{"id":"https://openalex.org/W6991734014","doi":null,"title":"Identification of immune cells in melanoma with single-cell RNA-sequencing","display_name":"Identification of immune cells in melanoma with single-cell RNA-sequencing","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W6991734014"},"language":"en","primary_location":{"id":"pmh:oai:iris.unil.ch:iris/106574","doi":null,"is_oa":true,"landing_page_url":"https://iris.unil.ch/handle/iris/106574","pdf_url":"https://iris.unil.ch/bitstreams/4a9a0cd9-c4dc-44df-8729-cb51aa2a3e13/download","source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://iris.unil.ch/bitstreams/4a9a0cd9-c4dc-44df-8729-cb51aa2a3e13/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"WICKY, A.","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"WICKY, A.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.878000020980835},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.8080000281333923},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9860000014305115},{"id":"https://openalex.org/keywords/single-cell-rna-sequencing","display_name":"single-cell RNA sequencing","score":0.6480000019073486},{"id":"https://openalex.org/keywords/mouse-melanoma-model","display_name":"mouse melanoma model","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7601000070571899},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.678600013256073},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6535000205039978},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5996999740600586},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5906999707221985},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5476999878883362},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.49140000343322754},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.48399999737739563},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.44530001282691956},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3946000039577484},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35760000348091125},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32910001277923584},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.31380000710487366},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3027999997138977},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2957000136375427},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2939000129699707},{"id":"https://openalex.org/C2778102761","wikidata":"https://www.wikidata.org/wiki/Q332181","display_name":"Natural killer cell","level":4,"score":0.2888000011444092},{"id":"https://openalex.org/C2778355321","wikidata":"https://www.wikidata.org/wiki/Q17079427","display_name":"Identity (music)","level":2,"score":0.2816999852657318},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.2761000096797943},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2574000060558319},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.25540000200271606},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.25279998779296875}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:iris.unil.ch:iris/106574","doi":null,"is_oa":true,"landing_page_url":"https://iris.unil.ch/handle/iris/106574","pdf_url":"https://iris.unil.ch/bitstreams/4a9a0cd9-c4dc-44df-8729-cb51aa2a3e13/download","source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},{"id":"pmh:oai:serval.unil.ch:BIB_6CA64A104A0D","doi":null,"is_oa":true,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_6CA64A104A0D","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/masterThesis"}],"best_oa_location":{"id":"pmh:oai:iris.unil.ch:iris/106574","doi":null,"is_oa":true,"landing_page_url":"https://iris.unil.ch/handle/iris/106574","pdf_url":"https://iris.unil.ch/bitstreams/4a9a0cd9-c4dc-44df-8729-cb51aa2a3e13/download","source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W6991734014.pdf","grobid_xml":"https://content.openalex.org/works/W6991734014.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4376871719","https://openalex.org/W4312564973","https://openalex.org/W3214132996","https://openalex.org/W2332292689","https://openalex.org/W4408280229","https://openalex.org/W2400314017","https://openalex.org/W4392852439","https://openalex.org/W2963580609","https://openalex.org/W7167462510","https://openalex.org/W4390496728"],"abstract_inverted_index":{"This":[0],"project":[1],"aims":[2],"to":[3,47,54,94,103],"determine":[4],"the":[5,9,13,29,35,49,60,71,105,116,134,148],"cellular":[6,106],"identity":[7,50,107],"of":[8,16,38,51,67,73,90,108,115,126,158,162],"immune":[10,91,109,150],"cells":[11,40,52,110],"composing":[12],"tumor":[14],"microenvironment":[15,151],"a":[17,84,159],"melanoma":[18,149],"mouse":[19,154],"model":[20,155],"using":[21],"single-cell":[22],"RNA-sequencing":[23],"(scRNA-seq).":[24],"The":[25,113],"recent":[26],"development":[27],"in":[28,101,111],"scRNA-seq":[30,68,143],"technology":[31],"has":[32,119,139],"now":[33],"made":[34],"full":[36,56],"transcriptome":[37],"individual":[39],"within":[41],"reach":[42],"and":[43,63,145,164],"therefore":[44],"enables":[45],"us":[46],"characterize":[48],"according":[53],"their":[55],"gene":[57,99,130],"expression.":[58],"However":[59],"substantial":[61],"stochasticity":[62],"high":[64],"dropout":[65],"rates":[66],"data":[69,144],"challenge":[70],"process":[72],"cell":[74,96,128,135],"type":[75,97,136],"identification.":[76],"To":[77],"overcome":[78],"these":[79],"limitations":[80],"I":[81],"apply":[82],"here":[83],"computational":[85],"approach":[86],"that":[87,147],"takes":[88],"advantages":[89],"transcriptomic":[92],"repositories":[93],"define":[95],"specific":[98],"markers":[100],"order":[102],"quantify":[104],"melanoma.":[112],"performance":[114],"identification":[117,137],"algorithm":[118,138],"been":[120,140],"first":[121],"tested":[122],"with":[123],"cross-validation":[124],"analysis":[125],"sorted":[127],"bulk":[129],"expression":[131],"profiles.":[132],"Then,":[133],"applied":[141],"on":[142],"revealed":[146],"from":[152],"our":[153],"is":[156],"composed":[157],"large":[160],"proportion":[161],"T":[163],"NK":[165],"cells.":[166]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}
