{"id":"https://openalex.org/W7005036340","doi":null,"title":"Pathogenic tau perturbs axonogenesis via loss of tau function","display_name":"Pathogenic tau perturbs axonogenesis via loss of tau function","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W7005036340"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org:ark:/13030/qt2bq8p1mx","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/2bq8p1mx","pdf_url":"https://escholarship.org/content/qt2bq8p1mx/qt2bq8p1mx.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.org/content/qt2bq8p1mx/qt2bq8p1mx.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073755067","display_name":"Gregory A. Mohl","orcid":"https://orcid.org/0000-0002-8036-7886","observed_orcids":["https://orcid.org/0000-0002-8036-7886"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mohl, Gregory","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5073755067"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.4390000104904175},{"id":"https://openalex.org/keywords/axonogenesis","display_name":"axonogenesis","score":0.7960000038146973},{"id":"https://openalex.org/keywords/axonal-branching","display_name":"axon branching","score":0.9729999899864197},{"id":"https://openalex.org/keywords/loss-of-function","display_name":"loss of function","score":0.7360000014305115},{"id":"https://openalex.org/keywords/myo1b","display_name":"MYO1B","score":0.9819999933242798},{"id":"https://openalex.org/keywords/ipsc-derived-neurons","display_name":"iPSC-derived neurons","score":0.8650000095367432},{"id":"https://openalex.org/keywords/frontotemporal-dementia","display_name":"frontotemporal dementia","score":0.9660000205039978},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.890999972820282},{"id":"https://openalex.org/keywords/tau-aggregation","display_name":"tau aggregation","score":0.7459999918937683},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.6779999732971191},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.652899980545044},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.633400022983551},{"id":"https://openalex.org/C105951970","wikidata":"https://www.wikidata.org/wiki/Q1036748","display_name":"Loss function","level":4,"score":0.6323999762535095},{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.5824999809265137},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4950999915599823},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.47769999504089355},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4250999987125397},{"id":"https://openalex.org/C69125201","wikidata":"https://www.wikidata.org/wiki/Q2034716","display_name":"Axon guidance","level":3,"score":0.4237000048160553},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.4065999984741211},{"id":"https://openalex.org/C3017833866","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tau pathology","level":4,"score":0.38999998569488525},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3767000138759613},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.36489999294281006},{"id":"https://openalex.org/C2777739294","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tauopathy","level":4,"score":0.34279999136924744},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.3093000054359436},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.29760000109672546},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.2822999954223633},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.28040000796318054},{"id":"https://openalex.org/C74254510","wikidata":"https://www.wikidata.org/wiki/Q7240508","display_name":"Premovement neuronal activity","level":2,"score":0.27709999680519104},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.2669999897480011},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26429998874664307},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.25699999928474426},{"id":"https://openalex.org/C2778641062","wikidata":"https://www.wikidata.org/wiki/Q18592","display_name":"Frontotemporal dementia","level":4,"score":0.2565000057220459}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:escholarship.org:ark:/13030/qt2bq8p1mx","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/2bq8p1mx","pdf_url":"https://escholarship.org/content/qt2bq8p1mx/qt2bq8p1mx.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"}],"best_oa_location":{"id":"pmh:oai:escholarship.org:ark:/13030/qt2bq8p1mx","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/2bq8p1mx","pdf_url":"https://escholarship.org/content/qt2bq8p1mx/qt2bq8p1mx.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7005036340.pdf","grobid_xml":"https://content.openalex.org/works/W7005036340.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7155651581","https://openalex.org/W2051495044","https://openalex.org/W4392746127","https://openalex.org/W2987665465","https://openalex.org/W4313478646","https://openalex.org/W4385230813","https://openalex.org/W7163533330","https://openalex.org/W2431821511","https://openalex.org/W2060695204","https://openalex.org/W2973501556"],"abstract_inverted_index":{"Neurodegenerative":[0],"diseases":[1],"are":[2,9,20,39,69,168],"a":[3,11,26,81,153,200],"major":[4,74,130,237],"public":[5],"health":[6],"burden.":[7],"There":[8,38],"only":[10],"few":[12],"effective":[13],"therapies":[14],"because":[15],"the":[16,44,49,77,99,124,208,230],"underlying":[17],"disease":[18,34,41,58,92,103],"mechanisms":[19,62],"poorly":[21],"understood.":[22,72],"Tau":[23],"aggregation":[24],"is":[25,54,80],"hallmark":[27],"of":[28,43,51,83,101,120,134,155,203,247],"several":[29],"neurodegenerative":[30],"diseases,":[31],"including":[32],"Alzheimer\u2019s":[33],"and":[35,48,91,93,188,242],"frontotemporal":[36],"dementia.":[37],"causal":[40,102],"variants":[42,104],"tau-encoding":[45],"gene,":[46],"MAPT,":[47],"presence":[50],"tau":[52,65,78,144,165,177,189,201,232,248],"aggregates":[53],"highly":[55],"correlated":[56],"with":[57],"progression.":[59],"The":[60],"molecular":[61],"linking":[63],"pathological":[64],"to":[66,150,159,163],"neuronal":[67,240],"dysfunction":[68],"not":[70,180],"well":[71],"A":[73],"challenge":[75],"for":[76],"field":[79],"lack":[82],"clarity":[84],"around":[85],"tau\u2019s":[86],"normal":[87],"function":[88,204],"in":[89,98,112,132,170,184,194,216,223,239],"development":[90],"how":[94],"these":[95,110],"processes":[96],"change":[97],"context":[100],"or":[105],"amyloid":[106],"beta":[107],"plaques.To":[108],"address":[109],"questions":[111],"an":[113],"unbiased":[114],"manner,":[115],"we":[116,174],"conducted":[117],"multi-omic":[118],"characterization":[119],"iPSC-derived":[121],"neurons":[122,138,218],"harboring":[123],"MAPT":[125,136,185,195,224,234],"V337M":[126,137,186,225,235],"mutation,":[127],"which":[128],"revealed":[129],"changes":[131,238],"regulators":[133],"axonogenesis.":[135],"have":[139,146],"increased":[140],"axon":[141,182,192,214,221],"branching.":[142],"Pathogenic":[143],"mutations":[145],"generally":[147],"been":[148],"assumed":[149],"act":[151],"through":[152],"gain":[154],"toxic":[156],"function,":[157],"leading":[158],"therapeutic":[160],"approaches":[161],"aiming":[162],"lower":[164],"levels":[166],"that":[167,176,229],"currently":[169],"clinical":[171],"trials.":[172],"Surprisingly,":[173],"found":[175],"knockdown":[178,190,207],"did":[179],"rescue":[181],"branching":[183,193,215,222],"neurons,":[187,197],"induced":[191],"WT":[196],"strongly":[198],"supporting":[199],"loss":[202,246],"effect.":[205],"Intriguingly,":[206],"tau-interacting":[209],"protein":[210],"MYO1B":[211],"also":[212],"increases":[213],"wild-type":[217],"without":[219],"modifying":[220],"neurons.":[226],"We":[227],"conclude":[228],"FTD-associated":[231],"mutation":[233],"drives":[236],"differentiation":[241],"maturation":[243],"caused":[244],"by":[245],"function.":[249]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}