{"id":"https://openalex.org/W7006283350","doi":null,"title":"Tat-SF: A Cellular Factor for Regulation of Transcriptional Elongation by HIV Tat","display_name":"Tat-SF: A Cellular Factor for Regulation of Transcriptional Elongation by HIV Tat","publication_year":1999,"publication_date":"1999-09-01","ids":{"openalex":"https://openalex.org/W7006283350"},"language":"en","primary_location":{"id":"pmh:ADA381206","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA381206","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC AND NTIS","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Zhou, Qiang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhou, Qiang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5032640496","display_name":"Kunxin Luo","orcid":"https://orcid.org/0000-0003-3711-2017","observed_orcids":["https://orcid.org/0000-0003-3711-2017"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luo, Kunxin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.28325618,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.6205999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.6205999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.3416000008583069,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-tat","display_name":"HIV-1 Tat protein","score":0.9210000038146973},{"id":"https://openalex.org/keywords/transcription-elongation","display_name":"transcription elongation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/p-tefb","display_name":"P-TEFb","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cdk9","display_name":"CDK9","score":0.9589999914169312},{"id":"https://openalex.org/keywords/ribonucleoprotein-complexes","display_name":"ribonucleoprotein complexes","score":0.875},{"id":"https://openalex.org/keywords/cyclin-box","display_name":"cyclin box","score":0.7900000214576721},{"id":"https://openalex.org/keywords/rna-polymerase-ii","display_name":"RNA polymerase II","score":0.8489999771118164},{"id":"https://openalex.org/keywords/hiv-1-transcription","display_name":"HIV-1 transcription","score":0.9049999713897705}],"concepts":[{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.6474000215530396},{"id":"https://openalex.org/C2777841055","wikidata":"https://www.wikidata.org/wiki/Q15314917","display_name":"P-TEFb","level":5,"score":0.6316999793052673},{"id":"https://openalex.org/C64350747","wikidata":"https://www.wikidata.org/wiki/Q15334993","display_name":"RNA polymerase II","level":5,"score":0.6258000135421753},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6057999730110168},{"id":"https://openalex.org/C139124968","wikidata":"https://www.wikidata.org/wiki/Q126252","display_name":"Elongation factor","level":5,"score":0.5870000123977661},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5239999890327454},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5141000151634216},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5091999769210815},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.447299987077713},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.42899999022483826},{"id":"https://openalex.org/C59143045","wikidata":"https://www.wikidata.org/wiki/Q15314942","display_name":"Cyclin-dependent kinase 9","level":5,"score":0.3824000060558319},{"id":"https://openalex.org/C75186080","wikidata":"https://www.wikidata.org/wiki/Q15996621","display_name":"Eukaryotic translation elongation factor 1 alpha 1","level":5,"score":0.3774000108242035},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.3666999936103821},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3589000105857849},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.35190001130104065},{"id":"https://openalex.org/C75934600","wikidata":"https://www.wikidata.org/wiki/Q419245","display_name":"Ribonucleoprotein","level":4,"score":0.34790000319480896},{"id":"https://openalex.org/C24284526","wikidata":"https://www.wikidata.org/wiki/Q204785","display_name":"Zinc finger","level":4,"score":0.32199999690055847},{"id":"https://openalex.org/C33947775","wikidata":"https://www.wikidata.org/wiki/Q271439","display_name":"Elongation","level":3,"score":0.32199999690055847},{"id":"https://openalex.org/C172768829","wikidata":"https://www.wikidata.org/wiki/Q14817959","display_name":"Transcription factor II D","level":5,"score":0.30140000581741333},{"id":"https://openalex.org/C25281209","wikidata":"https://www.wikidata.org/wiki/Q3502188","display_name":"RNA polymerase I","level":5,"score":0.29030001163482666},{"id":"https://openalex.org/C2191507","wikidata":"https://www.wikidata.org/wiki/Q7277185","display_name":"RNA silencing","level":5,"score":0.2660999894142151},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.26100000739097595},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.25679999589920044}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:ADA381206","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA381206","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC AND NTIS","raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2040132563","https://openalex.org/W1984064054","https://openalex.org/W1600012607","https://openalex.org/W1518524366","https://openalex.org/W2031708680","https://openalex.org/W2069869908","https://openalex.org/W2047348339","https://openalex.org/W2460955965","https://openalex.org/W2156748342","https://openalex.org/W1507166653"],"abstract_inverted_index":{"Deregulation":[0],"of":[1,8,24,45,74,83,99,102,109,163,183,202,222,228],"transcriptional":[2],"elongation":[3,25,56,188],"can":[4,192],"cause":[5],"the":[6,22,37,42,46,53,60,89,97,115,140,181,199,226,238],"development":[7],"certain":[9],"malignancies.":[10],"HIV-1":[11,61,166,223],"Tat":[12,30,63,91,135,141,173,177,190],"has":[13],"been":[14],"used":[15],"as":[16],"a":[17,100,152,216],"model":[18],"system":[19],"to":[20,59,88,147,170,175,185,214],"study":[21],"control":[23],"by":[26,35,51],"RNA":[27,39,146],"polymerase":[28],"ii.":[29],"stimulates":[31],"HIV-":[32],"1":[33],"transcription":[34,55],"recognizing":[36],"TAR":[38,145],"structure":[40],"near":[41],"5'":[43],"end":[44],"nascent":[47],"viral":[48],"transcript":[49],"and":[50,67,85,95,111,137,144,158,174,189,219,230],"recruiting":[52],"human":[54,66,80,125,130,159,203],"factor":[57],"P-TEFb":[58,105,122,184,204,213],"promoter.":[62],"functions":[64],"in":[65,72],"primate":[68],"cells,":[69],"but":[70],"not":[71],"cells":[73],"other":[75],"species.":[76,118],"To":[77],"investigate":[78],"whether":[79],"P-TEFb,":[81],"composed":[82],"Cdk9":[84,110,133,160],"CycT1,":[86],"contributes":[87],"species-specific":[90],"function,":[92],"we":[93],"generated":[94],"examined":[96],"activities":[98],"panel":[101],"human-rodent":[103],"\"hybrid\"":[104],"complexes":[106,123],"that":[107,121,180,198],"consist":[108],"CycT1":[112,126,157,209,229],"derived":[113],"from":[114],"two":[116],"different":[117],"We":[119],"found":[120],"containing":[124,155],"complexed":[127],"with":[128,139,172,205],"either":[129],"or":[131],"rodent":[132,156],"supported":[134],"transactivation":[136],"interacted":[138],"activation":[142,191,221],"domain":[143],"form":[148],"ribonucleoprotein":[149],"complexes.":[150],"While":[151],"stable":[153],"dimer":[154],"was":[161],"capable":[162],"mediating":[164],"basal":[165,187],"elongation,":[167],"it":[168],"failed":[169],"interact":[171],"mediate":[176,215],"transactivation,":[178],"indicating":[179],"abilities":[182],"support":[186],"be":[193],"separated.":[194],"Our":[195],"data":[196],"indicated":[197],"specific":[200,218,239],"interaction":[201],"Tat:TAR":[206],"mostly":[207],"through":[208],"is":[210],"crucial":[211],"for":[212,237],"Tat-":[217],"species-restricted":[220],"transcription.":[224],"Moreover,":[225],"cyclin-box":[227],"its":[231],"immediate":[232],"flanking":[233],"region":[234],"are":[235],"responsible":[236],"P-TEFb:Tat":[240],"interaction.":[241]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}