{"id":"https://openalex.org/W70093560","doi":null,"title":"Heparin monitoring during coronary intervention: activated clotting time versus activated partial thromboplastin time.","display_name":"Heparin monitoring during coronary intervention: activated clotting time versus activated partial thromboplastin time.","publication_year":1993,"publication_date":"1993-11-01","ids":{"openalex":"https://openalex.org/W70093560","mag":"70093560","pmid":"https://pubmed.ncbi.nlm.nih.gov/8281479"},"language":"en","primary_location":{"id":"pmid:8281479","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8281479","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Canadian journal of cardiology","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071645599","display_name":"F.Colin Nath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F C Nath","raw_affiliation_strings":["Department of Internal Medicine, University of Michigan, Ann Arbor","Dept. of Internal Medicine,, University of Michigan\u2013Ann Arbor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Dept. of Internal Medicine,, University of Michigan\u2013Ann Arbor","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136592184","display_name":"David W. Muller","orcid":"https://orcid.org/0000-0002-5281-0166","observed_orcids":["https://orcid.org/0000-0002-5281-0166"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D W Muller","raw_affiliation_strings":["Cleveland Clinic Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Foundation","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112326111","display_name":"Uri Rosenschein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"U Rosenschein","raw_affiliation_strings":["Cleveland Clinic Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Foundation","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067465521","display_name":"Stephen G. Ellis","orcid":"https://orcid.org/0000-0001-6239-9772","observed_orcids":["https://orcid.org/0000-0001-6239-9772"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S G Ellis","raw_affiliation_strings":["Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084515381","display_name":"Eric J. Topol","orcid":"https://orcid.org/0000-0002-1478-4729","observed_orcids":["https://orcid.org/0000-0002-1478-4729"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E J Topol","raw_affiliation_strings":["Cleveland Clinic Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Foundation","institution_ids":["https://openalex.org/I1316902750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2391,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.48324945,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"9","issue":"9","first_page":"797","last_page":"801"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.01510000042617321,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heparin-monitoring","display_name":"heparin monitoring","score":0.8510000109672546},{"id":"https://openalex.org/keywords/activated-clotting-time","display_name":"activated clotting time","score":0.9919999837875366},{"id":"https://openalex.org/keywords/activated-partial-thromboplastin-time","display_name":"activated partial thromboplastin time","score":1.0},{"id":"https://openalex.org/keywords/coronary-angioplasty","display_name":"coronary angioplasty","score":0.9419999718666077},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.8220000267028809},{"id":"https://openalex.org/keywords/subtherapeutic-anticoagulation","display_name":"subtherapeutic anticoagulation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/thromboprophylaxis","display_name":"thromboprophylaxis","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C2778261982","wikidata":"https://www.wikidata.org/wiki/Q1755136","display_name":"Partial thromboplastin time","level":3,"score":0.9550212621688843},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9222815036773682},{"id":"https://openalex.org/C2777987278","wikidata":"https://www.wikidata.org/wiki/Q4677454","display_name":"Activated clotting time","level":3,"score":0.9186902046203613},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.7812755107879639},{"id":"https://openalex.org/C2780326628","wikidata":"https://www.wikidata.org/wiki/Q539795","display_name":"Angioplasty","level":2,"score":0.553431510925293},{"id":"https://openalex.org/C77171857","wikidata":"https://www.wikidata.org/wiki/Q5135593","display_name":"Clotting time","level":3,"score":0.5291980504989624},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.47728386521339417},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.43609827756881714},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37891077995300293},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3711225986480713}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000787","descriptor_name":"Angina Pectoris","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D010314","descriptor_name":"Partial Thromboplastin Time","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014914","descriptor_name":"Whole Blood Coagulation Time","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015906","descriptor_name":"Angioplasty, Balloon, Coronary","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016903","descriptor_name":"Drug Monitoring","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:8281479","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8281479","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Canadian journal of cardiology","raw_type":"Comparative Study"},{"id":"mag:70093560","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8281479","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2016924992","https://openalex.org/W2064174308","https://openalex.org/W2139755001","https://openalex.org/W1539267720","https://openalex.org/W2394925762","https://openalex.org/W2037418908","https://openalex.org/W2413646989","https://openalex.org/W2156084460","https://openalex.org/W2026178107","https://openalex.org/W2073217185"],"abstract_inverted_index":{"Activated":[0],"clotting":[1],"time":[2,8],"(ACT)":[3],"and":[4,33,40,55,90,119,136],"activated":[5],"partial":[6],"thromboplastin":[7],"(APTT)":[9],"are":[10],"used":[11],"for":[12,84,167,181],"monitoring":[13,169],"heparin":[14,60],"therapy":[15],"during":[16,66],"coronary":[17,67],"angioplasty.":[18],"The":[19,42,100],"purpose":[20],"of":[21,102,165,170,179,183,192,200],"this":[22],"study":[23,148],"was":[24,129,151],"to":[25,34,74,92,185],"determine":[26],"which":[27,188],"parameter":[28],"is":[29],"more":[30,88,95,112],"useful":[31],"clinically,":[32],"assess":[35],"the":[36,147,162,176],"correlation":[37,133],"between":[38,134],"ACT":[39,105,118,135,166,191],"APTT.":[41],"authors":[43],"measured":[44],"these":[45,85],"parameters":[46],"at":[47],"fixed":[48],"intervals":[49],"(0,":[50],"15,":[51],"30,":[52],"60,":[53],"150":[54],"240":[56],"mins)":[57],"following":[58],"intravenous":[59],"administration":[61],"(12,500":[62],"+/-":[63],"3100":[64],"U)":[65],"intervention":[68],"in":[69,146],"39":[70],"patients.":[71,149],"APTT":[72,109,120,137,199],"rose":[73],"'therapeutic'":[75],"levels":[76,79,94],"(true":[77],"therapeutic":[78,108,117],"have":[80],"not":[81,206],"been":[82],"defined":[83],"coagulation":[86],"tests)":[87],"rapidly":[89],"fell":[91],"subtherapeutic":[93,104],"slowly":[96],"than":[97,114,194,202],"did":[98,115],"ACT.":[99],"combination":[101],"a":[103,107,130],"with":[106,156],"occurred":[110],"far":[111],"often":[113],"concordant":[116],"values":[121],"(69%":[122],"versus":[123],"31%,":[124],"P":[125],"<":[126],"0.0004).":[127],"There":[128,141],"relatively":[131],"poor":[132],"(r":[138],"=":[139],"0.76).":[140],"were":[142],"no":[143],"abrupt":[144],"closures":[145],"It":[150],"concluded":[152],"that":[153,187],"subthreshold":[154],"ACTs":[155],"high":[157],"APTTs":[158],"occur":[159],"frequently,":[160],"suggesting":[161],"improved":[163],"suitability":[164],"intraprocedural":[168],"anticoagulation":[171,180],"status.":[172],"If":[173],"one":[174],"accepts":[175],"minimum":[177],"amount":[178],"prevention":[182],"thrombosis":[184],"be":[186],"produces":[189],"an":[190,198],"greater":[193,201],"300":[195],"s,":[196],"then":[197],"90":[203],"s":[204],"does":[205],"predict":[207],"adequate":[208],"anticoagulation.":[209]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
