{"id":"https://openalex.org/W70046397","doi":null,"title":"New concepts in the pathogenesis, diagnosis and control of diseases caused by the bovine viral diarrhea virus.","display_name":"New concepts in the pathogenesis, diagnosis and control of diseases caused by the bovine viral diarrhea virus.","publication_year":1988,"publication_date":"1988-06-01","ids":{"openalex":"https://openalex.org/W70046397","mag":"70046397","pmid":"https://pubmed.ncbi.nlm.nih.gov/17423063","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1680792"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:439652","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1680849","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC1680849","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039429254","display_name":"Otto M. Radostits","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O M Radostits","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111858619","display_name":"I. R. Littlejohns","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I R Littlejohns","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":19.9001,"has_fulltext":false,"cited_by_count":151,"citation_normalized_percentile":{"value":0.99686291,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"29","issue":"6","first_page":"513","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11560","display_name":"Animal Disease Management and Epidemiology","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12733","display_name":"Vector-Borne Animal Diseases","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bovine-viral-diarrhea-virus","display_name":"bovine viral diarrhea virus","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pestivirus","display_name":"pestivirus","score":0.8050000071525574},{"id":"https://openalex.org/keywords/persistent-viremia","display_name":"persistent viremia","score":0.8159999847412109},{"id":"https://openalex.org/keywords/immune-tolerance","display_name":"immune tolerance","score":0.7210000157356262},{"id":"https://openalex.org/keywords/superinfection","display_name":"superinfection","score":0.7279999852180481},{"id":"https://openalex.org/keywords/congenital-infection","display_name":"congenital infection","score":0.6610000133514404},{"id":"https://openalex.org/keywords/mother-to-child-transmission","display_name":"mother-to-child transmission","score":0.4950000047683716},{"id":"https://openalex.org/keywords/subclinical-disease","display_name":"subclinical disease","score":0.6240000128746033},{"id":"https://openalex.org/keywords/reproductive-failure","display_name":"reproductive failure","score":0.6129999756813049},{"id":"https://openalex.org/keywords/vaccination","display_name":"vaccination","score":0.41999998688697815},{"id":"https://openalex.org/keywords/disease-control","display_name":"disease control","score":0.5009999871253967},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.7449129819869995},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6494157910346985},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.6462607383728027},{"id":"https://openalex.org/C2779906218","wikidata":"https://www.wikidata.org/wiki/Q7834818","display_name":"Transplacental","level":5,"score":0.5908728241920471},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5734045505523682},{"id":"https://openalex.org/C2778400998","wikidata":"https://www.wikidata.org/wiki/Q1816292","display_name":"Pestivirus","level":5,"score":0.5667403936386108},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5551234483718872},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5536841750144958},{"id":"https://openalex.org/C2781045504","wikidata":"https://www.wikidata.org/wiki/Q128578","display_name":"Porcine circovirus","level":3,"score":0.5188294649124146},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.514754056930542},{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.49039697647094727},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.44225043058395386},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.4128061532974243},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.3727736473083496},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3237389326095581},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.3172417879104614},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11906513571739197},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.09863880276679993},{"id":"https://openalex.org/C2777510210","wikidata":"https://www.wikidata.org/wiki/Q1331256","display_name":"Flaviviridae","level":4,"score":0.07638585567474365},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:europepmc.org:439652","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1680849","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:17423063","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17423063","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Canadian veterinary journal = La revue veterinaire canadienne","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1680792","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1680792/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Can Vet J","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1680849","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1680849/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Can Vet J","raw_type":"Text"},{"id":"mag:70046397","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17423063","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:439652","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1680849","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"},{"id":"https://metadata.un.org/sdg/2","score":0.5666999816894531,"display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":93,"referenced_works":["https://openalex.org/W6917144","https://openalex.org/W10698937","https://openalex.org/W24521248","https://openalex.org/W33826046","https://openalex.org/W55554904","https://openalex.org/W68935042","https://openalex.org/W107654018","https://openalex.org/W150782056","https://openalex.org/W163814898","https://openalex.org/W178596294","https://openalex.org/W181727392","https://openalex.org/W190465792","https://openalex.org/W191035137","https://openalex.org/W197899067","https://openalex.org/W287301459","https://openalex.org/W1500115975","https://openalex.org/W1524437508","https://openalex.org/W1572128337","https://openalex.org/W1592558219","https://openalex.org/W1620186294","https://openalex.org/W1964020941","https://openalex.org/W1965201283","https://openalex.org/W1976267179","https://openalex.org/W1977331541","https://openalex.org/W1978446718","https://openalex.org/W1979386559","https://openalex.org/W1989719693","https://openalex.org/W1993535285","https://openalex.org/W1995362868","https://openalex.org/W1997708887","https://openalex.org/W2003586619","https://openalex.org/W2010407756","https://openalex.org/W2010679429","https://openalex.org/W2010811204","https://openalex.org/W2013772642","https://openalex.org/W2026379453","https://openalex.org/W2036313493","https://openalex.org/W2039408436","https://openalex.org/W2043919078","https://openalex.org/W2045862823","https://openalex.org/W2054094502","https://openalex.org/W2058080941","https://openalex.org/W2058692815","https://openalex.org/W2059110432","https://openalex.org/W2061260937","https://openalex.org/W2075928374","https://openalex.org/W2099604757","https://openalex.org/W2103469339","https://openalex.org/W2109745237","https://openalex.org/W2132658849","https://openalex.org/W2133687662","https://openalex.org/W2137105298","https://openalex.org/W2168606841","https://openalex.org/W2168870378","https://openalex.org/W2217881304","https://openalex.org/W2222243965","https://openalex.org/W2231044328","https://openalex.org/W2233215919","https://openalex.org/W2246376398","https://openalex.org/W2280707708","https://openalex.org/W2314163920","https://openalex.org/W2398026117","https://openalex.org/W2402332049","https://openalex.org/W2403072820","https://openalex.org/W2403264818","https://openalex.org/W2403757107","https://openalex.org/W2404464601","https://openalex.org/W2405173600","https://openalex.org/W2406062150","https://openalex.org/W2414532563","https://openalex.org/W2416453049","https://openalex.org/W2417986044","https://openalex.org/W2418309558","https://openalex.org/W2419166324","https://openalex.org/W2419232850","https://openalex.org/W2461098023","https://openalex.org/W2467061857","https://openalex.org/W2470593561","https://openalex.org/W4238748856","https://openalex.org/W4289989604","https://openalex.org/W4290356954","https://openalex.org/W4290361442","https://openalex.org/W4407199320","https://openalex.org/W4407201785","https://openalex.org/W4407211606","https://openalex.org/W4407216574","https://openalex.org/W4407677833","https://openalex.org/W4409122659","https://openalex.org/W4409122671","https://openalex.org/W4409129057","https://openalex.org/W4409130368","https://openalex.org/W4409131068","https://openalex.org/W4409139594"],"related_works":["https://openalex.org/W2073420762","https://openalex.org/W1993535285","https://openalex.org/W119657865","https://openalex.org/W2058080941","https://openalex.org/W4255546164","https://openalex.org/W2075928374","https://openalex.org/W2045862823","https://openalex.org/W2132658849","https://openalex.org/W2185020468","https://openalex.org/W254894711"],"abstract_inverted_index":{"The":[0,84],"new":[1],"information":[2],"on":[3],"the":[4,110,125,130,156,176,182,187,201,230,238,250],"pathogenesis":[5,239],"and":[6,36,43,69,81,95,134,172,189,200],"epidemiology":[7],"of":[8,11,72,98,109,175,191,198,203,214,240,252],"mucosal":[9,21,58],"disease":[10,22,147],"cattle":[12,26],"is":[13,16,184,220,244],"reviewed.":[14],"It":[15],"now":[17],"known":[18],"that":[19,234],"clinical":[20],"occurs":[23,112],"only":[24],"in":[25,33,113,120,122,145,169,237],"which":[27,195],"were":[28,37],"infected":[29,88,119],"with":[30,39,63,151],"a":[31,152],"pestivirus":[32],"early":[34],"gestation":[35],"born":[38],"persistent":[40],"viral":[41,149],"infection":[42,108,142],"specific":[44],"immunotolerance.":[45],"These":[46],"animals":[47,100],"may":[48,55,75,101,105,117,158],"be":[49,92,102,118,160],"clinically":[50,78],"normal":[51,79,153],"at":[52,206],"birth":[53],"but":[54],"develop":[56,132],"fatal":[57],"disease,":[59],"perhaps":[60],"following":[61],"superinfection":[62],"another":[64],"pestivirus,":[65],"usually":[66],"between":[67,217],"6":[68],"24":[70],"months":[71],"age.":[73],"They":[74],"also":[76,159],"remain":[77],"indefinitely":[80],"breed":[82],"successfully.":[83],"progeny":[85],"from":[86],"persistently":[87,93,192],"females":[89,205],"will":[90,225],"similarly":[91],"viremic,":[94],"maternal":[96],"families":[97],"such":[99],"established.Congenital":[103],"defects":[104],"occur":[106],"when":[107],"fetus":[111],"mid-gestation.":[114],"Although":[115],"fetuses":[116,131],"utero":[121],"late":[123],"gestation,":[124],"infections":[126,233],"do":[127],"not":[128],"persist,":[129],"antibodies,":[133],"they":[135],"appear":[136],"to":[137,165,248],"suffer":[138],"no":[139,245],"ill-effects.":[140],"Postnatal":[141],"can":[143],"result":[144],"subclinical":[146],"(bovine":[148],"diarrhea)":[150],"immune":[154],"response;":[155],"virus":[157,183],"responsible":[161],"for":[162],"enhanced":[163],"susceptibility":[164],"other":[166],"infections,":[167],"diarrhea":[168],"newborn":[170],"calves,":[171],"reproductive":[173],"failure.Prevention":[174],"economically":[177],"important":[178,236],"diseases":[179],"caused":[180],"by":[181],"dependent":[185],"upon":[186],"identification":[188],"elimination":[190],"viremic":[193],"animals,":[194],"are":[196,235],"reservoirs":[197],"infection,":[199],"vaccination":[202,224,251],"immunocompetent":[204],"least":[207],"three":[208],"weeks":[209],"before":[210],"breeding.":[211],"However,":[212],"because":[213],"serotypic":[215],"differences":[216],"strains,":[218],"there":[219],"some":[221],"doubt":[222],"whether":[223],"reliably":[226],"provide":[227],"protection":[228],"against":[229],"transplacental":[231],"fetal":[232],"this":[241],"disease.":[242],"There":[243],"substantial":[246],"evidence":[247],"warrant":[249],"feedlot":[253],"cattle.":[254]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}