{"id":"https://openalex.org/W6991103510","doi":null,"title":"Ex vivo, in vitro and in silico characterization of human cardiac aging and its impact on Arrhythmic risk. Caracterizaci\u00f3n ex vivo, in vitro e in silico del envejecimiento cardiaco humano y su impacto en el riesgo arr\u00edtmico","display_name":"Ex vivo, in vitro and in silico characterization of human cardiac aging and its impact on Arrhythmic risk. Caracterizaci\u00f3n ex vivo, in vitro e in silico del envejecimiento cardiaco humano y su impacto en el riesgo arr\u00edtmico","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W6991103510"},"language":"es","primary_location":{"id":"pmh:oai:zaguan.unizar.es:145308","doi":null,"is_oa":true,"landing_page_url":"http://zaguan.unizar.es/record/145308","pdf_url":"https://zaguan.unizar.es/record/145308/files/TESIS-2024-463.pdf","source":{"id":"https://openalex.org/S4306402461","display_name":"Zaguan (Universidad de Zaragoza)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I255234318","host_organization_name":"Universidad de Zaragoza","host_organization_lineage":["https://openalex.org/I255234318"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://zaguan.unizar.es/record/145308/files/TESIS-2024-463.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077969656","display_name":"Laura Garc\u00eda\u2010Mend\u00edvil","orcid":"https://orcid.org/0000-0002-2954-1068","observed_orcids":["https://orcid.org/0000-0002-2954-1068"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Garc\u00eda Mend\u00edvil, Laura","raw_affiliation_strings":["Escuela de Doctorado Programa de Doctorado en Ingenier\u00eda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escuela de Doctorado Programa de Doctorado en Ingenier\u00eda","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065688490","display_name":"Esther Pueyo","orcid":"https://orcid.org/0000-0002-1960-407X","observed_orcids":["https://orcid.org/0000-0002-1960-407X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pueyo Paules, Esther","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5029658005","display_name":"Laura Ordov\u00e1s Vidal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ordov\u00e1s Vidal, Laura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-aging","display_name":"cardiac aging","score":0.9509999752044678},{"id":"https://openalex.org/keywords/arrhythmia-risk","display_name":"arrhythmia risk","score":0.7139999866485596},{"id":"https://openalex.org/keywords/sudden-cardiac-death","display_name":"sudden cardiac death","score":0.9290000200271606},{"id":"https://openalex.org/keywords/left-ventricle","display_name":"left ventricle","score":0.8640000224113464},{"id":"https://openalex.org/keywords/biological-age","display_name":"biological age","score":0.8080000281333923},{"id":"https://openalex.org/keywords/chronological-age","display_name":"chronological age","score":0.7900000214576721},{"id":"https://openalex.org/keywords/human-cardiac-tissue","display_name":"human cardiac tissue","score":0.3449999988079071},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.4790000021457672},{"id":"https://openalex.org/keywords/cardiomyocyte-senescence","display_name":"cardiomyocyte senescence","score":0.8429999947547913},{"id":"https://openalex.org/keywords/cardiomyocyte-heterogeneity","display_name":"cardiomyocyte heterogeneity","score":0.5329999923706055},{"id":"https://openalex.org/keywords/cardiomyocyte-proliferation","display_name":"cardiomyocyte proliferation","score":0.39500001072883606},{"id":"https://openalex.org/keywords/cardiomyocyte-differentiation","display_name":"cardiomyocyte differentiation","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.4106000065803528},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.31139999628067017},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.3093999922275543},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29910001158714294},{"id":"https://openalex.org/C3017819807","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Healthy aging","level":2,"score":0.28380000591278076},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27730000019073486},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27639999985694885},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.27489998936653137},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.26170000433921814},{"id":"https://openalex.org/C2983437453","wikidata":"https://www.wikidata.org/wiki/Q1072","display_name":"Human heart","level":2,"score":0.25380000472068787},{"id":"https://openalex.org/C3019207227","wikidata":"https://www.wikidata.org/wiki/Q10883614","display_name":"Human life","level":3,"score":0.24699999392032623},{"id":"https://openalex.org/C2987857752","wikidata":"https://www.wikidata.org/wiki/Q12147","display_name":"Human health","level":2,"score":0.21220000088214874},{"id":"https://openalex.org/C3018697994","wikidata":"https://www.wikidata.org/wiki/Q191089","display_name":"Elderly people","level":2,"score":0.19869999587535858},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.19120000302791595},{"id":"https://openalex.org/C2909947164","wikidata":"https://www.wikidata.org/wiki/Q6139748","display_name":"Premature aging","level":2,"score":0.17949999868869781},{"id":"https://openalex.org/C3020439559","wikidata":"https://www.wikidata.org/wiki/Q5","display_name":"Human being","level":3,"score":0.16099999845027924},{"id":"https://openalex.org/C2988540567","wikidata":"https://www.wikidata.org/wiki/Q12070446","display_name":"Model system","level":2,"score":0.1582999974489212},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.15129999816417694},{"id":"https://openalex.org/C2986834420","wikidata":"https://www.wikidata.org/wiki/Q5932254","display_name":"Age groups","level":2,"score":0.14249999821186066},{"id":"https://openalex.org/C2988516024","wikidata":"https://www.wikidata.org/wiki/Q441195","display_name":"Life span","level":2,"score":0.13979999721050262},{"id":"https://openalex.org/C2985445135","wikidata":"https://www.wikidata.org/wiki/Q13100823","display_name":"Life quality","level":2,"score":0.12919999659061432},{"id":"https://openalex.org/C2987742019","wikidata":"https://www.wikidata.org/wiki/Q11391","display_name":"Ultraviolet radiation","level":2,"score":0.1200999990105629},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.11240000277757645},{"id":"https://openalex.org/C2991733762","wikidata":"https://www.wikidata.org/wiki/Q82682","display_name":"Oxidation reduction","level":2,"score":0.11089999973773956},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.1103999987244606},{"id":"https://openalex.org/C3020610715","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medical science","level":2,"score":0.10980000346899033},{"id":"https://openalex.org/C3019892597","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Healthy ageing","level":3,"score":0.10980000346899033},{"id":"https://openalex.org/C3020255362","wikidata":"https://www.wikidata.org/wiki/Q747883","display_name":"Physical activity","level":2,"score":0.1096000000834465},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.10719999670982361},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.10429999977350235},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.10239999741315842},{"id":"https://openalex.org/C2779523775","wikidata":"https://www.wikidata.org/wiki/Q9075999","display_name":"Cellular senescence","level":4,"score":0.10140000283718109},{"id":"https://openalex.org/C2992708514","wikidata":"https://www.wikidata.org/wiki/Q48968323","display_name":"Quantitative biology","level":2,"score":0.09989999979734421},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.09939999878406525},{"id":"https://openalex.org/C2986104408","wikidata":"https://www.wikidata.org/wiki/Q179661","display_name":"Clinical treatment","level":2,"score":0.09889999777078629},{"id":"https://openalex.org/C2987190108","wikidata":"https://www.wikidata.org/wiki/Q925667","display_name":"Computational simulation","level":2,"score":0.09849999845027924},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.09830000251531601},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.09700000286102295},{"id":"https://openalex.org/C2984588014","wikidata":"https://www.wikidata.org/wiki/Q730675","display_name":"Quantitative assessment","level":2,"score":0.09669999778270721},{"id":"https://openalex.org/C2994204100","wikidata":"https://www.wikidata.org/wiki/Q5690942","display_name":"Sun exposure","level":2,"score":0.09669999778270721}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:zaguan.unizar.es:145308","doi":null,"is_oa":true,"landing_page_url":"http://zaguan.unizar.es/record/145308","pdf_url":"https://zaguan.unizar.es/record/145308/files/TESIS-2024-463.pdf","source":{"id":"https://openalex.org/S4306402461","display_name":"Zaguan (Universidad de Zaragoza)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I255234318","host_organization_name":"Universidad de Zaragoza","host_organization_lineage":["https://openalex.org/I255234318"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"}],"best_oa_location":{"id":"pmh:oai:zaguan.unizar.es:145308","doi":null,"is_oa":true,"landing_page_url":"http://zaguan.unizar.es/record/145308","pdf_url":"https://zaguan.unizar.es/record/145308/files/TESIS-2024-463.pdf","source":{"id":"https://openalex.org/S4306402461","display_name":"Zaguan (Universidad de Zaragoza)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I255234318","host_organization_name":"Universidad de Zaragoza","host_organization_lineage":["https://openalex.org/I255234318"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W6991103510.pdf","grobid_xml":"https://content.openalex.org/works/W6991103510.grobid-xml"},"referenced_works_count":386,"referenced_works":["https://openalex.org/W100934462","https://openalex.org/W150257603","https://openalex.org/W201521563","https://openalex.org/W934895593","https://openalex.org/W1485778651","https://openalex.org/W1510449384","https://openalex.org/W1523160355","https://openalex.org/W1533710382","https://openalex.org/W1538904872","https://openalex.org/W1540330830","https://openalex.org/W1562509057","https://openalex.org/W1581814476","https://openalex.org/W1593002915","https://openalex.org/W1604057945","https://openalex.org/W1605003779","https://openalex.org/W1607804102","https://openalex.org/W1747672433","https://openalex.org/W1768986764","https://openalex.org/W1810350704","https://openalex.org/W1889002087","https://openalex.org/W1891037876","https://openalex.org/W1898753515","https://openalex.org/W1911769041","https://openalex.org/W1965186696","https://openalex.org/W1965262464","https://openalex.org/W1966368662","https://openalex.org/W1967464880","https://openalex.org/W1968018974","https://openalex.org/W1968400996","https://openalex.org/W1969160861","https://openalex.org/W1969494129","https://openalex.org/W1969653234","https://openalex.org/W1969949090","https://openalex.org/W1971590660","https://openalex.org/W1971979813","https://openalex.org/W1972328139","https://openalex.org/W1973576889","https://openalex.org/W1973824606","https://openalex.org/W1974047233","https://openalex.org/W1974396693","https://openalex.org/W1974449792","https://openalex.org/W1975396085","https://openalex.org/W1976428272","https://openalex.org/W1976506286","https://openalex.org/W1976930285","https://openalex.org/W1977362098","https://openalex.org/W1977416023","https://openalex.org/W1977859104","https://openalex.org/W1978503253","https://openalex.org/W1979086153","https://openalex.org/W1979788386","https://openalex.org/W1980295643","https://openalex.org/W1980762813","https://openalex.org/W1981334514","https://openalex.org/W1982583532","https://openalex.org/W1983555611","https://openalex.org/W1984815851","https://openalex.org/W1985305462","https://openalex.org/W1985940938","https://openalex.org/W1986890635","https://openalex.org/W1987585151","https://openalex.org/W1989538619","https://openalex.org/W1990916340","https://openalex.org/W1991801094","https://openalex.org/W1992154841","https://openalex.org/W1993471474","https://openalex.org/W1994069214","https://openalex.org/W1995139426","https://openalex.org/W1998955714","https://openalex.org/W1999195342","https://openalex.org/W1999897159","https://openalex.org/W2000293915","https://openalex.org/W2003941221","https://openalex.org/W2006277797","https://openalex.org/W2010007998","https://openalex.org/W2010542201","https://openalex.org/W2011380505","https://openalex.org/W2012889350","https://openalex.org/W2013840481","https://openalex.org/W2016336169","https://openalex.org/W2017529721","https://openalex.org/W2018263065","https://openalex.org/W2018368975","https://openalex.org/W2018592311","https://openalex.org/W2019058917","https://openalex.org/W2023634656","https://openalex.org/W2030290211","https://openalex.org/W2030600914","https://openalex.org/W2031070609","https://openalex.org/W2032094196","https://openalex.org/W2032602706","https://openalex.org/W2034862301","https://openalex.org/W2036500346","https://openalex.org/W2037260153","https://openalex.org/W2037849727","https://openalex.org/W2038998835","https://openalex.org/W2041087432","https://openalex.org/W2041112929","https://openalex.org/W2042091538","https://openalex.org/W2042377388","https://openalex.org/W2042471279","https://openalex.org/W2044341880","https://openalex.org/W2044897807","https://openalex.org/W2047309639","https://openalex.org/W2047970481","https://openalex.org/W2048255936","https://openalex.org/W2049199904","https://openalex.org/W2049838934","https://openalex.org/W2049956841","https://openalex.org/W2050243734","https://openalex.org/W2050584392","https://openalex.org/W2050880607","https://openalex.org/W2052342903","https://openalex.org/W2053026053","https://openalex.org/W2055752231","https://openalex.org/W2056036909","https://openalex.org/W2058903192","https://openalex.org/W2059390518","https://openalex.org/W2060379181","https://openalex.org/W2061149068","https://openalex.org/W2061451182","https://openalex.org/W2062701917","https://openalex.org/W2063238401","https://openalex.org/W2063288946","https://openalex.org/W2064341415","https://openalex.org/W2064662817","https://openalex.org/W2066390373","https://openalex.org/W2066816830","https://openalex.org/W2067984643","https://openalex.org/W2070456203","https://openalex.org/W2071251073","https://openalex.org/W2072260252","https://openalex.org/W2073429636","https://openalex.org/W2073460054","https://openalex.org/W2073632869","https://openalex.org/W2073838741","https://openalex.org/W2075522000","https://openalex.org/W2076322865","https://openalex.org/W2076980156","https://openalex.org/W2077562802","https://openalex.org/W2077686023","https://openalex.org/W2081914422","https://openalex.org/W2082402714","https://openalex.org/W2082672875","https://openalex.org/W2082883714","https://openalex.org/W2083599207","https://openalex.org/W2084275033","https://openalex.org/W2085050235","https://openalex.org/W2085745662","https://openalex.org/W2085949935","https://openalex.org/W2088541033","https://openalex.org/W2090136057","https://openalex.org/W2090374150","https://openalex.org/W2090451215","https://openalex.org/W2091343613","https://openalex.org/W2092070193","https://openalex.org/W2092433968","https://openalex.org/W2092884443","https://openalex.org/W2094057283","https://openalex.org/W2096083625","https://openalex.org/W2096391100","https://openalex.org/W2098346778","https://openalex.org/W2099169137","https://openalex.org/W2099540110","https://openalex.org/W2101389618","https://openalex.org/W2101641414","https://openalex.org/W2102389881","https://openalex.org/W2103185389","https://openalex.org/W2104749146","https://openalex.org/W2104790299","https://openalex.org/W2105549148","https://openalex.org/W2106394784","https://openalex.org/W2106513436","https://openalex.org/W2107914045","https://openalex.org/W2108903695","https://openalex.org/W2109485370","https://openalex.org/W2111366557","https://openalex.org/W2115150337","https://openalex.org/W2115644752","https://openalex.org/W2115765852","https://openalex.org/W2117043336","https://openalex.org/W2117387411","https://openalex.org/W2118457257","https://openalex.org/W2120644107","https://openalex.org/W2121091193","https://openalex.org/W2121940740","https://openalex.org/W2122870737","https://openalex.org/W2123106337","https://openalex.org/W2125890475","https://openalex.org/W2125987139","https://openalex.org/W2126525177","https://openalex.org/W2126800086","https://openalex.org/W2127343541","https://openalex.org/W2127430952","https://openalex.org/W2127708563","https://openalex.org/W2128807350","https://openalex.org/W2129911237","https://openalex.org/W2130410032","https://openalex.org/W2131258412","https://openalex.org/W2131814958","https://openalex.org/W2131913960","https://openalex.org/W2133808555","https://openalex.org/W2134982681","https://openalex.org/W2138413381","https://openalex.org/W2138977668","https://openalex.org/W2139924285","https://openalex.org/W2140144738","https://openalex.org/W2140930678","https://openalex.org/W2142170772","https://openalex.org/W2142902382","https://openalex.org/W2144148024","https://openalex.org/W2144335262","https://openalex.org/W2146034808","https://openalex.org/W2146206232","https://openalex.org/W2146512944","https://openalex.org/W2147190151","https://openalex.org/W2147325352","https://openalex.org/W2147460924","https://openalex.org/W2148566367","https://openalex.org/W2148598424","https://openalex.org/W2148911867","https://openalex.org/W2152635048","https://openalex.org/W2154064433","https://openalex.org/W2155235762","https://openalex.org/W2159296038","https://openalex.org/W2160110517","https://openalex.org/W2161260472","https://openalex.org/W2163071496","https://openalex.org/W2163190102","https://openalex.org/W2163782497","https://openalex.org/W2163849426","https://openalex.org/W2163949420","https://openalex.org/W2164802216","https://openalex.org/W2165179483","https://openalex.org/W2167774643","https://openalex.org/W2169268511","https://openalex.org/W2169399243","https://openalex.org/W2170126521","https://openalex.org/W2170290057","https://openalex.org/W2170785868","https://openalex.org/W2171310378","https://openalex.org/W2171942713","https://openalex.org/W2172175673","https://openalex.org/W2173367702","https://openalex.org/W2176043226","https://openalex.org/W2178355441","https://openalex.org/W2179438025","https://openalex.org/W2280484610","https://openalex.org/W2289647240","https://openalex.org/W2291201176","https://openalex.org/W2300486115","https://openalex.org/W2318536322","https://openalex.org/W2321594851","https://openalex.org/W2324524302","https://openalex.org/W2328372803","https://openalex.org/W2340629483","https://openalex.org/W2342127666","https://openalex.org/W2346975891","https://openalex.org/W2357365910","https://openalex.org/W2363330678","https://openalex.org/W2395985699","https://openalex.org/W2397706209","https://openalex.org/W2410374774","https://openalex.org/W2437083546","https://openalex.org/W2462849184","https://openalex.org/W2468325590","https://openalex.org/W2510536171","https://openalex.org/W2524110715","https://openalex.org/W2555814565","https://openalex.org/W2571511532","https://openalex.org/W2583371454","https://openalex.org/W2587485759","https://openalex.org/W2596014457","https://openalex.org/W2599190942","https://openalex.org/W2606227689","https://openalex.org/W2606272480","https://openalex.org/W2606915822","https://openalex.org/W2616989237","https://openalex.org/W2617171469","https://openalex.org/W2620563284","https://openalex.org/W2623637581","https://openalex.org/W2729774234","https://openalex.org/W2743978568","https://openalex.org/W2748656499","https://openalex.org/W2749355267","https://openalex.org/W2749484562","https://openalex.org/W2757224515","https://openalex.org/W2758538841","https://openalex.org/W2759927322","https://openalex.org/W2765546416","https://openalex.org/W2775582148","https://openalex.org/W2787729717","https://openalex.org/W2790313400","https://openalex.org/W2794333713","https://openalex.org/W2794616878","https://openalex.org/W2797243013","https://openalex.org/W2797636268","https://openalex.org/W2798244438","https://openalex.org/W2801933430","https://openalex.org/W2802522067","https://openalex.org/W2803629855","https://openalex.org/W2809058317","https://openalex.org/W2869995163","https://openalex.org/W2884169738","https://openalex.org/W2884500308","https://openalex.org/W2888681013","https://openalex.org/W2889713233","https://openalex.org/W2891260646","https://openalex.org/W2892134972","https://openalex.org/W2897825874","https://openalex.org/W2899758630","https://openalex.org/W2900713795","https://openalex.org/W2901957853","https://openalex.org/W2907220995","https://openalex.org/W2912150594","https://openalex.org/W2912308947","https://openalex.org/W2913284769","https://openalex.org/W2917333786","https://openalex.org/W2918005975","https://openalex.org/W2920970965","https://openalex.org/W2925392792","https://openalex.org/W2930298293","https://openalex.org/W2931875016","https://openalex.org/W2945577827","https://openalex.org/W2946717857","https://openalex.org/W2947343895","https://openalex.org/W2952016771","https://openalex.org/W2967315965","https://openalex.org/W2967338832","https://openalex.org/W2967431677","https://openalex.org/W2974795043","https://openalex.org/W2983879864","https://openalex.org/W2994939802","https://openalex.org/W3001257633","https://openalex.org/W3008920100","https://openalex.org/W3010870651","https://openalex.org/W3012677677","https://openalex.org/W3014674295","https://openalex.org/W3019238719","https://openalex.org/W3020716964","https://openalex.org/W3022047361","https://openalex.org/W3026994248","https://openalex.org/W3027708159","https://openalex.org/W3028992072","https://openalex.org/W3035991087","https://openalex.org/W3038296507","https://openalex.org/W3039982086","https://openalex.org/W3040598213","https://openalex.org/W3044862312","https://openalex.org/W3045557308","https://openalex.org/W3045582016","https://openalex.org/W3082464276","https://openalex.org/W3084422373","https://openalex.org/W3086439315","https://openalex.org/W3088401235","https://openalex.org/W3092158408","https://openalex.org/W3100336543","https://openalex.org/W3101933813","https://openalex.org/W3105770287","https://openalex.org/W3108042503","https://openalex.org/W3121795081","https://openalex.org/W3127229298","https://openalex.org/W3128059144","https://openalex.org/W3135919486","https://openalex.org/W3158157267","https://openalex.org/W3160992829","https://openalex.org/W3167913052","https://openalex.org/W3168238292","https://openalex.org/W3191034371","https://openalex.org/W3207345586","https://openalex.org/W3209304539","https://openalex.org/W4210403786","https://openalex.org/W4210739579","https://openalex.org/W4224227877","https://openalex.org/W4226084107","https://openalex.org/W4231182105","https://openalex.org/W4244933903","https://openalex.org/W4246928383","https://openalex.org/W4247803213","https://openalex.org/W4280546587","https://openalex.org/W4283016888","https://openalex.org/W4285238517","https://openalex.org/W4310863239","https://openalex.org/W4313531093","https://openalex.org/W7098694755","https://openalex.org/W7099784222"],"related_works":["https://openalex.org/W7018907116","https://openalex.org/W4286379192","https://openalex.org/W4286228851","https://openalex.org/W7214786928","https://openalex.org/W7039306883","https://openalex.org/W3209152808","https://openalex.org/W2976488084","https://openalex.org/W2242358192","https://openalex.org/W4297900262","https://openalex.org/W2922105651"],"abstract_inverted_index":{"Las":[0],"enfermedades":[1],"cardiovasculares":[2],"(ECV)":[3],"son":[4,317],"la":[5,29,80,84,87,91,97,100,103,107,131,148,163,175,259,263,269,311,315,318,334,390,399,402,412,440,448,451,476,497,529,543,560,583,594,613,640,650,653,672,676,681,696,703,710,741,746,770,779,783,787,790,793,805,818,827,833,836,839,857,874,877,895,908,915,918,951,955,961,965,996,999,1001,1023,1047,1050,1067],"principal":[6,343],"causa":[7],"de":[8,16,23,37,41,43,49,89,96,102,114,117,126,137,177,189,199,243,246,254,265,291,293,295,333,344,387,411,420,427,432,442,453,465,531,542,553,556,562,597,603,639,680,705,709,740,745,756,761,769,789,804,809,826,832,848,856,873,879,894,907,917,931,950,954,960,985,1005,1027,1032,1049],"muerte":[9,30],"a":[10,28,61,79,142,147,162,218,268,324,439,540,637,649,795,824,852,854,940,1009,1074],"nivel":[11,808],"mundial.":[12],"Una":[13],"proporci\u00f3n":[14],"relevante":[15,729],"pacientes":[17],"con":[18,240,299,310,321,398,457,475,505,695,702,778,817,883,928,995],"ECV":[19],"desarrollan":[20],"arritmias,":[21],"algunas":[22],"las":[24,44,50,75,143,345,355,687,776,796,849,871],"cuales":[25],"pueden":[26],"conducir":[27],"cardiaca":[31],"s\u00fabita.":[32],"El":[33,383,525,624,798],"envejecimiento":[34,58,118,154,178,236,247,278,377,565,576,589,609,619,990,1033,1061,1076],"es":[35],"uno":[36],"los":[38,115,228,274,325,406,454,484,684,715,902,986,1010],"principales":[39],"factores":[40,211],"riesgo":[42,944,1004],"ECV,":[45],"en":[46,52,123,133,150,160,173,234,279,314,348,370,379,396,405,490,511,536,587,600,612,617,643,647,663,686,717,720,738,752,782,786,820,830,881,885,914,923,936,964,993,1015,1041],"general":[47],"y":[48,64,72,106,136,207,213,231,262,330,336,401,422,513,533,546,548,610,634,652,719,730,812,814,835,876,957,998,1017,1022,1025],"arritmias":[51,266,969,1006],"particular.":[53],"En":[54,838,976],"el":[55,57,94,153,186,235,241,252,280,286,331,349,371,376,380,418,491,506,537,564,588,618,628,644,660,669,723,734,766,802,821,1060],"coraz\u00f3n,":[56],"se":[59,82,120,156,359,459,500,658,749,843,934,967],"asocia":[60],"cambios":[62,437,611,685,1038],"moleculares":[63,230],"celulares":[65,232],"que":[66,170,215,375,447,479,508,563,582,593,775,900,911,966,1036,1064,1072],"acaban":[67],"provocando":[68],"un":[69,167,190,193,200,341,664,845,921,941,948,1028,1075],"remodelado":[70,95,332,629,735,803,846],"estructural":[71,206],"funcional.":[73],"Entre":[74],"alteraciones":[76,777],"cardiacas":[77],"asociadas":[78,146,267],"edad":[81,164,196,312,441,545,642,673,780,829],"encuentran":[83],"inestabilidad":[85],"gen\u00f3mica,":[86],"p\u00e9rdida":[88],"proteostasis,":[90],"senescencia":[92],"celular,":[93],"matriz":[98],"extracelular,":[99],"alteraci\u00f3n":[101],"comunicaci\u00f3n":[104],"intercelular":[105],"expresi\u00f3n":[108,319,413,530,554,595,614],"g\u00e9nica,":[109,320],"entre":[110,714,870],"otros.":[111],"La":[112,195,712],"mayor\u00eda":[113],"estudios":[116],"cardiaco":[119,155,237,248,577,590,991,1035,1062,1077],"han":[121,360,750,889],"realizado":[122],"modelos":[124,244,362,753,886,891],"animales,":[125],"limitado":[127],"valor":[128,724],"traslacional,":[129],"siendo":[130,338],"investigaci\u00f3n":[132,149,1051],"humanos":[134,721],"escasa":[135,693],"naturaleza":[138],"mayoritariamente":[139],"transversal":[140,389],"debido":[141],"limitaciones":[144],"inherentes":[145],"humanos.":[151,1042],"Adem\u00e1s,":[152,499,866,1043],"realiza":[157,659],"sobre":[158,227,483,1059],"todo":[159],"relaci\u00f3n":[161,397,648,694,816,994],"cronol\u00f3gica":[165],"(EC),":[166],"\u00edndice":[168],"temporal":[169,963],"no":[171,183,256,520,842,867],"tiene":[172,378],"cuenta":[174],"tasa":[176],"individual":[179],"y,":[180],"por":[181,472,488,496,515,568,861,864,947,970,973],"tanto,":[182,516],"explica":[184],"necesariamente":[185],"estado":[187,205],"biol\u00f3gico":[188],"individuo":[191],"o":[192,707],"\u00f3rgano.":[194],"biol\u00f3gica":[197],"(EB)":[198],"\u00f3rgano,":[201],"percibida":[202],"como":[203,353,408,424,727,785,933],"su":[204,433,815,924],"funcional":[208],"real,":[209],"comprende":[210],"gen\u00e9ticos":[212],"ambientales":[214],"act\u00faan":[216],"conjuntamente":[217],"lo":[219],"largo":[220],"del":[221,277,373,393,429,469,493,522,575,608,621,630,689,725,736,758,943,989,1003],"tiempo.":[222],"Un":[223],"conocimiento":[224,1058],"m\u00e1s":[225,445],"profundo":[226],"mecanismos":[229,307,486],"implicados":[233],"humano,":[238,249,1063],"junto":[239],"desarrollo":[242,253],"longitudinales":[245],"podr\u00edan":[250],"impulsar":[251],"herramientas":[255],"invasivas":[257],"para":[258,368,435,732,764,1055,1069],"detecci\u00f3n":[260],"precoz":[261],"prevenci\u00f3n":[264],"edad.":[270,498,711,742],"Esta":[271,415,579,772],"tesis":[272,316,416,580,773,979,1045],"investiga":[273],"rasgos":[275,606,987,1011],"distintivos":[276,607,988,1012],"ventr\u00edculo":[281],"izquierdo":[282],"(VI)":[283],"humano":[284,539,646,760,823,992],"mediante":[285],"an\u00e1lisis":[287,662],"molecular":[288],"e":[289,303,365,1053],"histol\u00f3gico":[290],"muestras":[292],"VI":[294,350,430,470,494,507,645,737,759,822],"donantes":[296],"vivos":[297],"combinado":[298],"metodolog\u00edas":[300],"in":[301,304,363,366,754,1030],"vitro":[302,364,1031],"silico.":[305],"Los":[306,743,905],"cardiacos":[308],"relacionados":[309,456,474,504,701],"estudiados":[313],"especial":[322],"atenci\u00f3n":[323],"miRNAs":[326,407,473,489],"(reguladores":[327],"pleiotr\u00f3picos":[328],"postranscripcionales)":[329],"fibrosis":[335,791,819],"CX43,":[337],"esta":[339,978,1044],"\u00faltima":[340],"componente":[342],"uniones":[346],"GAP":[347],"humano.":[351,382,623],"Tomando":[352],"base":[354,452,1068],"caracterizaciones":[356],"experimentales":[357],"realizadas,":[358],"creado":[361],"silico":[367,755],"avanzar":[369],"estudio":[372],"impacto":[374],"coraz\u00f3n":[381,622],"cap\u00edtulo":[384,526,625,799],"2":[385],"estudia":[386],"manera":[388,762],"din\u00e1mica":[391],"transcripcional":[392],"miocardio":[394,523,538],"envejecido":[395],"EC":[400,651,834,862,997],"EB,":[403],"centr\u00e1ndose":[404],"reguladores":[409],"clave":[410],"g\u00e9nica.":[414],"demuestra":[417,774,1046],"potencial":[419],"CDKN2A":[421],"AppAge":[423],"descriptores":[425],"transcript\u00f3micos":[426],"EB":[428,477],"adem\u00e1s":[431],"capacidad":[434],"revelar":[436],"asociados":[438],"una":[443,462,550,692,912,958,981],"forma":[444,656],"precisa":[446],"EC.":[449],"Sobre":[450],"resultados":[455,716,744,906],"CKDN2A,":[458],"ha":[460],"construido":[461,890],"red":[463],"bioinform\u00e1tica":[464],"regulaci\u00f3n":[466],"g\u00e9nica":[467,615],"espec\u00edfica":[468],"controlada":[471],"(BIO-AGEmiRNA)":[478],"proporciona":[480],"nuevos":[481],"conocimientos":[482],"posibles":[485,517],"regulados":[487],"deterioro":[492],"inducido":[495,567],"proponen":[501],"dos":[502],"BIO-AGEmiRNAs":[503],"est\u00e1n":[509,699],"presentes":[510],"plasma":[512],"son,":[514],"biomarcadores":[518],"sangu\u00edneos":[519],"invasivos":[521],"envejecido.":[524],"3":[527],"caracteriza":[528,549,801],"LMNA":[532,534,557,569,584,598],"\u039450":[535,558,570,585,599],"partir":[541,638,679,825,855],"mediana":[544,641,682,828,858],"desarrolla":[547],"l\u00ednea":[551],"hiPSC":[552,604],"inducible":[555,596],"bajo":[559],"hip\u00f3tesis":[561],"prematuro":[566],"puede":[571,1065],"recapitular":[572],"aspectos":[573],"fundamentales":[574],"natural.":[578],"descarta":[581],"intervenga":[586],"natural,":[591],"mientras":[592],"cardiomiocitos":[601],"derivados":[602],"recapitula":[605,1037],"observados":[616,1039],"fisiol\u00f3gico":[620],"4":[626],"analiza":[627],"col\u00e1geno":[631,690],"(cantidad,":[632],"agregaci\u00f3n":[633],"distribuci\u00f3n":[635],"espacial)":[636],"EB.":[654,837,865],"De":[655],"complementaria,":[657],"mismo":[661],"modelo":[665,728,1029],"animal":[666],"cl\u00ednicamente":[667],"relevante,":[668],"cerdo,":[670],"desde":[671],"adulta":[674],"hasta":[675],"vejez.":[677],"A":[678],"edad,":[683,859],"caracter\u00edsticas":[688,850,872],"muestran":[691,910],"EC,":[697],"pero":[698],"estrechamente":[700],"cantidad":[704,784,916],"lipofuscina":[706],"pigmento":[708],"consistencia":[713],"cerdos":[718],"destaca":[722],"cerdo":[726],"traslacional":[731],"estudiar":[733],"funci\u00f3n":[739,831],"caracterizaci\u00f3n":[747,982,1026],"experimental":[748,983],"integrado":[751],"electrofisiolog\u00eda":[757],"paciente-espec\u00edfica":[763],"evaluar":[765],"efecto":[767],"arr\u00edtmico":[768],"fibrosis.":[771],"tanto":[781],"organizaci\u00f3n":[788],"aumentan":[792],"vulnerabilidad":[794],"arritmias.":[797],"5":[800],"CX43":[806,853,875,919],"(contenido,":[807],"expresi\u00f3n,":[810],"heterogeneidad":[811,925],"lateralizaci\u00f3n)":[813],"poblaci\u00f3n":[840],"analizada,":[841],"observa":[844],"significativo":[847],"relativas":[851],"ni":[860,863],"existe":[868],"correlaci\u00f3n":[869],"deposici\u00f3n":[878],"fibrosis,":[880,932],"contraste":[882],"observaciones":[884],"animales.":[887],"Se":[888],"tisulares":[892],"computacionales":[893,1019],"actividad":[896],"el\u00e9ctrica":[897],"ventricular":[898],"humana,":[899],"representan":[901],"datos":[903],"obtenidos.":[904],"simulaci\u00f3n":[909],"reducci\u00f3n":[913],"y/o":[920],"incremento":[922,949],"espacial":[926,953],"combinados":[927],"mayores":[929],"niveles":[930],"cuantifica":[935],"algunos":[937],"individuos,":[938],"conducen":[939],"aumento":[942],"proarr\u00edtmico":[945],"determinado":[946],"dispersi\u00f3n":[952],"repolarizaci\u00f3n":[956],"ampliaci\u00f3n":[959],"ventana":[962],"producen":[968],"reentrada":[971],"desencadenadas":[972],"latidos":[974],"prematuros.":[975],"conclusi\u00f3n,":[977],"aporta":[980],"exhaustiva":[984],"EB;":[1000],"cuantificaci\u00f3n":[1002],"ventriculares":[1007],"asociado":[1008],"analizados,":[1013],"basada":[1014],"modelizaciones":[1016],"simulaciones":[1018],"biof\u00edsicamente":[1020],"detalladas;":[1021],"creaci\u00f3n":[1024],"celular":[1034],"experimentalmente":[1040],"importancia":[1048],"interdisciplinar":[1052],"integradora":[1054],"generar":[1056],"nuevo":[1057],"ser":[1066],"futuras":[1070],"estrategias":[1071],"lleven":[1073],"saludable.":[1078]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}
