{"id":"https://openalex.org/W6991812768","doi":null,"title":"Inhibition of Mitochondrial Dynamics by Mitochondrial Division Inhibitor-1 Suppresses Cell Migration and Metastatic Markers in Colorectal Cancer HCT116 Cells","display_name":"Inhibition of Mitochondrial Dynamics by Mitochondrial Division Inhibitor-1 Suppresses Cell Migration and Metastatic Markers in Colorectal Cancer HCT116 Cells","publication_year":2025,"publication_date":"2025-03-01","ids":{"openalex":"https://openalex.org/W6991812768"},"language":"en","primary_location":{"id":"pmh:oai:doaj.org/article:1b9d4518470a4302bbc3949c23c629bd","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1b9d4518470a4302bbc3949c23c629bd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Experimental Pharmacology, Vol Volume 17, Pp 143-157 (2025)","raw_type":"article"},"volume":null,"type":"article","indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/1b9d4518470a4302bbc3949c23c629bd","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051891717","display_name":"Tahir Mehmood","orcid":"https://orcid.org/0000-0002-6445-455X","observed_orcids":["https://orcid.org/0000-0002-6445-455X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mehmood T","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116687935","display_name":"Qandeel Nasir","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nasir Q","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Younis I","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Younis I","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Muanprasat C","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Muanprasat C","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.28141553,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mdivi-1","display_name":"Mdivi-1","score":0.8040000200271606},{"id":"https://openalex.org/keywords/mitochondrial-dynamics","display_name":"mitochondrial dynamics","score":0.9829999804496765},{"id":"https://openalex.org/keywords/mitochondrial-fission","display_name":"mitochondrial fission","score":0.8029999732971191},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8949999809265137},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9660000205039978},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.7310000061988831},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7870000004768372},{"id":"https://openalex.org/keywords/drp1","display_name":"Drp1","score":0.7509999871253967},{"id":"https://openalex.org/keywords/ampk-signaling","display_name":"AMPK signaling","score":0.7089999914169312},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.925000011920929},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.875},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.6710000038146973},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.8230000138282776},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.7940000295639038},{"id":"https://openalex.org/keywords/mitochondrial-mass","display_name":"mitochondrial mass","score":0.4869999885559082},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.6010000109672546},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.47099998593330383},{"id":"https://openalex.org/keywords/clonogenic-assay","display_name":"clonogenic assay","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5867999792098999},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5418999791145325},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5060999989509583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5008000135421753},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47620001435279846},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.4595000147819519},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4253999888896942},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.41909998655319214},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4034000039100647},{"id":"https://openalex.org/C17619807","wikidata":"https://www.wikidata.org/wiki/Q6881852","display_name":"Mitochondrial fission","level":3,"score":0.3815999925136566},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36059999465942383},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.35569998621940613},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.34940001368522644},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.3474999964237213},{"id":"https://openalex.org/C2777071529","wikidata":"https://www.wikidata.org/wiki/Q12796879","display_name":"Mitochondrial toxicity","level":3,"score":0.33489999175071716},{"id":"https://openalex.org/C163950672","wikidata":"https://www.wikidata.org/wiki/Q14905375","display_name":"mitochondrial fusion","level":4,"score":0.32839998602867126},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.3052000105381012},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3052000105381012},{"id":"https://openalex.org/C173358068","wikidata":"https://www.wikidata.org/wiki/Q6881847","display_name":"Mitochondrial apoptosis-induced channel","level":4,"score":0.30489999055862427},{"id":"https://openalex.org/C2777614518","wikidata":"https://www.wikidata.org/wiki/Q935710","display_name":"Mitochondrial disease","level":4,"score":0.2973000109195709},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.27900001406669617},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.27489998936653137},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2728999853134155},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.26969999074935913},{"id":"https://openalex.org/C92488253","wikidata":"https://www.wikidata.org/wiki/Q56592403","display_name":"Cell fusion","level":3,"score":0.2630000114440918},{"id":"https://openalex.org/C2775997469","wikidata":"https://www.wikidata.org/wiki/Q18029196","display_name":"MMP9","level":4,"score":0.2556000053882599}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:doaj.org/article:1b9d4518470a4302bbc3949c23c629bd","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1b9d4518470a4302bbc3949c23c629bd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Experimental Pharmacology, Vol Volume 17, Pp 143-157 (2025)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:1b9d4518470a4302bbc3949c23c629bd","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1b9d4518470a4302bbc3949c23c629bd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Experimental Pharmacology, Vol Volume 17, Pp 143-157 (2025)","raw_type":"article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Tahir":[0],"Mehmood,1,2":[1],"Qandeel":[2],"Nasir,2":[3],"Iqra":[4],"Younis,2":[5],"Chatchai":[6,33],"Muanprasat1":[7],"1Chakri":[8],"Naruebodindra":[9,36],"Medical":[10,37],"Institute,":[11,38],"Faculty":[12,39],"of":[13,25,40,76,90,112,120,126,162,199,222,285,287,304,311,322,355,396,408,444,452],"Medicine":[14,41],"Ramathibodi":[15,42],"Hospital,":[16,43],"Mahidol":[17,44],"University,":[18,29,45],"Bangpla,":[19,46],"Bangplee,":[20,47],"Samut":[21,48],"Prakarn,":[22,49],"Thailand;":[23],"2Department":[24],"Biological":[26],"Sciences,":[27],"Superior":[28],"Lahore,":[30],"Punjab,":[31],"PakistanCorrespondence:":[32],"Muanprasat,":[34],"Chakri":[35],"10540,":[50],"Thailand,":[51],"Email":[52],"chatchai.mua@mahidol.ac.thIntroduction:":[53],"The":[54,60,110,383],"mitochondria":[55,384],"are":[56,367,385],"highly":[57,386],"dynamic":[58,387],"organelles.":[59,388],"mitochondrial":[61,82,91,121,174,177,233,238,250,295,345,398,435,454],"morphology":[62,221],"and":[63,73,108,131,149,159,180,207,218,227,235,249,263,266,277,302,307,328,343,358,379,406,427,441],"spatial":[64],"distribution":[65],"within":[66],"the":[67,88,113,118,124,139,157,172,196,220,237,290,293,300,309,320,353,394,403,417,442,450],"cell":[68,147,313,356,377,425],"is":[69],"determined":[70],"by":[71],"fusion":[72],"fission":[74,399],"processes":[75],"mitochondria.":[77],"Several":[78],"studies":[79],"have":[80],"used":[81,136,169,193],"division":[83],"inhibitor-1":[84],"(Mdivi.1)":[85,401],"to":[86,116,137,155,170,194,254,292,352,392,432],"explore":[87],"roles":[89],"dynamics":[92,122,366,455],"in":[93,123,142,185,209,225,271,330,360,434],"various":[94],"pathological":[95],"conditions,":[96],"including":[97,325],"diabetic":[98],"cardiomyopathy,":[99],"myocardial":[100],"infarction,":[101],"cardiac":[102],"hypertrophy,":[103],"Alzheimer\u2019s":[104],"disease,":[105],"Huntington\u2019s":[106],"disease":[107],"cancers.Purpose:":[109],"objective":[111],"study":[114,335,390,448],"was":[115,135,168,192],"investigate":[117,393],"role":[119,395,451],"invasiveness":[125],"HCT116":[127,143,163,186,210,223,305,312,331,363],"colorectal":[128,361,375,409,462],"cancer":[129,362,376,410,463],"cells.Material":[130],"Methods:":[132],"MTT":[133],"assay":[134],"determine":[138,171,195],"Mdivi.1-induced":[140,173],"toxicity":[141,217],"cells.":[144,164,187,364],"Wound":[145],"healing,":[146],"migration":[148,158,303,378,428],"colony":[150],"forming":[151],"assays":[152],"were":[153],"adopted":[154],"measure":[156],"invasion":[160,301,357,407],"activity":[161],"Furthermore,":[165,241],"flow":[166],"cytometry":[167],"mass":[175,234,346],"quantification,":[176],"membrane":[178,239],"potential":[179,458],"reactive":[181,244,437],"oxygen":[182,245,438],"species":[183,246,439],"generation":[184,248],"Additionally,":[188],"Western":[189],"Blot":[190],"analysis":[191],"expression":[197,265,270,321],"level":[198],"Drp1,":[200,340,469],"p-Drp1,":[201],"Mnf2,":[202],"AMPK-\u03b1,":[203],"p-AMPK-\u03b1,":[204],"Cox-2,":[205,326],"iNos":[206],"MMP9":[208],"cells.Results:":[211],"We":[212,420],"found":[213,421],"that":[214,337,422],"Mdivi.1":[215,230,242,258,282,297,317,338,423],"induced":[216,243,283],"altered":[219,453],"cells":[224,306,411],"concentration-":[226],"time-dependent":[228],"manners.":[229],"significantly":[231,298,318],"increased":[232,267],"dissipated":[236],"potential.":[240],"(ROS)":[247],"superoxide":[251],"production,":[252],"leading":[253,351],"AMPK":[255],"activation.":[256],"Moreover,":[257],"decreased":[259,319],"dynamin-related":[260],"protein-1":[261],"(Drp1)":[262],"phosphorylated-Drp1":[264],"mitofusin-2":[268],"(Mfn2)":[269],"a":[272,397,457],"concentration-dependent":[273],"manner":[274],"at":[275],"48":[276],"72":[278],"h":[279],"post-treatment.":[280],"Notably,":[281],"inhibition":[284,354],"translocation":[286],"Drp1":[288],"from":[289],"cytosol":[291],"outer":[294],"membrane.":[296],"suppressed":[299],"inhibited":[308,424],"formation":[310],"colonies.":[314],"In":[315],"addition,":[316],"metastatic":[323,445],"markers":[324],"iNos,":[327],"MMP-9":[329],"cells.Conclusion:":[332],"Collectively,":[333],"this":[334],"revealed":[336],"downregulates":[339],"upregulates":[341],"Mfn2,":[342],"increases":[344],"with":[347],"attenuated":[348],"oxidative":[349],"metabolism,":[350],"metastasis":[359],"Mitochondrial":[365],"regarded":[368],"as":[369,414,416,456],"possible":[370],"drug":[371],"targets":[372],"for":[373,461],"interrupting":[374],"metastasis.Plain":[380],"language":[381],"summary:":[382],"This":[389,447],"aimed":[391],"inhibitor":[400],"on":[402],"viability,":[404],"migration,":[405],"(HCT116":[412],"cells),":[413],"well":[415],"underlying":[418],"mechanisms.":[419],"viability":[426],"via":[429],"mechanisms":[430],"linked":[431],"changes":[433],"dynamics,":[436],"generation,":[440],"downregulation":[443],"markers.":[446],"highlighted":[449],"therapeutic":[459],"approach":[460],"treatment.Keywords:":[464],"Mdivi.1,":[465],"mitochondria,":[466],"HCT116,":[467],"invasion,":[468],"Mfn2":[470]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
