{"id":"https://openalex.org/W7015099765","doi":null,"title":"Role of an isoflavone metabolite in prevention of skin cancer","display_name":"Role of an isoflavone metabolite in prevention of skin cancer","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W7015099765"},"language":"en","primary_location":{"id":"pmh:oai:ses.library.usyd.edu.au:2123/27847","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2123/27847","pdf_url":null,"source":{"id":"https://openalex.org/S4306402414","display_name":"The Sydney eScholarship Repository (The University of Sydney)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I129604602","host_organization_name":"The University of Sydney","host_organization_lineage":["https://openalex.org/I129604602"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005867653","display_name":"Sitarina Widyarini","orcid":"https://orcid.org/0000-0003-4461-8454","observed_orcids":["https://orcid.org/0000-0003-4461-8454"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Widyarini, Sitarina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5005867653"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/equol","display_name":"equol","score":0.9940000176429749},{"id":"https://openalex.org/keywords/isoflavone-metabolites","display_name":"isoflavone metabolites","score":0.9750000238418579},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.9480000138282776},{"id":"https://openalex.org/keywords/skin-cancer","display_name":"skin cancer","score":0.9049999713897705},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.8880000114440918},{"id":"https://openalex.org/keywords/topical-application","display_name":"topical application","score":0.800000011920929},{"id":"https://openalex.org/keywords/dose-dependent-protection","display_name":"dose-dependent protection","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C2779156968","wikidata":"https://www.wikidata.org/wiki/Q17141495","display_name":"Hairless","level":2,"score":0.8465999960899353},{"id":"https://openalex.org/C2777789703","wikidata":"https://www.wikidata.org/wiki/Q192102","display_name":"Skin cancer","level":3,"score":0.8148000240325928},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.7095000147819519},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5782999992370605},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5203999876976013},{"id":"https://openalex.org/C2987742019","wikidata":"https://www.wikidata.org/wiki/Q11391","display_name":"Ultraviolet radiation","level":2,"score":0.477400004863739},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44749999046325684},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3978999853134155},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.37720000743865967},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.36160001158714294},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3353999853134155},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33070001006126404},{"id":"https://openalex.org/C149151106","wikidata":"https://www.wikidata.org/wiki/Q4677569","display_name":"Active metabolite","level":3,"score":0.3246000111103058},{"id":"https://openalex.org/C2778370115","wikidata":"https://www.wikidata.org/wiki/Q2038676","display_name":"Stratum corneum","level":2,"score":0.32269999384880066},{"id":"https://openalex.org/C2909910311","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Skin Aging","level":2,"score":0.31869998574256897},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.31040000915527344},{"id":"https://openalex.org/C2780576536","wikidata":"https://www.wikidata.org/wiki/Q7451065","display_name":"Sensitive skin","level":2,"score":0.2985999882221222},{"id":"https://openalex.org/C2781262405","wikidata":"https://www.wikidata.org/wiki/Q5384747","display_name":"Equol","level":4,"score":0.28130000829696655},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.2624000012874603},{"id":"https://openalex.org/C2909987724","wikidata":"https://www.wikidata.org/wiki/Q827658","display_name":"Sunscreening Agents","level":4,"score":0.2565000057220459},{"id":"https://openalex.org/C2777216303","wikidata":"https://www.wikidata.org/wiki/Q866324","display_name":"Hair follicle","level":2,"score":0.2563000023365021},{"id":"https://openalex.org/C3018555722","wikidata":"https://www.wikidata.org/wiki/Q11391","display_name":"Ultraviolet b","level":2,"score":0.2547000050544739},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25099998712539673},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.24809999763965607},{"id":"https://openalex.org/C2779805795","wikidata":"https://www.wikidata.org/wiki/Q1645189","display_name":"Cabello","level":3,"score":0.24639999866485596},{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.24230000376701355},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.23819999396800995},{"id":"https://openalex.org/C2993162744","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Skin tumor","level":4,"score":0.2337999939918518},{"id":"https://openalex.org/C2991981033","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Skin barrier","level":2,"score":0.2303999960422516},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.2281000018119812},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.227400004863739},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.22609999775886536},{"id":"https://openalex.org/C2779112978","wikidata":"https://www.wikidata.org/wiki/Q423417","display_name":"Imiquimod","level":2,"score":0.2257000058889389},{"id":"https://openalex.org/C2777524492","wikidata":"https://www.wikidata.org/wiki/Q649717","display_name":"Sunburn","level":2,"score":0.22280000150203705},{"id":"https://openalex.org/C2909877630","wikidata":"https://www.wikidata.org/wiki/Q5119338","display_name":"Scarring alopecia","level":3,"score":0.2222999930381775},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.2207999974489212},{"id":"https://openalex.org/C2987116853","wikidata":"https://www.wikidata.org/wiki/Q11391","display_name":"Ultraviolet light","level":2,"score":0.21199999749660492},{"id":"https://openalex.org/C2778804307","wikidata":"https://www.wikidata.org/wiki/Q809758","display_name":"Basal cell carcinoma","level":3,"score":0.21130000054836273},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.2087000012397766},{"id":"https://openalex.org/C2910376424","wikidata":"https://www.wikidata.org/wiki/Q11006","display_name":"SOY ISOFLAVONES","level":3,"score":0.20839999616146088}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:ses.library.usyd.edu.au:2123/27847","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2123/27847","pdf_url":null,"source":{"id":"https://openalex.org/S4306402414","display_name":"The Sydney eScholarship Repository (The University of Sydney)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I129604602","host_organization_name":"The University of Sydney","host_organization_lineage":["https://openalex.org/I129604602"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2070481189","https://openalex.org/W4231935122","https://openalex.org/W2112310317","https://openalex.org/W2074199612","https://openalex.org/W2017016795","https://openalex.org/W2091496602","https://openalex.org/W6924653890","https://openalex.org/W2026952897","https://openalex.org/W2138561998","https://openalex.org/W2515561217"],"abstract_inverted_index":{"The":[0],"aims":[1],"of":[2,14,38,49,66],"the":[3],"experiments":[4],"presented":[5],"in":[6,25,41],"this":[7],"thesis":[8],"were":[9],"to":[10,58],"investigate":[11],"some":[12],"aspects":[13],"chemoprevention":[15],"by":[16],"a":[17],"topically":[18],"applied":[19],"isoflavone,":[20],"equol,":[21],"its":[22,27],"mechanisms":[23],"and,":[24],"particular,":[26],"effect":[28],"on":[29],"solar-simulated":[30],"ultraviolet":[31],"radiation":[32],"(SSUV)-induced":[33],"immunosuppression":[34],"and":[35,64],"subsequent":[36],"development":[37,65],"skin":[39,44,62,67],"cancer":[40],"hairless":[42],"mouse":[43],"(SkthR-l).":[45],"A":[46],"dose-dependent":[47],"efficacy":[48],"equol":[50],"at":[51],"micromolar":[52],"(pM)":[53],"concentrations":[54],"has":[55],"been":[56],"demonstrated":[57],"protect":[59],"against":[60],"SSUV-induced":[61],"damage":[63],"cancer.":[68]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}