{"id":"https://openalex.org/W6992032706","doi":null,"title":"I segni molecolari e cellulari dell'invecchiamento.","display_name":"I segni molecolari e cellulari dell'invecchiamento.","publication_year":2014,"publication_date":"2014-03-03","ids":{"openalex":"https://openalex.org/W6992032706"},"language":"it","primary_location":{"id":"pmh:oai:etd.adm.unipi.it:etd-02112014-202954","doi":null,"is_oa":true,"landing_page_url":"https://etd.adm.unipi.it/theses/available/etd-02112014-202954/","pdf_url":"https://etd.adm.unipi.it/theses/available/etd-02112014-202954/unrestricted/_tesi_.pdf","source":{"id":"https://openalex.org/S4306401800","display_name":"Electronic Theses and Dissertations Repository (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://etd.adm.unipi.it/theses/available/etd-02112014-202954/","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://etd.adm.unipi.it/theses/available/etd-02112014-202954/unrestricted/_tesi_.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"PIERONI, GAIA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"PIERONI, GAIA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.6478999853134155,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.6478999853134155,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.35010001063346863,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9470000267028809},{"id":"https://openalex.org/keywords/cellular-aging","display_name":"cellular aging","score":0.7409999966621399},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.9610000252723694},{"id":"https://openalex.org/keywords/telomere-shortening","display_name":"telomere shortening","score":0.9589999914169312},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.9190000295639038},{"id":"https://openalex.org/keywords/proteostasis","display_name":"proteostasis","score":0.8669999837875366},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.847000002861023},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9959999918937683},{"id":"https://openalex.org/keywords/stem-cell-depletion","display_name":"stem cell depletion","score":0.8930000066757202},{"id":"https://openalex.org/keywords/tissue-regeneration","display_name":"tissue regeneration","score":0.8140000104904175},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.8379999995231628},{"id":"https://openalex.org/keywords/lifespan-extension","display_name":"lifespan extension","score":0.4650000035762787},{"id":"https://openalex.org/keywords/anti-aging-drugs","display_name":"anti-aging drugs","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.8747000098228455},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.36039999127388},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.3370000123977661},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.2615000009536743},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.1762000024318695},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.14000000059604645},{"id":"https://openalex.org/C3017944768","wikidata":"https://www.wikidata.org/wiki/Q1450463","display_name":"Poison control","level":2,"score":0.0860000029206276},{"id":"https://openalex.org/C3018587665","wikidata":"https://www.wikidata.org/wiki/Q7268696","display_name":"Qualitative analysis","level":3,"score":0.07959999889135361},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.07580000162124634},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.06849999725818634}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:etd.adm.unipi.it:etd-02112014-202954","doi":null,"is_oa":true,"landing_page_url":"https://etd.adm.unipi.it/theses/available/etd-02112014-202954/","pdf_url":"https://etd.adm.unipi.it/theses/available/etd-02112014-202954/unrestricted/_tesi_.pdf","source":{"id":"https://openalex.org/S4306401800","display_name":"Electronic Theses and Dissertations Repository (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://etd.adm.unipi.it/theses/available/etd-02112014-202954/","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:etd.adm.unipi.it:etd-02112014-202954","doi":null,"is_oa":true,"landing_page_url":"https://etd.adm.unipi.it/theses/available/etd-02112014-202954/","pdf_url":"https://etd.adm.unipi.it/theses/available/etd-02112014-202954/unrestricted/_tesi_.pdf","source":{"id":"https://openalex.org/S4306401800","display_name":"Electronic Theses and Dissertations Repository (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://etd.adm.unipi.it/theses/available/etd-02112014-202954/","raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W6992032706.pdf","grobid_xml":"https://content.openalex.org/works/W6992032706.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W2094375019","https://openalex.org/W2112365416","https://openalex.org/W2126525177"],"related_works":["https://openalex.org/W2920517430","https://openalex.org/W7029924625","https://openalex.org/W1597108874","https://openalex.org/W3110751156","https://openalex.org/W2300352034","https://openalex.org/W2883978951","https://openalex.org/W7008565962","https://openalex.org/W92047648","https://openalex.org/W6922274397","https://openalex.org/W6922574326"],"abstract_inverted_index":{"L\u2019invecchiamento":[0],"\u00e8":[1,22],"un":[2,23,29],"tema":[3],"che":[4,44,70,128,158,166,212,223],"sta":[5],"diventando":[6],"sempre":[7],"di":[8,15,53,83,87,103,109,123,162,187,203],"maggior":[9],"interesse":[10],"poich\u00e9":[11],"interessa":[12],"una":[13,192],"fetta":[14],"popolazione":[16],"notevole,":[17],"destinata":[18],"ad":[19,137],"aumentare.":[20],"Esso":[21],"processo":[24,52,186],"molto":[25],"complesso":[26],"caratterizzato":[27],"da":[28],"declino":[30],"funzionale":[31],"tempo-dipendente":[32],"degli":[33],"organismi.":[34],"Sono":[35],"stati,":[36],"tuttavia,":[37],"individuati":[38],"nove":[39],"segni":[40,111],"molecolari":[41,209],"e":[42,93,132,146,183,191],"cellulari":[43],"sono":[45,115],"stati":[46],"riconosciuti":[47],"essere":[48],"denominatore":[49],"comune":[50],"del":[51,81,95,195,199],"invecchiamento:":[54],"instabilit\u00e0":[55],"genomica,":[56],"logoramento":[57],"dei":[58,68,98,143,156],"telomeri,":[59],"cambiamenti":[60],"nella":[61],"regolazione":[62],"epigenetica":[63],"dell\u2019espressione":[64],"genica,":[65],"riduzione":[66,154],"dell\u2019efficienza":[67,155],"sistemi":[69,145,157],"garantiscono":[71,159],"l\u2019omeostasi":[72],"proteica,":[73],"alterazioni":[74,127],"a":[75,169,178],"livello":[76],"metabolico,":[77],"disfunzioni":[78],"mitocondriali,":[79],"incremento":[80],"numero":[82],"cellule":[84,91],"in":[85,118,180],"fase":[86],"senescenza,":[88],"esaurimento":[89],"delle":[90,101],"staminali":[92],"quindi":[94],"potenziale":[96],"rigenerativo":[97],"tessuti,":[99],"modificazioni":[100],"vie":[102],"comunicazione":[104],"tra":[105,122],"cellule.":[106],"Sebbene":[107],"ciascuno":[108],"questi":[110],"abbia":[112],"caratteristiche":[113],"proprie,":[114],"state":[116],"poste":[117],"evidenza":[119],"numerose":[120],"connessioni":[121],"essi.":[124],"Tutte":[125],"le":[126],"riguardano":[129],"il":[130,164,185],"genoma":[131],"l\u2019espressione":[133],"genica":[134],"vanno,":[135],"difatti,":[136],"impattare":[138],"sulla":[139],"funzionalit\u00e0":[140],"della":[141,216],"cellula,":[142],"suoi":[144],"conseguentemente":[147],"sui":[148],"tessuti.":[149],"Allo":[150],"stesso":[151],"modo,":[152],"la":[153,160,214],"possibilit\u00e0":[161],"correggere":[163],"danno":[165],"si":[167,224],"viene":[168],"formare":[170],"favorisce":[171],"l\u2019accumulo":[172],"dello":[173],"stesso.":[174],"Tali":[175],"relazioni":[176],"concorrono":[177],"determinare,":[179],"maniera":[181],"inevitabile":[182],"irreversibile,":[184],"invecchiamento.":[188],"Tuttavia,":[189],"l\u2019approfondimento":[190],"maggiore":[193],"comprensione":[194],"disegno":[196],"alla":[197],"base":[198],"fenomeno":[200],"potr\u00e0":[201],"rivelarsi":[202],"notevole":[204],"utilit\u00e0":[205],"per":[206,210],"individuare":[207],"bersagli":[208],"farmaci":[211],"aumentino":[213],"durata":[215],"vita":[217],"limitando":[218],"gli":[219],"aspetti":[220],"non":[221],"auspicabili":[222],"verificano":[225],"durante":[226],"l\u2019invecchiamento.":[227]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}