{"id":"https://openalex.org/W7008499363","doi":null,"title":"Caracterizaci\u00f3n de la estructura y funci\u00f3n de la rabfilina 3A","display_name":"Caracterizaci\u00f3n de la estructura y funci\u00f3n de la rabfilina 3A","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W7008499363"},"language":"es","primary_location":{"id":"pmh:oai:www.tdx.cat:10803/620199","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10201/57699","pdf_url":"http://hdl.handle.net/10201/57699","source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10201/57699","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"P\u00e9rez S\u00e1nchez, Mar\u00eda Dolores","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"P\u00e9rez S\u00e1nchez, Mar\u00eda Dolores","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rabphilin-3a","display_name":"Rabphilin-3A","score":0.8790000081062317},{"id":"https://openalex.org/keywords/c2-domain","display_name":"C2 domain","score":0.8429999947547913},{"id":"https://openalex.org/keywords/c2a-domain","display_name":"C2A domain","score":0.7630000114440918},{"id":"https://openalex.org/keywords/c2b-domain","display_name":"C2B domain","score":0.9990000128746033},{"id":"https://openalex.org/keywords/snare-complex","display_name":"SNARE complex","score":0.7129999995231628},{"id":"https://openalex.org/keywords/snap-25","display_name":"SNAP-25","score":0.9409999847412109},{"id":"https://openalex.org/keywords/exocytosis","display_name":"exocytosis","score":0.8009999990463257},{"id":"https://openalex.org/keywords/vesicle-fusion","display_name":"vesicle fusion","score":0.7670000195503235},{"id":"https://openalex.org/keywords/calcium-binding","display_name":"calcium binding","score":0.7099999785423279},{"id":"https://openalex.org/keywords/phosphoinositides","display_name":"phosphoinositides","score":0.9229999780654907},{"id":"https://openalex.org/keywords/membrane-binding","display_name":"membrane binding","score":0.6610000133514404},{"id":"https://openalex.org/keywords/synaptic-transmission","display_name":"synaptic transmission","score":0.5879999995231628},{"id":"https://openalex.org/keywords/vesicle-recycling","display_name":"vesicle recycling","score":0.6259999871253967},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.4620000123977661}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.43309998512268066},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.43160000443458557},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.41510000824928284},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.2312999963760376},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.19210000336170197},{"id":"https://openalex.org/C146834321","wikidata":"https://www.wikidata.org/wiki/Q2979672","display_name":"Closure (psychology)","level":2,"score":0.1906999945640564},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.14249999821186066},{"id":"https://openalex.org/C2982832238","wikidata":"https://www.wikidata.org/wiki/Q5531640","display_name":"General purpose","level":2,"score":0.13830000162124634},{"id":"https://openalex.org/C2778012447","wikidata":"https://www.wikidata.org/wiki/Q1034415","display_name":"Scope (computer science)","level":2,"score":0.1363999992609024},{"id":"https://openalex.org/C62354387","wikidata":"https://www.wikidata.org/wiki/Q875399","display_name":"Boundary (topology)","level":2,"score":0.13359999656677246}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:www.tdx.cat:10803/620199","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10201/57699","pdf_url":"http://hdl.handle.net/10201/57699","source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:dnet:digitum_____::74af9a2bb31afc8776f6e36014c919a4","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10201/57699","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:hispana.mcu.es:61688550","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10201/57699","pdf_url":null,"source":{"id":"https://openalex.org/S4377196108","display_name":"Hispana","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:www.tdx.cat:10803/620199","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10201/57699","pdf_url":"http://hdl.handle.net/10201/57699","source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7008499363.pdf","grobid_xml":"https://content.openalex.org/works/W7008499363.grobid-xml"},"referenced_works_count":134,"referenced_works":["https://openalex.org/W1485297825","https://openalex.org/W1509054438","https://openalex.org/W1557426632","https://openalex.org/W1578142161","https://openalex.org/W1591639440","https://openalex.org/W1822252127","https://openalex.org/W1831476346","https://openalex.org/W1840662943","https://openalex.org/W1871478100","https://openalex.org/W1913308306","https://openalex.org/W1964375147","https://openalex.org/W1967817609","https://openalex.org/W1969288514","https://openalex.org/W1974606305","https://openalex.org/W1977239487","https://openalex.org/W1978302530","https://openalex.org/W1982320266","https://openalex.org/W1989396363","https://openalex.org/W1991767608","https://openalex.org/W1992374630","https://openalex.org/W1999226878","https://openalex.org/W2000003653","https://openalex.org/W2000302106","https://openalex.org/W2005593816","https://openalex.org/W2008389970","https://openalex.org/W2008456025","https://openalex.org/W2009671832","https://openalex.org/W2010413727","https://openalex.org/W2010439193","https://openalex.org/W2011940688","https://openalex.org/W2012212117","https://openalex.org/W2014228231","https://openalex.org/W2015894821","https://openalex.org/W2016266703","https://openalex.org/W2017196029","https://openalex.org/W2021285837","https://openalex.org/W2021315196","https://openalex.org/W2022480984","https://openalex.org/W2023819242","https://openalex.org/W2024136850","https://openalex.org/W2026718004","https://openalex.org/W2026862088","https://openalex.org/W2027876073","https://openalex.org/W2029583669","https://openalex.org/W2030142228","https://openalex.org/W2031057786","https://openalex.org/W2031412125","https://openalex.org/W2034266881","https://openalex.org/W2036664829","https://openalex.org/W2038721272","https://openalex.org/W2040866860","https://openalex.org/W2041423137","https://openalex.org/W2042055643","https://openalex.org/W2042089363","https://openalex.org/W2042920344","https://openalex.org/W2043019982","https://openalex.org/W2043312574","https://openalex.org/W2048112737","https://openalex.org/W2048280976","https://openalex.org/W2048465987","https://openalex.org/W2049308967","https://openalex.org/W2050427247","https://openalex.org/W2051707340","https://openalex.org/W2052138090","https://openalex.org/W2052198843","https://openalex.org/W2053920298","https://openalex.org/W2054799935","https://openalex.org/W2057833707","https://openalex.org/W2058035029","https://openalex.org/W2059335098","https://openalex.org/W2059690468","https://openalex.org/W2059933011","https://openalex.org/W2060384627","https://openalex.org/W2060982278","https://openalex.org/W2061825173","https://openalex.org/W2062702628","https://openalex.org/W2065782182","https://openalex.org/W2073260940","https://openalex.org/W2076386790","https://openalex.org/W2076859114","https://openalex.org/W2076881120","https://openalex.org/W2078230520","https://openalex.org/W2079405491","https://openalex.org/W2079628880","https://openalex.org/W2079750452","https://openalex.org/W2089913733","https://openalex.org/W2090374527","https://openalex.org/W2091884933","https://openalex.org/W2092029033","https://openalex.org/W2095352259","https://openalex.org/W2097750144","https://openalex.org/W2101335101","https://openalex.org/W2113596790","https://openalex.org/W2113632335","https://openalex.org/W2122296109","https://openalex.org/W2122470288","https://openalex.org/W2123355036","https://openalex.org/W2124026197","https://openalex.org/W2124897951","https://openalex.org/W2125514891","https://openalex.org/W2126412071","https://openalex.org/W2128007435","https://openalex.org/W2128846365","https://openalex.org/W2129430733","https://openalex.org/W2134283668","https://openalex.org/W2134371594","https://openalex.org/W2135290527","https://openalex.org/W2135779274","https://openalex.org/W2138936877","https://openalex.org/W2141518284","https://openalex.org/W2142311913","https://openalex.org/W2144447780","https://openalex.org/W2144660603","https://openalex.org/W2145258545","https://openalex.org/W2148277919","https://openalex.org/W2150190558","https://openalex.org/W2150213543","https://openalex.org/W2150717831","https://openalex.org/W2154100802","https://openalex.org/W2155650113","https://openalex.org/W2156207120","https://openalex.org/W2159529647","https://openalex.org/W2161367731","https://openalex.org/W2165578823","https://openalex.org/W2166747217","https://openalex.org/W2167279371","https://openalex.org/W2168315683","https://openalex.org/W2169142054","https://openalex.org/W2171279562","https://openalex.org/W2233262349","https://openalex.org/W2298794075","https://openalex.org/W2400673665","https://openalex.org/W2540355822","https://openalex.org/W2579463126"],"related_works":["https://openalex.org/W7207273923","https://openalex.org/W2699727820","https://openalex.org/W2308633883","https://openalex.org/W2128846365","https://openalex.org/W1964474508","https://openalex.org/W1603561844","https://openalex.org/W4297565187","https://openalex.org/W2048112737","https://openalex.org/W7206875091","https://openalex.org/W2059933011"],"abstract_inverted_index":{"En":[0],"el":[1,39,54,60,71,154,161,169,193,221,271,321,344,564],"desarrollo":[2,162],"de":[3,16,35,41,48,51,62,64,87,95,115,122,124,130,134,150,156,163,171,173,185,196,218,234,240,251,268,277,283,292,301,306,309,323,332,339,346,353,355,374,377,387,392,397,402,410,420,423,433,440,456,474,482,487,501,516,533,556,566,572],"esta":[4,174,544],"Tesis":[5],"Doctoral":[6],"se":[7,142,166,189,199,304,341,359,389,405,462,495,550],"han":[8,82],"caracterizado":[9,168],"estructural":[10],"y":[11,27,32,43,80,119,149,160,179,460,477,486,519,527,535,574],"funcionalmente":[12],"los":[13,88,104,120,131,299,324,381,408,447,466,524],"dominios":[14,24,89,132,300,369,467],"C2":[15,90,588,597,669],"la":[17,68,113,116,157,177,203,209,232,248,256,262,264,290,302,333,350,363,375,385,400,424,429,434,451,454,480,488,502,512,559,570],"Rabfilina":[18],"3A.":[19,592],"Esta":[20,57,529],"prote\u00edna":[21,58,158,175,265,303],"contiene":[22],"dos":[23,312],"C2,":[25],"C2A":[26,195,599,720,779,1015],"C2B":[28,244,439,722,828,1040,1108],"dispuestos":[29,469],"en":[30,38,112,128,212,220,320,399,407,450,470,491,563],"t\u00e1ndem":[31,129,471],"existen":[33],"evidencias":[34],"su":[36,49],"participaci\u00f3n":[37],"proceso":[40,61,565],"exocitosis":[42],"fusi\u00f3n":[44,354,567],"vesicular":[45,568],"a":[46,97,176,202,236,311,315,412,428,484,499,672,689,710,815,899,978,988,1019,1156],"trav\u00e9s":[47,500],"capacidad":[50,352,376,386,401],"interaccionar":[52,269],"con":[53,70,270,442,523,569],"complejo":[55,181,272],"SNARE.":[56,182,273],"controla":[59],"recaptaci\u00f3n":[63],"nuevas":[65],"ves\u00edculas,":[66],"siendo":[67],"interacci\u00f3n":[69,513],"SNAP25":[72,443,498,520,649,1047,1099,1127],"un":[73,92,138,318,552],"paso":[74],"regulador":[75],"clave.":[76],"Los":[77,238],"estudios":[78],"bioqu\u00edmicos":[79],"biof\u00edsicos":[81],"demostrado":[83],"que":[84,107,141,192,263,298,362,465,494,511,541,554],"cada":[85],"uno":[86],"presentan":[91],"modo":[93,170],"diferente":[94],"uni\u00f3n":[96,172,235,241,411,425,483,530],"calcio,":[98],"as\u00ed":[99],"como":[100,372,418],"diferentes":[101,457],"afinidades":[102],"por":[103,206,208,227,247,261,286,295,479],"fosfoinos\u00edtidos,":[105],"lo":[106],"podr\u00eda":[108,370],"implicar":[109],"una":[110],"diferencia":[111],"regulaci\u00f3n":[114],"transmisi\u00f3n":[117,340],"sin\u00e1ptica":[118],"procesos":[121],"secreci\u00f3n":[123],"ves\u00edculas.":[125,356],"El":[126,216,274],"comportamiento":[127,139],"C2AB":[133,276,468,515,708,844,866,1076,1122],"rabfilina":[135,197,278,441,517,560],"3A":[136,198,279,518,561,636,784,870,1044,1125,1163],"presenta":[137],"caracter\u00edstico":[140],"ha":[143,167,190,342,360,444,463,509],"estudiado":[144],"mediante":[145,329],"t\u00e9cnicas":[146,458],"biof\u00edsicas,":[147],"bioqu\u00edmicas":[148,459],"biolog\u00eda":[151],"molecular.":[152],"Mediante":[153,183,357,453],"estudio":[155],"silvestre":[159],"construcciones":[164],"mutantes":[165],"membrana":[178,204],"al":[180,225,497],"calorimetr\u00eda":[184],"titulaci\u00f3n":[186],"isot\u00e9rmica":[187],"(ITC)":[188,770],"determinado":[191,361,510],"dominio":[194,226,243,275,415,427,438,506,538],"une":[200,496],"principalmente":[201],"formadas":[205,294],"POPC/POPS/PI(4,5)P2":[207,791],"regi\u00f3n":[210,233,489],"rica":[211,490],"lisinas":[213],"del":[214,230,242,365,414,426,437,505,537],"dominio.":[215],"aumento":[217,319],"calcio":[219,310,413,476,485,534,573],"sistema":[222],"permite":[223,297],"anclar":[224],"otra":[228],"zona":[229,260,364,481],"mismo,":[231],"calcio.":[237],"puntos":[239],"permanecen":[245],"bloqueados":[246],"disposici\u00f3n":[249],"relativa":[250],"ambos":[252,368],"dominios,":[253],"quedando":[254],"accesible":[255],"h\u00e9lice":[257,503],"H2,":[258],"principal":[259],"es":[266,281,531],"capaz":[267,282],"no":[280],"formar":[284,403],"agregados":[285,325,348,404],"si":[287],"s\u00f3lo,":[288],"pero":[289],"presencia":[291],"ves\u00edculas":[293],"fosfol\u00edpidos":[296],"unan":[305],"forma":[307],"dependiente":[308,532],"membranas":[313],"acercando":[314],"ambas":[316],"observ\u00e1ndose":[317],"tama\u00f1o":[322,345],"cuando":[326,380],"son":[327,383,472],"estudiados":[328],"dispersi\u00f3n":[330],"din\u00e1mica":[331],"luz":[334],"(DLS).":[335],"Con":[336,546],"microscop\u00eda":[337],"electr\u00f3nica":[338],"corroborado":[343],"estos":[347,548],"visualiz\u00e1ndose":[349],"potencial":[351],"mutaciones":[358],"conector":[366],"entre":[367,514],"actuar":[371],"freno":[373],"agregaci\u00f3n,":[378],"porque":[379],"residuos":[382,448],"mutados":[384],"agregaci\u00f3n":[388],"ve":[390],"aumentada":[391],"manera":[393],"significativa.":[394],"Otro":[395],"punto":[396,419],"control":[398,421,1021],"encuentra":[406],"lazos":[409],"C2A,":[416],"actuando":[417],"positivo":[422],"membrana.":[430],"La":[431],"obtenci\u00f3n":[432],"estructura":[435],"cristalina":[436],"permitido":[445],"determinar":[446],"clave":[449],"interacci\u00f3n.":[452,545],"combinaci\u00f3n":[455],"biof\u00edsicas":[461],"propuesto":[464],"capaces":[473],"coordinar":[475],"PI(4,5)P2":[478,1084],"lisinas;":[492],"mientras":[493],"H2":[504,849,1104],"C2B.":[507],"Se":[508],"ocurr\u00eda":[521],"tambi\u00e9n":[522],"complejos":[525],"SNAP25/STX1A":[526,1133],"SNAP25/STX1A/VAMP2.":[528,1135],"precisa":[536],"completo":[539],"para":[540],"tenga":[542],"lugar":[543],"todos":[547],"resultados":[549],"propone":[551],"modelo":[553],"trata":[555],"explicar":[557],"c\u00f3mo":[558],"participa":[562],"cooperaci\u00f3n":[571],"PI(4,5)P2.This":[575],"PhD":[576],"thesis":[577],"deals":[578],"with":[579,631,648,745,861,927,1046,1171],"both":[580,970],"the":[581,587,611,632,638,646,650,655,668,692,695,699,718,738,741,753,760,763,778,782,787,802,805,808,811,820,827,834,839,843,848,855,862,881,889,892,908,911,914,925,928,942,948,967,974,981,985,992,998,1006,1009,1014,1024,1027,1030,1035,1039,1050,1053,1074,1086,1090,1095,1098,1103,1107,1117,1121,1131,1142,1161,1166,1172],"structural":[582],"and":[583,600,660,698,721,731,762,906,1065,1083,1089,1126,1134,1140,1176],"functional":[584],"characterization":[585],"of":[586,590,613,640,642,654,667,694,717,737,740,756,781,799,807,826,838,868,883,891,910,913,936,944,951,959,984,991,997,1008,1013,1023,1026,1034,1038,1042,1052,1062,1106,1120,1123,1174],"domains":[589,670,841,890,971,1077],"Rabphilin":[591,635,783,869,1043,1124,1162],"This":[593,917,1136],"protein":[594,615,744,758,953],"contains":[595],"two":[596,840,896],"domains,":[598,723],"C2B,":[601],"located":[602],"in":[603,616,691,801,842,852,898,1005,1057,1130,1151,1165],"tandem.":[604],"There":[605],"are":[606,1078],"some":[607],"precedents":[608],"that":[609,665,716,777,888,966,1073,1116],"show":[610],"participation":[612],"this":[614,757,952,1058],"several":[617,746,1063],"processes":[618,700],"such":[619],"as":[620,679,681,1018],"exocytosis":[621],"or":[622],"vesicle":[623,703,1167],"fusion":[624,1168],"due":[625,832],"to":[626,629,675,677,702,751,759,775,786,810,833,859,874,895,954,964,1000,1029,1071,1080,1097,1145,1158],"its":[627,794,878],"ability":[628,950,999],"interact":[630,860],"SNARE":[633,764,863],"complex.":[634,765,864],"controls":[637],"process":[639,1169],"recaption":[641],"new":[643],"vesicles,":[644],"being":[645,846],"interaction":[647,1118],"key":[651,1054],"regulation":[652,693],"step":[653],"overall":[656],"process.":[657],"Several":[658],"biochemical":[659,1066],"biophysical":[661,1064],"studies":[662],"have":[663,749,962,1068,1154],"demonstrated":[664],"each":[666],"shows":[671],"different":[673,682,714,816],"mode":[674,755],"bind":[676,894,1001],"calcium,":[678],"well":[680],"affinities":[683],"for":[684],"phosphoinositides,":[685],"what":[686],"could":[687,972],"imply":[688],"difference":[690],"synaptic":[696],"transmission":[697,937],"related":[701],"secretion.":[704],"The":[705,735,766,797,823,865,934,957,1032],"tandem":[706,836,1075],"domain":[707,780,809,829,867,1028,1041,1144],"has":[709,725,772,940,1048,1113],"characteristic":[711],"behaviour":[712,739],"markedly":[713],"form":[715,875],"independent":[719],"which":[724,851],"been":[726,773,1069,1114],"studied":[727],"through":[728,793,814,1085,1102],"biophysical,":[729],"biochemical,":[730],"molecular":[732],"biology":[733],"techniques.":[734],"comparison":[736],"wild":[742],"type":[743],"mutant":[747,960],"constructs":[748,961],"served":[750,963],"characterize":[752],"binding":[754,824,993,1011,1025,1096,1137],"membrane":[761,813,1002],"isothermal":[767],"titration":[768],"calorimetry":[769],"technique":[771],"used":[774,1070],"determine":[776,965],"binds":[785],"membranes":[788,897],"formed":[789],"by":[790,923],"mainly":[792],"lysine-rich":[795],"cluster.":[796],"presence":[798,882],"calcium":[800,1010,1082,1175],"media":[803],"allows":[804,887],"anchoring":[806],"lipid":[812],"region,":[817],"also":[818,1128],"called":[819],"calcium-binding":[821,1087],"region.":[822],"areas":[825],"remain":[830],"blocked":[831],"relative":[835],"orientation":[837],"structure,":[845],"accessible":[847],"helix,":[850],"turn":[853],"becomes":[854],"main":[856],"area":[857],"able":[858,873,1079],"is":[871,1138],"not":[872],"aggregates":[876],"on":[877,980],"own,":[879],"but":[880],"vesicles":[884],"containing":[885],"phopholipids":[886],"proteins":[893],"calcium-dependant":[900,1139],"manner,":[901],"hence":[902],"bringing":[903],"them":[904],"together":[905],"provoking":[907],"enlargement":[909],"size":[912,943],"aggregate":[915],"particles.":[916],"experimental":[918],"fact":[919],"can":[920],"easily":[921],"observed":[922,1119],"analyzing":[924],"sample":[926],"dynamic":[929],"light":[930],"scattering":[931],"(DLS)":[932],"technique.":[933],"use":[935],"electronic":[938],"microscopy":[939],"corroborated":[941],"these":[945,1149],"aggregates,":[946],"visualizing":[947],"potential":[949],"fuse":[955],"vesicles.":[956],"generation":[958],"linker":[968,986],"among":[969],"hamper":[973],"aggregation":[975],"ability,":[976],"since":[977],"mutation":[979],"aminoacid":[982],"residues":[983,1055],"provoked":[987],"significant":[989],"enhancement":[990],"capability.":[994],"Another":[995],"checkpoint":[996,1022],"was":[1003],"found":[1004],"loops":[1007],"region":[1012,1088],"domain,":[1016],"acting":[1017],"positive":[1020],"membrane.":[1031],"determination":[1033],"crystal":[1036],"structure":[1037],"interacting":[1045],"allowed":[1049],"identification":[1051],"involved":[1056],"interaction.":[1059],"A":[1060],"combination":[1061],"techniques":[1067],"propose":[1072],"coordinate":[1081],"lysine":[1091],"rich":[1092],"cluster,":[1093],"while":[1094],"takes":[1100],"place":[1101],"helix":[1105],"domain.":[1109],"In":[1110],"addition,":[1111],"it":[1112],"determined":[1115],"occurs":[1129],"complexes":[1132],"needs":[1141],"whole":[1143],"happen.":[1146],"With":[1147],"all":[1148],"results":[1150],"mind":[1152],"we":[1153],"proposed":[1155],"model":[1157],"explain":[1159],"how":[1160],"participates":[1164],"along":[1170],"cooperation":[1173],"PI(4,5)P2.":[1177]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}