{"id":"https://openalex.org/W6989313742","doi":null,"title":"Antimicrobial peptides: promising molecules for the treatment of biofilm-associated infections.","display_name":"Antimicrobial peptides: promising molecules for the treatment of biofilm-associated infections.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W6989313742"},"language":"en","primary_location":{"id":"pmh:oai:arpi.unipi.it:11568/753837","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11568/753837","pdf_url":"http://www.newmicrobiologica.org/PUB/allegati_pdf/2014/3/vol47_supplement1.pdf","source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.newmicrobiologica.org/PUB/allegati_pdf/2014/3/vol47_supplement1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066705302","display_name":"Giovanna Batoni","orcid":"https://orcid.org/0000-0002-4448-2385","observed_orcids":["https://orcid.org/0000-0002-4448-2385"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"BATONI, GIOVANNA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031085787","display_name":"Giuseppantonio Maisetta","orcid":"https://orcid.org/0000-0001-8043-9029","observed_orcids":["https://orcid.org/0000-0001-8043-9029"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MAISETTA, GIUSEPPANTONIO","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017175565","display_name":"Stefania Sandreschi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"SANDRESCHI, STEFANIA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"PIRAS, ANNA MARIA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"PIRAS, ANNA MARIA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"CHIELLINI, FEDERICA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"CHIELLINI, FEDERICA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010162843","display_name":"Semih Esin","orcid":"https://orcid.org/0000-0002-4358-5294","observed_orcids":["https://orcid.org/0000-0002-4358-5294"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ESIN, SEMIH","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055721343","display_name":"Mariagrazia Di Luca","orcid":"https://orcid.org/0000-0002-0688-034X","observed_orcids":["https://orcid.org/0000-0002-0688-034X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Di Luca, Mariagrazia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5069198387","display_name":"Giuseppe Maccari","orcid":"https://orcid.org/0000-0002-2894-3583","observed_orcids":["https://orcid.org/0000-0002-2894-3583"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maccari, Giuseppe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.07349999994039536,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":1.0},{"id":"https://openalex.org/keywords/biofilm-associated-infections","display_name":"biofilm-associated infections","score":0.8130000233650208},{"id":"https://openalex.org/keywords/antibiofilm-activity","display_name":"antibiofilm activity","score":0.9850000143051147},{"id":"https://openalex.org/keywords/biofilm-inhibition","display_name":"biofilm inhibition","score":0.8299999833106995},{"id":"https://openalex.org/keywords/biofilm-eradication","display_name":"biofilm eradication","score":0.8330000042915344},{"id":"https://openalex.org/keywords/chitosan-nanoparticles","display_name":"chitosan nanoparticles","score":0.6650000214576721},{"id":"https://openalex.org/keywords/controlled-release","display_name":"controlled release","score":0.5550000071525574},{"id":"https://openalex.org/keywords/peptide-encapsulation","display_name":"peptide encapsulation","score":0.6880000233650208},{"id":"https://openalex.org/keywords/gram-positive-bacteria","display_name":"Gram-positive bacteria","score":0.6050000190734863},{"id":"https://openalex.org/keywords/gram-negative-bacteria","display_name":"Gram-negative bacteria","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antimicrobial-resistance","display_name":"antimicrobial resistance","score":0.5889999866485596},{"id":"https://openalex.org/keywords/peptide-design","display_name":"peptide design","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.9868000149726868},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.8026000261306763},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.722599983215332},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.5558000206947327},{"id":"https://openalex.org/C2776020440","wikidata":"https://www.wikidata.org/wiki/Q420705","display_name":"Crystal violet","level":2,"score":0.5074999928474426},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4575999975204468},{"id":"https://openalex.org/C129968341","wikidata":"https://www.wikidata.org/wiki/Q1385446","display_name":"Extracellular polymeric substance","level":4,"score":0.40400001406669617},{"id":"https://openalex.org/C121587506","wikidata":"https://www.wikidata.org/wiki/Q6888113","display_name":"Mode of action","level":2,"score":0.3977000117301941},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39750000834465027},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.3693999946117401},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.34790000319480896},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.34549999237060547},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.32580000162124634},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.31929999589920044},{"id":"https://openalex.org/C2908569021","wikidata":"https://www.wikidata.org/wiki/Q2896740","display_name":"Anti-Infective Agents","level":3,"score":0.2955000102519989},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.2847000062465668},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.27219998836517334},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.27140000462532043},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.25780001282691956},{"id":"https://openalex.org/C24527192","wikidata":"https://www.wikidata.org/wiki/Q17149729","display_name":"Human pathogen","level":3,"score":0.2248000055551529},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2125999927520752},{"id":"https://openalex.org/C2993927895","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolic activity","level":2,"score":0.2117999941110611},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.20819999277591705},{"id":"https://openalex.org/C132215390","wikidata":"https://www.wikidata.org/wiki/Q461335","display_name":"Abiotic component","level":2,"score":0.20819999277591705},{"id":"https://openalex.org/C2778487471","wikidata":"https://www.wikidata.org/wiki/Q19903319","display_name":"Antimicrobial chemotherapy","level":3,"score":0.19920000433921814},{"id":"https://openalex.org/C118687296","wikidata":"https://www.wikidata.org/wiki/Q905754","display_name":"Quorum sensing","level":4,"score":0.1973000019788742},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.18930000066757202},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.188400000333786},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.18129999935626984},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.18000000715255737},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17389999330043793},{"id":"https://openalex.org/C2986762682","wikidata":"https://www.wikidata.org/wiki/Q964754","display_name":"Basic research","level":2,"score":0.17350000143051147},{"id":"https://openalex.org/C136622501","wikidata":"https://www.wikidata.org/wiki/Q6934671","display_name":"Multidrug tolerance","level":4,"score":0.1712999939918518},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.17110000550746918},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.17020000517368317},{"id":"https://openalex.org/C2777379352","wikidata":"https://www.wikidata.org/wiki/Q24739493","display_name":"Cathelicidin","level":4,"score":0.16760000586509705},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.164000004529953},{"id":"https://openalex.org/C2776102837","wikidata":"https://www.wikidata.org/wiki/Q3132229","display_name":"Surfactin","level":4,"score":0.16110000014305115},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.15700000524520874},{"id":"https://openalex.org/C168831097","wikidata":"https://www.wikidata.org/wiki/Q413248","display_name":"Depsipeptide","level":2,"score":0.155799999833107}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:arpi.unipi.it:11568/753837","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11568/753837","pdf_url":"http://www.newmicrobiologica.org/PUB/allegati_pdf/2014/3/vol47_supplement1.pdf","source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:arpi.unipi.it:11568/753837","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11568/753837","pdf_url":"http://www.newmicrobiologica.org/PUB/allegati_pdf/2014/3/vol47_supplement1.pdf","source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320326078","display_name":"Regione Lombardia","ror":"https://ror.org/020dw9k11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W6989313742.pdf","grobid_xml":"https://content.openalex.org/works/W6989313742.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1661293674","https://openalex.org/W2573406198","https://openalex.org/W1779541940","https://openalex.org/W2149561566","https://openalex.org/W3017832761","https://openalex.org/W2637225027","https://openalex.org/W4367844663","https://openalex.org/W2774385845","https://openalex.org/W2152142388","https://openalex.org/W3048244000"],"abstract_inverted_index":{"Introduction:":[0],"Biofilms":[1],"are":[2,71,120],"complex":[3],"bacterial":[4],"communities":[5],"living":[6],"attached":[7],"to":[8,34,48,74,91,143,148,192,223],"biotic":[9],"or":[10,135,147,169,203,220],"abiotic":[11],"surfaces":[12],"and":[13,45,50,85,119,130,179,208,272,281,313,316,342,359],"embedded":[14],"in":[15,41,53,66,122,276,277,291,340],"a":[16,30,228,258,305,327,333,353],"self-produced":[17],"extracellular":[18],"matrix.":[19],"It":[20],"is":[21,61,304,321],"now":[22],"clear":[23],"that":[24],"biofilm":[25,59,82,145,158,164,194,199,240,252],"formation":[26,146,195,241],"may":[27],"account":[28],"for":[29,95,140,356],"large":[31],"majority":[32],"(up":[33],"80%)":[35],"of":[36,58,69,79,89,98,103,200,206,232,247,254,257,268,294,301,318],"infections":[37,60,84],"treated":[38],"by":[39,156,170,332],"physicians":[40],"the":[42,86,96,109,251,269,292],"developed":[43,331],"world":[44],"contributes":[46],"significantly":[47],"morbidity":[49],"mortality":[51],"especially":[52],"hospital":[54],"settings.":[55],"The":[56,77],"treatment":[57],"particularly":[62],"challenging,":[63],"as":[64,125,296],"cells":[65],"this":[67,106,325],"mode":[68,253],"growth":[70],"intrinsically":[72],"refractory":[73],"antimicrobial":[75,112,181],"drugs.":[76,128],"difficulty":[78],"successfully":[80],"treating":[81],"associated":[83],"increasing":[87],"resistance":[88],"microbes":[90],"traditional":[92],"treatments":[93],"call":[94],"discovery":[97,315],"compounds":[99,182],"with":[100],"novel":[101],"mechanisms":[102,246],"action.":[104,234],"In":[105,235,283,324],"regard,":[107],"over":[108],"last":[110],"years,":[111,285],"peptides":[113,212,238,320],"(AMPs)":[114],"have":[115,189],"attracted":[116],"considerable":[117],"interest":[118,290],"taken":[121],"increasingly":[123],"consideration":[124],"new":[126,319,328],"antibiofilm":[127,215,233,297],"\\nMaterials":[129],"Methods:":[131],"AMPs":[132,178,188,295,346],"from":[133,336],"humans":[134],"frog":[136],"skin":[137],"were":[138,183],"tested":[139,347],"their":[141,214,224],"ability":[142,191],"inhibit":[144,193],"eradicate":[149,197],"preformed":[150,198],"biofilms.":[151],"Antibiofilm":[152],"activity":[153,216,275,303],"was":[154],"assessed":[155],"evaluating":[157],"biomass":[159],"(by":[160,166],"crystal":[161],"violet":[162],"\\nstaining)":[163],"architecture":[165],"confocal":[167],"microscopy)":[168],"counting":[171],"biofilm-associated":[172],"viable":[173],"cells.":[174],"Synergy":[175],"studies":[176],"between":[177],"other":[180,237],"also":[184],"performed.":[185],"\\nResults:":[186],"Different":[187],"shown":[190],"and/or":[196],"clinical":[201],"isolates":[202],"laboratory":[204],"strains":[205],"Gram-positive":[207],"Gram-negative":[209],"bacteria.":[210],"Some":[211],"exerted":[213],"at":[217,242,309],"concentrations":[218],"equal":[219],"very":[221],"close":[222],"MIC":[225],"values,":[226],"indicating":[227],"classical":[229],"bactericidal":[230],"mechanism":[231],"contrast,":[236],"inhibited":[239],"sub-MIC":[243],"values":[244],"suggesting":[245],"action":[248],"specifically":[249],"targeting":[250],"growth.":[255],"Encapsulation":[256],"model":[259],"peptide":[260,357],"into":[261],"chitosan":[262],"nanoparticles":[263],"demonstrated":[264],"linear":[265],"releasing":[266],"kinetics":[267],"loaded":[270],"molecule":[271],"prolonged":[273],"antibacterial":[274],"vitro":[278],"models.":[279],"\\nDiscussion":[280],"Conclusions:":[282],"recent":[284],"there":[286],"has":[287],"been":[288],"increased":[289],"use":[293],"molecules.":[298],"Nevertheless,":[299],"optimization":[300,358],"AMP-antibiofilm":[302],"research":[306,338],"area":[307],"still":[308],"an":[310],"early":[311],"stage":[312],"intensive":[314],"design":[317],"highly":[322],"desirable.":[323],"regards,":[326],"database":[329],"recently":[330],"collaborative":[334],"work":[335],"different":[337],"institutions":[339],"Pisa,":[341],"fully":[343],"dedicated":[344],"on":[345,348],"microbial":[349],"biofilms,":[350],"will":[351,360],"represent":[352],"valid":[354],"tool":[355],"be":[361],"briefly":[362],"presented.":[363]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}