{"id":"https://openalex.org/W70112797","doi":null,"title":"[Treatment of aplastic anemia with cyclosporine, prednisolone and androgens (primary results apropos of 10 cases].","display_name":"[Treatment of aplastic anemia with cyclosporine, prednisolone and androgens (primary results apropos of 10 cases].","publication_year":1996,"publication_date":"1996-11-01","ids":{"openalex":"https://openalex.org/W70112797","mag":"70112797","pmid":"https://pubmed.ncbi.nlm.nih.gov/9163998"},"language":"fr","primary_location":{"id":"pmid:9163998","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9163998","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapie","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110987841","display_name":"M. Frikha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110673","display_name":"Hopital Universitaire Hedi Chaker","ror":"https://ror.org/01vqqz948","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210110673"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"M Frikha","raw_affiliation_strings":["Service d'H\u00e9matologie Clinique, H\u00f4pital H\u00e9di Chaker de Sfax, Tunisie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'H\u00e9matologie Clinique, H\u00f4pital H\u00e9di Chaker de Sfax, Tunisie","institution_ids":["https://openalex.org/I4210110673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111676464","display_name":"Z. Sahnoun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Z Sahnoun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073400412","display_name":"Samira Kaabachi","orcid":"https://orcid.org/0000-0002-7939-4836","observed_orcids":["https://orcid.org/0000-0002-7939-4836"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Kaabachi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090308822","display_name":"M Elloumi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Elloumi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035370999","display_name":"Jalel Gargouri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Gargouri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003272882","display_name":"Jamel Dammak","orcid":"https://orcid.org/0000-0002-2862-3088","observed_orcids":["https://orcid.org/0000-0002-2862-3088","https://orcid.org/0000-0002-2856-4911"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Dammak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111484272","display_name":"Khaled Mounir Zeghal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K M Zeghal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113688222","display_name":"Taoufik Souissi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Souissi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00535126,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"51","issue":"6","first_page":"627","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.7567999958992004,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.7567999958992004,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13374","display_name":"Hematological disorders and diagnostics","score":0.14550000429153442,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.04989999905228615,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aplastic-anemia","display_name":"aplastic anemia","score":0.996999979019165},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9879999756813049},{"id":"https://openalex.org/keywords/prednisolone","display_name":"prednisolone","score":1.0},{"id":"https://openalex.org/keywords/androgens","display_name":"androgens","score":0.9900000095367432},{"id":"https://openalex.org/keywords/immunosuppressive-therapy","display_name":"immunosuppressive therapy","score":0.9210000038146973},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.527999997138977},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.9049999713897705},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.7549999952316284},{"id":"https://openalex.org/keywords/lymphoma","display_name":"lymphoma","score":0.6669999957084656},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.5170000195503235},{"id":"https://openalex.org/keywords/drug-monitoring","display_name":"drug monitoring","score":0.4959999918937683},{"id":"https://openalex.org/keywords/remission","display_name":"remission","score":0.45399999618530273}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8335961103439331},{"id":"https://openalex.org/C2776715498","wikidata":"https://www.wikidata.org/wiki/Q11426176","display_name":"Prednisolone","level":2,"score":0.8249205350875854},{"id":"https://openalex.org/C2781440808","wikidata":"https://www.wikidata.org/wiki/Q846316","display_name":"Aplastic anemia","level":3,"score":0.7742254734039307},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6371092796325684},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5486295819282532},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4730723798274994},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46748441457748413},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.38759028911590576},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.1842637062072754}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000728","descriptor_name":"Androgens","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000728","descriptor_name":"Androgens","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000741","descriptor_name":"Anemia, Aplastic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011241","descriptor_name":"Prednisone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011241","descriptor_name":"Prednisone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:9163998","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9163998","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapie","raw_type":"English Abstract"},{"id":"mag:70112797","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9163998","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2059450037","https://openalex.org/W2398267789","https://openalex.org/W2029046705","https://openalex.org/W139161234","https://openalex.org/W2341016096","https://openalex.org/W2504510994","https://openalex.org/W1999462002","https://openalex.org/W2461226721","https://openalex.org/W2368174467","https://openalex.org/W2572610784"],"abstract_inverted_index":{"Aplastic":[0],"anaemia":[1,25,37,187],"is":[2,10],"a":[3,84,100],"potentially":[4],"fatal":[5],"haematopoietic":[6],"disorder":[7],"whose":[8],"aetiology":[9],"not":[11,217],"yet":[12],"clarified.":[13],"In":[14,177],"our":[15,178],"preliminary":[16],"study":[17],"we":[18],"have":[19],"introduced":[20],"cyclosporin":[21,183],"in":[22,184,190],"the":[23,32,73,81,107,113,121,175,180,185,200,213,223,226],"aplastic":[24,36,186],"treatment":[26,82,188],"to":[27,80,198],"evaluate":[28],"its":[29,219],"effect":[30],"on":[31],"disease":[33],"evolution.":[34],"Ten":[35],"patients,":[38],"mean":[39],"age":[40],"33.33":[41],"+/-":[42,50],"20.01":[43],"years,":[44],"were":[45,69],"treated":[46],"with":[47,65,72,207],"cyclosporine":[48,74],"(9":[49],"2.35":[51],"mg/kg/d),":[52],"prednisolone":[53,61],"(0.5":[54],"mg/kg/d)":[55],"and":[56,127,161,212],"androgens":[57,68],"(1":[58],"mg/kg/d).":[59],"The":[60,67,129,138,146],"was":[62,134,143,169],"always":[63],"combined":[64],"cyclosporine.":[66,176],"administered":[70],"concomitantly":[71],"or":[75],"alternately.":[76],"Seven":[77],"patients":[78,110],"responded":[79],"after":[83,171],"median":[85,101,139],"remission":[86],"delay":[87],"of":[88,96,102,131,141,153,158,164,174,182,222,225],"6":[89],"weeks":[90,104],"(2-12":[91],"weeks).":[92],"They":[93],"became":[94],"independent":[95],"blood":[97],"requirements":[98],"at":[99],"36":[103],"(8-108":[105],"weeks);":[106],"three":[108],"other":[109],"died":[111],"during":[112],"first":[114],"trimester":[115],"without":[116],"showing":[117],"any":[118],"improvement.":[119],"Among":[120],"seven":[122],"responders,":[123],"two":[124],"relapsed":[125],"early":[126],"transiently.":[128],"rate":[130],"actuarial":[132],"survival":[133,142],"70":[135],"per":[136],"cent.":[137],"duration":[140],"10.5":[144],"months.":[145],"side":[147,214],"effects":[148,215],"observed":[149],"included":[150],"one":[151],"case":[152],"malignant":[154],"lymphoma,":[155],"six":[156],"cases":[157,163],"liver":[159],"toxicity":[160,168],"five":[162],"kidney":[165],"toxicity.":[166],"This":[167,203],"reversible":[170],"dose":[172],"adjustment":[173],"study,":[179],"introduction":[181],"resulted":[189],"improved":[191],"therapeutic":[192,204],"response.":[193,202],"Androgens":[194],"should":[195,216],"be":[196],"used":[197],"maintain":[199],"haematologic":[201],"protocol":[205],"associated":[206],"drug":[208],"monitoring":[209],"seems":[210],"promising":[211],"limit":[218],"use":[220],"because":[221],"severity":[224],"underlying":[227],"disease.":[228]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}