{"id":"https://openalex.org/W6992078124","doi":null,"title":"Investigating Kaiso and TGF\u03b2 signaling crosstalk in epithelial-to-mesenchymal transition in triple-negative breast cancer","display_name":"Investigating Kaiso and TGF\u03b2 signaling crosstalk in epithelial-to-mesenchymal transition in triple-negative breast cancer","publication_year":2025,"publication_date":"2025-03-22","ids":{"openalex":"https://openalex.org/W6992078124"},"language":"en","primary_location":{"id":"pmh:oai:scholar.uwindsor.ca:we-spark-conference-1114","doi":null,"is_oa":false,"landing_page_url":"https://scholar.uwindsor.ca/we-spark-conference/2025/postersessions/82","pdf_url":null,"source":{"id":"https://openalex.org/S4306400430","display_name":"Scholarship at UWindsor (University of Windsor)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74413500","host_organization_name":"University of Windsor","host_organization_lineage":["https://openalex.org/I74413500"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"WE-SPARK Health Research Conference","raw_type":"text"},"volume":null,"type":"conference-paper","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053107732","display_name":"Hanad Adan","orcid":"https://orcid.org/0000-0002-9476-134X","observed_orcids":["https://orcid.org/0000-0002-9476-134X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adan, Hanad","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046353510","display_name":"Lindyann R. Lessey","orcid":"https://orcid.org/0009-0009-7476-519X","observed_orcids":["https://orcid.org/0009-0009-7476-519X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lessey, Lindyann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Ali-Fairbairn, Stephanie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ali-Fairbairn, Stephanie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Cowan, Rob","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cowan, Rob","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5061000332","display_name":"Juliet M. Daniel","orcid":"https://orcid.org/0000-0002-3497-0772","observed_orcids":["https://orcid.org/0000-0002-3497-0772"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel, Juliet M.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.3900496,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.07169999927282333,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kaiso","display_name":"Kaiso","score":0.921999990940094},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.7829999923706055},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9950000047683716},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":1.0},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8009999990463257},{"id":"https://openalex.org/keywords/smad2-3","display_name":"Smad2/3","score":0.9459999799728394},{"id":"https://openalex.org/keywords/transcriptional-feedback-loop","display_name":"transcriptional feedback loop","score":0.7820000052452087},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9279999732971191},{"id":"https://openalex.org/keywords/histological-grade","display_name":"histological grade","score":0.550000011920929},{"id":"https://openalex.org/keywords/tumor-survival","display_name":"tumor survival","score":0.31299999356269836}],"concepts":[{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6730999946594238},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6141999959945679},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.5511000156402588},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5200999975204468},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5181000232696533},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.44690001010894775},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.4447000026702881},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.42669999599456787},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4034000039100647},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3944000005722046},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33480000495910645},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.32600000500679016},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30379998683929443},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.29409998655319214},{"id":"https://openalex.org/C146777309","wikidata":"https://www.wikidata.org/wiki/Q1132599","display_name":"Corepressor","level":5,"score":0.2874000072479248},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.25369998812675476},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.25279998779296875}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:scholar.uwindsor.ca:we-spark-conference-1114","doi":null,"is_oa":false,"landing_page_url":"https://scholar.uwindsor.ca/we-spark-conference/2025/postersessions/82","pdf_url":null,"source":{"id":"https://openalex.org/S4306400430","display_name":"Scholarship at UWindsor (University of Windsor)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74413500","host_organization_name":"University of Windsor","host_organization_lineage":["https://openalex.org/I74413500"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"WE-SPARK Health Research Conference","raw_type":"text"},{"id":"pmh:oai:uwindsor.scholaris.ca:20.500.14776/15801","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.14776/15801","pdf_url":null,"source":{"id":"https://openalex.org/S4306400430","display_name":"Scholarship at UWindsor (University of Windsor)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74413500","host_organization_name":"University of Windsor","host_organization_lineage":["https://openalex.org/I74413500"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Conference presentation"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/1","score":0.5080543756484985,"display_name":"No poverty"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Triple-negative":[0],"breast":[1,8],"cancer":[2,9],"(TNBC)":[3],"is":[4,91,195,233],"the":[5,27,50,94,100,112,124,130,169,174,181],"most":[6],"difficult-to-treat":[7],"(BCa)":[10],"subtype":[11],"due":[12],"to":[13,45,55,180,189,229],"its":[14],"aggressive,":[15],"highly":[16],"metastatic":[17,34,47],"nature,":[18],"and":[19,73,99,108,210,220,223],"lack":[20],"of":[21,68,96,102,126,141,168,200],"targeted":[22],"therapies.":[23],"Increasing":[24],"evidence":[25],"implicates":[26],"transcription":[28,176],"factor":[29],"Kaiso":[30,63,76,122,157,170,182,194,222],"in":[31,49,80,117,129,146,159,187,207,226],"TNBC's":[32],"increased":[33,61],"potential.":[35],"In":[36],"mouse":[37],"xenograft":[38],"models,":[39],"Kaiso-depleted":[40],"TNBC":[41,58,161,208,227],"cells":[42],"formed":[43],"little":[44],"no":[46],"lesions":[48],"lungs":[51],"or":[52],"liver":[53],"compared":[54],"parental":[56],"Kaiso-expressing":[57],"cells.":[59],"Furthermore,":[60],"nuclear":[62],"localization":[64],"correlates":[65],"with":[66],"tumors":[67],"a":[69,87,197,234],"higher":[70],"histological":[71],"grade":[72],"poorer":[74],"survival.":[75],"has":[77],"been":[78],"implicated":[79],"metastasis":[81],"by":[82,93],"promoting":[83],"epithelial-to-mesenchymal":[84],"transition":[85],"(EMT),":[86],"cellular":[88],"program":[89],"that":[90,105,121,143,153,173,186,238],"characterized":[92],"loss":[95],"cell-to-cell":[97],"adhesion":[98],"adoption":[101],"mesenchymal":[103],"properties":[104],"promote":[106],"migration":[107],"invasion.":[109],"While":[110],"characterizing":[111],"mechanisms":[113],"behind":[114],"Kaiso's":[115,205],"role":[116,206],"EMT,":[118],"we":[119,150,212],"determined":[120],"regulates":[123],"expression":[125,158,225],"various":[127],"proteins":[128],"Transforming":[131],"Growth":[132],"Factor":[133],"Beta":[134],"(TGF\u03b2)":[135],"signaling":[136,192],"pathway,":[137],"another":[138],"potent":[139],"inducer":[140],"EMT":[142],"also":[144,151,196],"participates":[145],"BCa":[147],"progression.":[148],"Interestingly,":[149],"observed":[152],"TGF\u03b21":[154],"treatment":[155],"increases":[156],"our":[160],"cell":[162],"lines.":[163],"Chromatin":[164],"immunoprecipitation":[165],"(ChIP)-PCR":[166],"analysis":[167],"promoter":[171,183],"revealed":[172],"TGF\u00ce\u00b2":[175,224],"factors":[177],"SMAD2/3":[178],"bind":[179],"directly,":[184],"indicating":[185],"addition":[188],"regulating":[190],"TGF\u03b2":[191],"proteins,":[193],"downstream":[198],"target":[199],"TGF\u00ce\u00b2.":[201],"To":[202],"further":[203],"examine":[204,221],"aggressiveness":[209],"metastasis,":[211],"will":[213],"fully":[214],"characterize":[215],"this":[216],"Kaiso-TGF\u00ce\u00b2":[217],"feedback":[218],"loop":[219],"tissues":[228],"determine":[230],"if":[231],"there":[232],"unique":[235],"Kaiso/TGF-\u00ce\u00b2":[236],"signature":[237],"could":[239],"be":[240],"used":[241],"as":[242],"diagnostic/prognostic":[243],"biomarkers":[244],"for":[245],"TNBC.":[246]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
