{"id":"https://openalex.org/W7008722211","doi":null,"title":"Cosmeceutical potential of apple pomace phenolic compounds: development of a natural-based dermal hydrogel as proof of concept","display_name":"Cosmeceutical potential of apple pomace phenolic compounds: development of a natural-based dermal hydrogel as proof of concept","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W7008722211"},"language":"en","primary_location":{"id":"pmh:oai:bibliotecadigital.unipb.pt:10198/18294","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10198/18294","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10198/18294","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055013963","display_name":"Ana Alvarez Arraibi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Alvarez Arraibi, Ana","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5055013963"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.36160001158714294,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.36160001158714294,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.3458999991416931,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.10130000114440918,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apple-pomace","display_name":"apple pomace","score":1.0},{"id":"https://openalex.org/keywords/phenolic-compounds","display_name":"phenolic compounds","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cosmeceuticals","display_name":"cosmeceuticals","score":0.9100000262260437},{"id":"https://openalex.org/keywords/pectin","display_name":"pectin","score":0.9409999847412109},{"id":"https://openalex.org/keywords/cutibacterium-acnes","display_name":"Propionibacterium acnes","score":0.9559999704360962},{"id":"https://openalex.org/keywords/acne-vulgaris","display_name":"acne","score":0.7160000205039978},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.8460000157356262},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.9290000200271606},{"id":"https://openalex.org/keywords/natural-ingredients","display_name":"natural ingredients","score":0.41999998688697815},{"id":"https://openalex.org/keywords/hydroxycinnamic-acids","display_name":"hydroxycinnamic acids","score":0.8389999866485596},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9739999771118164},{"id":"https://openalex.org/keywords/dihydrochalcones","display_name":"dihydrochalcones","score":0.9010000228881836},{"id":"https://openalex.org/keywords/ethanol-water-extraction","display_name":"ethanol-water extraction","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C35421065","wikidata":"https://www.wikidata.org/wiki/Q927202","display_name":"Pomace","level":2,"score":0.9832000136375427},{"id":"https://openalex.org/C2780532717","wikidata":"https://www.wikidata.org/wiki/Q866990","display_name":"Cosmeceutical","level":2,"score":0.7531999945640564},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.6632999777793884},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.6607000231742859},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6509000062942505},{"id":"https://openalex.org/C17857428","wikidata":"https://www.wikidata.org/wiki/Q533025","display_name":"Nutraceutical","level":2,"score":0.45669999718666077},{"id":"https://openalex.org/C93021684","wikidata":"https://www.wikidata.org/wiki/Q3816735","display_name":"Pressing","level":2,"score":0.3752000033855438},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.32260000705718994},{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.31040000915527344},{"id":"https://openalex.org/C3018122547","wikidata":"https://www.wikidata.org/wiki/Q5690813","display_name":"Health benefits","level":2,"score":0.3003000020980835},{"id":"https://openalex.org/C513059894","wikidata":"https://www.wikidata.org/wiki/Q540912","display_name":"Food industry","level":2,"score":0.29660001397132874},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.28679999709129333},{"id":"https://openalex.org/C188884661","wikidata":"https://www.wikidata.org/wiki/Q4677573","display_name":"Active packaging","level":3,"score":0.2799000144004822},{"id":"https://openalex.org/C2910634430","wikidata":"https://www.wikidata.org/wiki/Q866990","display_name":"Cosmeceuticals","level":3,"score":0.2572999894618988},{"id":"https://openalex.org/C2779129764","wikidata":"https://www.wikidata.org/wiki/Q1309614","display_name":"Propionibacterium","level":3,"score":0.25519999861717224},{"id":"https://openalex.org/C2993539680","wikidata":"https://www.wikidata.org/wiki/Q902552","display_name":"Antioxidant capacity","level":3,"score":0.24869999289512634},{"id":"https://openalex.org/C2983177254","wikidata":"https://www.wikidata.org/wiki/Q4899370","display_name":"Beverage industry","level":2,"score":0.2475000023841858},{"id":"https://openalex.org/C2993522384","wikidata":"https://www.wikidata.org/wiki/Q3405827","display_name":"Natural materials","level":2,"score":0.24650000035762787},{"id":"https://openalex.org/C2778236407","wikidata":"https://www.wikidata.org/wiki/Q1041116","display_name":"Generally recognized as safe","level":2,"score":0.2223999947309494},{"id":"https://openalex.org/C2991978453","wikidata":"https://www.wikidata.org/wiki/Q184573","display_name":"Brown seaweed","level":3,"score":0.22120000422000885},{"id":"https://openalex.org/C55952523","wikidata":"https://www.wikidata.org/wiki/Q3014419","display_name":"Wine","level":2,"score":0.2094999998807907},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.1964000016450882},{"id":"https://openalex.org/C2987857752","wikidata":"https://www.wikidata.org/wiki/Q12147","display_name":"Human health","level":2,"score":0.19619999825954437},{"id":"https://openalex.org/C2776144398","wikidata":"https://www.wikidata.org/wiki/Q12752882","display_name":"Cosmetic industry","level":3,"score":0.19529999792575836},{"id":"https://openalex.org/C3020442560","wikidata":"https://www.wikidata.org/wiki/Q4971815","display_name":"Broad spectrum","level":2,"score":0.19179999828338623},{"id":"https://openalex.org/C74139830","wikidata":"https://www.wikidata.org/wiki/Q25380418","display_name":"Food packaging","level":2,"score":0.19099999964237213},{"id":"https://openalex.org/C2779737534","wikidata":"https://www.wikidata.org/wiki/Q213376","display_name":"Winemaking","level":3,"score":0.18790000677108765},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.18389999866485596},{"id":"https://openalex.org/C58684123","wikidata":"https://www.wikidata.org/wiki/Q1810993","display_name":"Food microbiology","level":3,"score":0.18289999663829803},{"id":"https://openalex.org/C2987718291","wikidata":"https://www.wikidata.org/wiki/Q2095","display_name":"Food products","level":2,"score":0.18209999799728394},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18119999766349792},{"id":"https://openalex.org/C139145706","wikidata":"https://www.wikidata.org/wiki/Q189567","display_name":"Food additive","level":2,"score":0.1687999963760376},{"id":"https://openalex.org/C53007507","wikidata":"https://www.wikidata.org/wiki/Q2760809","display_name":"Browning","level":2,"score":0.16869999468326569},{"id":"https://openalex.org/C2776034682","wikidata":"https://www.wikidata.org/wiki/Q13184","display_name":"Berry","level":2,"score":0.16830000281333923},{"id":"https://openalex.org/C2780132029","wikidata":"https://www.wikidata.org/wiki/Q752276","display_name":"Functional food","level":2,"score":0.16740000247955322},{"id":"https://openalex.org/C2910226413","wikidata":"https://www.wikidata.org/wiki/Q13485782","display_name":"Convenience food","level":2,"score":0.1662999987602234},{"id":"https://openalex.org/C135704130","wikidata":"https://www.wikidata.org/wiki/Q173514","display_name":"Food preservation","level":2,"score":0.1656000018119812},{"id":"https://openalex.org/C2781216036","wikidata":"https://www.wikidata.org/wiki/Q902494","display_name":"Thermostability","level":3,"score":0.16339999437332153},{"id":"https://openalex.org/C45904493","wikidata":"https://www.wikidata.org/wiki/Q912807","display_name":"Active ingredient","level":2,"score":0.16019999980926514},{"id":"https://openalex.org/C2780719635","wikidata":"https://www.wikidata.org/wiki/Q4173974","display_name":"Flavor","level":2,"score":0.15940000116825104}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:bibliotecadigital.unipb.pt:10198/18294","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10198/18294","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"}],"best_oa_location":{"id":"pmh:oai:bibliotecadigital.unipb.pt:10198/18294","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10198/18294","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"sustainable_development_goals":[{"display_name":"Responsible consumption and production","score":0.807699978351593,"id":"https://metadata.un.org/sdg/12"},{"display_name":"Good health and well-being","score":0.745199978351593,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3194013741","https://openalex.org/W2947194998","https://openalex.org/W7017425997","https://openalex.org/W4403243269","https://openalex.org/W7017513408","https://openalex.org/W2734761879","https://openalex.org/W7138936252","https://openalex.org/W4400272457","https://openalex.org/W4400609030","https://openalex.org/W4390373025"],"abstract_inverted_index":{"Currently,":[0],"there":[1,49],"is":[2,50,112,230],"an":[3,51],"evident":[4],"trend":[5],"towards":[6],"incorporating":[7],"natural-based":[8],"ingredients":[9,22],"in":[10,35,114,119,129,190,260],"dermal":[11,263],"formulations.":[12],"In":[13,82,168],"addition":[14],"to":[15,54,154,160,207,232,245],"the":[16,36,105,123,162,191,224,238,247,289,297],"growing":[17],"consumers\u2019":[18],"acceptance,":[19],"these":[20,79,109],"natural":[21],"are":[23],"not":[24],"associated":[25],"with":[26],"such":[27],"a":[28,45,75,94,98,156,173,261],"high":[29,174],"number":[30,100],"of":[31,38,78,97,101,108,166,176,193,198,240,291,296],"side":[32],"effects":[33],"as":[34,67,74,211,213,277],"case":[37],"most":[39],"artificial":[40],"components.":[41],"Likewise,":[42],"and":[43,89,117,136,148,164,195,216,293],"following":[44],"circular":[46],"economy":[47],"approach,":[48],"overall":[52],"attempt":[53],"find":[55],"added-value":[56],"applications":[57],"among":[58],"materials":[59],"that":[60],"would":[61],"be":[62,72,155,180],"otherwise":[63],"discarded":[64],"or":[65],"considered":[66,73],"waste.":[68],"Apple":[69],"pomace":[70,85,121,131,171,201,270],"might":[71],"striking":[76],"example":[77],"industrial":[80],"by-products.":[81],"fact,":[83],"apple":[84,115,120,130,170,200,269],"remaining":[86],"from":[87,268],"cider":[88],"juice":[90],"pressing":[91,124],"industries":[92],"represents":[93],"competitive":[95],"source":[96],"large":[99],"phenolic":[102,209],"compounds.":[103],"Interestingly,":[104],"major":[106],"part":[107],"bioactive":[110,194],"compounds":[111,127],"found":[113],"peel":[116],"remain":[118],"after":[122],"procedure.":[125],"Phenolic":[126],"present":[128,222],"(e.g.,":[132],"hydroxycinnamic":[133],"acids,":[134],"flavonoids":[135],"di-hydrochalcones)":[137],"display":[138],"health":[139,163],"promoting":[140],"activities,":[141],"mainly":[142],"based":[143],"on":[144,223],"their":[145,208,214],"antioxidant,":[146],"anti-inflammatory":[147],"antimicrobial":[149,217,249],"properties.":[150,185],"Therefore,":[151],"they":[152],"seem":[153],"promising":[157],"cosmeceutical":[158],"aimed":[159],"promote":[161],"beauty":[165],"skin.":[167],"addition,":[169],"has":[172],"concentration":[175],"pectin,":[177,266],"which":[178,229,243],"can":[179],"used":[181,276],"for":[182,285],"its":[183,286],"jellifying":[184,278],"This":[186,280],"research":[187],"study":[188],"focused":[189],"evaluation":[192],"chemical":[196],"characterization":[197],"different":[199,220],"extracts.":[202],"Special":[203],"attention":[204],"was":[205,237,257,275,282],"dedicated":[206],"profile,":[210],"well":[212],"antioxidant":[215,292],"(specifically":[218],"against":[219,251],"bacteria":[221],"skin,":[225],"e.g.,":[226],"Propionibacterium":[227],"acnes,":[228],"linked":[231],"acne).":[233],"The":[234],"best":[235],"extract":[236,256],"mixture":[239],"ethanol:water":[241],"(80:20),":[242],"proved":[244],"have":[246],"highest":[248],"potential":[250],"P.":[252],"acnes.":[253],"Accordingly,":[254],"this":[255],"later":[258],"incorporated":[259,298],"novel":[262],"hydrogel,":[264],"where":[265],"extracted":[267],"by":[271],"hot":[272],"acid":[273],"extraction,":[274],"agent.":[279],"hydrogel":[281],"further":[283],"evaluated":[284],"bioactivity,":[287],"revealing":[288],"maintenance":[290],"antibacterial":[294],"activity":[295],"extract.":[299]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}