wiki/Q1767180","display_name":"Beta cell","level":4,"score":0.6470999717712402},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.5964000225067139},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.5813999772071838},{"id":"https://openalex.org/C103395026","wikidata":"https://www.wikidata.org/wiki/Q5380231","display_name":"Enteroendocrine cell","level":4,"score":0.5597000122070312},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.5422000288963318},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.4528999924659729},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.45179998874664307},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44279998540878296},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4020000100135803},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4002000093460083},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.3919000029563904},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.38690000772476196},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.376800000667572},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.35370001196861267},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.349700003862381},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.3197999894618988},{"id":"https://openalex.org/C152091265","wikidata":"https://www.wikidata.org/wiki/Q2621407","display_name":"Delta cell","level":4,"score":0.30079999566078186},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.29499998688697815},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.2937999963760376},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.2849999964237213},{"id":"https://openalex.org/C2780352109","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic hormone","level":4,"score":0.2648000121116638},{"id":"https://openalex.org/C2779855799","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic islets","level":4,"score":0.25949999690055847},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2587999999523163}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:escholarship.umassmed.edu:oapubs-4424","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.umassmed.edu/oapubs/3413","pdf_url":"https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4424&context=oapubs","source":{"id":"https://openalex.org/S4306400883","display_name":"The Journal of the American Medical Association (JAMA) Network (American Medical Association)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173654999","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/I173654999"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications by UMMS Authors","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:escholarship.umassmed.edu:oapubs-4424","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.umassmed.edu/oapubs/3413","pdf_url":"https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4424&context=oapubs","source":{"id":"https://openalex.org/S4306400883","display_name":"The Journal of the American Medical Association (JAMA) Network (American Medical Association)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173654999","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/I173654999"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications by UMMS Authors","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1096465410","display_name":null,"funder_award_id":"DK89572","funder_id":"https://openalex.org/F4320317722","funder_display_name":"Human Islet Research Network"},{"id":"https://openalex.org/G2466386384","display_name":"Molecular Mechanisms of Human and Murine Beta Cell Proliferation and Regeneration","funder_award_id":"U01DK089572","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2543861973","display_name":null,"funder_award_id":"DK108120","funder_id":"https://openalex.org/F4320317722","funder_display_name":"Human Islet Research Network"},{"id":"https://openalex.org/G2588140055","display_name":null,"funder_award_id":"DK-20593","funder_id":"https://openalex.org/F4320317722","funder_display_name":"Human Islet Research Network"},{"id":"https://openalex.org/G3433274139","display_name":null,"funder_award_id":"P30 CA68485","funder_id":"https://openalex.org/F4320309151","funder_display_name":"Vanderbilt University"},{"id":"https://openalex.org/G3577507879","display_name":null,"funder_award_id":"SCR_014393","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3865556588","display_name":null,"funder_award_id":"DK20593","funder_id":"https://openalex.org/F4320309151","funder_display_name":"Vanderbilt University"},{"id":"https://openalex.org/G3989539122","display_name":null,"funder_award_id":"DK 20593","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4148617410","display_name":null,"funder_award_id":"DK-20593","funder_id":"https://openalex.org/F4320334588","funder_display_name":"Vanderbilt Diabetes Research and Training Center, Vanderbilt University Medical Center"},{"id":"https://openalex.org/G4257221958","display_name":null,"funder_award_id":"DK112232","funder_id":"https://openalex.org/F4320317722","funder_display_name":"Human Islet Research Network"},{"id":"https://openalex.org/G4401921410","display_name":"Islet Biology in Cystic Fibrosis Related Diabetes","funder_award_id":"R01DK097829","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4849004728","display_name":null,"funder_award_id":"SCR_014393","funder_id":"https://openalex.org/F4320317722","funder_display_name":"Human Islet Research Network"},{"id":"https://openalex.org/G507535313","display_name":null,"funder_award_id":"DK106755","funder_id":"https://openalex.org/F4320317722","funder_display_name":"Human Islet Research Network"},{"id":"https://openalex.org/G5369194977","display_name":"Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas","funder_award_id":"UC4DK104211","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5523990553","display_name":null,"funder_award_id":"DK104211","funder_id":"https://openalex.org/F4320317722","funder_display_name":"Human Islet Research Network"},{"id":"https://openalex.org/G5853943267","display_name":null,"funder_award_id":"CA68485","funder_id":"https://openalex.org/F4320309151","funder_display_name":"Vanderbilt University"},{"id":"https://openalex.org/G5985243849","display_name":null,"funder_award_id":"DK94199","funder_id":"https://openalex.org/F4320317722","funder_display_name":"Human Islet Research Network"},{"id":"https://openalex.org/G6837715458","display_name":null,"funder_award_id":"BX000666","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G7359919950","display_name":null,"funder_award_id":"DK97829","funder_id":"https://openalex.org/F4320317722","funder_display_name":"Human Islet Research Network"},{"id":"https://openalex.org/G7364922087","display_name":"Integrated Program for Human Pancreas Procurement and Analysis","funder_award_id":"UC4DK112232","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7412428778","display_name":"Discovery of Pancreatic Signatures in Type 2 Diabetes Mellitus","funder_award_id":"R24DK106755","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7493470552","display_name":"High-resolution analysis of juvenile human pancreas maturation","funder_award_id":"UC4DK108120","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8066916288","display_name":"Coordinating Center for Beta Cell Biology Consortium","funder_award_id":"U01DK072473","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8878225359","display_name":"Islet Imaging with Monoclonal Antibodies","funder_award_id":"R01DK094199","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G891685765","display_name":null,"funder_award_id":"DK72473","funder_id":"https://openalex.org/F4320317722","funder_display_name":"Human Islet Research Network"},{"id":"https://openalex.org/G9000862353","display_name":"Molecular and Cellular Basis for Digestive Diseases","funder_award_id":"P30DK058404","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320309151","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34"},{"id":"https://openalex.org/F4320309446","display_name":"Leona M. and Harry B. Helmsley Charitable Trust","ror":"https://ror.org/011x6n313"},{"id":"https://openalex.org/F4320317722","display_name":"Human Islet Research Network","ror":null},{"id":"https://openalex.org/F4320334588","display_name":"Vanderbilt Diabetes Research and Training Center, Vanderbilt University Medical Center","ror":null},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7017098537.pdf","grobid_xml":"https://content.openalex.org/works/W7017098537.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2789611122","https://openalex.org/W7154534130","https://openalex.org/W4381337808","https://openalex.org/W2085594547","https://openalex.org/W2793899139","https://openalex.org/W3034222941","https://openalex.org/W4281649992","https://openalex.org/W4399687383","https://openalex.org/W4404500228","https://openalex.org/W3205215991"],"abstract_inverted_index":{"Many":[0],"patients":[1],"with":[2],"type":[3],"1":[4],"diabetes":[5],"(T1D)":[6],"have":[7],"residual":[8,35],"beta":[9,36,68,100],"cells":[10,37,40,69,85,91],"producing":[11],"small":[12],"amounts":[13],"of":[14,33,53,75,82,124],"C-peptide":[15],"long":[16],"after":[17,108],"disease":[18],"onset":[19],"but":[20],"develop":[21],"an":[22,131],"inadequate":[23],"glucagon":[24,138],"response":[25,139],"to":[26,50,71,140],"hypoglycemia":[27],"following":[28],"T1D":[29,59,83,111,136],"diagnosis.":[30],"The":[31],"features":[32],"these":[34,90],"and":[38,61,89,99,107],"alpha":[39,84,98],"in":[41,94,117],"the":[42,51,58,80,104,110,134],"islet":[43],"endocrine":[44],"compartment":[45],"are":[46],"largely":[47],"unknown,":[48],"due":[49],"difficulty":[52],"comprehensive":[54],"investigation.":[55],"By":[56],"studying":[57],"pancreas":[60,106],"isolated":[62],"islets,":[63],"we":[64],"show":[65],"that":[66],"remnant":[67],"appeared":[70],"maintain":[72],"several":[73],"aspects":[74],"regulated":[76],"insulin":[77],"secretion.":[78],"However,":[79],"function":[81],"was":[86,121],"markedly":[87],"reduced,":[88],"had":[92],"alterations":[93],"transcription":[95],"factors":[96],"constituting":[97],"cell":[101,126],"identity.":[102],"In":[103],"native":[105],"placing":[109],"islets":[112],"into":[113],"a":[114],"non-autoimmune,":[115],"normoglycemic":[116],"vivo":[118],"environment,":[119],"there":[120],"no":[122],"evidence":[123],"alpha-to-beta":[125],"conversion.":[127],"These":[128],"results":[129],"suggest":[130],"explanation":[132],"for":[133],"disordered":[135],"counterregulatory":[137],"hypoglycemia.":[141]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2025-10-10T00:00:00"}