{"id":"https://openalex.org/W7001975607","doi":null,"title":"Melatonin as a prototype of chronobiotic-cytoprotective drugs","display_name":"Melatonin as a prototype of chronobiotic-cytoprotective drugs","publication_year":2005,"publication_date":"2005-11-01","ids":{"openalex":"https://openalex.org/W7001975607"},"language":"en","primary_location":{"id":"pmh:oai:sedici.unlp.edu.ar:10915/146971","doi":null,"is_oa":true,"landing_page_url":"http://sedici.unlp.edu.ar/handle/10915/146971","pdf_url":null,"source":{"id":"https://openalex.org/S4306400803","display_name":"El Servicio de Difusi\u00f3n de la Creaci\u00f3n Intelectual (National University of La Plata)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I874386039","host_organization_name":"Universidad Nacional de La Plata","host_organization_lineage":["https://openalex.org/I874386039"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Articulo"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://sedici.unlp.edu.ar/handle/10915/146971","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065268240","display_name":"Daniel Pedro Cardinali","orcid":"https://orcid.org/0000-0002-0813-9088","observed_orcids":["https://orcid.org/0000-0002-0813-9088"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Cardinali, Daniel P.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5065268240"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1142,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.37703646,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":1.0},{"id":"https://openalex.org/keywords/cytoprotection","display_name":"cytoprotection","score":0.8640000224113464},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.996999979019165},{"id":"https://openalex.org/keywords/neuronal-death","display_name":"neuronal cell death","score":0.722000002861023},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8140000104904175},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9290000200271606},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9610000252723694},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9660000205039978},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9290000200271606},{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":0.8960000276565552},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.9750000238418579},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.9929999709129333},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.9139999747276306}],"concepts":[{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.8984000086784363},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.777899980545044},{"id":"https://openalex.org/C2778868616","wikidata":"https://www.wikidata.org/wiki/Q1076421","display_name":"Chorea","level":3,"score":0.6938999891281128},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6026999950408936},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5958999991416931},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.53329998254776},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5188000202178955},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5044000148773193},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.39410001039505005},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.35040000081062317},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.31690001487731934},{"id":"https://openalex.org/C2780059843","wikidata":"https://www.wikidata.org/wiki/Q198654","display_name":"Pineal gland","level":3,"score":0.2687999904155731},{"id":"https://openalex.org/C2993744773","wikidata":"https://www.wikidata.org/wiki/Q2945973","display_name":"Neuronal damage","level":3,"score":0.2671999931335449},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.26010000705718994},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2581999897956848},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.25679999589920044},{"id":"https://openalex.org/C2780647506","wikidata":"https://www.wikidata.org/wiki/Q190564","display_name":"Huntington's disease","level":3,"score":0.25429999828338623},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.24819999933242798},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.23989999294281006},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.23589999973773956},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.22660000622272491},{"id":"https://openalex.org/C2781458332","wikidata":"https://www.wikidata.org/wiki/Q720026","display_name":"Brain damage","level":2,"score":0.22599999606609344},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22339999675750732},{"id":"https://openalex.org/C2781269140","wikidata":"https://www.wikidata.org/wiki/Q24784310","display_name":"Melatonin receptor","level":3,"score":0.22139999270439148},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.21690000593662262},{"id":"https://openalex.org/C2780317758","wikidata":"https://www.wikidata.org/wiki/Q3339235","display_name":"Neurological disorder","level":3,"score":0.21279999613761902},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.20559999346733093},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.19779999554157257},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.19660000503063202},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19529999792575836},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.19439999759197235},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.1932000070810318},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.18970000743865967},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.18960000574588776},{"id":"https://openalex.org/C3454156","wikidata":"https://www.wikidata.org/wiki/Q1144241","display_name":"Side effect (computer science)","level":2,"score":0.18860000371932983},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.188400000333786},{"id":"https://openalex.org/C2778621155","wikidata":"https://www.wikidata.org/wiki/Q576349","display_name":"Encephalopathy","level":2,"score":0.18539999425411224},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.18279999494552612},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.17659999430179596},{"id":"https://openalex.org/C2780405171","wikidata":"https://www.wikidata.org/wiki/Q629444","display_name":"Dyskinesia","level":4,"score":0.17579999566078186}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:sedici.unlp.edu.ar:10915/146971","doi":null,"is_oa":true,"landing_page_url":"http://sedici.unlp.edu.ar/handle/10915/146971","pdf_url":null,"source":{"id":"https://openalex.org/S4306400803","display_name":"El Servicio de Difusi\u00f3n de la Creaci\u00f3n Intelectual (National University of La Plata)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I874386039","host_organization_name":"Universidad Nacional de La Plata","host_organization_lineage":["https://openalex.org/I874386039"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Articulo"}],"best_oa_location":{"id":"pmh:oai:sedici.unlp.edu.ar:10915/146971","doi":null,"is_oa":true,"landing_page_url":"http://sedici.unlp.edu.ar/handle/10915/146971","pdf_url":null,"source":{"id":"https://openalex.org/S4306400803","display_name":"El Servicio de Difusi\u00f3n de la Creaci\u00f3n Intelectual (National University of La Plata)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I874386039","host_organization_name":"Universidad Nacional de La Plata","host_organization_lineage":["https://openalex.org/I874386039"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Articulo"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3090956923","https://openalex.org/W7011519816","https://openalex.org/W2969543914","https://openalex.org/W2048428155","https://openalex.org/W2960257281","https://openalex.org/W2064479682","https://openalex.org/W6930113263","https://openalex.org/W2047730749","https://openalex.org/W2743367259","https://openalex.org/W2551772863"],"abstract_inverted_index":{"Melatonin":[0,16],"provides":[1],"an":[2],"innovative":[3],"neuroprotective":[4],"strategy":[5],"by":[6],"combining":[7],"its":[8,13],"effects":[9],"on":[10],"sleep":[11],"with":[12],"cytoprotective":[14],"properties.":[15],"protects":[17],"against":[18],"several":[19],"mechanisms":[20],"of":[21,33,36],"neuronal":[22],"death,":[23],"including":[24],"oxyradical-mediated":[25],"damage":[26],"and":[27,44,50],"apoptosis":[28],"implicated":[29],"in":[30],"the":[31],"pathogenesis":[32],"a":[34],"number":[35],"neurodegenerative":[37],"diseases":[38],"like":[39,47],"AD,":[40],"Parkinsonism,":[41],"Huntington\u2019s":[42],"chorea":[43],"neurological":[45],"conditions":[46],"stroke,":[48],"epilepsy":[49],"brain":[51],"trauma.":[52]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}