{"id":"https://openalex.org/W7014644186","doi":null,"title":"The principal pivot : new potent HDAC6 selective inhibitors with a non-hydroxamic acid zinc binding group for applications beyond oncology","display_name":"The principal pivot : new potent HDAC6 selective inhibitors with a non-hydroxamic acid zinc binding group for applications beyond oncology","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W7014644186"},"language":"en","primary_location":{"id":"pmh:oai:archive.ugent.be:8761508","doi":null,"is_oa":false,"landing_page_url":"https://biblio.ugent.be/publication/8761508","pdf_url":null,"source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS National Medicinal Chemistry Symposium, 37th, Abstracts","raw_type":"info:eu-repo/semantics/conferenceObject"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079926650","display_name":"Silke Geurs","orcid":"https://orcid.org/0000-0002-1072-901X","observed_orcids":["https://orcid.org/0000-0002-1072-901X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Geurs, Silke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5079926650"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hdac6","display_name":"HDAC6","score":0.9559999704360962},{"id":"https://openalex.org/keywords/hdac6-inhibitors","display_name":"HDAC6 inhibitors","score":0.9810000061988831},{"id":"https://openalex.org/keywords/zinc-binding-group","display_name":"zinc-binding groups","score":0.621999979019165},{"id":"https://openalex.org/keywords/mutagenicity","display_name":"mutagenicity","score":0.9240000247955322},{"id":"https://openalex.org/keywords/ames-test","display_name":"Ames test","score":0.5540000200271606},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.48100000619888306},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9869999885559082},{"id":"https://openalex.org/keywords/anticancer-drug-development","display_name":"anticancer drug development","score":0.4729999899864197}],"concepts":[{"id":"https://openalex.org/C23681527","wikidata":"https://www.wikidata.org/wiki/Q18034953","display_name":"HDAC6","level":5,"score":0.9114000201225281},{"id":"https://openalex.org/C2776281265","wikidata":"https://www.wikidata.org/wiki/Q420327","display_name":"Hydroxamic acid","level":2,"score":0.9090999960899353},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6459000110626221},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.635699987411499},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.47749999165534973},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.47690001130104065},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4668000042438507},{"id":"https://openalex.org/C121587506","wikidata":"https://www.wikidata.org/wiki/Q6888113","display_name":"Mode of action","level":2,"score":0.4577000141143799},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4521999955177307},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43230000138282776},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.39750000834465027},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.3935000002384186},{"id":"https://openalex.org/C2776262904","wikidata":"https://www.wikidata.org/wiki/Q905901","display_name":"Vorinostat","level":5,"score":0.385699987411499},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.3273000121116638},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.32519999146461487},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30979999899864197},{"id":"https://openalex.org/C197404232","wikidata":"https://www.wikidata.org/wiki/Q319827","display_name":"Chelation","level":2,"score":0.29739999771118164},{"id":"https://openalex.org/C535196362","wikidata":"https://www.wikidata.org/wiki/Q758","display_name":"Zinc","level":2,"score":0.2842000126838684},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.28220000863075256},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.26649999618530273},{"id":"https://openalex.org/C118792377","wikidata":"https://www.wikidata.org/wiki/Q108584245","display_name":"Selectivity","level":3,"score":0.2581000030040741},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.24690000712871552},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.24629999697208405},{"id":"https://openalex.org/C71723506","wikidata":"https://www.wikidata.org/wiki/Q18026859","display_name":"Histone deacetylase 2","level":5,"score":0.24449999630451202},{"id":"https://openalex.org/C2776980637","wikidata":"https://www.wikidata.org/wiki/Q427492","display_name":"Enzyme inhibitor","level":3,"score":0.2401999980211258},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.23980000615119934},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.23759999871253967},{"id":"https://openalex.org/C2778484676","wikidata":"https://www.wikidata.org/wiki/Q20707196","display_name":"Nonsteroidal","level":2,"score":0.23669999837875366},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.23000000417232513},{"id":"https://openalex.org/C4951695","wikidata":"https://www.wikidata.org/wiki/Q18046437","display_name":"HDAC11","level":5,"score":0.2231999933719635},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.21960000693798065},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.2184000015258789},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.2176000028848648},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.21369999647140503},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2126999944448471},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.20659999549388885},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20659999549388885},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.20409999787807465},{"id":"https://openalex.org/C2778942008","wikidata":"https://www.wikidata.org/wiki/Q305004","display_name":"Sodium butyrate","level":3,"score":0.19939999282360077},{"id":"https://openalex.org/C33618052","wikidata":"https://www.wikidata.org/wiki/Q6013136","display_name":"In vitro toxicology","level":3,"score":0.19670000672340393}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:archive.ugent.be:8761508","doi":null,"is_oa":false,"landing_page_url":"https://biblio.ugent.be/publication/8761508","pdf_url":null,"source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS National Medicinal Chemistry Symposium, 37th, Abstracts","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7012002047","https://openalex.org/W2944370167","https://openalex.org/W2465999258","https://openalex.org/W2766772940","https://openalex.org/W3090743378","https://openalex.org/W6902055005","https://openalex.org/W4322742851","https://openalex.org/W2202234387","https://openalex.org/W2984663997","https://openalex.org/W2611468691"],"abstract_inverted_index":{"Histone":[0],"deacetylase":[1],"6":[2],"(HDAC6)":[3],"is":[4,38],"a":[5,67,72,132],"crucial":[6],"regulator":[7],"in":[8,29,34,93,121,124],"various":[9],"cancer":[10],"types":[11],"and":[12,19,47,91,95,98,123,129],"several":[13],"non-oncological":[14],"conditions":[15],"such":[16],"as":[17,66,101,144],"inflammation":[18],"neurodegenerative":[20],"disorders.":[21],"Currently,":[22],"hydroxamic":[23,54,137],"acid-based":[24],"HDAC":[25,64],"inhibitors":[26,79],"are":[27],"used":[28],"oncology,":[30,71],"but":[31],"their":[32,42,136],"application":[33],"other":[35],"therapeutic":[36,68],"areas":[37],"hampered":[39],"because":[40],"of":[41,45,62,74,108],"non-selective":[43],"mode":[44],"action":[46],"the":[48,53,60,102,106],"potential":[49],"mutagenicity":[50],"associated":[51],"with":[52,111,140],"acid":[55,76,138],"zinc":[56,114],"binding":[57],"group.":[58,116],"Meeting":[59],"challenge":[61],"enabling":[63],"inhibition":[65],"strategy":[69],"beyond":[70],"set":[73],"non-hydroxamic":[75],"HDAC6":[77,85,128],"selective":[78],"was":[80],"synthesized.":[81],"Our":[82],"previously":[83],"developed":[84],"inhibitors,":[86],"Tubathians,":[87],"demonstrate":[88],"excellent":[89],"activity":[90,126],"selectivity":[92],"enzymatic":[94],"cellular":[96],"assays":[97],"therefore":[99],"served":[100],"starting":[103],"point":[104],"for":[105],"generation":[107],"new":[109],"HDAC6i":[110],"an":[112],"alternative":[113,134],"chelating":[115],"These":[117],"compounds":[118],"show":[119],"strong":[120],"vitro":[122],"cellulo":[125],"against":[127],"can":[130],"represent":[131],"safe":[133],"to":[135,142],"counterparts":[139],"regard":[141],"mutagenicity,":[143],"observed":[145],"through":[146],"Ames":[147],"assays.":[148]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2025-10-10T00:00:00"}
