{"id":"https://openalex.org/W7005965778","doi":null,"title":"Role of macrophages in cardiac homeostasis and repair following myocardial infarction","display_name":"Role of macrophages in cardiac homeostasis and repair following myocardial infarction","publication_year":null,"publication_date":null,"ids":{"openalex":"https://openalex.org/W7005965778"},"language":"en","primary_location":{"id":"pmh:oai:www.tdx.cat:10486/662754","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10486/662754","pdf_url":"http://hdl.handle.net/10486/662754","source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10486/662754","any_repository_has_fulltext":true},"authorships":[],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.949999988079071},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cardiac-homeostasis","display_name":"cardiac homeostasis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cardiac-repair","display_name":"cardiac repair","score":0.984000027179718},{"id":"https://openalex.org/keywords/cardiac-resident-macrophages","display_name":"cardiac resident macrophages","score":0.8109999895095825},{"id":"https://openalex.org/keywords/m2-macrophages","display_name":"M2 macrophages","score":0.7580000162124634},{"id":"https://openalex.org/keywords/ly6c","display_name":"Ly6C","score":0.6779999732971191},{"id":"https://openalex.org/keywords/monocyte-subsets","display_name":"monocyte subsets","score":0.7419999837875366},{"id":"https://openalex.org/keywords/coronary-revascularization","display_name":"coronary revascularization","score":0.7850000262260437},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.546999990940094},{"id":"https://openalex.org/keywords/cryoinjury","display_name":"cryoinjury","score":0.5270000100135803},{"id":"https://openalex.org/keywords/coronary-artery-ligation","display_name":"coronary artery ligation","score":0.9300000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7192999720573425},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.6657000184059143},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6008999943733215},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5418000221252441},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5264000296592712},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.3702000081539154},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.35120001435279846},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.29829999804496765},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.28139999508857727},{"id":"https://openalex.org/C3018906752","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary heart disease","level":2,"score":0.2680000066757202}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:www.tdx.cat:10486/662754","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10486/662754","pdf_url":"http://hdl.handle.net/10486/662754","source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:www.tdx.cat:10486/662754","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10486/662754","pdf_url":"http://hdl.handle.net/10486/662754","source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7005965778.pdf","grobid_xml":"https://content.openalex.org/works/W7005965778.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3010145310","https://openalex.org/W7095116731","https://openalex.org/W4296553863","https://openalex.org/W2763341318","https://openalex.org/W2089477170","https://openalex.org/W4313988041","https://openalex.org/W4387777502","https://openalex.org/W4290997111","https://openalex.org/W2902050841","https://openalex.org/W4388599928"],"abstract_inverted_index":{"Recent":[0],"studies":[1,809,1197],"show":[2,861],"that":[3,115,128,159,167,233,248,264,824,996,1046,1057,1293],"macrophages":[4,46,106,131,158,193,211,673,694,697,704,727,834,860,916,947,995,1033,1090,1155,1185,1264,1283],"are":[5,214,236,674,728,779,825,836,1058,1248,1296],"present":[6,47,216],"in":[7,16,48,59,88,108,133,141,162,217,227,238,253,269,388,653,676,716,731,750,760,838,920,967,1002,1021,1080,1121,1158,1178,1201,1204,1210,1238,1250,1284,1306,1311],"the":[8,22,49,60,66,134,163,199,223,228,254,257,736,751,756,761,776,781,787,793,812,900,982,999,1024,1115,1147,1159,1188,1191,1205,1211,1239,1251,1275,1278,1285,1291,1312,1317,1324,1354,1363],"healthy":[9,135],"myocardium":[10,136,165,230,259,1001],"and":[11,51,56,63,77,85,97,114,123,145,157,166,196,219,231,242,272,287,664,685,695,701,712,765,852,855,866,877,887,905,908,930,1008,1053,1056,1136,1154,1184,1234,1263,1301,1329,1331,1337,1351,1357,1360,1382],"can":[12],"also":[13,215],"be":[14,251],"recruited":[15,237,826],"response":[17,239,941,968,1225],"to":[18,28,181,240,277,282,666,714,758,881,942,969,1113,1316,1322,1333,1376],"myocardial":[19,178,1227,1307],"infarction":[20],"(MI).However,":[21],"specific":[23],"contribution":[24],"of":[25,74,103,155,203,208,225,256,266,657,690,738,755,771,784,814,818,864,992,1026,1030,1077,1097,1134,1140,1149,1190,1230,1243,1280,1288,1389],"these":[26,204,234,1047,1071,1294],"cells":[27,113,174,187,205,235,740,871,875,1007,1015,1048,1143,1262,1295,1359,1391],"either":[29],"cardiac":[30,33,104,129,143,273,285,289,993,1031,1088,1099,1132,1244,1299,1302,1335],"homeostasis":[31,144,271,326,357,457,613,663,707],"or":[32,892,945,950,962,971],"repair":[34,1100,1300],"following":[35,260],"injury":[36,179,241],"is":[37,786,795,1084,1175,1320,1345],"not":[38],"fully":[39],"understood.In":[40],"our":[41,1075],"study,":[42,1271],"we":[43,68,86,150],"focus":[44],"on":[45],"heart":[50,1117,1287],"examine":[52],"their":[53,1235],"subsets,":[54],"phenotype":[55,1020],"functional":[57,686],"properties":[58],"steady":[61,1064],"state":[62,1065],"after":[64,177,773,1226,1246],"MI.For":[65],"analysis,":[67],"developed":[69],"two":[70,152,691],"different":[71,169,1028],"mouse":[72,986],"models":[73],"MI:":[75],"cryoinjury":[76],"left":[78,1340],"anterior":[79],"descending":[80],"coronary":[81,146],"artery":[82],"ligation":[83],"(LADligation),":[84],"used":[87],"vivo":[89,389],"tracing":[90],"flow":[91],"cytometry,":[92],"state-of-the-art":[93],"confocal":[94],"microscopy,":[95],"transcriptional":[96],"ecocardiography":[98],"analysis.We":[99],"identified":[100],"a":[101,139,328,385,418,534,551,557,575,637,648,682,815,896,918,923,1394,1399],"population":[102,817,991],"resident":[105,130,994,1032,1089],"located":[107],"close":[109],"proximity":[110],"with":[111,121,1005,1327],"endothelial":[112,1006,1358,1390],"exhibit":[116,243,1016],"an":[117,658,989,1017,1094,1199],"M2-like/tissue-homeostatic":[118],"signature":[119],"consistent":[120],"anti-inflammatory":[122,195],"pro-angiogenic":[124,197,209,244,1350],"activity.These":[125],"findings":[126,262,1072],"suggest":[127,263],"found":[132,151,175,188,232,675,730],"might":[137,250,275],"have":[138,651,810,917],"role":[140,919],"maintaining":[142],"vasculature":[147],"integrity.After":[148],"MI,":[149,1309],"distinct":[153],"subsets":[154,1232],"monocytes":[156,822,1183],"sequentially":[160],"appeared":[161],"infarcted":[164,1286],"showed":[168],"gene":[170,200],"expression":[171,201],"profiles.Ly6C":[172],"hi":[173,496],"soon":[176],"correspond":[180],"pro-inflammatory":[182,847,955],"monocytes/macrophages,":[183],"whereas":[184],"Ly6C":[185,495,525,598],"lo":[186,444,526,599],"at":[189,747,768,790,1063,1362],"later":[190,769,1208],"stages":[191,770],"represent":[192],"exhibiting":[194],"activity.Notably,":[198],"profile":[202],"had":[206],"features":[207],"Tie2-expressing":[210,833],"(TEMs),":[212,543],"which":[213,645,835],"tumors":[218],"ischemic":[220,229,258,1318,1377],"tissues.We":[221],"examined":[222],"presence":[224],"TEMs":[226,249,565],"properties.These":[245],"results":[246],"indicate":[247],"involved":[252,837],"revascularization":[255],"MI.Our":[261],"modulation":[265],"macrophage":[267,958,1078],"activation":[268,964],"both":[270],"disease":[274],"help":[276],"develop":[278],"novel":[279],"therapeutic":[280],"approaches":[281],"avoid":[283],"adverse":[284,1339],"remodeling":[286,1342],"improve":[288,1074],"repair.11":[290],"RESUMEN":[291,292],"13":[293],"El":[294],"coraz\u00f3n":[295,333,355,486],"alberga":[296],"poblaciones":[297,321,538],"de":[298,312,319,324,332,346,350,370,372,392,399,407,410,425,439,449,455,460,472,475,481,491,499,523,539,561,564,577,588,595,612,615,620,633,640],"macr\u00f3fagos":[299,351,411,429,478,502,524,540,578,597],"tanto":[300,611],"en":[301,305,343,353,356,359,452,484,510,546,580,603,608],"condiciones":[302],"fisiol\u00f3gicas,":[303],"como":[304,614,627],"respuesta":[306,360,464],"al":[307,322,361,465],"da\u00f1o":[308],"card\u00edaco":[309],"por":[310,390,436,537],"infarto":[311],"miocardio":[313,582],"(IM).No":[314],"obstante,":[315],"la":[316,325,329,344,374,377,400,405,426,437,456,461,470,562,618,621,638,641],"contribuci\u00f3n":[317],"espec\u00edfica":[318],"estas":[320,450,572],"mantenimiento":[323,454],"y":[327,358,376,381,397,421,442,459,477,487,501,531,592],"reparaci\u00f3n":[330],"card\u00edaca":[331,458],"adulto":[334],"no":[335],"ha":[336,403,468,555,569],"sido":[337],"completamente":[338],"dilucidada.Nuestro":[339],"estudio":[340,560,605],"se":[341,364,382,467,497,507,519,554],"centra":[342],"caracterizaci\u00f3n":[345],"las":[347,535],"distintas":[348,594],"subpoblaciones":[349,474,576],"presentes":[352,509,579],"el":[354,453,485,514,559,567,581,609,631],"IM.Para":[362],"ello,":[363],"han":[365,383],"desarrollado":[366],"dos":[367,473],"modelos":[368],"distintos":[369,489,547],"inducci\u00f3n":[371],"IM:":[373],"criolesi\u00f3n":[375],"ligaci\u00f3n":[378],"permanente":[379],"coronaria":[380],"llevado":[384,556],"cabo":[386,558],"estudios":[387],"citometr\u00eda":[391],"flujo,":[393],"microscop\u00eda":[394],"confocal,":[395],"ecocardiograf\u00eda":[396],"an\u00e1lisis":[398],"expresi\u00f3n":[401,438,589],"g\u00e9nica.Se":[402],"identificado":[404,469],"existencia":[406],"una":[408,447],"poblaci\u00f3n":[409],"residentes":[412],"card\u00edacos":[413],"cuya":[414],"localizaci\u00f3n":[415],"es":[416],"cercana":[417],"los":[419,596],"peque\u00f1os":[420],"grandes":[422],"vasos":[423],"sangu\u00edneos":[424],"vasculatura":[427],"coronaria.Estos":[428],"exhiben":[430,528,585],"un":[431,521,586],"perfil":[432],"g\u00e9nico":[433],"anti-inflamatorio":[434],"caracterizado":[435],"marcadores":[440],"homeost\u00e1ticos":[441],"pro-angiog\u00e9nicos,":[443],"que":[445,479,506,527,571,584,607],"sugiere":[446],"funci\u00f3n":[448,642],"c\u00e9lulas":[451,573],"integridad":[462],"vascular.En":[463],"IM,":[466],"presencia":[471,563],"monocitos":[476,500],"aparecen":[480],"forma":[482],"secuencial":[483],"muestran":[488],"perfiles":[490],"expresi\u00f3n.La":[492],"subpoblaci\u00f3n":[493,522],"celular":[494],"compone":[498],"con":[503],"car\u00e1cter":[504],"pro-inflamatorio,":[505],"hallan":[508],"fases":[511,516],"tempranas":[512],"tras":[513,566],"IM.En":[515],"m\u00e1s":[517],"tard\u00edas,":[518],"encuentra":[520],"propiedades":[529],"anti-inflamatorias":[530],"pro-angiog\u00e9nicas":[532],"similares":[533],"mostradas":[536],"Tie2":[541],"+":[542],"previamente":[544],"descritos":[545],"procesos":[548],"isqu\u00e9micos.De":[549],"acorde":[550],"este":[552,604],"hallazgo,":[553],"IM.Se":[568],"demostrado":[570],"corresponden":[574],"da\u00f1ado,":[583],"patr\u00f3n":[587],"altamente":[590],"pro-angiog\u00e9nico":[591],"son":[593],".Los":[600],"resultados":[601],"obtenidos":[602],"sugieren":[606],"contexto":[610],"enfermedad":[616],"card\u00edaca,":[617],"modulaci\u00f3n":[619],"activaci\u00f3n":[622],"del":[623],"macr\u00f3fago":[624],"puede":[625],"servir":[626],"herramienta":[628],"\u00fatil":[629],"para":[630],"desarrollo":[632],"nuevas":[634],"terapias":[635],"enfocadas":[636],"mejora":[639],"card\u00edaca.phagocytic":[643],"granules,":[644],"give":[646],"them":[647],"'foamy'":[649],"appearance.Macrophages":[650],"roles":[652],"almost":[654],"every":[655],"aspect":[656],"organism's":[659],"biology;":[660],"from":[661,722,741,1050,1254],"development,":[662],"repair,":[665],"immune":[667],"responses":[668],"against":[669,922],"pathogens.In":[670],"adult":[671],"mammals,":[672],"all":[677],"tissues":[678,828],"where":[679,829],"they":[680,830],"display":[681],"wide":[683],"anatomical":[684],"diversity.Macrophages":[687],"broadly":[688],"consist":[689,1388],"classes:":[692],"tissue-resident":[693],"infiltrating":[696,726],"(Pollard":[698],"2009;":[699],"Murray":[700],"Wynn":[702],"2011).Tissueresident":[703],"regulate":[705],"tissue":[706],"by":[708,899,1195,1347],"acting":[709],"as":[710,718,720,775,868,885,1093,1130,1144,1146,1193],"sentinels":[711],"responding":[713],"changes":[715],"physiology":[717],"well":[719,1145],"challenges":[721],"external":[723],"environment.In":[724],"contrast,":[725,957],"only":[729,1387],"inflammatory":[732],"Definitive":[733],"hematopoiesis":[734,785],"(i.e.,":[735],"generation":[737],"hematopoietic":[739,743],"multipotent":[742],"stem":[744,1261],"cells)":[745],"starts":[746],"E9.5":[748],"-E10":[749],"Aorto-Gonado-Mesonephron":[752],"(AGM)":[753],"region":[754,1319],"embryo":[757],"continue":[759],"fetal":[762,1054],"liver,":[763],"spleen":[764],"bone":[766,788,1141],"marrow":[767,1142],"development.Therefore,":[772],"birth,":[774],"bony":[777],"structures":[778],"formed":[780],"main":[782],"site":[783],"marrow;":[789],"this":[791,1179,1270],"stage,":[792],"MPS":[794],"established":[796],"(van":[797,1163,1214],"Furth,":[798],"Cohn":[799],"et":[800,804,844,912,934,973,977,1012,1040,1068,1103,1168,1219,1256,1267,1368],"al,":[801,805,845,913,935,974,978,1013,1041,1069,1104,1169,1220,1257,1268,1369],"1972).Wynn,":[802],"Chawla":[803],"2013).In":[806],"addition,":[807,858],"recent":[808],"described":[811],"existence":[813,1025],"minor":[816],"circulating":[819],"Tie-2":[820],"expressing":[821],"(TEMs)":[823],"into":[827,832,960,1187,1274],"differentiate":[831],"angiogenic":[839],"processes":[840],"(De":[841],"Palma,":[842],"Venneri":[843],"2005).producing":[846],"cytokines":[848,883],"like":[849,1019],"IL-12,":[850],"IL-1\ud835\udefd,":[851],"TNF\ud835\udefc":[853,944],"(Biswas":[854],"Mantovani":[856,878],"2010).In":[857],"M1":[859,949],"enhanced":[862],"phagocytosis":[863],"microorganisms,":[865],"act":[867],"antigen":[869],"presenting":[870],"(APC)":[872],"for":[873,1298],"T":[874],"(Sica":[876],"2012).Macrophages":[879],"exposed":[880],"Th2-type":[882],"such":[884,1129],"IL4":[886],"IL13,":[888],"undergo":[889,948],"alternatively":[890,963],"activated":[891,939],"M2":[893,915,961,1282],"polarization":[894,959],"state,":[895],"process":[897],"controlled":[898],"transcription":[901],"factors":[902],"IRF4,":[903],"STAT6":[904],"PPAR\uf067":[906],"(Ohmori":[907],"Hamilton":[909],"1997;Satoh,":[910],"Takeuchi":[911],"2010).These":[914],"protection":[921],"continuum":[924],"rather":[925],"than":[926,1209],"discrete":[927],"entities":[928],"(Mosser":[929],"Edwards":[931],"2008;Geissmann,":[932],"Manz":[933],"2010).Figure":[936],"3":[937],"Macrophage":[938],"phenotypes.In":[940],"IFN\ud835\udefe":[943],"LPS,":[946],"classically-activated":[951],"phenotype,":[952],"releasing":[953],"several":[954,1127],"cytokines.In":[956],"takes":[965],"place":[966],"IL-13":[970],"IL-4Hasleton":[972],"1997;Azzawi,":[975],"Kan":[976],"2005).Recent":[979],"work":[980],"using":[981,1109],"CX3CR1":[983],"GFP/+":[984],"transgenic":[985],"model,":[987],"describes":[988],"abundant":[990],"appears":[997],"within":[998],"normal":[1000],"direct":[1003],"contact":[1004],"myocytes":[1009],"(Pinto,":[1010],"Paolicelli":[1011],"2012).These":[1014],"alternative":[1018],"resting":[1022,1081],"conditions.Furthermore,":[1023],"four":[1027],"populations":[1029],"has":[1034,1043,1118,1126],"been":[1035,1044,1119],"recently":[1036],"demonstrated":[1037,1194],"(Epelman,":[1038,1066],"Lavine":[1039,1067],"2014).It":[1042],"shown":[1045],"arise":[1049],"yolk":[1051],"sac":[1052],"progenitors":[1055],"maintained":[1059],"through":[1060,1108,1379],"local":[1061],"proliferation":[1062],"2014).Although":[1070],"clearly":[1073],"knowledge":[1076],"biology":[1079],"myocardium,":[1082],"it":[1083],"currently":[1085],"unclear":[1086],"how":[1087],"since":[1091],"2000":[1092],"alternate":[1095],"means":[1096],"achieving":[1098],"(Bolli,":[1101],"Chugh":[1102],"2011).Stem":[1105],"cell":[1106,1111],"therapy":[1107],"multiple":[1110],"types":[1112],"regenerate":[1114],"injured":[1116],"tested":[1120],"clinical":[1122],"trials.Nonetheless,":[1123],"its":[1124],"efficacy":[1125],"limitations,":[1128],"low":[1131,1137],"engraftment":[1133],"cells,":[1135],"cardiomyogenic":[1138],"potential":[1139],"necessity":[1148],"optimizing":[1150],"more":[1151,1395],"efficient":[1152],"Monocytes":[1153],"initially":[1156],"accumulate":[1157],"infarct":[1160,1192,1206,1276,1326],"border":[1161,1212,1313,1364],"zone":[1162,1213,1314,1365],"der":[1164,1215],"Laan,":[1165,1216],"Ter":[1166,1217],"Horst":[1167,1218],"2014),":[1170],"probably":[1171],"because":[1172],"vascular":[1173],"access":[1174],"still":[1176],"intact":[1177],"area.Presumably,":[1180],"over":[1181],"time,":[1182],"migrate":[1186],"core":[1189,1207],"human":[1196],"reporting":[1198],"increase":[1200],"monocyte":[1202,1224,1231],"number":[1203],"2014).Figure":[1221],"5":[1222],"Biphasic":[1223],"infarction.Time":[1228],"course":[1229],"recruitment":[1233],"function":[1236,1303,1336],"depicted":[1237,1249],"lower":[1240],"panel.Distinct":[1241],"phases":[1242],"healing":[1245,1325],"MI":[1247],"upper":[1252],"panel.Adapted":[1253],"Nahrendorf":[1255],"2007.crosstalk":[1258],"between":[1259,1349],"injected":[1260],"(Dayan,":[1265],"Yannarelli":[1266],"2011).In":[1269],"MSC":[1272],"transplantation":[1273],"increases":[1277],"percentage":[1279],"reparative":[1281],"mice":[1289],"supporting":[1290],"concept":[1292],"crucial":[1297],"recovery.":[1304],"Macrophages":[1305],"angiogenesisAfter":[1308],"neovascularization":[1310],"adjacent":[1315],"critical":[1321],"supply":[1323],"oxygen":[1328],"nutrients":[1330],"thus,":[1332],"preserve":[1334],"attenuate":[1338],"ventricular":[1341],"(Frangogiannis":[1343],"2012).Neovascularization":[1344],"orchestrated":[1346],"interactions":[1348],"anti-angiogenic":[1352],"factors,":[1353],"extracellular":[1355],"matrix,":[1356],"pericytes":[1361],"(Frangogiannis,":[1366],"Smith":[1367],"2002).The":[1370],"new":[1371,1385],"blood":[1372],"vessels":[1373,1386],"restore":[1374],"perfusion":[1375],"areas":[1378],"connecting":[1380],"patent":[1381],"occluded":[1383],"arteries.Initially,":[1384],"but":[1392],"acquire":[1393],"mature":[1396],"morphology,":[1397],"including":[1398],"pericyt":[1400]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}