{"id":"https://openalex.org/W6992876501","doi":null,"title":"MMP-9 as predictive factor for response and progression free survival in breast cancer patients treated with bevacizumab and pegylated liposomal doxorubicin. A multicenter, single-arm phase II trial (SAKK24/06). On behalf of the Swiss Group for Clinical Cancer Research (SAKK).","display_name":"MMP-9 as predictive factor for response and progression free survival in breast cancer patients treated with bevacizumab and pegylated liposomal doxorubicin. A multicenter, single-arm phase II trial (SAKK24/06). On behalf of the Swiss Group for Clinical Cancer Research (SAKK).","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W6992876501"},"language":"en","primary_location":{"id":"pmh:oai:serval.unil.ch:BIB_140190B7EDBB","doi":null,"is_oa":true,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_140190B7EDBB","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"33rd Annual San Antonio Breast Cancer Symposium","raw_type":"info:eu-repo/semantics/conferenceObject"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://serval.unil.ch/notice/serval:BIB_140190B7EDBB","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Zaman, K.","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Zaman, K.","raw_affiliation_strings":["CePO , University Hospital , Lausanne ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CePO , University Hospital , Lausanne ;","institution_ids":["https://openalex.org/I2802229882"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065302460","display_name":"C.F. Rochlitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Rochlitz, C.","raw_affiliation_strings":["University Hospital Basel ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Basel ;","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006229315","display_name":"Thomas Ruhstaller","orcid":"https://orcid.org/0000-0002-4175-3784","observed_orcids":["https://orcid.org/0000-0002-4175-3784"]},"institutions":[{"id":"https://openalex.org/I2799884508","display_name":"Kantonsspital St. Gallen","ror":"https://ror.org/00gpmb873","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2799884508"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Ruhstaller, T.","raw_affiliation_strings":["Kantonsspital St. Gallen ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kantonsspital St. Gallen ;","institution_ids":["https://openalex.org/I2799884508"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Th\u00fcrlimann, B.","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799884508","display_name":"Kantonsspital St. Gallen","ror":"https://ror.org/00gpmb873","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2799884508"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Th\u00fcrlimann, B.","raw_affiliation_strings":["Kantonsspital St. Gallen ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kantonsspital St. Gallen ;","institution_ids":["https://openalex.org/I2799884508"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Aebi, S.","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Aebi, S.","raw_affiliation_strings":["Medical Oncology , University Hospital Bern ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology , University Hospital Bern ;","institution_ids":["https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Von Moos, R.","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148531","display_name":"Kantonsspital Graub\u00fcnden","ror":"https://ror.org/04wpn1218","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210148531"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Von Moos, R.","raw_affiliation_strings":["Kantonsspital Chur ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kantonsspital Chur ;","institution_ids":["https://openalex.org/I4210148531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082248258","display_name":"Christoph Mamot","orcid":"https://orcid.org/0000-0002-8838-6360","observed_orcids":["https://orcid.org/0000-0002-8838-6360"]},"institutions":[{"id":"https://openalex.org/I4210161075","display_name":"Kantonsspital Aarau","ror":"https://ror.org/056tb3809","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210161075"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Mamot, C.","raw_affiliation_strings":["Kantonsspital Aarau ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kantonsspital Aarau ;","institution_ids":["https://openalex.org/I4210161075"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Gabriel, N.","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Gabriel, N.","raw_affiliation_strings":["University Hospital Z\u00fcrich ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Z\u00fcrich ,","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081248161","display_name":"Laetitia Rossier","orcid":"https://orcid.org/0000-0003-4905-2920","observed_orcids":["https://orcid.org/0000-0003-4905-2920"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Rossier-Pansier, L.","raw_affiliation_strings":["CePO , University Hospital , Lausanne ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CePO , University Hospital , Lausanne ;","institution_ids":["https://openalex.org/I2802229882"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Stupp, R.","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Stupp, R.","raw_affiliation_strings":["CePO , University Hospital , Lausanne ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CePO , University Hospital , Lausanne ;","institution_ids":["https://openalex.org/I2802229882"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Crowe, S.","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148109","display_name":"Swiss Group For Clinical Cancer Research","ror":"https://ror.org/04rtrpb08","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I4210148109"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Crowe, S.","raw_affiliation_strings":["Statistics Unit , SAKK Coordination Center , Bern , Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Statistics Unit , SAKK Coordination Center , Bern , Switzerland","institution_ids":["https://openalex.org/I4210148109"]}]},{"author_position":"last","author":{"id":null,"display_name":"Ruegg, C.","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I4210148109","display_name":"Swiss Group For Clinical Cancer Research","ror":"https://ror.org/04rtrpb08","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I4210148109"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Ruegg, C.","raw_affiliation_strings":["CePO , University Hospital , Lausanne ;","SAKK Coordinating Center Effingerstrasse 40 , CH-3008 Bern"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CePO , University Hospital , Lausanne ;","institution_ids":["https://openalex.org/I2802229882"]},{"raw_affiliation_string":"SAKK Coordinating Center Effingerstrasse 40 , CH-3008 Bern","institution_ids":["https://openalex.org/I4210148109"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.6553000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.6553000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.334199994802475,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9800000190734863},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8569999933242798},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":1.0},{"id":"https://openalex.org/keywords/pegylated-liposomal-doxorubicin","display_name":"pegylated liposomal doxorubicin","score":1.0},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.7590000033378601},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.9309999942779541},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.7749999761581421},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9259999990463257},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9350000023841858},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9064000248908997},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.8858000040054321},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.7609999775886536},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.732699990272522},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5304999947547913},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4438000023365021},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.42750000953674316},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.4244000017642975},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.35589998960494995},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.3481999933719635},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.33160001039505005},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33079999685287476},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.31940001249313354},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.3188000023365021},{"id":"https://openalex.org/C2780739268","wikidata":"https://www.wikidata.org/wiki/Q2112244","display_name":"Progression-free survival","level":3,"score":0.3147999942302704},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.3021000027656555},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.28459998965263367},{"id":"https://openalex.org/C3019719930","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value","level":2,"score":0.2687000036239624}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:serval.unil.ch:BIB_140190B7EDBB","doi":null,"is_oa":true,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_140190B7EDBB","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"33rd Annual San Antonio Breast Cancer Symposium","raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"pmh:oai:iris.unil.ch:iris/70073","doi":null,"is_oa":true,"landing_page_url":"https://iris.unil.ch/handle/iris/70073","pdf_url":"https://iris.unil.ch/bitstreams/297d29f0-2089-48d9-8361-b1359e7a6ced/download","source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"conference poster"}],"best_oa_location":{"id":"pmh:oai:serval.unil.ch:BIB_140190B7EDBB","doi":null,"is_oa":true,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_140190B7EDBB","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"33rd Annual San Antonio Breast Cancer Symposium","raw_type":"info:eu-repo/semantics/conferenceObject"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322445","display_name":"Oncosuisse","ror":"https://ror.org/05pvet403"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W6992876501.pdf","grobid_xml":"https://content.openalex.org/works/W6992876501.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7038270266","https://openalex.org/W2028001096","https://openalex.org/W7070622176","https://openalex.org/W3128705022","https://openalex.org/W1997016066","https://openalex.org/W1968700928","https://openalex.org/W2094912909","https://openalex.org/W2070743887","https://openalex.org/W2891363713","https://openalex.org/W2012543941"],"abstract_inverted_index":{"The":[0],"benefit":[1],"of":[2,36,43,51,70,83],"bevacizumab":[3],"(Bv)":[4],"has":[5],"been":[6],"shown":[7],"in":[8],"different":[9,76],"tumors":[10],"including":[11],"colorectal":[12],"cancer,":[13,15],"renal":[14],"pulmonary":[16],"non-small":[17],"cell":[18],"cancer":[19],"and":[20,39,57,79],"also":[21],"breast":[22],"cancer.":[23],"However":[24],"to":[25],"date,":[26],"there":[27],"is":[28,48,61],"no":[29],"established":[30],"test":[31],"evaluating":[32],"the":[33,41,49,68,71,75,80],"angiogenic":[34],"status":[35],"a":[37,52],"patient":[38],"monitoring":[40],"effects":[42],"anti-angiogenic":[44,72],"treatments.":[45],"Tumor":[46],"angiogenesis":[47],"result":[50],"balance":[53],"between":[54],"multiple":[55],"pro-":[56],"anti\u00acangiogenic":[58],"molecules.":[59],"There":[60],"very":[62],"little":[63],"published":[64],"clinical":[65],"data":[66],"exploring":[67],"impact":[69],"therapy":[73],"on":[74],"angiogenesis-related":[77],"molecules":[78,85],"potential":[81],"role":[82],"these":[84],"as":[86],"prognostic":[87],"or":[88],"predictive":[89],"factors.":[90]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}
