{"id":"https://openalex.org/W6989263106","doi":null,"title":"Analysis of genomewide expression profiles of thyroid tumors and of their in vitro models","display_name":"Analysis of genomewide expression profiles of thyroid tumors and of their in vitro models","publication_year":2009,"publication_date":"2009-05-18","ids":{"openalex":"https://openalex.org/W6989263106"},"language":"en","primary_location":{"id":"pmh:oai:dipot.ulb.ac.be:2013/210296","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210296","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210296","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Weiss, David","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Weiss, David","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-tumors","display_name":"thyroid tumors","score":0.9900000095367432},{"id":"https://openalex.org/keywords/gene-expression-profiles","display_name":"gene expression profiles","score":0.75},{"id":"https://openalex.org/keywords/in-vitro-cancer-models","display_name":"in vitro tumor model","score":0.671999990940094},{"id":"https://openalex.org/keywords/thyroid-cell-lines","display_name":"thyroid cell lines","score":0.6629999876022339},{"id":"https://openalex.org/keywords/autonomous-thyroid-adenoma","display_name":"autonomous thyroid adenoma","score":0.8999999761581421},{"id":"https://openalex.org/keywords/dedifferentiation","display_name":"dedifferentiation","score":0.6629999876022339},{"id":"https://openalex.org/keywords/anaplastic-thyroid-carcinoma","display_name":"anaplastic thyroid carcinoma","score":0.9399999976158142},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.9279999732971191},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5559999942779541},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.4880000054836273},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.9700000286102295},{"id":"https://openalex.org/keywords/kidney-cancer","display_name":"kidney cancer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.953000009059906},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":1.0}],"concepts":[{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.6276999711990356},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5989999771118164},{"id":"https://openalex.org/C6045943","wikidata":"https://www.wikidata.org/wiki/Q21014462","display_name":"Immortalised cell line","level":3,"score":0.5939000248908997},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.592199981212616},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5848000049591064},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.5676000118255615},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5047000050544739},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.48820000886917114},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.48339998722076416},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4510999917984009},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.43720000982284546},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4359000027179718},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.4327999949455261},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.41339999437332153},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4101000130176544},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.3977000117301941},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.335099995136261},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3296999931335449},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.32519999146461487},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.30160000920295715},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.29679998755455017},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.28459998965263367},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.2838999927043915},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.28119999170303345},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.27889999747276306},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.26989999413490295},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2689000070095062},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.263700008392334},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.25609999895095825}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:dipot.ulb.ac.be:2013/210296","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210296","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:dipot.ulb.ac.be:2013/210296","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210296","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7095603399","https://openalex.org/W2119644508","https://openalex.org/W1968134619","https://openalex.org/W1431693663","https://openalex.org/W2427903304","https://openalex.org/W2890921698","https://openalex.org/W2336337771","https://openalex.org/W2098372329","https://openalex.org/W3042912106","https://openalex.org/W2015614769"],"abstract_inverted_index":{"New":[0],"technologies":[1,390],"to":[2,37,64,89,104,159,174,259,286,333,363,392,411],"probe":[3],"the":[4,8,48,106,119,151,160,165,178,208,217,237,281,289,298,303,306,326,347,358,361,394,406,413],"global":[5],"output":[6],"of":[7,50,109,117,142,154,167,169,180,184,197,223,234,239,264,268,305,318,328,335,350,360,375,382,405],"normal":[9,200],"and":[10,31,39,52,68,77,80,86,95,112,126,138,183,205,227,331,343,353,384,403],"cancer":[11,51,66,378],"genomes":[12],"have":[13,42,257,367],"recently":[14],"reached":[15],"widespread":[16],"use.":[17],"The":[18,92],"resulting":[19],"genomewide":[20],"gene":[21,26,30,171,319],"expression":[22,27,172,320],"profiles,":[23,173],"e.g,":[24],"a":[25,189,221,231,260,372],"measurement":[28],"per":[29,32],"tissue":[33],"sample,":[34],"remain":[35],"challenging":[36],"analyze":[38],"interpret,":[40],"but":[41],"already":[43],"provided":[44],"new":[45],"insights":[46],"into":[47,177,230],"pathophysiology":[49],"towards":[53],"personalized":[54],"care.":[55],"In":[56,131,188],"vitro":[57,98,157],"cell":[58,136,246,255,273,290,299,329],"culture-based":[59],"experimental":[60,99,110,397,407],"models":[61,100,111,141,158,352,398,408],"are":[62,101,399,409],"used":[63,285],"elucidate":[65],"onset":[67],"progression":[69],"because":[70,81],"experimentation":[71],"in":[72,97,156,161,186,396,415],"humans":[73],"is":[74],"difficult":[75],"practically":[76],"ethically":[78],"unacceptable,":[79],"they":[82,369],"provide":[83,228],"simplified,":[84],"reproducible":[85],"controlled":[87],"systems":[88],"test":[90],"hypotheses.":[91],"thyroid":[93,181,201,219,225,253,272,312],"tumors":[94,128,185,332,376],"their":[96,170,265],"particularly":[102],"suited":[103],"compare":[105],"molecular":[107],"phenotypes":[108],"tumors.":[113],"From":[114],"one":[115],"type":[116,222],"cell,":[118],"thyrocyte,":[120],"at":[121],"least":[122],"five":[123,336],"distinct":[124],"benign":[125,224],"malignant":[127],"can":[129],"arise.":[130],"addition,":[132],"many":[133],"immortalized":[134,252],"tumor-derived":[135,254],"lines":[137,256,291,300,330],"primary":[139,195],"cultures":[140,196],"these":[143,155,351,365],"cells":[144,202,366],"exist.":[145],"This":[146],"thesis":[147],"has":[148],"focused":[149],"on":[150],"bioinformatic":[152],"comparison":[153,327],"vivo":[162],"tumors,":[163,182],"from":[164,277],"point":[166],"view":[168],"gain":[175],"insight":[176,229],"pathogenesis":[179],"general.":[187],"first":[190,282],"study,":[191,283],"we":[192,249,295,324],"showed":[193,296],"that":[194,242,251,288,297],"freshly":[198],"isolated":[199],"where":[203],"proliferation":[204],"differentiation":[206,274],"through":[207],"TSHR/cAMP":[209,271],"pathway":[210],"was":[211,284],"chronically":[212],"activated":[213],"experimentally":[214],"resemble":[215,301],"specifically":[216],"autonomous":[218],"adenomas,":[220],"tumor,":[226],"general":[232],"mechanism":[233],"tumor":[235,266,386],"progression:":[236],"suppression":[238],"negative":[240],"feedbacks":[241],"normally":[243],"restrain":[244],"excessive":[245],"division.":[247],"Subsequently,":[248],"found":[250],"converged":[258],"common":[261],"phenotype":[262,304],"regardless":[263],"subtype":[267],"origin.":[269],"A":[270],"signature,":[275],"derived":[276],"data":[278],"obtained":[279],"for":[280],"show":[287],"were":[292],"dedifferentiated.":[293],"Accordingly,":[294],"most":[302],"more":[307],"dedifferentiated,":[308],"clinically":[309],"aggressive":[310],"anaplastic":[311],"cancers.":[313],"Finally,":[314],"using":[315],"large":[316],"databases":[317],"profiles":[321],"publicly":[322],"available,":[323],"extended":[325],"cancers":[334],"other":[337,389],"organs:":[338],"breast,":[339],"colon,":[340],"kidney,":[341],"ovary":[342],"lung.":[344],"We":[345],"discuss":[346],"correct":[348],"use":[349],"advance":[354],"an":[355],"hypothesis":[356],"regarding":[357],"nature":[359],"state":[362],"which":[364],"converged:":[368],"could":[370],"represent":[371],"surviving":[373],"subpopulation":[374],"cells,":[377,380],"stem":[379],"capable":[381],"initiating":[383],"maintaining":[385],"growth.":[387],"As":[388],"designed":[391],"perturb":[393],"genome":[395],"emerging,":[400],"careful":[401],"characterization":[402],"validation":[404],"needed":[410],"extrapolate":[412],"results":[414],"vivo.":[416]},"counts_by_year":[],"updated_date":"2026-08-08T01:25:22.217667","created_date":"2025-10-10T00:00:00"}
