{"id":"https://openalex.org/W6989388483","doi":null,"title":"Aufkl\u00e4rung der Strukturen und Mechanismen von gro\u00dfen nicht-kanonischen Cullin-RING-Ligasen","display_name":"Aufkl\u00e4rung der Strukturen und Mechanismen von gro\u00dfen nicht-kanonischen Cullin-RING-Ligasen","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W6989388483"},"language":"en","primary_location":{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-035587107","doi":null,"is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/?id=1735958","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Hochschulschrift"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://nbn-resolving.de/urn:nbn:de:bvb:91-diss-20240408-1735958-1-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040692380","display_name":"Linus V. M. Hopf","orcid":"https://orcid.org/0000-0002-4372-694X","observed_orcids":["https://orcid.org/0000-0002-4372-694X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hopf, Linus Valentin Moritz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Brenda A. Schulman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Schulman, Brenda A. 1967-","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Technische Universit\u00e4t M\u00fcnchen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Technische Universit\u00e4t M\u00fcnchen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cul7","display_name":"CUL7","score":0.9589999914169312},{"id":"https://openalex.org/keywords/substrate-receptor","display_name":"substrate receptor","score":0.7360000014305115},{"id":"https://openalex.org/keywords/f-box-protein","display_name":"F-box protein","score":0.7799999713897705},{"id":"https://openalex.org/keywords/hexameric-assembly","display_name":"hexameric assembly","score":0.6690000295639038},{"id":"https://openalex.org/keywords/protein-complex-structure","display_name":"protein complex structure","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.8357999920845032},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.7077000141143799},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5827999711036682},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45750001072883606},{"id":"https://openalex.org/C2908868211","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin-Protein Ligases","level":5,"score":0.44620001316070557},{"id":"https://openalex.org/C2994592520","wikidata":"https://www.wikidata.org/wiki/Q5090496","display_name":"Substrate specificity","level":3,"score":0.4422999918460846},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.4178999960422516},{"id":"https://openalex.org/C175114707","wikidata":"https://www.wikidata.org/wiki/Q408483","display_name":"DNA ligase","level":3,"score":0.3774000108242035},{"id":"https://openalex.org/C2988375501","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein stability","level":2,"score":0.35850000381469727},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3580000102519989},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3549000024795532},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.28690001368522644},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.28049999475479126},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.2581000030040741}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-035587107","doi":null,"is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/?id=1735958","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Hochschulschrift"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1735958","doi":null,"is_oa":true,"landing_page_url":"http://nbn-resolving.de/urn:nbn:de:bvb:91-diss-20240408-1735958-1-7","pdf_url":null,"source":{"id":"https://openalex.org/S4306400453","display_name":"mediaTUM \u2013 the media and publications repository of the Technical University Munich (Technical University Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"thesis"}],"best_oa_location":{"id":"pmh:oai:mediatum.ub.tum.de:node/1735958","doi":null,"is_oa":true,"landing_page_url":"http://nbn-resolving.de/urn:nbn:de:bvb:91-diss-20240408-1735958-1-7","pdf_url":null,"source":{"id":"https://openalex.org/S4306400453","display_name":"mediaTUM \u2013 the media and publications repository of the Technical University Munich (Technical University Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7018874573","https://openalex.org/W2029890158","https://openalex.org/W2998201645","https://openalex.org/W4394718269","https://openalex.org/W4292223715","https://openalex.org/W596614133","https://openalex.org/W2791274892","https://openalex.org/W2033380235","https://openalex.org/W2744058451","https://openalex.org/W2624244777"],"abstract_inverted_index":{"This":[0],"study":[1],"elucidates":[2],"structures":[3],"and":[4,19,38,67],"mechanisms":[5],"of":[6],"complexes":[7],"formed":[8],"by":[9],"the":[10,39,46],"two":[11,62],"non-canonical":[12],"cullin-RING":[13],"ubiquitin":[14],"E3":[15,63],"ligases":[16],"(CRLs),":[17],"CUL7":[18,21,33],"CUL9.":[20],"forms":[22,54],"a":[23,55,75],"unique":[24],"CRL":[25],"E3-E3":[26,82],"assembly":[27,59],"that":[28,60],"inverts":[29],"classic":[30],"roles,":[31],"with":[32],"acting":[34],"as":[35,42],"substrate":[36,85],"receptor":[37],"F-box":[40],"protein":[41],"adaptor,":[43],"linking":[44],"to":[45],"catalytical":[47],"CUL1-RBX1":[48],"complex,":[49],"mediating":[50],"TP53":[51],"ubiquitylation.":[52,86],"CUL9":[53],"1.8":[56],"MDa":[57],"hexameric":[58],"unifies":[61],"ligase":[64],"classes":[65],"(cullin-RING":[66],"RBR)":[68],"in":[69],"one":[70],"complex.":[71],"Our":[72],"studies":[73],"opened":[74],"new":[76],"chapter":[77],"on":[78],"how":[79],"CRLs":[80],"use":[81],"super-assemblies":[83],"for":[84]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}
