{"id":"https://openalex.org/W7015572989","doi":null,"title":"Successful Guselkumab Treatment in a Patient with Comorbid Psoriasis and Amyotrophic Lateral Sclerosis: A Case Study and Literature Review","display_name":"Successful Guselkumab Treatment in a Patient with Comorbid Psoriasis and Amyotrophic Lateral Sclerosis: A Case Study and Literature Review","publication_year":2025,"publication_date":"2025-03-01","ids":{"openalex":"https://openalex.org/W7015572989"},"language":"en","primary_location":{"id":"pmh:oai:doaj.org/article:2b6886a087884c9ea895c6164c202370","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2b6886a087884c9ea895c6164c202370","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical, Cosmetic and Investigational Dermatology, Vol Volume 18, Pp 735-741 (2025)","raw_type":"article"},"volume":null,"type":"article","indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/2b6886a087884c9ea895c6164c202370","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Xiong J","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiong J","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Chen X","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chen X","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Huang K","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huang K","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Pan Y","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pan Y","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.35637936,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/guselkumab","display_name":"guselkumab","score":0.9800000190734863},{"id":"https://openalex.org/keywords/plaque-psoriasis","display_name":"plaque psoriasis","score":0.953000009059906},{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":1.0},{"id":"https://openalex.org/keywords/il-17a-inhibitor","display_name":"IL-17A inhibitor","score":0.6230000257492065},{"id":"https://openalex.org/keywords/il-23-inhibitors","display_name":"IL-23 inhibitors","score":0.9950000047683716},{"id":"https://openalex.org/keywords/biological-therapy","display_name":"biologic therapy","score":0.9160000085830688},{"id":"https://openalex.org/keywords/tnf-alpha-inhibitors","display_name":"TNF-alpha inhibitors","score":0.7670000195503235},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.7390000224113464},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9909999966621399},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9079999923706055},{"id":"https://openalex.org/keywords/motor-neuron-disease","display_name":"motor neuron disease","score":0.4860000014305115}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9282000064849854},{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.8203999996185303},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.7723000049591064},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.6015999913215637},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.527899980545044},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4821000099182129},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.4722999930381775},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.4560000002384186},{"id":"https://openalex.org/C3020604521","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Plaque psoriasis","level":3,"score":0.44209998846054077},{"id":"https://openalex.org/C2780247198","wikidata":"https://www.wikidata.org/wiki/Q633403","display_name":"Weakness","level":2,"score":0.37459999322891235},{"id":"https://openalex.org/C2776418732","wikidata":"https://www.wikidata.org/wiki/Q270421","display_name":"Muscle weakness","level":2,"score":0.3127000033855438},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3077999949455261},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.28769999742507935},{"id":"https://openalex.org/C3017923315","wikidata":"https://www.wikidata.org/wiki/Q621558","display_name":"Symptomatic treatment","level":3,"score":0.2847000062465668},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.27300000190734863},{"id":"https://openalex.org/C2776819417","wikidata":"https://www.wikidata.org/wiki/Q418123","display_name":"Dimethyl fumarate","level":3,"score":0.2669999897480011}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:doaj.org/article:2b6886a087884c9ea895c6164c202370","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2b6886a087884c9ea895c6164c202370","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical, Cosmetic and Investigational Dermatology, Vol Volume 18, Pp 735-741 (2025)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:2b6886a087884c9ea895c6164c202370","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2b6886a087884c9ea895c6164c202370","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical, Cosmetic and Investigational Dermatology, Vol Volume 18, Pp 735-741 (2025)","raw_type":"article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Jianxia":[0],"Xiong,":[1],"Xiaoli":[2],"Chen,":[3],"Kun":[4],"Huang,":[5],"Yun":[6,31],"Pan":[7],"Department":[8],"of":[9,15,29,80,104,108,125,139,168,193,199,223,271],"Dermatology,":[10],"The":[11,106],"First":[12],"Affiliated":[13],"Hospital":[14],"Chongqing":[16],"Medical":[17],"University,":[18],"No.":[19],"1":[20],"Youyi":[21],"Road,":[22],"Yuzhong":[23],"District,":[24],"Chongqing,":[25],"400016,":[26],"People\u2019s":[27],"Republic":[28],"ChinaCorrespondence:":[30],"Pan,":[32],"Email":[33],"403518388@qq.comAbstract:":[34],"Psoriasis":[35],"is":[36,72,91,98,112],"genetically":[37],"influenced":[38],"and":[39,49,63,87,96,110,157,212,245,253],"can":[40],"be":[41],"triggered":[42],"by":[43,77,146,257],"factors":[44],"such":[45],"as":[46,261],"infections,":[47],"stress,":[48],"lifestyle.":[50],"Chronic":[51],"plaque":[52,127,155,215],"psoriasis,":[53,128,251,276],"the":[54,78,123,137,194,197,220],"most":[55],"prevalent":[56],"form,":[57],"involves":[58],"key":[59],"roles":[60],"for":[61,94,142,182],"IL-17":[62],"IL-23":[64,254],"in":[65,84,122,236,243],"its":[66],"pathogenesis.":[67],"Amyotrophic":[68],"lateral":[69,278],"sclerosis":[70,210],"(ALS)":[71],"a":[73,151,161,172,179,190,262],"neurodegenerative":[74,200,281],"disorder":[75,282],"characterized":[76],"degeneration":[79],"motor":[81],"neurons,":[82],"resulting":[83],"muscle":[85],"weakness":[86],"atrophy.":[88],"Currently,":[89],"there":[90],"no":[92],"cure":[93],"ALS,":[95,213],"treatment":[97,124,180,224],"symptomatic,":[99],"aimed":[100],"at":[101],"improving":[102],"quality":[103],"life.":[105],"combination":[107],"psoriasis":[109,144,156,185],"ALS":[111,158,169,248,273],"relatively":[113],"rare.":[114],"Although":[115],"biologic":[116,140],"agents":[117,141],"have":[118,130,233],"shown":[119],"remarkable":[120],"efficacy":[121],"chronic":[126],"we":[129,227],"not":[131],"found":[132,228],"any":[133],"case":[134],"reports":[135],"regarding":[136],"use":[138],"treating":[143],"accompanied":[145],"ALS.":[147],"Our":[148],"study":[149],"presents":[150],"patient":[152],"with":[153,184,187,214,250],"severe":[154],"who":[159],"exhibited":[160],"positive":[162],"response":[163],"to":[164,267],"Guselkumab,":[165,258],"without":[166],"worsening":[167,272],"symptoms,":[170],"suggesting":[171],"promising":[173],"therapeutic":[174],"strategy.":[175],"This":[176,217],"could":[177,239],"provide":[178,240],"option":[181],"patients":[183,249],"combined":[186],"ALS.We":[188],"conducted":[189],"comprehensive":[191],"review":[192,218],"literature":[195],"on":[196],"comorbidity":[198],"diseases,":[201],"including":[202],"Alzheimer\u2019s":[203],"disease":[204,207],"(AD),":[205],"Parkinson\u2019s":[206],"(PD),":[208],"multiple":[209],"(MS),":[211],"psoriasis.":[216],"highlights":[219],"differential":[221],"impact":[222],"modalities.":[225],"Specifically,":[226],"that":[229],"TNF-\u03b1":[230],"inhibitors":[231],"may":[232],"adverse":[234],"effects":[235],"MS":[237],"but":[238],"protective":[241],"benefits":[242],"AD":[244],"PD.":[246],"In":[247],"IL-17A":[252],"inhibitors,":[255],"exemplified":[256],"are":[259],"suggested":[260],"more":[263],"suitable":[264],"alternative":[265],"due":[266],"their":[268],"lower":[269],"risk":[270],"symptoms.Keywords:":[274],"biologics,":[275],"amyotrophic":[277],"sclerosis,":[279],"guselkumab,":[280]},"counts_by_year":[],"updated_date":"2026-05-06T06:10:43.113611","created_date":"2025-10-10T00:00:00"}
