{"id":"https://openalex.org/W69984283","doi":null,"title":"[RT-PCR use for the diagnostic of chronic myeloid leukaemia].","display_name":"[RT-PCR use for the diagnostic of chronic myeloid leukaemia].","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W69984283","mag":"69984283","pmid":"https://pubmed.ncbi.nlm.nih.gov/19388595"},"language":"fr","primary_location":{"id":"pmid:19388595","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19388595","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives de l'Institut Pasteur de Tunis","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041753374","display_name":"Samia Menif","orcid":"https://orcid.org/0000-0003-4897-1925","observed_orcids":["https://orcid.org/0000-0003-4897-1925"]},"institutions":[{"id":"https://openalex.org/I4210142087","display_name":"Institut Pasteur de Tunis","ror":"https://ror.org/04pwyer06","country_code":"TN","type":"facility","lineage":["https://openalex.org/I4210142087"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"S Menif","raw_affiliation_strings":["Laboratoire d'H\u00e9matologie Mol\u00e9culaire et Cellulaire, Institut Pasteur de Tunis. samia.menif@rns.tn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'H\u00e9matologie Mol\u00e9culaire et Cellulaire, Institut Pasteur de Tunis. samia.menif@rns.tn","institution_ids":["https://openalex.org/I4210142087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031440400","display_name":"Wijd\u00e8ne El Borgi","orcid":"https://orcid.org/0000-0002-4346-3668","observed_orcids":["https://orcid.org/0000-0002-4346-3668"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W El Borgi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063236502","display_name":"Ramzi Jeddi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Jeddi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053746880","display_name":"R Belakhal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Belakhal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111531088","display_name":"M. Elloumi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Elloumi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022856436","display_name":"Adn\u00e8ne Laatiri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Laatiri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019341062","display_name":"Balkis Meddeb","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Meddeb","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5035971626","display_name":"Koussay Dellagi","orcid":"https://orcid.org/0000-0001-7920-7490","observed_orcids":["https://orcid.org/0000-0001-7920-7490"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Dellagi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.00617809,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"83","issue":"1-4","first_page":"35","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/rt-pcr","display_name":"RT-PCR","score":0.8119999766349792},{"id":"https://openalex.org/keywords/bcr-abl-fusion","display_name":"BCR-ABL fusion gene","score":0.9409999847412109},{"id":"https://openalex.org/keywords/22-q34","display_name":"22)(q34","score":0.9089999794960022},{"id":"https://openalex.org/keywords/philadelphia-chromosome","display_name":"Philadelphia chromosome","score":0.9380000233650208},{"id":"https://openalex.org/keywords/molecular-diagnosis","display_name":"molecular diagnosis","score":0.8709999918937683},{"id":"https://openalex.org/keywords/disease-surveillance","display_name":"disease surveillance","score":0.8949999809265137},{"id":"https://openalex.org/keywords/complex-chromosomal-rearrangements","display_name":"complex chromosomal rearrangements","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6091770529747009},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.585453450679779},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5780448913574219},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.5469874739646912},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3397619426250458},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2247670292854309},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.11508584022521973}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001856","descriptor_name":"Bone Marrow Examination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002892","descriptor_name":"Chromosomes, Human, Pair 22","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004587","descriptor_name":"Electrophoresis, Agar Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014416","descriptor_name":"Tunisia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016044","descriptor_name":"Fusion Proteins, bcr-abl","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D020732","descriptor_name":"Cytogenetic Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:19388595","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19388595","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives de l'Institut Pasteur de Tunis","raw_type":"Journal Article"},{"id":"mag:69984283","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19388595","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391154907","https://openalex.org/W2804233426","https://openalex.org/W2346665916","https://openalex.org/W322231011","https://openalex.org/W2331511338","https://openalex.org/W2058815470","https://openalex.org/W901132540","https://openalex.org/W243482386","https://openalex.org/W2414682263","https://openalex.org/W2130157398"],"abstract_inverted_index":{"The":[0],"molecular":[1,114],"analysis":[2],"of":[3,13,22,42,87,113],"chromosomal":[4,132],"abnormalities":[5],"associated":[6],"with":[7,106,130],"hematological":[8],"malignancies":[9],"allowed":[10],"the":[11,85,93,111],"identification":[12],"genes":[14],"involved":[15],"in":[16,60,92],"theses":[17],"rearrangements":[18,133],"as":[19,21,100,128],"well":[20],"some":[23],"recurrent":[24],"mechanisms.":[25],"Polymerase":[26],"chain":[27,67],"reaction":[28,68],"(PCR)":[29],"tools":[30,115],"are":[31,125],"now":[32],"available":[33],"to":[34,72,75,79,116],"detect":[35,73],"these":[36,43],"rearrangements,":[37],"allowing":[38],"a":[39,49,54,61],"better":[40],"follow-up":[41],"diseases.":[44],"Chronic":[45],"myeloid":[46,102],"leukemia":[47,103],"is":[48,70],"myeloproliferative":[50],"disorder":[51],"characterized":[52],"by":[53],"reciprocal":[55],"translocation":[56],"t(9;22)(q34;q11)":[57],"which":[58],"results":[59,86,109],"bcr-abl":[62,74],"fusion":[63],"gene.":[64],"Retro-transcription":[65],"polymerase":[66],"(RT-PCR)":[69],"used":[71],"establish":[76],"diagnosis":[77],"and":[78,104,118],"monitor":[80,119],"patients.":[81],"We":[82],"report":[83],"here":[84],"30":[88],"patients":[89,120,136],"samples":[90],"tested":[91],"hematology":[94],"laboratory":[95],"at":[96],"Pasteur":[97],"Institute,":[98],"diagnosed":[99],"chronic":[101],"monitored":[105],"RT-PCR.":[107],"Our":[108],"highlight":[110],"interest":[112],"diagnose":[117],"mainly":[121],"when":[122,135],"cytogenetic":[123],"techniques":[124],"irrelevant":[126],"such":[127],"cases":[129],"complex":[131],"or":[134],"achieve":[137],"Philadelphia":[138],"negativity":[139],"after":[140],"treatment.":[141]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}