{"id":"https://openalex.org/W6991845702","doi":null,"title":"Inhibitie van histon-demethylases als een manier om de verminderde activiteit van DOT1L bij artrose te herstellen","display_name":"Inhibitie van histon-demethylases als een manier om de verminderde activiteit van DOT1L bij artrose te herstellen","publication_year":2024,"publication_date":"2024-12-10","ids":{"openalex":"https://openalex.org/W6991845702"},"language":"en","primary_location":{"id":"pmh:oai:lirias2repo.kuleuven.be:20.500.12942/754876","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/20.500.12942/754876","pdf_url":"https://lirias.kuleuven.be/retrieve/15e0d689-c096-462f-ae55-af7a1fe3fead","source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://lirias.kuleuven.be/retrieve/15e0d689-c096-462f-ae55-af7a1fe3fead","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007073413","display_name":"Reem Assi","orcid":"https://orcid.org/0000-0002-3956-5610","observed_orcids":["https://orcid.org/0000-0002-3956-5610"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Assi, Reem","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5007073413"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.878000020980835},{"id":"https://openalex.org/keywords/dot1l","display_name":"DOT1L","score":0.8899999856948853},{"id":"https://openalex.org/keywords/histone-demethylase","display_name":"histone demethylase","score":0.9599999785423279},{"id":"https://openalex.org/keywords/h3k79-methylation","display_name":"H3K79 methylation","score":0.9470000267028809},{"id":"https://openalex.org/keywords/articular-cartilage","display_name":"articular cartilage","score":0.8920000195503235},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.843999981880188},{"id":"https://openalex.org/keywords/histone-demethylase-inhibition","display_name":"histone demethylase inhibition","score":0.7590000033378601},{"id":"https://openalex.org/keywords/intra-articular-drug-delivery","display_name":"intra-articular drug delivery","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cartilage-homeostasis","display_name":"cartilage homeostasis","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6011999845504761},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.4869999885559082},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48069998621940613},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.45339998602867126},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4041999876499176},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.35409998893737793},{"id":"https://openalex.org/C150425827","wikidata":"https://www.wikidata.org/wiki/Q2560317","display_name":"Histone methyltransferase","level":4,"score":0.3343000113964081},{"id":"https://openalex.org/C3020000666","wikidata":"https://www.wikidata.org/wiki/Q17112037","display_name":"Bench to bedside","level":2,"score":0.30070000886917114},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2728999853134155},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.26809999346733093},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2678999900817871},{"id":"https://openalex.org/C172268261","wikidata":"https://www.wikidata.org/wiki/Q4764988","display_name":"Animal studies","level":2,"score":0.2671000063419342},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.25780001282691956},{"id":"https://openalex.org/C3018263421","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Human studies","level":2,"score":0.2522999942302704},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25220000743865967}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:lirias2repo.kuleuven.be:20.500.12942/754876","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/20.500.12942/754876","pdf_url":"https://lirias.kuleuven.be/retrieve/15e0d689-c096-462f-ae55-af7a1fe3fead","source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:lirias2repo.kuleuven.be:20.500.12942/754876","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/20.500.12942/754876","pdf_url":"https://lirias.kuleuven.be/retrieve/15e0d689-c096-462f-ae55-af7a1fe3fead","source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6622692942619324}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W6991845702.pdf","grobid_xml":"https://content.openalex.org/works/W6991845702.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Joint":[0],"homeostasis":[1],"is":[2,50,65],"critically":[3],"regulated":[4],"by":[5],"epigenetic":[6,145],"mechanisms,":[7],"particularly":[8],"post-translational":[9],"modifications":[10],"of":[11,120,134],"histones.":[12],"Our":[13],"team":[14],"has":[15],"identified":[16],"that":[17,96],"the":[18,55,73,93,117,131],"enzyme":[19],"DOT1L,":[20],"through":[21],"its":[22,68,80],"methyltransferase":[23],"activity":[24],"on":[25],"histone":[26,75,94],"H3":[27],"at":[28],"lysine":[29],"79":[30],"(H3K79me),":[31],"plays":[32],"a":[33],"pivotal":[34],"role":[35,69],"in":[36,70,99,112,123],"maintaining":[37],"cartilage":[38],"integrity":[39],"and":[40,114],"protecting":[41],"against":[42],"osteoarthritis":[43],"(OA).":[44],"While":[45],"preserving":[46],"or":[47],"restoring":[48],"H3K79me":[49,64,98,110],"essential":[51],"for":[52,67,78,138],"joint":[53],"health,":[54],"regulatory":[56],"mechanisms":[57],"beyond":[58],"DOT1L":[59],"remain":[60],"poorly":[61],"understood.":[62],"Although":[63],"recognized":[66],"transcriptional":[71],"regulation,":[72],"specific":[74],"demethylases":[76,95],"responsible":[77],"modulating":[79],"levels":[81],"have":[82],"yet":[83],"to":[84,90,144],"be":[85],"elucidated.":[86],"This":[87],"research":[88],"aims":[89],"(1)":[91],"identify":[92],"regulate":[97],"articular":[100],"cartilage,":[101],"(2)":[102],"explore":[103],"whether":[104],"their":[105,141],"pharmacological":[106],"inhibition":[107],"can":[108],"mitigate":[109],"deficiency":[111],"OA,":[113,139],"(3)":[115],"assess":[116],"therapeutic":[118],"potential":[119],"this":[121],"approach":[122],"countering":[124],"disease":[125],"progression.":[126],"Additionally,":[127],"we":[128],"will":[129],"review":[130],"current":[132],"landscape":[133],"intra-articular":[135],"drug":[136],"therapies":[137],"highlighting":[140],"translational":[142],"relevance":[143],"targets.":[146]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}