{"id":"https://openalex.org/W6999734007","doi":null,"title":"Discovery of synthetic lethal or viable interactions between DNA repair pathways","display_name":"Discovery of synthetic lethal or viable interactions between DNA repair pathways","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W6999734007"},"language":"ca","primary_location":{"id":"pmh:oai:www.tdx.cat:10803/675626","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10803/675626","pdf_url":null,"source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ddd.uab.cat/pub/tesis/2023/hdl_10803_675626/dast1de1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Steigerwald, Daniela","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Steigerwald, Daniela","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synthetic-lethality","display_name":"synthetic lethality","score":0.9940000176429749},{"id":"https://openalex.org/keywords/dna-repair-pathways","display_name":"DNA repair pathways","score":0.9169999957084656},{"id":"https://openalex.org/keywords/fanconi-anemia-brca-pathway","display_name":"Fanconi anemia/BRCA pathway","score":0.7789999842643738},{"id":"https://openalex.org/keywords/fancd2-monoubiquitination","display_name":"FANCD2 monoubiquitination","score":0.8320000171661377},{"id":"https://openalex.org/keywords/dna-crosslink-repair","display_name":"DNA crosslink repair","score":0.628000020980835},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.8870000243186951},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.7099999785423279},{"id":"https://openalex.org/keywords/translesion-synthesis","display_name":"translesion synthesis","score":0.7559999823570251},{"id":"https://openalex.org/keywords/fanconi-anemia","display_name":"Fanconi anemia","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.5870000123977661},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8320000171661377}],"concepts":[{"id":"https://openalex.org/C144251240","wikidata":"https://www.wikidata.org/wiki/Q7068229","display_name":"Nucleofection","level":4,"score":0.2621000111103058},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.18700000643730164},{"id":"https://openalex.org/C2778012447","wikidata":"https://www.wikidata.org/wiki/Q1034415","display_name":"Scope (computer science)","level":2,"score":0.16949999332427979},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.16609999537467957},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15449999272823334},{"id":"https://openalex.org/C126042441","wikidata":"https://www.wikidata.org/wiki/Q1324888","display_name":"Frame (networking)","level":2,"score":0.149399995803833},{"id":"https://openalex.org/C2779403534","wikidata":"https://www.wikidata.org/wiki/Q2944360","display_name":"Centenarian","level":3,"score":0.14300000667572021},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.14180000126361847},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.14090000092983246},{"id":"https://openalex.org/C45235069","wikidata":"https://www.wikidata.org/wiki/Q278425","display_name":"Table (database)","level":2,"score":0.13979999721050262}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.tdx.cat:10803/675626","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10803/675626","pdf_url":null,"source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:ddd.uab.cat:268638","doi":null,"is_oa":true,"landing_page_url":"https://ddd.uab.cat/record/268638","pdf_url":"https://ddd.uab.cat/pub/tesis/2023/hdl_10803_675626/dast1de1.pdf","source":{"id":"https://openalex.org/S4306400380","display_name":"Dip\u00f2sit Digital de Documents de la UAB (Universitat Aut\u00f2noma de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123044942","host_organization_name":"Universitat Aut\u00f2noma de Barcelona","host_organization_lineage":["https://openalex.org/I123044942"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Tesi doctoral"}],"best_oa_location":{"id":"pmh:oai:ddd.uab.cat:268638","doi":null,"is_oa":true,"landing_page_url":"https://ddd.uab.cat/record/268638","pdf_url":"https://ddd.uab.cat/pub/tesis/2023/hdl_10803_675626/dast1de1.pdf","source":{"id":"https://openalex.org/S4306400380","display_name":"Dip\u00f2sit Digital de Documents de la UAB (Universitat Aut\u00f2noma de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123044942","host_organization_name":"Universitat Aut\u00f2noma de Barcelona","host_organization_lineage":["https://openalex.org/I123044942"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Tesi doctoral"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W6999734007.pdf","grobid_xml":"https://content.openalex.org/works/W6999734007.grobid-xml"},"referenced_works_count":185,"referenced_works":["https://openalex.org/W101557296","https://openalex.org/W126562021","https://openalex.org/W166404207","https://openalex.org/W1127055839","https://openalex.org/W1491753399","https://openalex.org/W1521943738","https://openalex.org/W1528119152","https://openalex.org/W1531540594","https://openalex.org/W1563822242","https://openalex.org/W1571913556","https://openalex.org/W1795141977","https://openalex.org/W1845321470","https://openalex.org/W1964376076","https://openalex.org/W1966730768","https://openalex.org/W1968158491","https://openalex.org/W1968245004","https://openalex.org/W1970184435","https://openalex.org/W1971563221","https://openalex.org/W1971777367","https://openalex.org/W1975621550","https://openalex.org/W1977284533","https://openalex.org/W1978773870","https://openalex.org/W1978947118","https://openalex.org/W1980034972","https://openalex.org/W1980842169","https://openalex.org/W1981148605","https://openalex.org/W1982957001","https://openalex.org/W1983795887","https://openalex.org/W1986550053","https://openalex.org/W1986947222","https://openalex.org/W1987610133","https://openalex.org/W1987871280","https://openalex.org/W1990039985","https://openalex.org/W1995390673","https://openalex.org/W1995515648","https://openalex.org/W2002484799","https://openalex.org/W2002495174","https://openalex.org/W2005567329","https://openalex.org/W2008207745","https://openalex.org/W2008561915","https://openalex.org/W2009007206","https://openalex.org/W2012867725","https://openalex.org/W2013210712","https://openalex.org/W2014091491","https://openalex.org/W2016286342","https://openalex.org/W2016648136","https://openalex.org/W2019034413","https://openalex.org/W2020481544","https://openalex.org/W2022460501","https://openalex.org/W2023620387","https://openalex.org/W2028637581","https://openalex.org/W2028928303","https://openalex.org/W2034100797","https://openalex.org/W2037936898","https://openalex.org/W2041615416","https://openalex.org/W2044000184","https://openalex.org/W2044592981","https://openalex.org/W2045435533","https://openalex.org/W2047938417","https://openalex.org/W2048097176","https://openalex.org/W2049470371","https://openalex.org/W2049598883","https://openalex.org/W2052626813","https://openalex.org/W2053772974","https://openalex.org/W2056473812","https://openalex.org/W2060201374","https://openalex.org/W2067792518","https://openalex.org/W2067818712","https://openalex.org/W2070821144","https://openalex.org/W2071411482","https://openalex.org/W2071457560","https://openalex.org/W2074529613","https://openalex.org/W2076046893","https://openalex.org/W2078022036","https://openalex.org/W2080726979","https://openalex.org/W2083946902","https://openalex.org/W2084310601","https://openalex.org/W2084369408","https://openalex.org/W2084695608","https://openalex.org/W2085896453","https://openalex.org/W2086860427","https://openalex.org/W2087634145","https://openalex.org/W2088857928","https://openalex.org/W2094020226","https://openalex.org/W2097124161","https://openalex.org/W2099613936","https://openalex.org/W2100675082","https://openalex.org/W2102193166","https://openalex.org/W2102209369","https://openalex.org/W2102265131","https://openalex.org/W2104425537","https://openalex.org/W2109816131","https://openalex.org/W2111461823","https://openalex.org/W2112158920","https://openalex.org/W2115107913","https://openalex.org/W2115694409","https://openalex.org/W2117511932","https://openalex.org/W2117743516","https://openalex.org/W2121178654","https://openalex.org/W2123746851","https://openalex.org/W2124156743","https://openalex.org/W2126525177","https://openalex.org/W2134071049","https://openalex.org/W2134259738","https://openalex.org/W2136367213","https://openalex.org/W2140345256","https://openalex.org/W2140677853","https://openalex.org/W2149751339","https://openalex.org/W2152112318","https://openalex.org/W2154111088","https://openalex.org/W2156442575","https://openalex.org/W2157899948","https://openalex.org/W2161588324","https://openalex.org/W2163241233","https://openalex.org/W2163313836","https://openalex.org/W2165068523","https://openalex.org/W2165912346","https://openalex.org/W2166043527","https://openalex.org/W2166776471","https://openalex.org/W2169244146","https://openalex.org/W2172064842","https://openalex.org/W2172631200","https://openalex.org/W2203229763","https://openalex.org/W2298876126","https://openalex.org/W2375351600","https://openalex.org/W2387193491","https://openalex.org/W2401802453","https://openalex.org/W2429819149","https://openalex.org/W2469711085","https://openalex.org/W2469726318","https://openalex.org/W2476261929","https://openalex.org/W2476568892","https://openalex.org/W2494174731","https://openalex.org/W2500008420","https://openalex.org/W2503553921","https://openalex.org/W2512730870","https://openalex.org/W2528285141","https://openalex.org/W2528836475","https://openalex.org/W2564055409","https://openalex.org/W2570196263","https://openalex.org/W2587250579","https://openalex.org/W2587610309","https://openalex.org/W2614952490","https://openalex.org/W2622921857","https://openalex.org/W2704159227","https://openalex.org/W2729105878","https://openalex.org/W2746010076","https://openalex.org/W2766696573","https://openalex.org/W2768807911","https://openalex.org/W2788085902","https://openalex.org/W2795227812","https://openalex.org/W2813551238","https://openalex.org/W2883861546","https://openalex.org/W2889030797","https://openalex.org/W2898301712","https://openalex.org/W2901200418","https://openalex.org/W2902993140","https://openalex.org/W2908469091","https://openalex.org/W2910053627","https://openalex.org/W2914604310","https://openalex.org/W2914641123","https://openalex.org/W2931814734","https://openalex.org/W2965094510","https://openalex.org/W2966768523","https://openalex.org/W2972171376","https://openalex.org/W2982570657","https://openalex.org/W2983106163","https://openalex.org/W3002698677","https://openalex.org/W3004366112","https://openalex.org/W3007516256","https://openalex.org/W3014348148","https://openalex.org/W3032587498","https://openalex.org/W3033889308","https://openalex.org/W3045518591","https://openalex.org/W3082138527","https://openalex.org/W3110293579","https://openalex.org/W3116275460","https://openalex.org/W3155364700","https://openalex.org/W3162894130","https://openalex.org/W3165591844","https://openalex.org/W3201849543","https://openalex.org/W3212652612","https://openalex.org/W4206561758","https://openalex.org/W4238106194","https://openalex.org/W4244842284"],"related_works":["https://openalex.org/W7009110568","https://openalex.org/W3149034333","https://openalex.org/W2007500392","https://openalex.org/W2488232318","https://openalex.org/W3112517475","https://openalex.org/W2184524307","https://openalex.org/W7096071138","https://openalex.org/W2027661242","https://openalex.org/W7015803835","https://openalex.org/W2944498052"],"abstract_inverted_index":{"Les":[0,94],"c\u00e8l\u00b7lules":[1,195,231],"de":[2,7,9,16,27,29,36,40,53,69,77,88,96,103,151,154,163,174,204,265,276,281,332,352,354,362,364,376,407,409,421,430,432,457,459,477,493,511,513],"mam\u00edfer":[3],"han":[4],"desenvolupat":[5],"rutes":[6,351],"reparaci\u00f3":[8,28,41,70,153,158,171,353,408,431],"l'ADN":[10,30,433],"per":[11,139,161,191,201,252,326,387,399,440],"protegir":[12],"el":[13,121,187,272,327,379],"material":[14],"gen\u00e8tic":[15],"mutacions":[17],"que":[18,50,65,124,147,207,214,248,315,366,471],"podrien":[19],"provocar":[20],"c\u00e0ncer":[21,190,280],"o":[22,283,341,370,420,444,450],"mort":[23,211],"cel\u00b7lular.":[24],"Cada":[25],"ruta":[26,39,68,98,312,322,406],"respon":[31],"a":[32,209,228,236,310,388,505],"un":[33,85,107,125,135,237,401],"tipus":[34],"espec\u00edfic":[35],"dany.":[37],"La":[38,157,180],"Fanconi/BRCA":[42],"corregeix":[43],"els":[44],"enlla\u00e7os":[45],"creuats":[46],"entre":[47,343,481,488],"cadenes":[48],"d'ADN":[49],"provoquen":[51],"trencaments":[52],"doble":[54,175],"cadena":[55,176],"altament":[56],"perjudicials":[57],"si":[58],"no":[59,220,249,461],"es":[60,100,159,183,199,269,293,358,382,393,413,435],"reparen.":[61],"Mutacions":[62],"als":[63],"gens":[64,206,288,291,427],"constitueixen":[66],"aquesta":[67,82,321,453],"causen":[71],"una":[72,246,405,480,486],"malaltia":[73,83],"rara":[74],"anomenada":[75],"anemia":[76],"Fanconi.":[78,514],"Els":[79,290],"pacients":[80,422],"amb":[81,274,285,397,423,438,448,455],"tenen":[84],"alt":[86],"risc":[87],"patir":[89],"fallada":[90],"medul\u00b7lar":[91],"i":[92,134,169,347,349,390,392,434,483,485,490,498],"c\u00e0ncer.":[93,330],"prote\u00efnes":[95,129,141,345,492],"la":[97,110,116,152,166,170,202,210,215,222,226,240,253,266,277,311,317,323,333,368,371,442,445,494],"FA/BRCA":[99],"classifiquen":[101],"dins":[102],"tres":[104],"grans":[105],"grups:":[106],"primer":[108],"grup":[109,137],"principal":[111],"funci\u00f3":[112],"del":[113,118,132,145,172,189,279,329],"qual":[114],"\u00e9s":[115],"ubiquitinaci\u00f3":[117],"complex":[119,122],"FANCD2-I,":[120],"FANCD2-I":[123],"cop":[126],"monoubiquitinat":[127],"recluta":[128],"al":[130,143,509],"lloc":[131,144,504],"dany":[133,146],"\u00faltim":[136],"format":[138],"les":[140,149,194,344],"reclutades":[142],"s\u00f3n":[148],"encarregades":[150],"lenlla\u00e7":[155],"creuat.":[156],"produir\u00e0":[160],"l'eliminaci\u00f3":[162],"l'enlla\u00e7":[164],"creuat,":[165],"s\u00edntesi":[167],"translesi\u00f3":[168],"trencament":[173],"via":[177,495],"recombinaci\u00f3":[178],"hom\u00f2loga.":[179],"letalitat":[181,198,267,324,369,443],"sint\u00e8tica":[182,268,325,373,447,467],"fa":[184,244],"servir":[185,396,416],"en":[186,271,287,297,320,404,426],"tractament":[188,273,328,510],"eliminar":[192],"espec\u00edficament":[193],"canceroses.":[196],"Aquesta":[197],"produeix":[200],"inhibici\u00f3":[203,216,241,254],"dos":[205],"condueix":[208],"cel\u00b7lular,":[212],"mentre":[213],"\u00fanicament":[217],"d'un":[218,242,255],"d'ells":[219],"afecta":[221],"viabilitat.":[223],"D'altra":[224],"banda,":[225],"resist\u00e8ncia":[227],"f\u00e0rmacs":[229],"d'algunes":[230],"tumorals":[232],"pot":[233],"ser":[234,336],"deguda":[235],"proc\u00e9s":[238,259],"on":[239],"gen":[243,403],"viable":[245],"c\u00e8l\u00b7lula":[247],"ho":[250],"era":[251],"altre":[256],"gen.":[257],"Aquest":[258,500],"s'anomena":[260],"viabilitat":[261,372,446,478],"sint\u00e8tica.":[262],"Una":[263],"aplicaci\u00f3":[264],"troba":[270],"inhibidors":[275],"PARP":[278],"mama":[282],"d'ovari":[284],"defici\u00e8ncia":[286],"BRCA.":[289],"FA":[292],"troben":[294],"freq\u00fcentment":[295],"mutats":[296],"tumors":[298],"i,":[299],"fins":[300],"ara,":[301],"nom\u00e9s":[302],"hi":[303],"ha":[304],"descrites":[305],"algunes":[306],"interaccions":[307,338,476],"letals":[308,340],"sint\u00e8tiques":[309,339],"FA,":[313],"cosa":[314],"obre":[316],"possibilitat":[318],"d'explorar":[319],"L'objectiu":[331],"tesi":[334,454],"va":[335,359],"trobar":[337],"viables":[342],"FANCA":[346,389,449,482,489],"FANCD2":[348,391],"altres":[350],"l'ADN.":[355,410],"Per":[356],"aix\u00f2":[357],"desenvolupar":[360],"l'assaig":[361,456],"compet\u00e8ncia":[363],"color":[365],"detecta":[367],"mitjan\u00e7ant":[374],"citometria":[375],"flux.":[377],"Amb":[378],"m\u00e8tode":[380],"CRISPR/Cas9,":[381],"van":[383,394,414,436],"generar":[384],"clons":[385],"knock-out":[386],"fer":[395,415],"shRNA":[398,439],"silenciar":[400],"segon":[402],"A":[411],"m\u00e9s,":[412],"l\u00ednies":[417],"cel\u00b7lulars":[418],"comercials":[419],"knock-outs":[424],"coneguts":[425],"d'altres":[428],"vies":[429],"tractar":[437],"provar":[441],"FANCD2.":[451],"En":[452],"competici\u00f3":[458],"color,":[460],"s'ha":[462],"detectat":[463,473],"cap":[464],"interacci\u00f3":[465],"letal":[466],"nova.":[468],"Tanmateix,":[469],"s\u00ed":[470],"s'han":[472],"dues":[474,491],"noves":[475],"sint\u00e8tica;":[479],"FEN1":[484],"segona":[487],"NER,":[496],"XPA":[497],"XPF.":[499],"descobriment":[501],"podria":[502],"donar":[503],"possibles":[506],"aplicacions":[507],"terap\u00e8utiques":[508],"l'an\u00e8mia":[512]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}
