{"id":"https://openalex.org/W7000757409","doi":null,"title":"Functional roles of chromatin recruitment to the nuclear periphery","display_name":"Functional roles of chromatin recruitment to the nuclear periphery","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W7000757409"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org:ark:/13030/qt9tv1b0dm","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/9tv1b0dm","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008571536","display_name":"Harold C. Marin","orcid":"https://orcid.org/0000-0001-7691-398X","observed_orcids":["https://orcid.org/0000-0001-7691-398X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Marin, Harold Cesar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5008571536"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.8877000212669373,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.8877000212669373,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.1103999987244606,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nuclear-periphery","display_name":"nuclear periphery","score":0.8980000019073486},{"id":"https://openalex.org/keywords/heterochromatin","display_name":"heterochromatin","score":0.9539999961853027},{"id":"https://openalex.org/keywords/nuclear-lamins","display_name":"nuclear lamins","score":0.7480000257492065},{"id":"https://openalex.org/keywords/lamin-b-receptor","display_name":"lamin B receptor","score":0.9950000047683716},{"id":"https://openalex.org/keywords/h3k9me2","display_name":"H3K9me2","score":0.9589999914169312},{"id":"https://openalex.org/keywords/h3k9me3","display_name":"H3K9me3","score":0.9150000214576721},{"id":"https://openalex.org/keywords/hp1alpha","display_name":"HP1\u03b1","score":0.8960000276565552},{"id":"https://openalex.org/keywords/hp1beta","display_name":"HP1\u03b2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.7739999890327454},{"id":"https://openalex.org/keywords/mouse-embryonic-stem-cells","display_name":"mouse embryonic stem cells","score":0.847000002861023},{"id":"https://openalex.org/keywords/epiblast-like-cells","display_name":"epiblast-like cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/nuclear-shape","display_name":"nuclear shape","score":0.781000018119812},{"id":"https://openalex.org/keywords/chromatin-spatial-organization","display_name":"chromatin spatial organization","score":0.7149999737739563},{"id":"https://openalex.org/keywords/rescue-experiments","display_name":"rescue experiments","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C103435993","wikidata":"https://www.wikidata.org/wiki/Q837783","display_name":"Heterochromatin","level":4,"score":0.951200008392334},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.8278999924659729},{"id":"https://openalex.org/C179093185","wikidata":"https://www.wikidata.org/wiki/Q424506","display_name":"Lamin","level":3,"score":0.7839000225067139},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7602999806404114},{"id":"https://openalex.org/C100924687","wikidata":"https://www.wikidata.org/wiki/Q910324","display_name":"Euchromatin","level":5,"score":0.670199990272522},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5611000061035156},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5231999754905701},{"id":"https://openalex.org/C92149661","wikidata":"https://www.wikidata.org/wiki/Q1616164","display_name":"Heterochromatin protein 1","level":5,"score":0.49390000104904175},{"id":"https://openalex.org/C94912109","wikidata":"https://www.wikidata.org/wiki/Q687194","display_name":"Nuclear lamina","level":5,"score":0.4830999970436096},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.4648999869823456},{"id":"https://openalex.org/C101152365","wikidata":"https://www.wikidata.org/wiki/Q838135","display_name":"Histone H1","level":4,"score":0.40400001406669617},{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.39910000562667847},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3564999997615814},{"id":"https://openalex.org/C72391661","wikidata":"https://www.wikidata.org/wiki/Q5164350","display_name":"Constitutive heterochromatin","level":5,"score":0.35120001435279846},{"id":"https://openalex.org/C2776745794","wikidata":"https://www.wikidata.org/wiki/Q24777451","display_name":"Histone H3","level":4,"score":0.3402000069618225},{"id":"https://openalex.org/C130321593","wikidata":"https://www.wikidata.org/wiki/Q7196845","display_name":"Pioneer factor","level":5,"score":0.3375000059604645},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.336899995803833},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.298799991607666},{"id":"https://openalex.org/C125215638","wikidata":"https://www.wikidata.org/wiki/Q3720216","display_name":"Position effect","level":3,"score":0.2930000126361847},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.2924000024795532},{"id":"https://openalex.org/C87026931","wikidata":"https://www.wikidata.org/wiki/Q3408226","display_name":"Non-histone protein","level":4,"score":0.29100000858306885},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2897000014781952},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.27959999442100525},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.2759999930858612},{"id":"https://openalex.org/C84750089","wikidata":"https://www.wikidata.org/wiki/Q21130793","display_name":"PELP-1","level":5,"score":0.27489998936653137},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.272599995136261},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.27000001072883606},{"id":"https://openalex.org/C183873130","wikidata":"https://www.wikidata.org/wiki/Q30869","display_name":"Nucleolus","level":3,"score":0.2551000118255615}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:escholarship.org:ark:/13030/qt9tv1b0dm","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/9tv1b0dm","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4412552460","https://openalex.org/W2959313738","https://openalex.org/W2140718627","https://openalex.org/W6966535058","https://openalex.org/W1513568273","https://openalex.org/W1943427713","https://openalex.org/W1924323830","https://openalex.org/W6910558788","https://openalex.org/W7131246240","https://openalex.org/W3045446800"],"abstract_inverted_index":{"The":[0],"eukaryotic":[1],"nucleus":[2],"houses":[3],"deoxyribonucleic":[4],"acid":[5],"(DNA)":[6],"along":[7],"with":[8,41],"scaffolding":[9],"proteins":[10],"which":[11],"together":[12],"form":[13],"chromatin.":[14],"Cells":[15],"organize":[16],"their":[17],"chromatin":[18,130],"as":[19,162,208,210],"transcriptionally":[20],"silent,":[21],"compacted":[22],"heterochromatin":[23,64,123,152,213],"and":[24,37,50,61,108,129,138,165,175,204],"active,":[25],"relaxed":[26],"euchromatin.":[27],"Heterochromatin":[28],"is":[29,101],"enriched":[30,81],"at":[31,82],"the":[32,67,83,87,109,120,127,149,197,201],"nuclear":[33,48,68,84,156,198],"periphery":[34,199],"in":[35,55,113,135,183],"metazoans":[36],"peripheral":[38,189],"position":[39,91,125,154,203],"correlates":[40],"transcriptional":[42],"repression.":[43],"Here,":[44],"we":[45],"remove":[46],"three":[47],"lamins":[49],"lamin":[51],"B":[52],"receptor":[53],"(LBR)":[54],"mouse":[56],"embryonic":[57],"stem":[58],"cells":[59,141],"(mESCs)":[60],"show":[62],"that":[63,185,196],"detaches":[65],"from":[66],"periphery.":[69],"Heterochromatic":[70],"loci":[71],"marked":[72],"by":[73],"histone":[74],"H3":[75],"lysine":[76],"9":[77],"di-methylation":[78],"(H3K9me2)":[79],"are":[80,186],"periphery;":[85],"however,":[86],"effect":[88,121],"of":[89,105,122,132,151,191],"spatial":[90,124,153,202],"on":[92,119,126,148,155,158,167,176],"H3K9me2-modified":[93,133],"genes":[94,134],"has":[95],"not":[96],"been":[97],"defined.":[98],"Chapter":[99,116,143],"1":[100],"a":[102,168],"brief":[103],"overview":[104],"genome":[106],"organization":[107],"major":[110],"players":[111],"studied":[112],"this":[114],"dissertation.":[115],"2":[117],"focuses":[118],"transcription":[128],"state":[131],"na\u00efve":[136],"mESCs":[137],"differentiated":[139],"Epiblast-like":[140],"(EpiLCs).":[142],"3":[144],"shows":[145,195],"preliminary":[146],"work":[147,194],"effects":[150],"shape,":[157],"heterochromatin-associated":[159],"factors":[160],"such":[161],"H3K9me3,":[163],"HP1\u03b1":[164],"HP1\u03b2,":[166],"degron":[169],"system":[170],"to":[171,180],"rapidly":[172],"deplete":[173],"LBR,":[174],"structure-function":[177],"rescue":[178],"experiments":[179],"identify":[181],"regions":[182],"LBR":[184],"important":[187],"for":[188],"enrichment":[190],"H3K9me2.":[192],"This":[193],"controls":[200],"repressive":[205],"functions":[206],"H3K9me2,":[207],"well":[209],"potentially":[211],"other":[212],"marks.":[214]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2025-10-10T00:00:00"}