{"id":"https://openalex.org/W6991986572","doi":null,"title":"Interpretable models of gene expression in single-cell immunology","display_name":"Interpretable models of gene expression in single-cell immunology","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W6991986572"},"language":"en","primary_location":{"id":"pmh:oai:mediatum.ub.tum.de:node/1634060","doi":null,"is_oa":true,"landing_page_url":"https://mediatum.ub.tum.de/1634060","pdf_url":"http://nbn-resolving.de/urn:nbn:de:bvb:91-diss-20220719-1634060-1-1","source":{"id":"https://openalex.org/S4377196330","display_name":"mediaTUM  (Technical University of Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://nbn-resolving.de/urn:nbn:de:bvb:91-diss-20220719-1634060-1-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000053965","display_name":"David S. Fischer","orcid":"https://orcid.org/0000-0002-1293-7656","observed_orcids":["https://orcid.org/0000-0002-1293-7656"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fischer, David Sebastian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149444451","display_name":"Fabian J. Theis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Theis, Fabian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5142092838","display_name":"Technische Universit\u00e4t M\u00fcnchen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Technische Universit\u00e4t M\u00fcnchen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.8619999885559082},{"id":"https://openalex.org/keywords/model-interpretability","display_name":"model interpretability","score":0.9950000047683716},{"id":"https://openalex.org/keywords/antigen-recognition","display_name":"antigen recognition","score":0.9950000047683716},{"id":"https://openalex.org/keywords/spatial-transcriptomics","display_name":"spatial transcriptomics","score":0.7390000224113464},{"id":"https://openalex.org/keywords/epigenetic-variation","display_name":"epigenetic variation","score":0.968999981880188},{"id":"https://openalex.org/keywords/automated-analysis","display_name":"automated analysis","score":0.4410000145435333}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6180999875068665},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5583000183105469},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5454999804496765},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4767000079154968},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4586000144481659},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.45730000734329224},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.4478999972343445},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.36719998717308044},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.3465999960899353},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.31839999556541443},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.31619998812675476},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.30889999866485596},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2980000078678131},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.29739999771118164},{"id":"https://openalex.org/C2908738225","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunopharmacology","level":3,"score":0.2946999967098236},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.29030001163482666},{"id":"https://openalex.org/C3017712846","wikidata":"https://www.wikidata.org/wiki/Q4891747","display_name":"Tumor immunology","level":4,"score":0.2827000021934509},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.28220000863075256},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.27549999952316284},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.27320000529289246},{"id":"https://openalex.org/C179463898","wikidata":"https://www.wikidata.org/wiki/Q10273301","display_name":"Epigenesis","level":5,"score":0.27239999175071716},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.2687000036239624},{"id":"https://openalex.org/C1547928","wikidata":"https://www.wikidata.org/wiki/Q1660177","display_name":"Immunogenetics","level":3,"score":0.26570001244544983},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.2628999948501587},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.2596000134944916},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.25920000672340393},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2587999999523163},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.2587999999523163},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.2524999976158142}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:mediatum.ub.tum.de:node/1634060","doi":null,"is_oa":true,"landing_page_url":"https://mediatum.ub.tum.de/1634060","pdf_url":"http://nbn-resolving.de/urn:nbn:de:bvb:91-diss-20220719-1634060-1-1","source":{"id":"https://openalex.org/S4377196330","display_name":"mediaTUM  (Technical University of Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-034260124","doi":null,"is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/?id=1634060","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Hochschulschrift"}],"best_oa_location":{"id":"pmh:oai:mediatum.ub.tum.de:node/1634060","doi":null,"is_oa":true,"landing_page_url":"https://mediatum.ub.tum.de/1634060","pdf_url":"http://nbn-resolving.de/urn:nbn:de:bvb:91-diss-20220719-1634060-1-1","source":{"id":"https://openalex.org/S4377196330","display_name":"mediaTUM  (Technical University of Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},"sustainable_development_goals":[{"score":0.4000000059604645,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W6991986572.pdf","grobid_xml":"https://content.openalex.org/works/W6991986572.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1513618424","https://openalex.org/W1904365287","https://openalex.org/W2005136695","https://openalex.org/W2035444281","https://openalex.org/W2038210983","https://openalex.org/W2061423359","https://openalex.org/W2078409719","https://openalex.org/W2103111465","https://openalex.org/W2173027866","https://openalex.org/W2225156818","https://openalex.org/W2519887557","https://openalex.org/W2735067671","https://openalex.org/W2766453196","https://openalex.org/W2786672974","https://openalex.org/W2953405766","https://openalex.org/W2962001321","https://openalex.org/W2964121744","https://openalex.org/W3012657554","https://openalex.org/W3021920958","https://openalex.org/W3030163527","https://openalex.org/W3112100299","https://openalex.org/W3134181354","https://openalex.org/W3164766680","https://openalex.org/W3194078460","https://openalex.org/W3198658154","https://openalex.org/W3217151720","https://openalex.org/W4224059281","https://openalex.org/W4254770871","https://openalex.org/W4289406437"],"related_works":["https://openalex.org/W7128141192","https://openalex.org/W4399766536","https://openalex.org/W4381251806","https://openalex.org/W2578841491","https://openalex.org/W7139078577","https://openalex.org/W4399546383","https://openalex.org/W4399502848","https://openalex.org/W2980476706","https://openalex.org/W2302100084","https://openalex.org/W4206738105"],"abstract_inverted_index":{"Single-cell":[0],"omics":[1],"assays":[2,18],"provide":[3],"molecular":[4,20],"characterisations":[5],"of":[6,16,22],"cells.":[7],"Immunology":[8],"has":[9],"stood":[10],"out":[11],"as":[12],"a":[13],"key":[14],"application":[15],"these":[17],"and":[19,59,62],"states":[21],"immune":[23],"cell":[24],"have":[25],"been":[26],"described":[27],"in":[28,51],"detail.":[29],"However,":[30],"mechanistic":[31],"insights":[32],"into":[33],"diseases":[34],"are":[35],"often":[36],"still":[37],"incomplete.":[38],"I":[39],"addressed":[40],"this":[41],"limitation":[42],"using":[43],"interpretable":[44],"machine":[45],"learning":[46],"models":[47],"for":[48],"single-cell":[49],"immunology":[50],"population":[52],"dynamics,":[53],"antigen":[54],"recognition,":[55],"spatial":[56],"data,":[57],"sample":[58],"epigenetic":[60],"variation,":[61],"automated":[63],"analyses.":[64]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}
