{"id":"https://openalex.org/W7007941331","doi":null,"title":"ADAR1 is a central regulator of the dsRNA response : from A-to-Z RNA","display_name":"ADAR1 is a central regulator of the dsRNA response : from A-to-Z RNA","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W7007941331"},"language":"en","primary_location":{"id":"pmh:oai:archive.ugent.be:01HNF8KA893WR9ARCTCH8FACPE","doi":null,"is_oa":true,"landing_page_url":"https://biblio.ugent.be/publication/01HNF8KA893WR9ARCTCH8FACPE","pdf_url":"https://biblio.ugent.be/publication/01HNF8KA893WR9ARCTCH8FACPE/file/01HNF97NTZ69BS2WYB0CH3AY0J.pdf","source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://biblio.ugent.be/publication/01HNF8KA893WR9ARCTCH8FACPE/file/01HNF97NTZ69BS2WYB0CH3AY0J.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034902701","display_name":"Richard de Reuver","orcid":"https://orcid.org/0000-0001-8703-0701","observed_orcids":["https://orcid.org/0000-0001-8703-0701"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"de Reuver, Richard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5034902701"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.5971999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.5971999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.39649999141693115,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adar1","display_name":"ADAR1","score":1.0},{"id":"https://openalex.org/keywords/a-to-i-rna-editing","display_name":"A-to-I RNA editing","score":0.7919999957084656},{"id":"https://openalex.org/keywords/aicardi-goutieres-syndrome","display_name":"Aicardi-Gouti\u00e8res syndrome","score":0.9620000123977661},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.9850000143051147},{"id":"https://openalex.org/keywords/mda5","display_name":"MDA5","score":0.9240000247955322},{"id":"https://openalex.org/keywords/pkr","display_name":"PKR","score":0.9350000023841858},{"id":"https://openalex.org/keywords/zbp1","display_name":"ZBP1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/integrated-stress-response","display_name":"integrated stress response","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.7329999804496765},{"id":"https://openalex.org/keywords/immunopathology","display_name":"immunopathology","score":0.6899999976158142},{"id":"https://openalex.org/keywords/genotype-phenotype-correlation","display_name":"genotype-phenotype correlation","score":0.6660000085830688},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.7689999938011169}],"concepts":[{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.679099977016449},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5260999798774719},{"id":"https://openalex.org/C2191507","wikidata":"https://www.wikidata.org/wiki/Q7277185","display_name":"RNA silencing","level":5,"score":0.48969998955726624},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.483599990606308},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45010000467300415},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3953999876976013},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36500000953674316},{"id":"https://openalex.org/C134474686","wikidata":"https://www.wikidata.org/wiki/Q21111069","display_name":"MDA5","level":5,"score":0.3531000018119812},{"id":"https://openalex.org/C2991743866","wikidata":"https://www.wikidata.org/wiki/Q417379","display_name":"Rna processing","level":4,"score":0.30720001459121704},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.305400013923645},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.3012999892234802},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.2842999994754791},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.27480000257492065},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.257999986410141},{"id":"https://openalex.org/C3017607883","wikidata":"https://www.wikidata.org/wiki/Q25325354","display_name":"Master regulator","level":4,"score":0.25290000438690186},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25200000405311584},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.25200000405311584},{"id":"https://openalex.org/C2780791683","wikidata":"https://www.wikidata.org/wiki/Q846785","display_name":"Action (physics)","level":2,"score":0.25040000677108765}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:archive.ugent.be:01HNF8KA893WR9ARCTCH8FACPE","doi":null,"is_oa":true,"landing_page_url":"https://biblio.ugent.be/publication/01HNF8KA893WR9ARCTCH8FACPE","pdf_url":"https://biblio.ugent.be/publication/01HNF8KA893WR9ARCTCH8FACPE/file/01HNF97NTZ69BS2WYB0CH3AY0J.pdf","source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:archive.ugent.be:01HNF8KA893WR9ARCTCH8FACPE","doi":null,"is_oa":true,"landing_page_url":"https://biblio.ugent.be/publication/01HNF8KA893WR9ARCTCH8FACPE","pdf_url":"https://biblio.ugent.be/publication/01HNF8KA893WR9ARCTCH8FACPE/file/01HNF97NTZ69BS2WYB0CH3AY0J.pdf","source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2023642260","display_name":null,"funder_award_id":"BOF16/MET_V/007","funder_id":"https://openalex.org/F4320327336","funder_display_name":"Vlaamse regering"},{"id":"https://openalex.org/G3778452221","display_name":"Factors that determine RIPK1-dependent necroptosis","funder_award_id":"G0C7618N","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G5086636032","display_name":"Investigating the role of ferroptosis in acute liver injury and multiple sclerosis with newly developed chemical tool compounds","funder_award_id":"G0B7118N","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G5843063039","display_name":null,"funder_award_id":"F/2016/865","funder_id":"https://openalex.org/F4320328144","funder_display_name":"Fondation contre le Cancer"},{"id":"https://openalex.org/G649776571","display_name":null,"funder_award_id":"BOF16/MET_V/007","funder_id":"https://openalex.org/F4320322603","funder_display_name":"Universiteit Gent"},{"id":"https://openalex.org/G7724930489","display_name":null,"funder_award_id":"BOF16/MET_V/007","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G82999393","display_name":"Unraveling the in vivo role of RIPK1: Physiological and pathological consequences of kinase-dependent and kinase-independent functions ","funder_award_id":"G0E0416N","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G8980775851","display_name":null,"funder_award_id":"30826052","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"}],"funders":[{"id":"https://openalex.org/F4320321730","display_name":"Fonds Wetenschappelijk Onderzoek","ror":"https://ror.org/03qtxy027"},{"id":"https://openalex.org/F4320322603","display_name":"Universiteit Gent","ror":"https://ror.org/00cv9y106"},{"id":"https://openalex.org/F4320327336","display_name":"Vlaamse regering","ror":null},{"id":"https://openalex.org/F4320328144","display_name":"Fondation contre le Cancer","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7007941331.pdf","grobid_xml":"https://content.openalex.org/works/W7007941331.grobid-xml"},"referenced_works_count":8,"referenced_works":["https://openalex.org/W3214268753","https://openalex.org/W4379791584","https://openalex.org/W4387045151","https://openalex.org/W4387343457","https://openalex.org/W4387675477","https://openalex.org/W4389993056","https://openalex.org/W4399428956","https://openalex.org/W4416943539"],"related_works":["https://openalex.org/W4387045151","https://openalex.org/W3190886770","https://openalex.org/W4310702097","https://openalex.org/W2206825594","https://openalex.org/W2341952836","https://openalex.org/W2161413838","https://openalex.org/W3207324369","https://openalex.org/W7212067950","https://openalex.org/W2562294469","https://openalex.org/W2784970793"],"abstract_inverted_index":{"Recent":[0],"progress":[1],"in":[2,30,39,62,138,141],"human":[3],"and":[4,80,98,108,126],"mouse":[5,25],"genetics":[6],"has":[7],"transformed":[8],"our":[9],"understanding":[10],"of":[11,18,53,58,76,85,94,101,136],"the":[12,31,59,86,92,102,133,139,143],"molecular":[13],"mechanisms":[14],"by":[15,110,114,121],"which":[16],"recognition":[17],"self":[19],"double-stranded":[20],"RNA":[21,32],"(self-dsRNA)":[22],"causes":[23],"immunopathology.Novel":[24],"models":[26],"recapitulate":[27],"loss-of-function":[28],"mutations":[29],"editing":[33],"enzyme":[34],"ADAR1":[35,137],"that":[36],"are":[37],"found":[38],"patients":[40],"with":[41,50],"Aicardi-Gouti\u00e8res":[42],"syndrome":[43],"(AGS)":[44],"-a":[45],"monogenic":[46],"inflammatory":[47],"disease":[48],"associated":[49],"increased":[51,73],"levels":[52],"type":[54,81,95],"I":[55,82,96],"interferon.Extensive":[56],"analyses":[57],"genotype-phenotype":[60],"relationships":[61],"these":[63],"mice":[64],"have":[65],"now":[66],"firmly":[67],"established":[68],"a":[69,130],"causal":[70],"relationship":[71],"between":[72],"intracellular":[74],"concentrations":[75],"endogenous":[77],"immunostimulatory":[78],"dsRNA":[79,111],"interferon-driven":[83],"immunopathology.Activation":[84],"dsRNA-specific":[87],"immune":[88,105],"sensor":[89],"MDA5":[90],"perpetuates":[91],"overproduction":[93],"interferons,":[97],"chronic":[99],"engagement":[100],"interferon-inducible":[103],"innate":[104],"receptors":[106],"PKR":[107],"ZBP1":[109],"drives":[112],"immunopathology":[113],"activating":[115],"an":[116],"integrated":[117],"stress":[118],"response":[119,146],"or":[120],"inducing":[122],"excessive":[123],"cell":[124],"death.Biochemical":[125],"genetic":[127],"data":[128],"support":[129],"role":[131],"for":[132],"p150":[134],"isoform":[135],"cytosol":[140],"suppressing":[142],"spontaneous,":[144],"pathological":[145],"to":[147],"self-dsRNA.":[148]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}