{"id":"https://openalex.org/W7002117833","doi":null,"title":"Maternal Autoimmunity and Inflammation are associated with Childhood Tics and Obsessive-Compulsive Disorder","display_name":"Maternal Autoimmunity and Inflammation are associated with Childhood Tics and Obsessive-Compulsive Disorder","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W7002117833"},"language":"en","primary_location":{"id":"pmh:oai:ses.library.usyd.edu.au:2123/26281","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2123/26281","pdf_url":null,"source":{"id":"https://openalex.org/S4306402414","display_name":"The Sydney eScholarship Repository (The University of Sydney)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I129604602","host_organization_name":"The University of Sydney","host_organization_lineage":["https://openalex.org/I129604602"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jones, Hannah","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jones, Hannah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maternal-autoimmunity","display_name":"maternal autoimmunity","score":0.9769999980926514},{"id":"https://openalex.org/keywords/maternal-inflammation","display_name":"maternal inflammation","score":0.9559999704360962},{"id":"https://openalex.org/keywords/pediatric-obsessive-compulsive-disorder","display_name":"pediatric obsessive-compulsive disorder","score":0.8619999885559082},{"id":"https://openalex.org/keywords/tourette-syndrome","display_name":"Tourette syndrome","score":0.921999990940094},{"id":"https://openalex.org/keywords/neurodevelopmental-disorders","display_name":"neurodevelopmental disorders","score":0.9369999766349792},{"id":"https://openalex.org/keywords/maternal-autoimmune-disease","display_name":"maternal autoimmune disease","score":0.6290000081062317},{"id":"https://openalex.org/keywords/innate-immune-pathways","display_name":"innate immune pathways","score":0.7710000276565552},{"id":"https://openalex.org/keywords/maternal-transcriptome","display_name":"maternal transcriptome","score":0.6349999904632568},{"id":"https://openalex.org/keywords/environmental-risk-factors","display_name":"environmental risk factors","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7009000182151794},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.6784999966621399},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6735000014305115},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.6717000007629395},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5827999711036682},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5192999839782715},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.508400022983551},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.486299991607666},{"id":"https://openalex.org/C2777200579","wikidata":"https://www.wikidata.org/wiki/Q738538","display_name":"Tics","level":2,"score":0.4812000095844269},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.47510001063346863},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.4415000081062317},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.4253000020980835},{"id":"https://openalex.org/C2780194698","wikidata":"https://www.wikidata.org/wiki/Q6005429","display_name":"Immune dysregulation","level":3,"score":0.40720000863075256},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.40209999680519104},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.3801000118255615},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.35989999771118164},{"id":"https://openalex.org/C201934248","wikidata":"https://www.wikidata.org/wiki/Q2492999","display_name":"Neuroimmunology","level":3,"score":0.3273000121116638},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.32330000400543213},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.3183000087738037},{"id":"https://openalex.org/C2777026814","wikidata":"https://www.wikidata.org/wiki/Q191779","display_name":"Tourette syndrome","level":2,"score":0.30379998683929443},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.29840001463890076},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.26570001244544983},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.265500009059906},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.2581000030040741},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.257999986410141}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:ses.library.usyd.edu.au:2123/26281","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2123/26281","pdf_url":null,"source":{"id":"https://openalex.org/S4306402414","display_name":"The Sydney eScholarship Repository (The University of Sydney)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I129604602","host_organization_name":"The University of Sydney","host_organization_lineage":["https://openalex.org/I129604602"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3119211957","https://openalex.org/W2086758012","https://openalex.org/W4408137125","https://openalex.org/W4386264737","https://openalex.org/W1980594128","https://openalex.org/W4285807152","https://openalex.org/W1985287412","https://openalex.org/W4311147034","https://openalex.org/W2014123635","https://openalex.org/W2912951552"],"abstract_inverted_index":{"Although":[0],"genetic":[1],"variation":[2],"is":[3,40],"a":[4,93,124,202,246],"major":[5],"risk":[6,261],"factor":[7],"of":[8,52,57,126,140,144,156,167,186,192,219,231,241,248],"neurodevelopmental":[9],"disorders":[10],"(NDDs)":[11],"such":[12],"as":[13],"tics":[14],"and":[15,24,34,67,70,91,114,118,163,211,243,269],"childhood":[16],"obsessive-compulsive":[17],"disorder":[18],"(OCD),":[19],"environmental":[20,43],"factors":[21],"during":[22],"pregnancy":[23],"early":[25],"life":[26],"are":[27],"important":[28],"in":[29,55,123,136,184,206,223,238,254],"disease":[30,150],"expression.":[31],"Epidemiological":[32],"studies":[33],"animal":[35],"models":[36],"indicate":[37,229],"maternal":[38,101,112],"inflammation":[39,268],"one":[41],"potential":[42],"factor.":[44],"In":[45],"my":[46],"thesis,":[47],"I":[48,74],"compared":[49,151],"the":[50,86,207,239],"frequency":[51],"proinflammatory":[53,178],"states":[54,179],"mothers":[56,127,143,155,166,185,191],"200":[58],"children":[59,77,145,157,187,263],"with":[60,62,78,104,111,146,152,158,188,201],"tics/OCD":[61,79,105,147,189],"100":[63,68],"autoimmune":[64,149,159],"neurological":[65,160],"controls":[66,169,194],"age-":[69],"sex-matched":[71],"healthy":[72,168,193],"controls.":[73],"prospectively":[75],"recruited":[76],"aged":[80],"\u226416":[81],"years":[82],"sequentially":[83],"referred":[84],"to":[85,96,108,128,134,259,262,267],"Children\u2019s":[87],"Hospital":[88],"at":[89],"Westmead,":[90],"used":[92],"structured":[94],"interview":[95],"capture":[97],"data,":[98],"focusing":[99],"on":[100],"autoimmunity.":[102],"Children":[103],"were":[106,121,180],"phenotyped":[107],"identify":[109,129],"associations":[110],"autoimmunity,":[113],"exploratory":[115],"biomarker":[116],"testing":[117],"transcriptome":[119],"analysis":[120],"performed":[122],"subgroup":[125],"immune":[130,225,233,252],"pathways":[131,234],"potentially":[132],"relevant":[133],"neurodevelopment":[135,255],"offspring.":[137],"\\nA":[138],"total":[139],"61":[141],"(30.5%)":[142],"had":[148],"20":[153],"(20%)":[154],"conditions":[161],"(p=0.054)":[162],"12":[164],"(12%)":[165],"(p=0.0004,":[170],"adj":[171],"OR":[172],"2.7":[173],"(95th":[174],"CI":[175],"1.28-5.68)).":[176],"Other":[177],"also":[181],"more":[182],"common":[183,217],"than":[190],"(p<0.0001).":[195],"Maternal":[196,209],"autoimmunity":[197],"was":[198],"not":[199],"associated":[200],"distinct":[203],"clinical":[204],"phenotype":[205],"child.":[208],"blood":[210],"published":[212],"Tourette":[213],"brain":[214],"transcriptomes":[215],"showed":[216],"enrichment":[218],"differentially":[220],"expressed":[221],"genes":[222],"innate":[224,232],"pathways.":[226],"\\nOur":[227],"results":[228],"dysregulation":[230],"may":[235],"be":[236,245],"pivotal":[237],"expression":[240],"NDDs":[242],"should":[244],"focus":[247],"further":[249],"research.":[250],"Understanding":[251],"mechanisms":[253],"could":[256],"unveil":[257],"opportunities":[258],"mitigate":[260],"by":[264],"reducing":[265],"exposure":[266],"open":[270],"new":[271],"avenues":[272],"for":[273],"treatment.":[274]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2025-10-10T00:00:00"}
