{"id":"https://openalex.org/W7002173161","doi":null,"title":"A multifaceted approach to gain insight into the mechanisms underlying novel phage-host interactions","display_name":"A multifaceted approach to gain insight into the mechanisms underlying novel phage-host interactions","publication_year":2023,"publication_date":"2023-09-05","ids":{"openalex":"https://openalex.org/W7002173161"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:45136","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/45136/19/Binsabaan%20-%20ETD%20%20-%20Final.pdf","pdf_url":"http://d-scholarship.pitt.edu/45136/19/Binsabaan%20-%20ETD%20%20-%20Final.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/45136/19/Binsabaan%20-%20ETD%20%20-%20Final.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092505107","display_name":"Saeed A. Binsabaan","orcid":"https://orcid.org/0009-0009-6590-0564","observed_orcids":["https://orcid.org/0009-0009-6590-0564"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Binsabaan, Saeed","raw_affiliation_strings":["Biological Sciences iii","University of Pittsburgh , 2023"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences iii","institution_ids":[]},{"raw_affiliation_string":"University of Pittsburgh , 2023","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5092505107"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacteriophages","display_name":"mycobacteriophages","score":0.8320000171661377},{"id":"https://openalex.org/keywords/phage-host-interactions","display_name":"phage-host interactions","score":0.9539999961853027},{"id":"https://openalex.org/keywords/phaedrus","display_name":"Phaedrus","score":0.8190000057220459},{"id":"https://openalex.org/keywords/gp82","display_name":"gp82","score":0.8980000019073486},{"id":"https://openalex.org/keywords/mycobacterium-smegmatis","display_name":"Mycobacterium smegmatis","score":0.972000002861023},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.550000011920929},{"id":"https://openalex.org/keywords/disordered-loop","display_name":"disordered loop","score":0.734000027179718},{"id":"https://openalex.org/keywords/atpase-activity","display_name":"ATPase activity","score":0.7210000157356262},{"id":"https://openalex.org/keywords/chaperone-activity","display_name":"chaperone activity","score":0.7490000128746033},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.4569999873638153},{"id":"https://openalex.org/keywords/phage-genome-diversity","display_name":"phage genome diversity","score":0.39399999380111694},{"id":"https://openalex.org/keywords/phage-bacteria-coevolution","display_name":"phage-bacteria coevolution","score":0.41100001335144043}],"concepts":[{"id":"https://openalex.org/C2777204207","wikidata":"https://www.wikidata.org/wiki/Q606230","display_name":"Mycobacterium smegmatis","level":4,"score":0.8259999752044678},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7599999904632568},{"id":"https://openalex.org/C2776441376","wikidata":"https://www.wikidata.org/wiki/Q165028","display_name":"Bacteriophage","level":4,"score":0.7372999787330627},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.667900025844574},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6517000198364258},{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.5024999976158142},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4771000146865845},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4595000147819519},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4415999948978424},{"id":"https://openalex.org/C2993175405","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Bacterial protein","level":3,"score":0.4171999990940094},{"id":"https://openalex.org/C3742359","wikidata":"https://www.wikidata.org/wiki/Q4839988","display_name":"Bacterial genome size","level":4,"score":0.41589999198913574},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.3930000066757202},{"id":"https://openalex.org/C2780374374","wikidata":"https://www.wikidata.org/wiki/Q194309","display_name":"Mycobacterium","level":3,"score":0.3734000027179718},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3521000146865845},{"id":"https://openalex.org/C2779878436","wikidata":"https://www.wikidata.org/wiki/Q5448274","display_name":"Filamentous bacteriophage","level":5,"score":0.32420000433921814},{"id":"https://openalex.org/C2910978944","wikidata":"https://www.wikidata.org/wiki/Q165028","display_name":"Bacterial virus","level":5,"score":0.31529998779296875},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.3116999864578247},{"id":"https://openalex.org/C24432333","wikidata":"https://www.wikidata.org/wiki/Q2068526","display_name":"Whole genome sequencing","level":4,"score":0.29789999127388},{"id":"https://openalex.org/C53645450","wikidata":"https://www.wikidata.org/wiki/Q907093","display_name":"Scaffold protein","level":3,"score":0.29089999198913574},{"id":"https://openalex.org/C180223184","wikidata":"https://www.wikidata.org/wiki/Q4839986","display_name":"Bacterial genetics","level":4,"score":0.287200003862381},{"id":"https://openalex.org/C10010492","wikidata":"https://www.wikidata.org/wiki/Q3142557","display_name":"Protein sequencing","level":4,"score":0.27410000562667847},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.2736999988555908},{"id":"https://openalex.org/C2779256223","wikidata":"https://www.wikidata.org/wiki/Q611870","display_name":"Phage therapy","level":5,"score":0.2639999985694885},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2590000033378601},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.25870001316070557},{"id":"https://openalex.org/C91779695","wikidata":"https://www.wikidata.org/wiki/Q3780824","display_name":"Coding region","level":3,"score":0.2563000023365021}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:45136","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/45136/19/Binsabaan%20-%20ETD%20%20-%20Final.pdf","pdf_url":"http://d-scholarship.pitt.edu/45136/19/Binsabaan%20-%20ETD%20%20-%20Final.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:45136","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/45136/19/Binsabaan%20-%20ETD%20%20-%20Final.pdf","pdf_url":"http://d-scholarship.pitt.edu/45136/19/Binsabaan%20-%20ETD%20%20-%20Final.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7002173161.pdf","grobid_xml":"https://content.openalex.org/works/W7002173161.grobid-xml"},"referenced_works_count":248,"referenced_works":["https://openalex.org/W30656619","https://openalex.org/W117244899","https://openalex.org/W1492765989","https://openalex.org/W1536886974","https://openalex.org/W1539787751","https://openalex.org/W1539796472","https://openalex.org/W1540514666","https://openalex.org/W1552724685","https://openalex.org/W1595344516","https://openalex.org/W1802421655","https://openalex.org/W1822103663","https://openalex.org/W1825360107","https://openalex.org/W1869714721","https://openalex.org/W1870140643","https://openalex.org/W1903734129","https://openalex.org/W1906318254","https://openalex.org/W1916922087","https://openalex.org/W1921449831","https://openalex.org/W1960529837","https://openalex.org/W1963860512","https://openalex.org/W1964140467","https://openalex.org/W1964601681","https://openalex.org/W1964901213","https://openalex.org/W1966448483","https://openalex.org/W1967457339","https://openalex.org/W1969426617","https://openalex.org/W1970409435","https://openalex.org/W1970752390","https://openalex.org/W1972269365","https://openalex.org/W1977151336","https://openalex.org/W1977293483","https://openalex.org/W1977563716","https://openalex.org/W1982286661","https://openalex.org/W1986085242","https://openalex.org/W1987963421","https://openalex.org/W1988037647","https://openalex.org/W1990224836","https://openalex.org/W1990849633","https://openalex.org/W1992128867","https://openalex.org/W1993787023","https://openalex.org/W1996631459","https://openalex.org/W1998566510","https://openalex.org/W2002043114","https://openalex.org/W2004490529","https://openalex.org/W2006431107","https://openalex.org/W2007435893","https://openalex.org/W2010958487","https://openalex.org/W2011325665","https://openalex.org/W2014783118","https://openalex.org/W2016776575","https://openalex.org/W2019197162","https://openalex.org/W2020229410","https://openalex.org/W2021427972","https://openalex.org/W2021625708","https://openalex.org/W2022703044","https://openalex.org/W2027826836","https://openalex.org/W2028431045","https://openalex.org/W2028904598","https://openalex.org/W2032619610","https://openalex.org/W2035503835","https://openalex.org/W2038193041","https://openalex.org/W2038477559","https://openalex.org/W2039110868","https://openalex.org/W2041353321","https://openalex.org/W2042979171","https://openalex.org/W2043083543","https://openalex.org/W2044530165","https://openalex.org/W2044892607","https://openalex.org/W2044902100","https://openalex.org/W2046861479","https://openalex.org/W2048144060","https://openalex.org/W2050783903","https://openalex.org/W2051506232","https://openalex.org/W2052515110","https://openalex.org/W2053819479","https://openalex.org/W2055043387","https://openalex.org/W2057282918","https://openalex.org/W2057742269","https://openalex.org/W2059265460","https://openalex.org/W2061617125","https://openalex.org/W2061657754","https://openalex.org/W2067147999","https://openalex.org/W2069087157","https://openalex.org/W2071522430","https://openalex.org/W2072709771","https://openalex.org/W2073895233","https://openalex.org/W2074515928","https://openalex.org/W2078689375","https://openalex.org/W2084196805","https://openalex.org/W2086588775","https://openalex.org/W2087181090","https://openalex.org/W2088101132","https://openalex.org/W2089085945","https://openalex.org/W2090817404","https://openalex.org/W2091728028","https://openalex.org/W2094201044","https://openalex.org/W2094458603","https://openalex.org/W2097044860","https://openalex.org/W2098132478","https://openalex.org/W2098811056","https://openalex.org/W2098855160","https://openalex.org/W2099539515","https://openalex.org/W2101642564","https://openalex.org/W2103512536","https://openalex.org/W2103714813","https://openalex.org/W2104178347","https://openalex.org/W2104821962","https://openalex.org/W2107527796","https://openalex.org/W2108666079","https://openalex.org/W2109442030","https://openalex.org/W2116613551","https://openalex.org/W2116661894","https://openalex.org/W2116914094","https://openalex.org/W2119738836","https://openalex.org/W2121453804","https://openalex.org/W2123950233","https://openalex.org/W2124019099","https://openalex.org/W2124026197","https://openalex.org/W2124236601","https://openalex.org/W2127020553","https://openalex.org/W2129138058","https://openalex.org/W2130661602","https://openalex.org/W2130747214","https://openalex.org/W2133079587","https://openalex.org/W2134221163","https://openalex.org/W2134832431","https://openalex.org/W2135614314","https://openalex.org/W2136564653","https://openalex.org/W2137450588","https://openalex.org/W2138952930","https://openalex.org/W2140490100","https://openalex.org/W2140739992","https://openalex.org/W2140951166","https://openalex.org/W2141490444","https://openalex.org/W2142456941","https://openalex.org/W2142529984","https://openalex.org/W2142678478","https://openalex.org/W2143660875","https://openalex.org/W2144010669","https://openalex.org/W2144300164","https://openalex.org/W2144998676","https://openalex.org/W2147044107","https://openalex.org/W2147208616","https://openalex.org/W2147702777","https://openalex.org/W2151311229","https://openalex.org/W2151395332","https://openalex.org/W2151907194","https://openalex.org/W2152770371","https://openalex.org/W2153606739","https://openalex.org/W2154709258","https://openalex.org/W2155201844","https://openalex.org/W2155837642","https://openalex.org/W2157737997","https://openalex.org/W2158714788","https://openalex.org/W2159874398","https://openalex.org/W2160517489","https://openalex.org/W2160521062","https://openalex.org/W2160826972","https://openalex.org/W2164501001","https://openalex.org/W2165456482","https://openalex.org/W2167149952","https://openalex.org/W2167279371","https://openalex.org/W2168521460","https://openalex.org/W2168745206","https://openalex.org/W2169244146","https://openalex.org/W2169273731","https://openalex.org/W2170174366","https://openalex.org/W2170343590","https://openalex.org/W2172281886","https://openalex.org/W2180229411","https://openalex.org/W2182501559","https://openalex.org/W2226059528","https://openalex.org/W2235238101","https://openalex.org/W2248145546","https://openalex.org/W2265024698","https://openalex.org/W2271867127","https://openalex.org/W2283452112","https://openalex.org/W2291003704","https://openalex.org/W2291802992","https://openalex.org/W2294460080","https://openalex.org/W2296186783","https://openalex.org/W2305704688","https://openalex.org/W2306404099","https://openalex.org/W2328398973","https://openalex.org/W2416892151","https://openalex.org/W2440610582","https://openalex.org/W2465903376","https://openalex.org/W2514230236","https://openalex.org/W2564579600","https://openalex.org/W2566616286","https://openalex.org/W2570615709","https://openalex.org/W2594385802","https://openalex.org/W2614566708","https://openalex.org/W2621428191","https://openalex.org/W2623277795","https://openalex.org/W2754210454","https://openalex.org/W2756507036","https://openalex.org/W2758888404","https://openalex.org/W2765322245","https://openalex.org/W2765780755","https://openalex.org/W2767774935","https://openalex.org/W2769649361","https://openalex.org/W2773114814","https://openalex.org/W2774178591","https://openalex.org/W2781564139","https://openalex.org/W2792589100","https://openalex.org/W2799790987","https://openalex.org/W2803161579","https://openalex.org/W2807515370","https://openalex.org/W2883204807","https://openalex.org/W2883285900","https://openalex.org/W2886168820","https://openalex.org/W2887223800","https://openalex.org/W2898384637","https://openalex.org/W2922107828","https://openalex.org/W2943878465","https://openalex.org/W2947430595","https://openalex.org/W2979671922","https://openalex.org/W2985962667","https://openalex.org/W2996690426","https://openalex.org/W3007882709","https://openalex.org/W3016083036","https://openalex.org/W3048040712","https://openalex.org/W3049666959","https://openalex.org/W3083447372","https://openalex.org/W3110138379","https://openalex.org/W3127885930","https://openalex.org/W3161884749","https://openalex.org/W3175158490","https://openalex.org/W4211043921","https://openalex.org/W4211045835","https://openalex.org/W4211104832","https://openalex.org/W4211126430","https://openalex.org/W4221102664","https://openalex.org/W4223444619","https://openalex.org/W4250175284","https://openalex.org/W4255578408","https://openalex.org/W4280526308","https://openalex.org/W4282922306","https://openalex.org/W4283219612","https://openalex.org/W4284677074","https://openalex.org/W4284680620","https://openalex.org/W4284891873","https://openalex.org/W4285743091","https://openalex.org/W4285799781","https://openalex.org/W4309438076","https://openalex.org/W4313312601","https://openalex.org/W4320492136"],"related_works":["https://openalex.org/W4386530410","https://openalex.org/W4389034164","https://openalex.org/W2593922226","https://openalex.org/W1232006855","https://openalex.org/W791645748","https://openalex.org/W6986904933","https://openalex.org/W7221536188","https://openalex.org/W2946733598","https://openalex.org/W2143263614","https://openalex.org/W7000771037"],"abstract_inverted_index":{"Several":[0],"billions":[1],"of":[2,4,22,42,53,69,99,104,108,128,221,241,258,341,347,355,385,392,419,434],"years":[3],"bacteriophage":[5],"evolution":[6],"have":[7,25,74,89,110,236],"given":[8],"rise":[9],"to":[10,46,135,194,235,361,381,426],"different":[11],"mechanisms":[12,24,43,158],"by":[13,38,143,163,174,336],"which":[14,109,144,278],"phages":[15,73],"interact":[16],"with":[17,150,184,224,293],"their":[18,363],"bacterial":[19],"hosts.":[20],"Many":[21],"these":[23],"been":[26,75,90],"characterized;":[27],"however,":[28],"metagenomics":[29],"studies":[30,60],"suggest":[31,61],"that":[32,55,62,113,198,205,254,271,304,332,357,383],"phage-host":[33,413],"interactions":[34,162],"are":[35,50,65,315],"potentially":[36],"regulated":[37],"a":[39,51,78,132,181,202,231,275,324,423],"wide":[40],"variety":[41],"still":[44],"waiting":[45],"be":[47,389],"discovered.":[48],"Mycobacteriophages":[49],"group":[52],"bacteriophages":[54],"infect":[56],"mycobacterial":[57,80,435],"species.":[58],"Metagenomic":[59],"mycobacteriophage":[63,167,178,420],"genomes":[64,88,94],"remarkably":[66],"diverse.":[67],"As":[68],"March":[70],"2023,":[71],"12,381":[72],"isolated":[76],"from":[77,218],"single":[79],"species,":[81],"Mycobacterium":[82,213],"smegmatis":[83,228],"mc2":[84],"155,":[85],"and":[86,263,295,308,313,321,415],"2184":[87],"completely":[91],"sequenced.":[92],"These":[93],"harbor":[95],"an":[96,225],"extensive":[97],"reservoir":[98],"genes":[100],"coding":[101],"for":[102,281,317,431],"proteins":[103,130,146,356],"unknown":[105],"function,":[106],"many":[107],"unique":[111],"sequences":[112],"do":[114],"not":[115],"match":[116],"any":[117],"protein":[118,123,183,204,256,373],"sequence":[119],"in":[120,212,286,327,396],"the":[121,139,148,151,175,219,255,261,291,297,305,318,338,345,371,393,417,432],"available":[122],"database.":[124],"This":[125,154,215],"vast":[126],"array":[127],"unexplored":[129],"represents":[131],"great":[133],"source":[134],"gain":[136],"insight":[137,407],"into":[138,408],"potential":[140,409],"novel":[141,166],"pathways":[142,411],"phage":[145],"mediate":[147],"interaction":[149,220,292],"host":[152,161],"cell.":[153],"thesis":[155],"explores":[156],"new":[157,406,428],"regulating":[159],"phage-mycobacterial":[160],"investigating":[164],"selected":[165,170],"proteins.":[168],"We":[169,196,301,330],"Phaedrus":[171,199,222,242,272,333,386],"gp82,":[172],"encoded":[173],"Cluster":[176],"B":[177],"Phaedrus,":[179],"as":[180,422],"candidate":[182],"no":[185],"known":[186,234],"function":[187],"or":[188],"structural":[189],"homolog":[190],"but":[191,368],"is":[192,201,366,375,379],"predicted":[193],"crystallize.":[195],"showed":[197],"gp82":[200,223,243,273,334,387],"toxic":[203],"severely":[206],"reduces":[207],"colony":[208,299],"size":[209],"when":[210],"overexpressed":[211],"smegmatis.":[214],"effect":[216],"arises":[217],"essential":[226,372],"M.":[227],"protein,":[229],"MoxR,":[230,342],"multifunctional":[232],"ATPase":[233,339],"chaperone":[237],"function.":[238],"The":[239,266,352,401],"structure":[240],"was":[244,279],"solved":[245],"using":[246],"x-ray":[247],"crystallography":[248],"at":[249],"1.4":[250],"\u00c5":[251],"resolution":[252],"revealing":[253],"consists":[257],"two":[259],"domains,":[260],"base":[262],"wing":[264,306],"domain.":[265],"electron":[267],"density":[268],"map":[269],"revealed":[270,303],"contains":[274],"disordered":[276,288],"loop,":[277],"critical":[280,316],"MoxR":[282,294,328,350,359,399],"binding.":[283],"A":[284],"mutation":[285],"this":[287],"loop":[289],"disrupts":[290],"abolishes":[296],"small":[298],"phenotype.":[300],"also":[302],"domain":[307],"acidic":[309],"residues":[310],"D38,":[311],"E43,":[312],"D45":[314],"resulting":[319,394],"phenotype":[320],"likely":[322],"play":[323],"secondary":[325],"role":[326],"interactions.":[329],"propose":[331],"functions":[335],"reducing":[337,344],"activity":[340,360],"thereby":[343],"levels":[346],"properly":[348,397],"folded":[349,364,398],"clients.":[351,400],"complete":[353],"collection":[354],"require":[358],"achieve":[362],"state":[365],"unknown,":[367],"one":[369],"example,":[370],"RipA":[374],"known.":[376],"Therefore,":[377],"it":[378],"reasonable":[380],"speculate":[382],"overexpression":[384],"may":[388],"cytotoxic":[390],"because":[391],"decrease":[395],"findings":[402],"presented":[403],"here":[404],"provide":[405],"undiscovered":[410],"governing":[412],"interactions;":[414],"underline":[416],"importance":[418],"genomics":[421],"promising":[424],"tool":[425],"identify":[427],"drug":[429],"targets":[430],"treatment":[433],"pathogens.":[436]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}
