{"id":"https://openalex.org/W6990597489","doi":null,"title":"Efeito antinociceptivo de Ocimum gratissimum L. e seus princ\u00edpios ativos isolados em um modelo de dor neurop\u00e1tica em camundongos.","display_name":"Efeito antinociceptivo de Ocimum gratissimum L. e seus princ\u00edpios ativos isolados em um modelo de dor neurop\u00e1tica em camundongos.","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W6990597489"},"language":"pt","primary_location":{"id":"pmh:oai:americanae.aecid.es:3196317","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.unifesp.br/handle/11600/22721","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UNIFESP","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://repositorio.unifesp.br/handle/11600/22721","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053825038","display_name":"Lyvia Izaura Gomes de Paula-Freire","orcid":"https://orcid.org/0000-0002-2063-7346","observed_orcids":["https://orcid.org/0000-0002-2063-7346"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Paula-Freire, Lyvia Izaura Gomes de [UNIFESP]","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5053825038"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.5806000232696533,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.5806000232696533,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.3935999870300293,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ocimum-gratissimum","display_name":"Ocimum gratissimum","score":0.9980000257492065},{"id":"https://openalex.org/keywords/antinociceptive-activity","display_name":"antinociceptive activity","score":0.7670000195503235},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.8859999775886536},{"id":"https://openalex.org/keywords/essential-oils","display_name":"essential oils","score":0.8600000143051147},{"id":"https://openalex.org/keywords/eugenol","display_name":"eugenol","score":0.984000027179718},{"id":"https://openalex.org/keywords/beta-caryophyllene","display_name":"\u03b2-caryophyllene","score":0.8960000276565552},{"id":"https://openalex.org/keywords/myrcene","display_name":"myrcene","score":0.9539999961853027},{"id":"https://openalex.org/keywords/chronic-constriction-injury","display_name":"chronic constriction injury","score":0.8090000152587891},{"id":"https://openalex.org/keywords/sciatic-nerve","display_name":"sciatic nerve","score":0.5870000123977661},{"id":"https://openalex.org/keywords/hot-plate-test","display_name":"hot plate test","score":0.6039999723434448},{"id":"https://openalex.org/keywords/formalin-test","display_name":"formalin test","score":0.9760000109672546},{"id":"https://openalex.org/keywords/paw-withdrawal-latency","display_name":"paw withdrawal latency","score":0.35899999737739563},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.6359999775886536},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.4659999907016754},{"id":"https://openalex.org/keywords/isolated-organ-perfusion","display_name":"isolated organ perfusion","score":0.41100001335144043},{"id":"https://openalex.org/keywords/isolated-perfused-brain","display_name":"isolated perfused brain","score":0.3479999899864197},{"id":"https://openalex.org/keywords/langendorff-preparation","display_name":"isolated perfused heart","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5184000134468079},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32260000705718994},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27889999747276306},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.26899999380111694},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26010000705718994},{"id":"https://openalex.org/C2780962921","wikidata":"https://www.wikidata.org/wiki/Q2355390","display_name":"Ocimum gratissimum","level":2,"score":0.2425999939441681},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.21699999272823334},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.20389999449253082},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.19449999928474426},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.18870000541210175}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:americanae.aecid.es:3196317","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.unifesp.br/handle/11600/22721","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UNIFESP","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:repositorio.unifesp.br:11600/22721","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.unifesp.br/handle/11600/22721","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UNIFESP","raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:3196317","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.unifesp.br/handle/11600/22721","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UNIFESP","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2265155464","https://openalex.org/W2101081308","https://openalex.org/W2901831248","https://openalex.org/W7064368860","https://openalex.org/W2146170381","https://openalex.org/W7097762054","https://openalex.org/W7119394131","https://openalex.org/W4313421920","https://openalex.org/W1996059978","https://openalex.org/W7019104620"],"abstract_inverted_index":{"A":[0,431],"planta":[1,295,437],"Ocimum":[2,27],"gratissimum":[3,28],"L.":[4],"e":[5,30,37,71,79,106,117,127,138,149,263,275,288,296,300,408,421,457],"muito":[6],"utilizada":[7],"na":[8,113,246,261],"medicina":[9],"popular":[10],"para":[11,75,144,209,224,323,343],"tratar":[12],"condicoes":[13],"dolorosas.":[14],"Assim,":[15],"o":[16,109,239,284,325,334,345,364,383,406,423,441],"presente":[17],"estudo":[18],"avaliou":[19],"a":[20,77,146,222,234,257,272,353,444],"atividade":[21,414,434],"antihipernociceptiva":[22],"do":[23,50,136,266,291,336,341,349,355],"oleo":[24,159,292],"essencial":[25,293],"de":[26,41,101,115,131,160,166,175,186,198,281,308,328,347,391,404,418,428,433,446,461],"(OEOg)":[29],"seus":[31,409,455,458],"principios":[32,304,410],"ativos":[33,305,411],"isolados":[34,412],"(eugenol,":[35],"trans-cariofileno":[36,97,193],"mirceno)":[38],"no":[39,133,312,450],"modelo":[40],"dor":[42,170,179,258,273,282,419,429],"neuropatica":[43,180],"induzida":[44],"pela":[45],"injuria":[46],"por":[47,155],"constricao":[48],"cronica":[49],"nervo":[51],"ciatico.":[52],"Para":[53],"todos":[54,213],"os":[55,81,151,214,225,400],"experimentos":[56,322],"realizados":[57],"foram":[58,73,89,153,217,253,306],"utilizados":[59],"camundongos":[60,152],"machos":[61],"adultos":[62],"da":[63,206,244,294,402,436],"linhagem":[64],"C57BL/6J.":[65],"Testes":[66],"preliminares,":[67],"como":[68,251],"triagem":[69],"farmacologica":[70],"rota-rod":[72],"feitos":[74],"direcionar":[76],"pesquisa":[78],"determinar":[80],"efeitos":[82],"adversos":[83],"das":[84,122,330],"substancias":[85,249],"testadas.":[86],"Poucas":[87],"alteracoes":[88,103,139],"observadas":[90],"nesses":[91],"testes.":[92],"Os":[93,321,339],"animais":[94,226,260],"tratados":[95,154],"com":[96,158,238,286,399],"apresentaram":[98],"poucos":[99],"indicios":[100],"toxicidade,como":[102],"comportamentais,":[104],"bioquimicas":[105],"histopatologicas.":[107],"Ja":[108],"mirceno,":[110],"quando":[111,236],"administrado":[112],"dose":[114],"250":[116],"500":[118],"mg/kg,":[119,191],"promoveu":[120],"aumento":[121,132],"enzimas":[123],"hepaticas":[124],"aspartato":[125],"aminotransferase":[126],"alanina":[128],"aminotransferase,":[129],"alem":[130],"peso":[134],"relativo":[135],"figado":[137],"morfologicas":[140],"hepaticas.":[141],"Nos":[142],"testes":[143,280,427],"averiguar":[145],"antinocicepcao":[147],"aguda":[148,420],"cronica,":[150],"via":[156,358],"oral":[157],"milho":[161],"(grupo":[162],"controle),":[163],"5":[164,200,299],"mg/kg":[165,174,290,302],"morfina":[167],"(controle":[168,177],"positivo":[169,178],"aguda-":[171],"ip),":[172,182],"20":[173,188,287],"pregabalina":[176],"u":[181],"OEOg":[183,407],"nas":[184,196],"doses":[185,197,298],"10,":[187],"ou":[189,194,201],"40":[190,289],"eugenol,":[192],"mirceno":[195],"1,":[199],"10":[202,301],"mg/kg.":[203],"No":[204,242],"teste":[205,243,313,342],"placa":[207],"quente,":[208],"avaliar":[210],"limiar":[211],"nociceptivo,":[212],"xenobioticos":[215],"testados":[216],"eficazes":[218],"em":[219,255,416],"aumentar":[220],"significativamente":[221],"latencia":[223],"lamberem":[227],"a(s)":[228],"pata(s),":[229],"mesmo":[230],"4":[231],"horas":[232],"apos":[233],"administracao,":[235],"comparados":[237],"grupo":[240],"controle.":[241],"formalina":[245],"pata,":[247],"as":[248,297],"utilizadas":[250],"tratamento":[252,285],"efetivas":[254],"minimizar":[256],"dos":[259,303],"primeira":[262],"segunda":[264],"fase":[265],"teste,":[267],"mostrando":[268],"efeito":[269,365,375,384,424],"benefico":[270],"contra":[271],"neurogenica":[274],"inflamatoria.":[276],"Com":[277],"relacao":[278],"aos":[279,454],"neuropatica,":[283],"capazes":[307],"promover":[309],"antihipernocicepcao,":[310],"tanto":[311],"mecanico":[314],"(von":[315],"Frey)":[316],"quanto":[317],"termico":[318],"(placa":[319],"quente).":[320],"investigar":[324],"possivel":[326],"mecanismo":[327,346],"acao":[329,348,462],"drogas":[331],"testadas":[332],"indicaram":[333],"envolvimento":[335],"sistema":[337,356],"opioide.":[338],"dados":[340],"elucidar":[344],"transcariofileno":[350],"tambem":[351,387],"comprovaram":[352],"participacao":[354],"canabinoide":[357],"receptor":[359],"CB2,":[360],"uma":[361],"vez":[362],"que":[363,382,405,442,451],"foi":[366],"revertido":[367],"pelo":[368],"antagonista":[369,379],"CB2":[370],"JWH-015.":[371],"O":[372],"eugenol":[373],"apresentou":[374],"antihipernociceptivo":[376,425],"equivalente":[377],"ao":[378,389],"TRPV1,(SB366791),":[380],"sugerindo":[381],"antinociceptivo":[385],"seja":[386],"devido":[388],"bloqueio":[390],"receptores":[392],"vaniloides.":[393],"Em":[394],"sintese,":[395],"nossos":[396],"achados":[397],"corroboram":[398],"relatos":[401],"literatura":[403],"possuem":[413],"antinociceptiva":[415],"modelos":[417],"comprovam":[422],"nos":[426],"neuropatica.":[430],"presenca":[432],"biologica":[435],"justifica":[438],"ouso":[439],"popular,":[440],"incentiva":[443],"realizacao":[445],"outros":[447],"estudos,":[448],"principalmente":[449],"diz":[452],"respeito":[453],"constituintes":[456],"respectivos":[459],"mecanismos":[460]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}